1,012 research outputs found

    Local cohomology in classical rings

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    The aim of this paper is to stablish the close connection between prime ideals and torsion theories in anon necessarily commutative noetherian ring. We introduce a new definition of support of a module and characterize some kinds of torsion theories in terms of prime ideals. Using the machinery introduced before, we prove a version of the Mayer-Vietoris Theorem for local cohomology and stablish a relationship between the classical dimension and the vanishing of the groups of local cohomology on a classical ring

    Chronic proliferative rhinitis in sheep: An update

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    Chronic proliferative rhinitis (CPR) is a slow and progressive upper respiratory tract disease of sheep with a poor prognosis for affected animals. It causes a proliferative inflammation of the ventral nasal turbinates with uni or bilateral affection that may totally obstruct the nasal cavity. Salmonella enterica subspecies diarizonae serovar 61:k:1, 5, (7) has been associated with the disease. This microorganism, host-adapted of tonsils and nasal cavity of sheep, has been isolated in pure culture from the nasal cavity in all reported cases of CPR. However, its etiopathogenesis, mechanism of transmission and its involvement with the disease are still unknown. The present article focuses on describing the current knowledge about this disease gathering the published information and offering some new data on the latest research carried out on chronic proliferative rhinitis in sheep

    An Effective Method for InSAR Mapping of Tropical Forest Degradation in Hilly Areas

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    Current satellite remote sensing methods struggle to detect and map forest degradation, which is a critical issue as it is likely a major and growing source of carbon emissions and biodiveristy loss. TanDEM-X InSAR phase height (hϕ) is a promising variable for measuring forest disturbances, as it is closely related to the mean canopy height, and thus should decrease if canopy trees are removed. However, previous research has focused on relatively flat terrains, despite the fact that much of the world’s remaining tropical forests are found in hilly areas, and this inevitably introduces artifacts in sideways imaging systems. In this paper, we find a relationship between hϕ and aboveground biomass change in four selectively logged plots in a hilly region of central Gabon. We show that minimising multilooking prior to the calculation of hϕ strengthens this relationship, and that degradation estimates across steep slopes in the surrounding region are improved by selecting data from the most appropriate pass directions on a pixel-by-pixel basis. This shows that TanDEM-X InSAR can measure the magnitude of degradation, and that topographic effects can be mitigated if data from multiple SAR viewing geometries are available

    Designing and implementing a massive open online course: Lessons learnt

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    •In this paper, we describe the design, implementation, and evaluation of a Massive Open Online Course, or MOOC, on good practice in the application of Intellectual Property. It is aimed primarily at teachers and students, and taught in Spanish. We have used the Spanish legislation on Intellectual Property. This paper outlines the structure and content of a course developed on an ad-hoc basis, and describes its evaluation by participants in questionnaires and a final survey. The results of the initial questionnaire are framed by a) the participant''s profile, and b) by consideration of the MOOC''s implementation, given the results of the satisfaction survey. In this paper we describe the advantages of the MOOC and identify areas for improvement

    Clinical features of De Novo acute myeloid leukemia with concurrent DNMT3A, FLT3 and NPM1 mutations

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    BACKGROUND: De novo acute myeloid leukemia (AML) with concurrent DNMT3A, FLT3 and NPM1 mutations (AML(DNMT3A/FLT3/NPM1)) has been suggested to represent a unique AML subset on the basis of integrative genomic analysis, but the clinical features of such patients have not been characterized systematically. METHODS: We assessed the features of patients (n = 178) harboring mutations in DNMT3A, FLT3 and/or NPM1, including an index group of AML(DNMT3A/FLT3/NPM1) patients. RESULTS: Patients with AML(DNMT3A/FLT3/NPM1) (n = 35) were significantly younger (median, 56.0 vs. 62.0 years; p = 0.025), mostly women (65.7% vs. 46.9%; p = 0.045), and presented with a higher percentage of bone marrow blasts (p < 0.001) and normal cytogenetics (p = 0.024) in comparison to patients within other mutation groups in this study. Among patients <60 years old, those with AML(DNMT3A/FLT3/NPM1) had a shorter event-free survival (EFS) (p = 0.047). DNMT3A mutations and not FLT3 or NPM1 mutations were independently associated with overall survival (OS) (p = 0.026). Within mutation subgroups, patients with AML(DNMT3A/NPM1) had a significantly shorter OS compared to those with AML(FLT3-ITD/NPM1) (p = 0.047) suggesting that the adverse impact of DNMT3A mutations is more pronounced than that of FLT3-ITD among patients with NPM1 mutation. CONCLUSIONS: DNMT3A has a significant dominant effect on the clinical features and outcomes of de novo AML patients with concurrent DNMT3A, FLT3 and NPM1 mutations. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13045-014-0074-4) contains supplementary material, which is available to authorized users

    Bigger, Better, Faster, More at the LHC

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    Multijet plus missing energy searches provide universal coverage for theories that have new colored particles that decay into a dark matter candidate and jets. These signals appear at the LHC further out on the missing energy tail than two-to-two scattering indicates. The simplicity of the searches at the LHC contrasts sharply with the Tevatron where more elaborate searches are necessary to separate signal from background. The searches presented in this article effectively distinguish signal from background for any theory where the LSP is a daughter or granddaughter of the pair-produced colored parent particle without ever having to consider missing energies less than 400 GeV.Comment: 26 pages, 8 Figures. Minor textual changes, typos fixed and references adde
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