151 research outputs found
Local Drivers of Marine Heatwaves: A Global Analysis With an Earth System Model
Marine heatwaves (MHWs) are periods of extreme warm ocean temperatures that can have devastating impacts on marine organisms and socio-economic systems. Despite recent advances in understanding the underlying processes of individual events, a global view of the local oceanic and atmospheric drivers of MHWs is currently missing. Here, we use daily-mean output of temperature tendency terms from a comprehensive fully coupled coarse-resolution Earth system model to quantify the main local processes leading to the onset and decline of surface MHWs in different seasons. The onset of MHWs in the subtropics and mid-to-high latitudes is primarily driven by net ocean heat uptake associated with a reduction of latent heat loss in all seasons, increased shortwave heat absorption in summer and reduced sensible heat loss in winter, dampened by reduced vertical mixing from the non-local portion of the K-Profile Parameterization boundary layer scheme (KPP) especially in summer. In the tropics, ocean heat uptake is reduced and lowered vertical local mixing and diffusion cause the warming. In the subsequent decline phase, increased ocean heat loss to the atmosphere due to enhanced latent heat loss in all seasons together with enhanced vertical local mixing and diffusion in the high latitudes during summer dominate the temperature decrease globally. The processes leading to the onset and decline of MHWs are similar for short and long MHWs, but there are differences in the drivers between summer and winter. Different types of MHWs with distinct driver combinations are identified within the large variability among events. Our analysis contributes to a better understanding of MHW drivers and processes and may therefore help to improve the prediction of high-impact marine heatwaves
Metal artifact reduction in Ga-PSMA-11 PET/MRI for prostate cancer patients with hip joint replacement using multiacquisition variable-resonance image combination
BACKGROUND
PET/MRI has a high potential in oncology imaging, especially for tumor indications where high soft tissue contrast is crucial such as genitourinary tumors. One of the challenges for PET/MRI acquisition is handling of metal implants. In addition to conventional methods, more innovative techniques have been developed to reduce artifacts caused by those implants such as the selective multiacquisition variable-image combination (MAVRIC-SL). The aim of this study is to perform a quantitative and qualitative assessment of metal artifact reduction in Ga-PSMA-11 PET/MRI for prostate cancer patients with hip joint replacement using a selective MAVRIC-SL sequence for the whole pelvis.
METHODS
We retrospectively analyzed data of 20 men with 37 metal hip implants diagnosed with PCA, staged or restaged by Ga-PSMA-11 PET/MRI from June 2016 to December 2017. Each signal cancellation per side or metal implant was analyzed on the reference sequence LAVA-FLEX, as well as T1-weighted fast spin echo (T1w-FSE) sequence and MAVRIC-SL. Two independent reviewers reported on a four-point scale whether abnormal pelvic Ga-PSMA-11 uptake could be assigned to an anatomical structure in the tested sequences.
RESULTS
The smallest averaged signal void was observed on MAVRIC-SL sequences with a mean artifact size of 26.17 cm (range 12.63 to 42.93 cm, p < 0.001). The best image quality regarding anatomical assignment of pathological PSMA uptakes in the pelvis by two independent readers was noted for MAVRIC-SL sequences, followed by T1w-FSE with excellent interreader agreement.
CONCLUSIONS
MAVRIC-SL sequence allows better image quality in the surrounding of hip implants by reducing MR signal voids and increasing so the accuracy of anatomical assignment of pathological Ga-PSMA-11 uptake in the pelvis over LAVA-FLEX and T1w-FSE sequences
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Cryogenic Neutron Spectrometer Development
Cryogenic microcalorimeter detectors operating at temperatures around {approx}0.1 K have been developed for the last two decades, driven mostly by the need for ultra-high energy resolution (<0.1%) in X-ray astrophysics and dark matter searches [1]. The Advanced Detector Group at Lawrence Livermore National Laboratory has developed different cryogenic detector technologies for applications ranging from X-ray astrophysics to nuclear science and non-proliferation. In particular, we have adapted cryogenic detector technologies for ultra-high energy resolution gamma-spectroscopy [2] and, more recently, fast-neutron spectroscopy [3]. Microcalorimeters are essentially ultra-sensitive thermometers that measure the energy of the radiation from the increase in temperature upon absorption. They consist of a sensitive superconducting thermometer operated at the transition between its superconducting and its normal state, where its resistance changes very rapidly with temperature such that even the minute energies deposited by single radiation quanta are sufficient to be detectable with high precision. The energy resolution of microcalorimeters is fundamentally limited by thermal fluctuations to {Delta}E{sub FWHM} {approx} 2.355 (k{sub B}T{sup 2}C{sub abs}){sup 1/2}, and thus allows an energy below 1 keV for neutron spectrometers for an operating temperature of T {approx} 0.1 K . The {Delta}E{sub FWHM} does not depend on the energy of the incident photon or particle. This expression is equivalent to the familiar (F{var_epsilon}E{sub {gamma}}){sup 1/2} considering that an absorber at temperature T contains a total energy C{sub abs}T, and the associated fluctuation are due to variations in uncorrelated (F=1) phonons ({var_epsilon} = k{sub B}T) dominated by the background energy C{sub abs}T >> E{gamma}. The rationale behind developing a cryogenic neutron spectrometer is the very high energy resolution combined with the high efficiency. Additionally, the response function is simple and the instrument is transportable. We are currently developing a fast neutron spectrometer with 0.1% energy resolution at 1 MeV neutron energy with an efficiency of > 1%. Our fast-neutron spectrometers use boron-based and {sup 6}LiF absorber crystals with Mo/Cu thermistors readout. They have achieved an energy resolution of 5.5 keV FWHM for 2.79 MeV deposited in {sup 10}B by thermal neutron capture (fig. 1), and 46 keV FWHM for fast (MeV) neutrons absorbed in {sup 6}LiF (fig. 2). Since the energy resolution does not depend on the neutron energy, we expect a similar energy resolution for MeV neutron energies. The response function is given simply by the cross section of the capture reaction, offset from zero by the Q-value of the capture reaction. This allows straightforward discrimination against gamma-events, most of which deposit less that Q{sub 6Li} = 4.79 MeV in the {sup 6}LiF absorber, and easy deconvolution of the neutron spectrum, since there is only a single capture reaction in {sup 6}Li and the spectrum is not affected by edge effects or geometric broadening. The current challenge for microcalorimeters is their necessarily small effective pixel area, {approx}1cm{sup 3} for neutron spectrometer pixels, and their slow decay time, {approx}10ms for neutron spectrometers. The pixel size is limited by the requirement for low Cabs for high energy resolution; the decay time is set by the intrinsically weak thermal coupling between materials at low temperatures. Both issues can be addressed by fabricating large detector arrays. This will enable high-precision neutron spectrometry with high statistics, such as simulated for Pu analysis in fig 3
Irreversible loss in marine ecosystem habitability after a temperature overshoot
Anthropogenic warming of the oceans and associated deoxygenation are altering marine ecosystems. Current knowledge suggests these changes may be reversible on a centennial timescale at the ocean surface but irreversible at deeper depths even if global warming were to ameliorate. In contrast, the marine ecosystem’s response to these persistent changes remains poorly elucidated. Here we explore to what extent global warming may drive alterations in marine habitats by exploring the evolution of a metabolic index that captures marine organisms’ ecophysiological response to both temperature and oxygen changes, throughout an idealised ramp-up/ramp-down atmospheric carbon dioxide concentration and an overshoot scenarios. Using a multi-model approach; we find that changes in ocean temperature and oxygen drive a centuries-long irreversible loss in the habitable volume of the upper 1000 m of the world ocean. These results suggest that the combined effect of warming and deoxygenation will have profound and long-lasting impacts on the viability of marine ecosystems, well after global temperatures have peaked.publishedVersio
KiDS-1000 Cosmology: Constraints from density split statistics
Context. Weak lensing and clustering statistics beyond two-point functions
can capture non-Gaussian information about the matter density field, thereby
improving the constraints on cosmological parameters relative to the mainstream
methods based on correlation functions and power spectra. Aims. This paper
presents a cosmological analysis of the fourth data release of the Kilo Degree
Survey based on the density split statistics, which measures the mean shear
profiles around regions classified according to foreground densities. The
latter is constructed from a bright galaxy sample, which we further split into
red and blue samples, allowing us to probe their respective connection to the
underlying dark matter density. Methods. We use the state-of-the-art model of
the density splitting statistics and validate its robustness against mock data
infused with known systematic effects such as intrinsic galaxy alignment and
baryonic feedback. Results. After marginalising over the photometric redshift
uncertainty and the residual shear calibration bias, we measure for the full
KiDS-bright sample a structure growth parameter of that is competitive to and
consistent with two-point cosmic shear results, a matter density of
, and a constant galaxy bias of .Comment: 18 pages, 23 Figures. Submitted to A&
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The Zero Emissions Commitment Model Intercomparison Project (ZECMIP) contribution to C4MIP: Quantifying committed climate changes following zero carbon emissions
The amount of additional future temperature change following a complete cessation of CO2 emissions is a measure of the unrealized warming to which we are committed due to CO2 already emitted to the atmosphere. This “zero emissions commitment” (ZEC) is also an important quantity when estimating the remaining carbon budget – a limit on the total amount of CO2 emissions consistent with limiting global mean temperature at a particular level. In the recent IPCC Special Report on Global Warming of 1.5 ∘C, the carbon budget framework used to calculate the remaining carbon budget for 1.5 ∘C included the assumption that the ZEC due to CO2 emissions is negligible and close to zero. Previous research has shown significant uncertainty even in the sign of the ZEC. To close this knowledge gap, we propose the Zero Emissions Commitment Model Intercomparison Project (ZECMIP), which will quantify the amount of unrealized temperature change that occurs after CO2 emissions cease and investigate the geophysical drivers behind this climate response. Quantitative information on ZEC is a key gap in our knowledge, and one that will not be addressed by currently planned CMIP6 simulations, yet it is crucial for verifying whether carbon budgets need to be adjusted to account for any unrealized temperature change resulting from past CO2 emissions. We request only one top-priority simulation from comprehensive general circulation Earth system models (ESMs) and Earth system models of intermediate complexity (EMICs) – a branch from the 1 % CO2 run with CO2 emissions set to zero at the point of 1000 PgC of total CO2 emissions in the simulation – with the possibility for additional simulations, if resources allow. ZECMIP is part of CMIP6, under joint sponsorship by C4MIP and CDRMIP, with associated experiment names to enable data submissions to the Earth System Grid Federation. All data will be published and made freely available
Is there warming in the pipeline? A multi-model analysis of the Zero Emissions Commitment from CO<sub>2</sub>
The Zero Emissions Commitment (ZEC) is the change in global mean temperature expected to occur following the cessation of net CO2 emissions and as such is a critical parameter for calculating the remaining carbon budget. The Zero Emissions Commitment Model Intercomparison Project (ZECMIP) was established to gain a better understanding of the potential magnitude and sign of ZEC, in addition to the processes that underlie this metric. A total of 18 Earth system models of both full and intermediate complexity participated in ZECMIP. All models conducted an experiment where atmospheric CO2 concentration increases exponentially until 1000 PgC has been emitted. Thereafter emissions are set to zero and models are configured to allow free evolution of atmospheric CO2 concentration. Many models conducted additional second-priority simulations with different cumulative emission totals and an alternative idealized emissions pathway with a gradual transition to zero emissions. The inter-model range of ZEC 50 years after emissions cease for the 1000 PgC experiment is −0.36 to 0.29 ∘C, with a model ensemble mean of −0.07 ∘C, median of −0.05 ∘C, and standard deviation of 0.19 ∘C. Models exhibit a wide variety of behaviours after emissions cease, with some models continuing to warm for decades to millennia and others cooling substantially. Analysis shows that both the carbon uptake by the ocean and the terrestrial biosphere are important for counteracting the warming effect from the reduction in ocean heat uptake in the decades after emissions cease. This warming effect is difficult to constrain due to high uncertainty in the efficacy of ocean heat uptake. Overall, the most likely value of ZEC on multi-decadal timescales is close to zero, consistent with previous model experiments and simple theory
Spaces of Yoga – Towards a Non-Essentialist Understanding of Yoga
This chapter will examine some of the spaces that yoga occupies in the contemporary world, both physical and social. By looking at yoga through the focus of particular, contested spaces and locations, it will be argued that overarching essentialist definitions of yoga are impossible, although individuals and social groups can and do create essentialist definitions that are more or less useful for particular purposes. By exploring these narratives and boundaries in the context of specific locations, we can better understand what people are doing with the collection of beliefs and practices known as yoga
Lung Volume, Breathing Pattern and Ventilation Inhomogeneity in Preterm and Term Infants
BACKGROUND: Morphological changes in preterm infants with bronchopulmonary dysplasia (BPD) have functional consequences on lung volume, ventilation inhomogeneity and respiratory mechanics. Although some studies have shown lower lung volumes and increased ventilation inhomogeneity in BPD infants, conflicting results exist possibly due to differences in sedation and measurement techniques. METHODOLOGY/PRINCIPAL FINDINGS: We studied 127 infants with BPD, 58 preterm infants without BPD and 239 healthy term-born infants, at a matched post-conceptional age of 44 weeks during quiet natural sleep according to ATS/ERS standards. Lung function parameters measured were functional residual capacity (FRC) and ventilation inhomogeneity by multiple breath washout as well as tidal breathing parameters. Preterm infants with BPD had only marginally lower FRC (21.4 mL/kg) than preterm infants without BPD (23.4 mL/kg) and term-born infants (22.6 mL/kg), though there was no trend with disease severity. They also showed higher respiratory rates and lower ratios of time to peak expiratory flow and expiratory time (t(PTEF)/t(E)) than healthy preterm and term controls. These changes were related to disease severity. No differences were found for ventilation inhomogeneity. CONCLUSIONS: Our results suggest that preterm infants with BPD have a high capacity to maintain functional lung volume during natural sleep. The alterations in breathing pattern with disease severity may reflect presence of adaptive mechanisms to cope with the disease process
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