9 research outputs found
Synchronisation d'un récepteur Chaos Shift Keying par filtrage Unscented Kalman
International audienc
Rheumatoid arthritis and polymyalgia rheumatica occurring after immune checkpoint inhibitor treatment
International audienc
Tocilizumab-treated convalescent COVID-19 patients retain the cross-neutralization potential against SARS-CoV-2 variants
International audienceAlthough tocilizumab treatment in severe and critical coronavirus disease 2019 (COVID-19) patients has proven its efficacy at the clinical level, there is little evidence supporting the effect of short-term use of interleukin-6 receptor blocking therapy on the B cell sub-populations and the cross-neutralization of SARS-CoV-2 variants in convalescent COVID-19 patients. We performed immunological profiling of 69 tocilizumab-treated and non-treated convalescent COVID-19 patients in total. We observed that SARS-CoV-2-specific IgG1 titers depended on disease severity but not on tocilizumab treatment. The plasma of both treated and non-treated patients infected with the ancestral variant exhibit strong neutralizing activity against the ancestral virus and the Alpha, Beta, and Delta variants of SARS-CoV-2, whereas the Gamma and Omicron viruses were less sensitive to seroneutralization. Overall, we observed that, despite the clinical benefits of short-term tocilizumab therapy in modifying the cytokine storm associated with COVID-19 infections, there were no modifications in the robustness of B cell and IgG responses to Spike antigens
OME-Zarr : A cloud-optimized bioimaging file format with international community support
A growing community is constructing a next-generation file format (NGFF) for bioimaging to overcome problems of scalability and heterogeneity. Organized by the Open Microscopy Environment (OME), individuals and institutes across diverse modalities facing these problems have designed a format specification process (OME-NGFF) to address these needs. This paper brings together a wide range of those community members to describe the cloud-optimized format itself-OME-Zarr-along with tools and data resources available today to increase FAIR access and remove barriers in the scientific process. The current momentum offers an opportunity to unify a key component of the bioimaging domain-the file format that underlies so many personal, institutional, and global data management and analysis tasks
Le développement durable à découvert
Vingt ans aprĂšs la premiĂšre confĂ©rence de Rio, quâest devenue la proposition de conduire nos sociĂ©tĂ©s vers un dĂ©veloppement durable ? AdoptĂ© par les uns, utilisĂ© comme faire-valoir par les autres, ce concept de dĂ©veloppement durable est souvent vidĂ© de son sens. Or, lâimpact exponentiel des activitĂ©s humaines sur les ressources naturelles, la santĂ© des populations et le milieu exige dâexpliquer ce quâil est prĂ©cisĂ©ment. Quâest-ce que le dĂ©veloppement durable aujourdâhui ? Quâen est-il de la disponibilitĂ© des ressources et de lâusage que nous en faisons ? Dans le domaine de lâeau, du climat, des sols, de la biodiversitĂ© ? En milieu rural, sur le littoral ou encore en milieu urbain, lĂ oĂč la majoritĂ© de la population va vivre dâici 2050, comment consommons-nous au fil du temps, Ă travers les territoires ? Quelles incidences les activitĂ©s humaines ont-elles sur les ressources, sur la santĂ© des populations et sur le milieu lui-mĂȘme ? Les relations entre lâhumanitĂ© et lâenvironnement doivent-elles Ă©voluer ? Autant de questions posĂ©es Ă des scientifiques qui Ă©claircissent la complexitĂ© des interactions entre les systĂšmes et proposent des solutions pour un avenir sur le long terme. De nos Ă©cosystĂšmes Ă nos modes de consommation, des risques naturels aux nouvelles technologies ou aux pollutions, des usines du futur au traitement des dĂ©chets, Le dĂ©veloppement durable Ă dĂ©couvert informe, explique, partage tout ce que la science actuelle est capable dâapporter au dĂ©fi majeur du xxie siĂšcle : comment mieux comprendre la complexitĂ© des enjeux qui nous concernent tous et assurer le dĂ©veloppement de lâhumanitĂ© sans dĂ©truire son biotope. Ăconomistes, physiciens, sociologues, agronomes, Ă©cologues... plus de 150 chercheurs se sont mobilisĂ©s pour associer leur expertise Ă leur regard critique et dĂ©crire, comprendre, modĂ©liser, imaginer, illustrations et schĂ©mas Ă lâappui, les outils destinĂ©s Ă construire les sociĂ©tĂ©s Ă©quitables de demain
Mechanical Thrombectomy for Acute Ischemic Stroke Amid the COVID-19 Outbreak
International audienceBackground and Purpose: The efficiency of prehospital care chain response and the adequacy of hospital resources are challenged amid the coronavirus disease 2019 (COVID-19) outbreak, with suspected consequences for patients with ischemic stroke eligible for mechanical thrombectomy (MT). Methods: We conducted a prospective national-level data collection of patients treated with MT, ranging 45 days across epidemic containment measures instatement, and of patients treated during the same calendar period in 2019. The primary end point was the variation of patients receiving MT during the epidemic period. Secondary end points included care delays between onset, imaging, and groin puncture. To analyze the primary end point, we used a Poisson regression model. We then analyzed the correlation between the number of MTs and the number of COVID-19 cases hospitalizations, using the Pearson correlation coefficient (compared with the null value). Results: A total of 1513 patients were included at 32 centers, in all French administrative regions. There was a 21% significant decrease (0.79; [95%CI, 0.76â0.82]; P <0.001) in MT case volumes during the epidemic period, and a significant increase in delays between imaging and groin puncture, overall (mean 144.9±SD 86.8 minutes versus 126.2±70.9; P <0.001 in 2019) and in transferred patients (mean 182.6±SD 82.0 minutes versus 153.25±67; P <0.001). After the instatement of strict epidemic mitigation measures, there was a significant negative correlation between the number of hospitalizations for COVID and the number of MT cases ( R 2 â0.51; P =0.04). Patients treated during the COVID outbreak were less likely to receive intravenous thrombolysis and to have unwitnessed strokes (both P <0.05). Conclusions: Our study showed a significant decrease in patients treated with MTs during the first stages of the COVID epidemic in France and alarming indicators of lengthened care delays. These findings prompt immediate consideration of local and regional stroke networks preparedness in the varying contexts of COVID-19 pandemic evolution
Successful Thrombectomy Improves Functional Outcome in Tandem Occlusions with a Large Ischemic Core
International audienceBackground: Emergent stenting in tandem occlusions and mechanical thrombectomy (MT) of acute ischemic stroke related to large vessel occlusion (LVO-AIS) with a large core are tested independently. We aim to assess the impact of reperfusion with MT in patients with LVO-AIS with a large core and a tandem occlusion and to compare the safety of reperfusion between large core with tandem and nontandem occlusions in current practice. Methods: We analyzed data of all consecutive patients included in the prospective Endovascular Treatment in Ischemic Stroke Registry in France between January 2015 and March 2023 who presented with a pretreatment ASPECTS (Alberta Stroke Program Early CT Score) of 0â5 and angiographically proven tandem occlusion. The primary end point was a favorable outcome defined by a modified Rankin Scale (mRS) score of 0â3 at 90 days. Results: Among 262 included patients with a tandem occlusion and ASPECTS 0â5, 203 patients (77.5%) had a successful reperfusion (modified Thrombolysis in Cerebral Infarction grade 2b-3). Reperfused patients had a favorable shift in the overall mRS score distribution (adjusted odds ratio [aOR], 1.57 [1.22â2.03]; P < 0.001), higher rates of mRS score 0â3 (aOR, 7.03 [2.60â19.01]; P < 0.001) and mRS score 0â2 at 90 days (aOR, 3.85 [1.39â10.68]; P = 0.009) compared with nonreperfused. There was a trend between the occurrence of successful reperfusion and a decreased rate of symptomatic intracranial hemorrhage (aOR, 0.5 [0.22â1.13]; P = 0.096). Similar safety outcomes were observed after large core reperfusion in tandem and nontandem occlusions. Conclusions: Successful reperfusion was associated with a higher rate of favorable outcome in large core LVO-AIS with a tandem occlusion, with a safety profile similar to nontandem occlusion