1,742 research outputs found
Photoacoustic Characterization Of A Two-layer System
In this paper the use of the so-called open photoacoustic cell for thermal characterization of two-layer systems of variable thickness is described. It is shown that the thermal diffusivity as well as the thermal conductivity are completely determined, based upon the effective sample model widely used in heat-transfer problems.70117046705
Groot draagvlak voor water en natuur in de uiterwaarden
Om de veiligheid te waarborgen worden momenteel nieuwe veiligheidsmaatregelen de rivieren overwogen. In het verleden zijn dergelijke maatregelen vaak gecombineerd met natuurontwikkeling in de uiterwaarden. De bevolking heeft bij aanvang van dergelijke projecten regelmatig geprotesteerd tegen de maatregelen. Enige jaren nadat de natuurontwikkeling is afgerond, blijken de meeste omwonenden echter opvallend positief te zijn over de genomen maatregelen. De weerstand vooraf wordt echter niet veroorzaakt door algemene weerstand tegen veranderingen, maar vooral doordat de binding met het landschap voor de omwonenden erop achteruitgaat. Vooral boeren en oudere omwonenden vinden dat een verlies aan kwaliteit. Voor de meeste omwonenden en recreanten wordt dit verlies aan binding echter ruimschoots gecompenseerd, doordat de aantrekkelijkheid van het landschap erop vooruitgaa
Solubility of sulfur compounds in commercial physical solvents and an ionic liquid from Monte Carlo simulations
Unfolding-Based Process Discovery
This paper presents a novel technique for process discovery. In contrast to
the current trend, which only considers an event log for discovering a process
model, we assume two additional inputs: an independence relation on the set of
logged activities, and a collection of negative traces. After deriving an
intermediate net unfolding from them, we perform a controlled folding giving
rise to a Petri net which contains both the input log and all
independence-equivalent traces arising from it. Remarkably, the derived Petri
net cannot execute any trace from the negative collection. The entire chain of
transformations is fully automated. A tool has been developed and experimental
results are provided that witness the significance of the contribution of this
paper.Comment: This is the unabridged version of a paper with the same title
appearead at the proceedings of ATVA 201
Synthesis and photophysical properties of benzotriazole-derived unnatural α -amino acids
The synthesis of a new class of benzotriazole-derived α-amino acid is described using a highly efficient nucleophilic aromatic substitution of ortho-fluoronitrobenzenes with l-3-aminoalanine and a polymer-supported nitrite reagent-mediated diazotization and cyclization of the subsequent 1,2-aryldiamines as the key steps. Further functionalization of the benzotriazole unit by preparation of halogenated analogues and Suzuki–Miyaura cross-coupling with aryl boronic acids allowed the synthesis of α-amino acids with conjugated side chains. Analysis of the photophysical properties of these α-amino acids revealed that incorporation of electron-rich substituents results in charge-transfer-based, fluorescent compounds with MegaStokes shifts
Translocation of BCR to chromosome 9: A new cytogenetic variant detected by FISH in two Ph-negative, BCR-positive patients with chronic myeloid leukemia
Leukemic cells from two patients with Philadelphia-negative chronic myeloid leukemia (CML) were investigated: I) Cytogenetics showed a normal 46.XY karyotype in both cases, 2) molecular studies revealed rearrangement of the M-BCR region and formation of BCR-ABL fusion mRNA with b2a2 (patient I) or b3a2 (patient 2) configuration, and 3) fluorescence in situ hybridization (FISH) demonstrated relocation of the 5′ BCR sequences from one chromosome 22 to one chromosome 9. The ABL probe hybridized to both chromosomes 9 at band q34, while two other probes which map centromeric and telomeric of BCR on 22q 11 hybridized solely with chromosome 22. For the first time, a BCR-ABL rearrangement is shown to take place on 9q34 instead of in the usual location on 22q 11. A rearrangement in the latter site is found in all Ph-positive CML and in almost all investigated CML with variant Ph or Ph-negative, BCR-positive cases. The few aberrant chromosomal localizations of BCR-ABL recombinant genes found previously were apparently the result of complex and successive changes. Furthermore in patient 2, both chromosomes 9 showed positive FISH signals with both ABL and BCR probes. Restriction fragment length polymorphism (RFLP) analysis indicated that mitotic recombination had occurred on the long arm of chromosome 9 and that the rearranged chromosome 9 was of paternal origin. The leukemic cells of this patient showed a duplication of the BCR-ABL gene, analogous to duplication of the Ph chromosome in classic CML. In addition they had lost the maternal alleles of the 9q34 chromosomal region. The lymphocytes of patient 2 carried the maternal chromosome 9 alleles and were Ph-negative as evidenced by RFLP and FISH analyses, respectively. © 1993 Wiley-Liss, Inc
Measurement of fraction unbound paclitaxel in human plasma
The clinical pharmacokinetic behavior of paclitaxel (Taxol) is distinctly
nonlinear, with disproportional increases in systemic exposure with an
increase in dose. We have recently shown that Cremophor EL, the
formulation vehicle used for i.v. administration of paclitaxel, alters
drug distribution as a result of micellar entrapment of paclitaxel, and we
speculated that the free drug fraction (fu) is dependent on dose and
time-varying concentrations of Cremophor EL in the central plasma
compartment. To test this hypothesis, a reproducible equilibrium dialysis
method has been developed for the measurement of paclitaxel fu in plasma.
Equilibrium dialysis was performed at 37 degrees C in a humidified
atmosphere of 5% CO(2) using 2.0-ml polypropylene test tubes. Experiments
were carried out with 260-microliter aliquots of plasma containing a
tracer amount of [G-(3)H]paclitaxel with high-specific activity against an
equal volume of 0.01 M phosphate buffer (pH 7.4). Drug concentrations were
measured by both reversed-phase HPLC and liquid scintillation counting.
Using this method, fu has been measured in three patients receiving three
consecutive 3-weekly courses of paclitaxel at dose levels of 135, 175, and
225 mg/m(2) and found to range between 0.036 and 0.079. The method was
also used to define concentration-time profiles of unbound drug, estimated
from the product of the total plasma concentration and fu
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