2,210 research outputs found
A code for the reconstruction of spin distribution
In Nuclear Magnetic Resonance (NMR), it is of crucial importance to have an
accurate knowledge of the sample probability distribution corresponding to
inhomogeneities of the magnetic fields. An accurate identification of the
sample distribution requires a set of experimental data that is sufficiently
rich to extract all fundamental information. These data depend strongly on the
control fields (and their number) used experimentally. In this work, we present
and analyze a greedy reconstruction algorithm, and provide the corresponding
code, for the computation of a set of control functions
allowing the generation of data that are appropriate for the accurate
reconstruction of a sample distribution. In particular, the focus is on NMR and
the Bloch system with inhomogeneities in the magnetic fields in all spatial
directions. Numerical examples illustrate this general study.Comment: 31 pages, 6 figure
Unmet challenges in septoplasty-nordic studies from a uniform healthcare and geographical area
PurposeNasal septoplasty is one of the most common surgical procedures in otorhinolaryngology and optimising both patient selection and the surgery is a challenge. The Nordic countries have similar public healthcare systems and comparable populations in terms of size. MethodsThis is a review of studies of outcome and predictors related to septoplasty from Denmark, Finland, Norway and Sweden, published during the last decade. The aim of this review was to identify areas in need of further research to meet the challenges of septoplasty in the Nordic countries with reference to international data. ResultsPostoperative patient satisfaction at 6-12 months was reported in around 2/3 of the patients and well in line with international data. Patients with more severe symptoms had a higher chance of improvement. Lack of standardisation in patient selection, surgical methods and skills, and follow up procedures, still makes it difficult to explain the 25% failure rate in septoplasty surgery. ConclusionThis review of the Nordic studies from the last decade shows that septoplasty in general is effective in relieving nasal obstruction. There is a need for studies addressing the standardisation of diagnostic tools and algorithms and the systematic and continuous implementation of follow-up of the surgical results at both departmental and personal level. This includes an awareness of how surgical skills in septoplasty are obtained and maintained.Peer reviewe
The paranasal sinuses are focus for colonisation and chronic biofilm lung infection in CF patients
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Search for Magnetic Monopoles Trapped in Matter
There have been many searches for magnetic monopoles in flight, but few for
monopoles in matter. We have searched for magnetic monopoles in meteorites,
schists, ferromanganese nodules, iron ores and other materials. The detector
was a superconducting induction coil connected to a SQUID (Superconducting
Quantum Interference Device) with a room temperature bore 15 cm in diameter. We
tested a total of more than 331 kg of material including 112 kg of meteorites.
We found no monopole and conclude the overall monopole/nucleon ratio in the
samples is with a 90\% confidence level.Comment: 6 pages, rev tex, no figure
Four Poynting Theorems
The Poynting vector is an invaluable tool for analysing electromagnetic
problems. However, even a rigorous stress-energy tensor approach can still
leave us with the question: is it best defined as \Vec{E} \cross \Vec{H} or
as \Vec{D} \cross \Vec{B}? Typical electromagnetic treatments provide yet
another perspective: they regard \Vec{E} \cross \Vec{B} as the appropriate
definition, because \Vec{E} and \Vec{B} are taken to be the fundamental
electromagnetic fields. The astute reader will even notice the fourth possible
combination of fields: i.e. \Vec{D} \cross \Vec{H}. Faced with this diverse
selection, we have decided to treat each possible flux vector on its merits,
deriving its associated energy continuity equation but applying minimal
restrictions to the allowed host media. We then discuss each form, and how it
represents the response of the medium. Finally, we derive a propagation
equation for each flux vector using a directional fields approach; a useful
result which enables further interpretation of each flux and its interaction
with the medium.Comment: 8 pages. Updated slightly from EJP versio
In-Depth Assessment of the Palladium-Catalyzed Fluorination of Five-Membered Heteroaryl Bromides
A thorough investigation of the challenging Pd-catalyzed fluorination of five-membered heteroaryl bromides is presented. Crystallographic studies and density functional theory (DFT) calculations suggest that the challenging step of this transformation is C–F reductive elimination of five-membered heteroaryl fluorides from Pd(II) complexes. On the basis of these studies, we have found that various heteroaryl bromides bearing phenyl groups in the ortho position can be effectively fluorinated under catalytic conditions. Highly activated 2-bromoazoles, such as 8-bromocaffeine, are also viable substrates for this reaction.National Institutes of Health (U.S.) (GM46059)National Science Foundation (U.S.) (Predoctoral Fellowship 2010094243)Amgen Inc
The age of Wolfe Creek meteorite crater (Kandimalal), Western Australia
Wolfe Creek crater lies in northwestern Australia at the edge of the Great Sandy Desert. Together with Meteor Crater, it is one of the two largest craters on Earth from which meteorite fragments have been recovered. The age of the impact is poorly constrained and unpublished data places the event at about 300,000 years ago. In comparison, Meteor Crater is well constrained by exposure dating. In this paper, we present new ages for Wolfe Creek Crater from exposure dating using the cosmogenic nuclides 10Be and 26Al, together with optically stimulated luminescence ages (OSL) on sand from a site created by the impact. We also present a new topographic survey of the crater using photogrammetry. The exposure ages range from ~86 to 128 ka. The OSL ages indicate that the age of the impact is most likely to be ~120 ka with a maximum age of 137 ka. Considering the geomorphic setting, the most likely age of the crater is 120 ± 9 ka. Last, we review the age of Meteor Crater in Arizona. Changes in production rates and scaling factors since the original dating work revise the impact age to 61.1 ± 4.8 ka, or ~20% older than previously reported
Virtual screening for inhibitors of the human TSLP:TSLPR interaction
The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) plays a pivotal role in the pathophysiology of various allergy disorders that are mediated by type 2 helper T cell (Th2) responses, such as asthma and atopic dermatitis. TSLP forms a ternary complex with the TSLP receptor (TSLPR) and the interleukin-7-receptor subunit alpha (IL-7Ra), thereby activating a signaling cascade that culminates in the release of pro-inflammatory mediators. In this study, we conducted an in silico characterization of the TSLP: TSLPR complex to investigate the drugability of this complex. Two commercially available fragment libraries were screened computationally for possible inhibitors and a selection of fragments was subsequently tested in vitro. The screening setup consisted of two orthogonal assays measuring TSLP binding to TSLPR: a BLI-based assay and a biochemical assay based on a TSLP: alkaline phosphatase fusion protein. Four fragments pertaining to diverse chemical classes were identified to reduce TSLP: TSLPR complex formation to less than 75% in millimolar concentrations. We have used unbiased molecular dynamics simulations to develop a Markov state model that characterized the binding pathway of the most interesting compound. This work provides a proof-ofprinciple for use of fragments in the inhibition of TSLP: TSLPR complexation
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