Entwicklung von neuen Algorithmen der Computerarithmetik in Hinsicht auf ihre Nutzung in der Kryptographie

In dieser Arbeit wird eine Reihe neuer Algorithmen aus dem Bereich der ganzzahligen Langzahlcomputerarithmetik für die Anwendungen vor allem aus dem Bereich der modernen Kryptographie entwickelt. Alle hier behandelten Verfahren wurden weiterhin in Bezug auf eine Realisierung in Hardware optimiert. Es werden drei thematische Schwerpunkte behandelt. Als erstes werden neue Methoden zur Berechnung der Modularmultiplikation aufgezeigt, die sich durch ein besonders günstiges Flächen-Zeit-Produkt auszeichnen. Das zweite Thema ist ein zeitoptimaler paralleler Algorithmus für die Modularmultiplikation, der eine Zeitkomplexität von O(log n) aufweist. Das dritte Thema behandelt ein Verfahren für die zeitoptimale Multiplikation, das eine bessere Flächen-Zeit-Komplexität als der in den meisten Prozessoren benutzte Wallace Tree und die Schönhage-Strassen-Multiplikation, welche in ihrer asymptotischen Flächen-Zeit-Komplexität besser ist als alle bisher bekannten Verfahren, aufweist

Enhanced translation by Nucleolin via G-rich elements in coding and non-coding regions of target mRNAs

RNA-binding proteins (RBPs) regulate gene expression at many post-transcriptional levels, including mRNA stability and translation. The RBP nucleolin, with four RNA-recognition motifs, has been implicated in cell proliferation, carcinogenesis and viral infection. However, the subset of nucleolin target mRNAs and the influence of nucleolin on their expression had not been studied at a transcriptome-wide level. Here, we globally identified nucleolin target transcripts, many of which encoded cell growth- and cancer-related proteins, and used them to find a signature motif on nucleolin target mRNAs. Surprisingly, this motif was very rich in G residues and was not only found in the 3′-untranslated region (UTR), but also in the coding region (CR) and 5′-UTR. Nucleolin enhanced the translation of mRNAs bearing the G-rich motif, since silencing nucleolin did not change target mRNA stability, but decreased the size of polysomes forming on target transcripts and lowered the abundance of the encoded proteins. In summary, nucleolin binds G-rich sequences in the CR and UTRs of target mRNAs, many of which encode cancer proteins, and enhances their translation

La ciudad del domingo: análisis del uso singular del espacio público

Las ciudades están en constante flujo, se adaptan y ajustan respondiendo a las necesidades y cambios de la sociedad. En la concepción de una ciudad sostenible hay que considerar esta capacidad de adaptación, se trata de poder transformar y ajustar los espacios existentes a nuevos paradigmas. Planteamos la adaptabilidad a través de estrategias temporales. Estas estrategias tienen la característica de encontrarse dentro del marco de lo singular, son fenómenos que no estaban previstos para capturar el espacio, pero consiguen acomodarse y establecer nuevas formas de usarlo. Es lo que denominamos la ciudad del domingo, y se diferencia del resto de días de la semana por su capacidad de modificar temporalmente el imaginario colectivo de un lugar. Son estas actividades singulares de ocupación las que promueven nuevas maneras de usar y habitar la ciudad, es un ensayo de lo que podría ser. El trabajo es un ejercicio de observación en el que se analizan estos fenómenos singulares que tienen lugar en el soporte de la ciudad. A través de la representación de diferentes casos, se grafían los usos y como estos se relacionan con el espacio. Buscamos extraer observaciones que puedan ayudar a entender cómo estos fenómenos se adaptan y dan diferentes usos a la ciudad.Objectius de Desenvolupament Sostenible::11 - Ciutats i Comunitats Sostenible

A Complexity-Effective Version of Montgomery’s Algorithm

Abstract--A new version of Montgomery’s algorithm for modular multiplication of large integers and its implementation in hardware is presented. It has been designed to meet the predominant requirements of most modern devices: small chip area and low power consumption. The algorithm is superior to the original method by a factor of 2, with respect to both area and latency. The new method has a simple structure. It requires a small amount of precomputation and storage in order to reduce the number of neccessary additions by a factor of 2. Index terms—modulo multiplication, carry save addition, Montgomery algorithm A

A Complexity-Effective Version of Montgomery's Algorihm

A new version of Montgomery’s algorithm for modular multiplication of large integers and its implementation in hardware is presented. It has been designed to meet the predominant requirements of most modern devices: small chip area and low power consumption. The algorithm is superior to the original method by a factor of 2, with respect to both area and latency. The new method has a simple structure. It requires a small amount of precomputation and storage in order to reduce the number of neccessary additions by a factor of 2

Early Successes in an Open Access, Provincially Funded Hepatitis C Treatment Program in Prince Edward Island

Introduction. The availability of curative hepatitis C therapies has created an opportunity to improve treatment delivery and access. Local providers, government, industry, and community groups in Prince Edward Island developed an innovative province-wide care model. Our goal was to describe the first year of program implementation.Material and methods. Using a communitybased prospective observational study design, all chronic hepatitis C referrals received from April 2015 to April 2016 were recorded in a database. Primary analysis assessed the time from referral to assessment/treatment, as well as the number of referrals, assessments, and treatment initiations. Secondary objectives included: (1) treatment effectiveness using intention-to-treat analysis; and (2) patient treatment experience assessed using demographics, adverse events, and medication adherence.Results. During the study period 242 referrals were received, 123 patients were seen for intake assessments, and 93 initiated direct-acting antiviral therapy based on medical need. This is compared to 4 treatment initiations in the previous 2 years. The median time from assessment to treatment initiation was 3 weeks. Eighty-two of 84 (97.6%, 95% CI 91.7 - 99.7%) patients for whom outcome data were available achieved sustained virologic response at 12 weeks post-treatment; 1 was lost to follow-up and 1 died from an unrelated event. In the voluntary registry, 39.7% of patients reported missed treatment doses.Conclusion. In conclusion, results from the first 12 months of this multi-phase hepatitis C elimination strategy demonstrate improved access to treatment, and high rates of safe engagement and cure for patients living with chronic hepatitis C genotype 1 infections