Concentration of rocuronium in cerebrospinal fluid of patients undergoing cerebral aneurysm clipping†

Background. This study assessed the concentration of rocuronium in the cerebrospinal fluid (CSF) of patients undergoing cerebral aneurysm clipping, and investigated whether the mode of administration (single bolus vs continuous infusion) influenced the CSF concentration. Methods. Twenty patients with subarachnoid haemorrhage were randomly allocated to receive a bolus dose (bolus group), or a bolus followed by a continuous infusion of rocuronium (infusion group) (n=10 for each group). Arterial blood and ventricular CSF were sampled 2 h after the rocuronium bolus. Samples were analysed by liquid chromatography electrospray ionization‐tandem mass spectrometry. Results. Rocuronium could be detected in all the CSF samples. The mean (range) CSF concentration was 2.2 (0.9-4.6) ng ml-1 in the bolus group and 12.4 (2.4-34.6) ng ml-1 in the infusion group; P<0.01. Conclusions. This study demonstrated that rocuronium, normally not considered to cross the blood-brain barrier, is regularly found in the CSF of patients undergoing cerebral clipping; continuous infusion of the drug led to higher plasma and CSF concentrations than after a single bolus dose. Br J Anaesth 2004; 92: 419-2

A survey on the availability, usage and perception of neuromuscular monitors in Europe

Funding This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. This research was funded by the Flanders Innovation and Entrepreneurship Fund (VLAIO), the Willy Gepts Fund for Scientific Research, the Society for Anesthesia and Resuscitation of Belgium (BeSARPP), and the Vrije Universiteit Brussel (VUB).Peer reviewedPostprin

Chasing the impact of the Gaia-Sausage-Enceladus merger on the formation of the Milky Way thick disc

We employ our Bayesian Machine Learning framework BINGO (Bayesian INference for Galactic archaeOlogy) to obtain high-quality stellar age estimates for 68 360 red giant and red clump stars present in the 17th data release of the Sloan Digital Sky Survey, the APOGEE-2 high-resolution spectroscopic survey. By examining the denoised age-metallicity relationship of the Galactic disc stars, we identify a drop in metallicity with an increase in [Mg/Fe] at an early epoch, followed by a chemical enrichment episode with increasing [Fe/H] and decreasing [Mg/Fe]. This result is congruent with the chemical evolution induced by an early-epoch gas-rich merger identified in the Milky Way-like zoom-in cosmological simulation Auriga. In the initial phase of the merger of Auriga 18 there is a drop in metallicity due to the merger diluting the metal content and an increase in the [Mg/Fe] of the primary galaxy. Our findings suggest that the last massive merger of our Galaxy, the Gaia-Sausage-Enceladus, was likely a significant gas-rich merger and induced a starburst, contributing to the chemical enrichment and building of the metal-rich part of the thick disc at an early epoch

BICEP3: a 95 GHz refracting telescope for degree-scale CMB polarization

BICEP3 is a 550 mm-aperture refracting telescope for polarimetry of radiation in the cosmic microwave background at 95 GHz. It adopts the methodology of BICEP1, BICEP2 and the Keck Array experiments - it possesses sufficient resolution to search for signatures of the inflation-induced cosmic gravitational-wave background while utilizing a compact design for ease of construction and to facilitate the characterization and mitigation of systematics. However, BICEP3 represents a significant breakthrough in per-receiver sensitivity, with a focal plane area 5$\times$ larger than a BICEP2/Keck Array receiver and faster optics ($f/1.6$ vs. $f/2.4$). Large-aperture infrared-reflective metal-mesh filters and infrared-absorptive cold alumina filters and lenses were developed and implemented for its optics. The camera consists of 1280 dual-polarization pixels; each is a pair of orthogonal antenna arrays coupled to transition-edge sensor bolometers and read out by multiplexed SQUIDs. Upon deployment at the South Pole during the 2014-15 season, BICEP3 will have survey speed comparable to Keck Array 150 GHz (2013), and will significantly enhance spectral separation of primordial B-mode power from that of possible galactic dust contamination in the BICEP2 observation patch.Comment: 12 pages, 5 figures. Presented at SPIE Astronomical Telescopes and Instrumentation 2014: Millimeter, Submillimeter, and Far-Infrared Detectors and Instrumentation for Astronomy VII. To be published in Proceedings of SPIE Volume 915

Chasing the impact of the Gaia-Sausage-Enceladus merger on the formation of the Milky Way thick disc

We employ our Bayesian Machine Learning framework BINGO (Bayesian INference for Galactic archaeOlogy) to obtain high-quality stellar age estimates for 68,360 red giant and red clump stars present in the 17th data release of the Sloan Digital Sky Survey, the APOGEE-2 high-resolution spectroscopic survey. By examining the denoised age-metallicity relationship of the Galactic disc stars, we identify a drop in metallicity with an increase in [Mg/Fe] at an early epoch, followed by a chemical enrichment episode with increasing [Fe/H] and decreasing [Mg/Fe]. This result is congruent with the chemical evolution induced by an early-epoch gas-rich merger identified in the Milky Way-like zoom-in cosmological simulation Auriga. In the initial phase of the merger of Auriga 18 there is a drop in metallicity due to the merger diluting the metal content and an increase in the [Mg/Fe] of the primary galaxy. Our findings suggest that the last massive merger of our Galaxy, the Gaia-Sausage-Enceladus, was likely a significant gas-rich merger and induced a starburst, contributing to the chemical enrichment and building of the metal-rich part of the thick disc at an early epoch.Comment: 5 pages, 5 figures, submitted to MNRAS Letters (comments are welcome

YETI observations of the young transiting planet candidate CVSO 30 b

CVSO 30 is a unique young low-mass system, because, for the first time, a close-in transiting and a wide directly imaged planet candidates are found around a common host star. The inner companion, CVSO 30 b, is the first possible young transiting planet orbiting a previously known weak-lined T-Tauri star. With five telescopes of the 'Young Exoplanet Transit Initiative' (YETI) located in Asia, Europe and South America we monitored CVSO 30 over three years in a total of 144 nights and detected 33 fading events. In two more seasons we carried out follow-up observations with three telescopes. We can confirm that there is a change in the shape of the fading event between different observations and that the fading event even disappears and reappears. A total of 38 fading event light curves were simultaneously modelled. We derived the planetary, stellar, and geometrical properties of the system and found them slightly smaller but in agreement with the values from the discovery paper. The period of the fading event was found to be 1.36 s shorter and 100 times more precise than the previous published value. If CVSO 30 b would be a giant planet on a precessing orbit, which we cannot confirm, yet, the precession period may be shorter than previously thought. But if confirmed as a planet it would be the youngest transiting planet ever detected and will provide important constraints on planet formation and migration time-scales.Comment: 14 pages (20 with appendix), 7 figures (16 with appendix), 6 tables (7 with appendix

Neutron-capture elements record the ordered chemical evolution of the disc over time

An ensemble of chemical abundances probing different nucleosynthetic channels can be leveraged to build a comprehensive understanding of the chemical and structural evolution of the Galaxy. Using GALAH DR3 data, we seek to trace the enrichment by the supernovae Ia, supernovae II, asymptotic giant branch stars, and neutron-star mergers and/or collapsars nucleosynthetic sources by studying the [Fe/H], [α/Fe], [Ba/Fe], and [Eu/Fe] chemical compositions of ∼50 000 red giant stars, respectively. Employing small [Fe/H]–[α/Fe] cells, which serve as an effective reference-frame of supernovae contributions, we characterize the abundance-age profiles for [Ba/Fe] and [Eu/Fe]. Our results disclose that these age–abundance relations vary across the [Fe/H]–[α/Fe] plane. Within cells, we find negative age–[Ba/Fe] relations and flat age–[Eu/Fe] relations. Across cells, we see the slope of the age–[Ba/Fe] relations evolve smoothly and the [Eu/Fe] relations vary in amplitude. We subsequently model our empirical findings in a theoretical setting using the flexible Chempy Galactic chemical evolution (GCE) code, using the mean [Fe/H], [Mg/Fe], [Ba/Fe], and age values for stellar populations binned in [Fe/H], [Mg/Fe], and age space. We find that within a one-zone framework, an ensemble of GCE model parameters vary to explain the data. Using present day orbits from Gaia EDR3 measurements we infer that the GCE model parameters, which set the observed chemical abundance distributions, vary systematically across mean orbital radii. Under our modelling assumptions, the observed chemical abundances are consistent with a small gradient in the high-mass end of the initial mass function (IMF) across the disc, where the IMF is more top heavy towards the inner disc and more bottom heavy in the outer disc

BICEP2 and Keck Array: upgrades and improved beam characterization

Searching for evidence of inflation by measuring B-modes in the cosmic microwave background (CMB) polarization at degree angular scales remains one of the most compelling experimental challenges in cosmology. BICEP2 and the Keck Array are part of a program of experiments at the South Pole whose main goal is to achieve the sensitivity and systematic control necessary for measurements of the tensor-to-scalar ratio at σ(r) ~0:01. Beam imperfections that are not sufficiently accounted for are a potential source of spurious polarization that could interfere with that goal. The strategy of BICEP2 and the Keck Array is to completely characterize their telescopes' polarized beam response with a combination of in-lab, pre-deployment, and on-site calibrations. We report the status of these experiments, focusing on continued improved understanding of their beams. Far-field measurements of the BICEP2 beam with a chopped thermal source, combined with analysis improvements, show that the level of residual beam-induced systematic errors is acceptable for the goal of σ(r)~ 0:01 measurements. Beam measurements of the Keck Array side lobes helped identify a way to reduce optical loading with interior cold baffles, which we installed in late 2013. These baffles reduced total optical loading, leading to a ~ 10% increase in mapping speed for the 2014 observing season. The sensitivity of the Keck Array continues to improve: for the 2013 season it was 9:5 μK _/s noise equivalent temperature (NET). In 2014 we converted two of the 150-GHz cameras to 100 GHz for foreground separation capability. We have shown that the BICEP2 and the Keck Array telescope technology is sufficient for the goal of σ(r) ~ 0:01 measurements. Furthermore, the program is continuing with BICEP3, a 100-GHz telescope with 2560 detectors