Sinonasal tract malignancies: prognostic factors and surgery outcomes

WOS: 000333960400009PubMed: 24693395Background: Cancers of the sinonasal region are rare and its survival rate remains poor because most of the patients are asymptomatic and diagnosed in advanced stages with surrounding important structures. Objectives: This study attempted to analyze the clinical and histological features in addition to survival and prognostic factors of surgical treatment of sinonasal cancers. Patients and Methods: A retrospective cohort study, involving 36 patients with sinonasal cancer who were treated with surgery in our hospital between 2000 and 2010, was performed. Patients were selected based on the convenience sampling. Patients treated with radiotherapy and/or chemotherapy were excluded from the analysis. Clinical symptoms and histologic findings of patients as well as malignant tumor staging and its prognosis were collected from archives. Results: We found that overall 3 and 5-year survival rates of subjects were 52.8%, and 41.6%, respectively. There was a negative correlation between the clinical stage and survival. There was a significant difference between infrastructural and suprastructural localization in 5-year survival rate (P = 0.018). in the present study, there was a strong relationship between the local control and overall survival (P 0.05). Conclusions: the present study has demonstrated that clinical stage, suprastructural tumor, and the presence of tumor-positive resection margins are the most significant prognostic factors affecting local tumor control and survival. As a result of this study, these tumors should be treated in early stages by surgical margin of resection followed by adjuvant radiotherapy

Absence of the epiglottis in an infant with pierre robin sequence

Epiglottis anomaly associated with Pierre Robin sequence (PRS) is a rare occurrence. Most infants with PRS have presented life-threatening symptoms of respiratory distress and severe feeding problems that usually end with death. To the knowledge of the authors, this is the first reported case of epiglottis agenesis associated with PRS. The clinician must be aware of this unusual presentation in a PRS, and the presented case reveals the challenges in the treatment of the respiratory and feeding problems. This case is discussed with a review of the literature. © 2010 Elsevier Ireland Ltd. All rights reserved

Differences Between Right and Left Colon Cancers in Terms of Clinicopathological Features and Long-term Oncological Outcomes

Aim:Although there are clinical differences in colon cancer according to the location of the tumor, the differences between right and left colon cancers (CC) in terms of survival are not clear. Our aim was to analyze the clinicopathological differences between right and left CC and to investigate the effect of primary tumor location on recurrence and survival.Method:The data of 330 patients who underwent curative surgery for right (n=155) or left (n=175) colon cancer between 2011 and 2018 were retrospectively analyzed. Demographic characteristics, surgical data, pathological data, recurrence and survival rates of the patients were examined and the two groups were compared in terms of these parameters.Results:Male to female ratio was significantly higher and operative time was significantly longer in the left CC than in the right CC. The mean number of harvested lymph nodes was significantly higher in the right CC than the left CC (32±3 and 27±9, respectively, p=0.001). Compared to patients with left CC, those with right CC had higher tumor diameter and tumor volume, had more poorly differentiation and tended to have more mucinous and medullary type cancer. As a result of a median follow-up of 54 months, it was determined that the 5-year overall survival in stage I-III patients was worse in the right CC than in the left CC. Especially in stage III patients, both overall and disease-free survival rates were found to be statistically significantly lower in the right CC compared to the left CC (In stage III disease, overall survival was 66.9% in right CC and 81.8% in left CC, p=0.03; disease-free survival was 54.2% in right CC and 70.6% in left CC, p=0.04).Conclusion:There may be clinicopathological and prognostic differences in CC depending on the location of the tumor. As a result of the long followup period in our case series, the prognosis in the right CC was worse, especially in stage III patients