Is there any evidence that ionised outflows quench star formation in type 1 quasars at z<1?

The aim of this paper is to test the basic model of negative AGN feedback. According to this model, once the central black hole accretes at the Eddington limit and reaches a certain critical mass, AGN driven outflows blow out gas, suppressing star formation in the host galaxy and self-regulating black hole growth. We consider a sample of 224 quasars selected from the SDSS at z<1 observed in the infrared band by Herschel. We evaluate the star formation rate in relation to several outflow signatures traced by the [OIII]4959,5007 and [OII]3726,3729 emission lines in about half of the sample with high quality spectra. Most of the quasars show asymmetric and broad wings in [OIII], which we interpret as outflow signatures. We separate the quasars in two groups, ``weakly'' and ``strongly'' outflowing, using three different criteria. When we compare the mean star formation rate in five redshift bins in the two groups, we find that the SFRs are comparable or slightly larger in the strongly outflowing quasars. We estimate the stellar mass from SED fitting and the quasars are distributed along the star formation main sequence, although with a large scatter. The scatter from this relation is uncorrelated with respect to the kinematic properties of the outflow. Moreover, for quasars dominated in the infrared by starburst or by AGN emission, we do not find any correlation between the star formation rate and the velocity of the outflow, a trend previously reported in the literature for pure starburst galaxies. We conclude that the basic AGN negative feedback scenario seems not to agree with our results. Although we use a large sample of quasars, we did not find any evidence that the star formation rate is suppressed in the presence of AGN driven outflows on large scale. A possibility is that feedback is effective over much longer timescales than those of single episodes of quasar activity.Comment: 18 pages, new version that implements the suggestions of the referee and matches the AA published versio

Noncoding RNAs in Duchenne and Becker muscular dystrophies: role in pathogenesis and future prognostic and therapeutic perspectives

Noncoding RNAs (ncRNAs), such as miRNAs and long noncoding RNAs, are key regulators of gene expression at the post-transcriptional level and represent promising therapeutic targets and biomarkers for several human diseases, including Duchenne and Becker muscular dystrophies (DMD/BMD). A role for ncRNAs in the pathogenesis of muscular dystrophies has been suggested, even if it is still incompletely understood. Here, we discuss current progress leading towards the clinical utility of ncRNAs for DMD/BMD. Long and short noncoding RNAs are differentially expressed in DMD/BMD and have a mechanism of action via targeting mRNAs. A subset of muscle-enriched miRNAs, the so-called myomiRs (miR-1, miR-133, and miR-206), are increased in the serum of patients with DMD and in dystrophin-defective animal models. Interestingly, myomiRs might be used as biomarkers, given that their levels can be corrected after dystrophin restoration in dystrophic mice. Remarkably, further evidence demonstrates that ncRNAs also play a role in dystrophin expression; thus, their modulations might represent a potential therapeutic strategy with the aim of upregulating the dystrophin protein in combination with other oligonucleotides/gene therapy approaches

Prediction of Tail-Off Pressure Peak Anomaly on Small-Scale Rocket Motors

Numerical studies intended to predict solid rocket motors anomalies are the major contributors when developing strategies to both limit expensive fire tests and to investigate and understand the physical phenomena from which anomalies can arise. This paper aims to present a mathematical–physical method to evaluate the pressure peak, namely Friedman Curl, occurring at the tail-off phase of small-scale rocket motors. Such phenomenon is linked to the grain solid particles arrangement (i.e., packing effect); indeed, those particles show a tendency to accumulate at a certain distance from the metallic case, implying a local burn rate increment and a combustion chamber pressure rise close to the tail-off phase. Comparisons between experimental and simulated combustion chamber pressure profiles are outlined to prove the effectiveness of the mathematical–physical approach. Simulations were carried out with an internal ballistic simulation tool developed by the authors of this work

The primordial environment of super massive black holes: large scale galaxy overdensities around z∼6z\sim6 QSOs with LBT

We investigated the presence of galaxy overdensities around four $z\sim6$ QSOs, namely SDSS J1030+0524 (z = 6.28), SDSS J1148+5251 (z = 6.41), SDSS J1048+4637 (z = 6.20) and SDSS J1411+1217 (z = 5.95), through deep $r$-, $i$- and $z$- band imaging obtained with the wide-field ($\sim23'\times25'$) Large Binocular Camera (LBC) at the Large Binocular Telescope (LBT). We adopted color-color selections within the $i-z$ vs $r-z$ plane to identify samples of $i$-band dropouts at the QSO redshift and measure their relative abundance and spatial distribution in the four LBC fields, each covering $\sim8\times8$ physical Mpc at $z\sim6$. The same selection criteria were then applied to $z$-band selected sources in the $\sim$1 deg$^2$ Subaru-XMM Newton Deep Survey to derive the expected number of dropouts over a blank LBC-sized field ($\sim$0.14 deg$^2$). The four observed QSO fields host a number of candidates larger than what is expected in a blank field. By defining as $i$-band dropouts objects with $z_{AB}1.4$ and undetected in the $r$-band, we found 16, 10, 9, 12 dropouts in SDSS J1030+0524, SDSS J1148+5251, SDSS J1048+4637, and SDSS J1411+1217, respectively, whereas only 4.3 such objects are expected over a 0.14 deg$^2$ blank field. This corresponds to overdensity significances of 3.3, 1.9, 1.7, 2.5$\sigma$, respectively. By considering the total number of dropouts in the four LBC fields and comparing it with what is expected in four blank fields of 0.14 deg$^2$ each, we find that high-z QSOs reside in overdense environments at the $3.7\sigma$ level. This is the first direct and unambiguous measurement of the large scale structures around $z\sim6$ QSOs. [shortened]Comment: 12 pages, 8 figures. Accepted for publication in A&

Demography of obscured and unobscured AGN: prospects for a Wide Field X-ray Telescope

We discuss some of the main open issues in the evolution of Active Galactic Nuclei which can be solved by the sensitive, wide area surveys to be performed by the proposed Wide Field X-ray Telescope mission.Comment: Proceedings of "The Wide Field X-ray Telescope Workshop", held in Bologna, Italy, Nov. 25-26 2009. To appear in Memorie della Societa' Astronomica Italiana 2010 (arXiv:1010.5889

Magellan Spectroscopy of AGN Candidates in the COSMOS Field

We present spectroscopic redshifts for the first 466 X-ray and radio-selected AGN targets in the 2 deg^2 COSMOS field. Spectra were obtained with the IMACS instrument on the Magellan (Baade) telescope, using the nod-and-shuffle technique. We identify a variety of Type 1 and Type 2 AGN, as well as red galaxies with no emission lines. Our redshift yield is 72% down to i_AB=24, although the yield is >90% for i_AB<22. We expect the completeness to increase as the survey continues. When our survey is complete and additional redshifts from the zCOSMOS project are included, we anticipate ~1100 AGN with redshifts over the entire COSMOS field. Our redshift survey is consistent with an obscured AGN population that peaks at z~0.7, although further work is necessary to disentangle the selection effects.Comment: 19 pages, 14 figures. Accepted to ApJS special COSMOS issue. The full electronic version of Table 2 can be found at http://shaihulud.as.arizona.edu/~jtrump/tab2.tx

The HELLAS2XMM survey. IX. Spectroscopic identification of super-EROs hosting AGNs

We present VLT near-IR spectroscopic observations of three X-ray sources characterized by extremely high X-ray-to-optical ratios (X/O>40), extremely red colors (6.3<R-K<7.4, i.e. EROs) and bright infrared magnitudes (17.6<K<18.3). These objects are very faint in the optical, making their spectroscopic identification extremely challenging. Instead, our near-IR spectroscopic observations have been successful in identifying the redshift of two of them (z=2.08 and z=1.35), and tentatively even of the third one (z=2.13). When combined with the X-ray properties, our results clearly indicate that all these objects host obscured QSOs (4e44 < L(2-10keV) < 1.5e45 erg/s, 2e22 < N_H < 4e23 cm-2) at high redshift. The only object with unresolved morphology in the K band shows broad Halpha emission, but not broad Hbeta, implying a type 1.9 AGN classification. The other two objects are resolved and dominated by the host galaxy light in the K band, and appear relatively quiescent: one of them has a LINER-like emission line spectrum and the other presents only a single, weak emission line which we tentatively identify with Halpha. The galaxy luminosities for the latter two objects are an order of magnitude brighter than typical local L* galaxies and the derived stellar masses are well in excess of 10^11 Msun. For these objects we estimate black hole masses higher than 10^9 Msun and we infer that they are radiating at Eddington ratios L/L_Edd < 0.1. We discuss the implications of these findings for the coevolution of galaxies and black hole growth. Our results provide further support that X-ray sources with high X/O ratios and very red colors tend to host obscured QSO in very massive galaxies at high redshift.Comment: 7 pages, 5 figures, accepted for publication in A&

Tailoring CD19xCD3-DART exposure enhances T-cells to eradication of B-cell neoplasms.

Many patients with B-cell malignancies can be successfully treated, although tumor eradication is rarely achieved. T-cell-directed killing of tumor cells using engineered T-cells or bispecific antibodies is a promising approach for the treatment of hematologic malignancies. We investigated the efficacy of CD19xCD3 DART bispecific antibody in a broad panel of human primary B-cell malignancies. The CD19xCD3 DART identified 2 distinct subsets of patients, in which the neoplastic lymphocytes were eliminated with rapid or slow kinetics. Delayed responses were always overcome by a prolonged or repeated DART exposure. Both CD4 and CD8 effector cytotoxic cells were generated, and DART-mediated killing of CD4+ cells into cytotoxic effectors required the presence of CD8+ cells. Serial exposures to DART led to the exponential expansion of CD4 + and CD8 + cells and to the sequential ablation of neoplastic cells in absence of a PD-L1-mediated exhaustion. Lastly, patient-derived neoplastic B-cells (B-Acute Lymphoblast Leukemia and Diffuse Large B Cell Lymphoma) could be proficiently eradicated in a xenograft mouse model by DART-armed cytokine induced killer (CIK) cells. Collectively, patient tailored DART exposures can result in the effective elimination of CD19 positive leukemia and B-cell lymphoma and the association of bispecific antibodies with unmatched CIK cells represents an effective modality for the treatment of CD19 positive leukemia/lymphoma

Comparison of open volumes in silica based thin films produced by different precursors

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Characterization of sputtered W–Si–N thin films by a monoenergetic positron beam

A monoenergetic positron beam was employed to characterize the uniformity and the microstructural variation of thermally treated W–Si–N thin film. As the annealing temperature is increased, positrons are found to be progressively trapped in sites rich in silicon. This behavior is explained by the formation of W clusters from which positrons are favorably trapped into the Si–N amorphous matrix. Positron results are discussed together with information obtained on similar samples by Rutheford backscattering, infrared spectroscopy and transmission electron microscopy measurements