62 research outputs found
Efficacy and safety of lipegfilgrastim compared with placebo in patients with non-small cell lung cancer receiving chemotherapy: post hoc analysis of elderly versus younger patients
Purpose Lipegfilgrastim, a glycoPEGylated recombinant
granulocyte colony-stimulating factor (G-CSF), reduces neutropenia duration and febrile neutropenia (FN) incidence in patients with cancer receiving myelosuppressive chemotherapy.
A phase 3 trial of lipegfilgrastim was conducted in patients
with advanced non-small cell lung cancer (NSCLC) receiving
cisplatin/etoposide (which produces mild-to-moderate
myelosuppression). Because patients aged >65 years are at
higher risk for FN versus younger patients, this post hoc analysis compared outcomes in elderly (>65 years) versus younger participants in this trial.
Methods Patients were randomized 2:1 to receive a once-percycle single subcutaneous injection of lipegfilgrastim 6 mg or placebo, with up to 4 cycles of every-3-week cisplatin (day 1) and etoposide (days 1–3). The primary end point was FN incidence during cycle 1. Outcomes were compared across
treatment groups and by age groups (≤65 and >65 years).
Results For patients aged ≤65 years, FN incidence during cycle 1 was similar in the lipegfilgrastim and placebo groups (3.0 vs 3.2 %, respectively), whereas for elderly patients, there was a reduction in FN incidence with lipegfilgrastim (0 vs 13.3 %, respectively). In both age subgroups, lipegfilgrastim showed a propensity to reduce the incidence and duration of severe neutropenia, time to absolute neutrophil count (ANC) recovery, and depth of ANC nadir. Adverse events were generally similar between groups.
Conclusions This analysis suggests that in patients with a
higher FN risk, such as the elderly patients of this study,
lipegfilgrastim reduces not only the duration of severe neutropenia but also the incidence of FN
CANDELS/GOODS-S, CDFS, ECDFS: Photometric Redshifts For Normal and for X-Ray-Detected Galaxies
We present photometric redshifts and associated probability distributions for
all detected sources in the Extended Chandra Deep Field South (ECDFS). The work
makes use of the most up-to-date data from the Cosmic Assembly Near-IR Deep
Legacy Survey (CANDELS) and the Taiwan ECDFS Near-Infrared Survey (TENIS) in
addition to other data. We also revisit multi-wavelength counterparts for
published X-ray sources from the 4Ms-CDFS and 250ks-ECDFS surveys, finding
reliable counterparts for 1207 out of 1259 sources (). Data used for
photometric redshifts include intermediate-band photometry deblended using the
TFIT method, which is used for the first time in this work. Photometric
redshifts for X-ray source counterparts are based on a new library of
AGN/galaxy hybrid templates appropriate for the faint X-ray population in the
CDFS. Photometric redshift accuracy for normal galaxies is 0.010 and for X-ray
sources is 0.014, and outlier fractions are and respectively. The
results within the CANDELS coverage area are even better as demonstrated both
by spectroscopic comparison and by galaxy-pair statistics. Intermediate-band
photometry, even if shallow, is valuable when combined with deep broad-band
photometry. For best accuracy, templates must include emission lines.Comment: The paper has been accepted by ApJ. The materials we provide are
available under [Surveys] > [CDFS] through the portal
http://www.mpe.mpg.de/XraySurvey
X-UDS: The Chandra Legacy Survey of the UKIDSS Ultra Deep Survey Field
We present the X-UDS survey, a set of wide and deep Chandra observations
of the Subaru-XMM Deep/UKIDSS Ultra Deep Survey (SXDS/UDS) field. The
survey consists of 25 observations that cover a total area of 0.33
deg(2). The observations are combined to provide a nominal depth of
similar to 600 ks in the central 100 arcmin(2) region of the field that
has been imaged with Hubble/WFC3 by the CANDELS survey and similar to
200 ks in the remainder of the field. In this paper, we outline the
survey's scientific goals, describe our observing strategy, and detail
our data reduction and point source detection algorithms. Our analysis
has resulted in a total of 868 band-merged point sources detected with a
false-positive Poisson probability of <1 x 10(-4). In addition, we
present the results of an X-ray spectral analysis and provide
best-fitting neutral hydrogen column densities, N-H, as well as a sample
of 51 Compton-thick active galactic nucleus candidates. Using this
sample, we find the intrinsic Compton-thick fraction to be 30%-35%
over a wide range in redshift (z = 0.1-3), suggesting the obscured
fraction does not evolve very strongly with epoch. However, if we assume
that the Compton-thick fraction is dependent on luminosity, as is seen
for Compton-thin sources, then our results are consistent with a rise in
the obscured fraction out to z similar to 3. Finally, an examination of
the host morphologies of our Compton-thick candidates shows a high
fraction of morphological disturbances, in agreement with our previous
results. All data products described in this paper are made available
via a public website
The Eighteenth Data Release of the Sloan Digital Sky Surveys: Targeting and First Spectra from SDSS-V
The eighteenth data release of the Sloan Digital Sky Surveys (SDSS) is the
first one for SDSS-V, the fifth generation of the survey. SDSS-V comprises
three primary scientific programs, or "Mappers": Milky Way Mapper (MWM), Black
Hole Mapper (BHM), and Local Volume Mapper (LVM). This data release contains
extensive targeting information for the two multi-object spectroscopy programs
(MWM and BHM), including input catalogs and selection functions for their
numerous scientific objectives. We describe the production of the targeting
databases and their calibration- and scientifically-focused components. DR18
also includes ~25,000 new SDSS spectra and supplemental information for X-ray
sources identified by eROSITA in its eFEDS field. We present updates to some of
the SDSS software pipelines and preview changes anticipated for DR19. We also
describe three value-added catalogs (VACs) based on SDSS-IV data that have been
published since DR17, and one VAC based on the SDSS-V data in the eFEDS field.Comment: Accepted to ApJ
The eighteenth data release of the Sloan Digital Sky Surveys : targeting and first spectra from SDSS-V
The eighteenth data release of the Sloan Digital Sky Surveys (SDSS) is the first one for SDSS-V, the fifth generation of the survey. SDSS-V comprises three primary scientific programs, or "Mappers": Milky Way Mapper (MWM), Black Hole Mapper (BHM), and Local Volume Mapper (LVM). This data release contains extensive targeting information for the two multi-object spectroscopy programs (MWM and BHM), including input catalogs and selection functions for their numerous scientific objectives. We describe the production of the targeting databases and their calibration- and scientifically-focused components. DR18 also includes ~25,000 new SDSS spectra and supplemental information for X-ray sources identified by eROSITA in its eFEDS field. We present updates to some of the SDSS software pipelines and preview changes anticipated for DR19. We also describe three value-added catalogs (VACs) based on SDSS-IV data that have been published since DR17, and one VAC based on the SDSS-V data in the eFEDS field.Publisher PDFPeer reviewe
The United Stamens of Rubiaceae. Morphology, Anatomy; Their Role in Pollination Ecology
Volume: 82Start Page: 357End Page: 38
Immunogenicity Assessment of Lipegfilgrastim in Patients with Breast Cancer Receiving Chemotherapy
Lipegfilgrastim is a long-acting, once-per-cycle, glycopegylated recombinant granulocyte colony-stimulating factor (G-CSF) used to prevent neutropenia in patients receiving myelosuppressive chemotherapy. This integrated analysis examined the immunogenicity of lipegfilgrastim and its potential clinical impact in two double-blind randomized studies (phases II and III) of patients with breast cancer receiving chemotherapy. Serum samples were analyzed using sequential assays for screening, confirmation, antibody titer, and characterization of antidrug antibodies (ADA). Neutropenia-related efficacy measures were reviewed for each ADA-positive patient. Among 255 patients receiving lipegfilgrastim (154 in phase II, 101 in phase III) and 155 patients receiving pegfilgrastim (54 in phase II, 101 in phase III), the incidence of treatment-emergent ADA was low and similar between the lipegfilgrastim (phase II: 1.3%; phase III: 1.0%) and pegfilgrastim (phase II: 1.9%; phase III: 1.0%) arms. None of the treatment-emergent ADA-positive samples exhibited neutralizing activity against lipegfilgrastim, pegfilgrastim, or glycosylated G-CSF in a cell-based neutralizing antibody assay. No changes were observed in neutropenia-related efficacy measures among ADA-positive patients, and no treatment-related hypersensitivity or anaphylaxis occurred. These results indicate that there is no apparent impact of ADA on lipegfilgrastim efficacy and safety
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