Heterogeneous Consumers, Vertical Product Differentiation and the Rate of Innovation

This paper studies the impact of income inequality on the level of innovative activities in a model where innovations result in quality improvements. The market for quality goods is characterized by a natural oligopoly with three types of consumers - rich, middle class and poor. In general, we find that for reasons of strategic price setting a more equal distribution of income is favourable for innovation incentives. This is consistent with empirical evidence suggesting that countries with a more equal distribution of income have grown faster.Inequality, Income Distribution, Heterogeneity, Innovation, Endogeneous Growth, Product Quality, Vertical Product Differentiation

The Protein-Conducting Channel in the Membrane of the Endoplasmic Reticulum Is Open Laterally toward the Lipid Bilayer

Lipids and proteins were found to contact a nascent type II membrane protein, as well as a nascent secretory protein, during their insertion into the membrane of the endoplasmic reticulum. This suggests that the protein-conducting channel is open laterally toward the lipid bilayer during an early stage of protein insertion. Contact to lipids was confined to the hydrophobic core region of the respective signal or signal anchor sequence. Thus, the nascent polypeptide is positioned in the translocation complex such that the signal or signal anchor sequence faces the lipid bilayer, whereas the hydrophilic, translocating portion is in proteinaceous environment

Continuous use of an adaptive lung ventilation controller in critically ill patients in a multidisciplinary intensive care unit

No Abstract

The Sec61p Complex Mediates the Integration of a Membrane Protein by Allowing Lipid Partitioning of the Transmembrane Domain

AbstractWe have investigated how the transmembrane (TM) domain of a membrane protein is cotranslationally integrated into the endoplasmic reticulum. We demonstrate that the Sec61p channel allows the TM domain to bypass the barrier posed by the polar head groups of the lipid bilayer and come into contact with the hydrophobic interior of the membrane. Together with the TRAM protein, Sec61p provides a site in the membrane, at the interface of channel and lipid, through which a TM domain can dynamically equilibrate between the lipid and aqueous phases, depending on the hydrophobicity of the TM domain and the length of the polypeptide segment tethering it to the ribosome. Our results suggest a unifying, lipid-partitioning model which can explain the general behavior of hydrophobic topogenic sequences

Experimental evaluation of the cloud-native application design

Cloud-Native Applications (CNA) are designed to run on top of cloud computing infrastructure services with inherent support for self-management, scalability and resilience across clustered units of application logic. Their systematic design is promising especially for recent hybrid virtual machine and container environments for which no dominant application development model exists. In this paper, we present a case study on a business application running as CNA and demonstrate the advantages of the design experimentally. We also present Dynamite, an application auto-scaler designed for containerised CNA. Our experiments on a Vagrant host, on a private OpenStack installation and on a public Amazon EC2 testbed show that CNA require little additional engineering

Self-managing cloud-native applications : design, implementation and experience

Running applications in the cloud efficiently requires much more than deploying software in virtual machines. Cloud applications have to be continuously managed: (1) to adjust their resources to the incoming load and (2) to face transient failures replicating and restarting components to provide resiliency on unreliable infrastructure. Continuous management monitors application and infrastructural metrics to provide automated and responsive reactions to failures (health management) and changing environmental conditions (auto-scaling) minimizing human intervention. In the current practice, management functionalities are provided as infrastructural or third party services. In both cases they are external to the application deployment. We claim that this approach has intrinsic limits, namely that separating management functionalities from the application prevents them from naturally scaling with the application and requires additional management code and human intervention. Moreover, using infrastructure provider services for management functionalities results in vendor lock-in effectively preventing cloud applications to adapt and run on the most effective cloud for the job. In this paper we discuss the main characteristics of cloud native applications, propose a novel architecture that enables scalable and resilient self-managing applications in the cloud, and relate on our experience in porting a legacy application to the cloud applying cloud-native principles

Interleukin-22 predicts severity and death in advanced liver cirrhosis: a prospective cohort study

Background: Interleukin-22 (IL-22), recently identified as a crucial parameter of pathology in experimental liver damage, may determine survival in clinical end-stage liver disease. Systematic analysis of serum IL-22 in relation to morbidity and mortality of patients with advanced liver cirrhosis has not been performed so far. Methods: This is a prospective cohort study including 120 liver cirrhosis patients and 40 healthy donors to analyze systemic levels of IL-22 in relation to survival and hepatic complications. Results: A total of 71% of patients displayed liver cirrhosis-related complications at study inclusion. A total of 23% of the patients died during a mean follow-up of 196 +/- 165 days. Systemic IL-22 was detectable in 74% of patients but only in 10% of healthy donors (P 18 pg/ml, n = 57) showed significantly reduced survival compared to patients with regular ([less than or equal to]18 pg/ml) levels of IL-22 (321 days versus 526 days, P = 0.003). Other factors associated with overall survival were high CRP ([greater than or equal to]2.9 mg/dl, P = 0.005, hazard ratio (HR) 0.314, confidence interval (CI) (0.141 to 0.702)), elevated serum creatinine (P = 0.05, HR 0.453, CI (0.203 to 1.012)), presence of liver-related complications (P = 0.028, HR 0.258 CI (0.077 to 0.862)), model of end stage liver disease (MELD) score [greater than or equal to]20 (P = 0.017, HR 0.364, CI (0.159 to 0.835)) and age (P = 0.011, HR 1.047, CI (1.011 to 1.085)). Adjusted multivariate Cox proportional-hazards analysis identified elevated systemic IL-22 levels as independent predictors of reduced survival (P = 0.007, HR 0.218, CI (0.072 to 0.662)). Conclusions: In patients with liver cirrhosis, elevated systemic IL-22 levels are predictive for reduced survival independently from age, liver-related complications, CRP, creatinine and the MELD score. Thus, processes that lead to a rise in systemic interleukin-22 may be relevant for prognosis of advanced liver cirrhosis

Characterization of high-gamma activity in electrocorticographic signals

INTRODUCTION: Electrocorticographic (ECoG) high-gamma activity (HGA) is a widely recognized and robust neural correlate of cognition and behavior. However, fundamental signal properties of HGA, such as the high-gamma frequency band or temporal dynamics of HGA, have never been systematically characterized. As a result, HGA estimators are often poorly adjusted, such that they miss valuable physiological information. METHODS: To address these issues, we conducted a thorough qualitative and quantitative characterization of HGA in ECoG signals. Our study is based on ECoG signals recorded from 18 epilepsy patients while performing motor control, listening, and visual perception tasks. In this study, we first categorize HGA into HGA types based on the cognitive/behavioral task. For each HGA type, we then systematically quantify three fundamental signal properties of HGA: the high-gamma frequency band, the HGA bandwidth, and the temporal dynamics of HGA. RESULTS: The high-gamma frequency band strongly varies across subjects and across cognitive/behavioral tasks. In addition, HGA time courses have lowpass character, with transients limited to 10 Hz. The task-related rise time and duration of these HGA time courses depend on the individual subject and cognitive/behavioral task. Task-related HGA amplitudes are comparable across the investigated tasks. DISCUSSION: This study is of high practical relevance because it provides a systematic basis for optimizing experiment design, ECoG acquisition and processing, and HGA estimation. Our results reveal previously unknown characteristics of HGA, the physiological principles of which need to be investigated in further studies