An Outbreak of Q fever in a prison in Italy

We observed an outbreak of Q fever in a prison population. Overall, 65 of the 600 prison inmates developed the disease. The location of the prison cells had no apparent effect on the risk of infection. The outbreak was probably due to exposure to dust contaminated by a passing flock of sheep, which at the time of the outbreak was engaged in lambing. These findings highlight the possible emergence of Q fever in settings and populations not normally thought of as being at risk of exposure to the infection

On the prosodic marking of contrast in Romance sentence topic: evidence from Neapolitan Italian

International audienceIn this paper we present data in Neapolitan Italian that show a clear phonological difference in intonation between a clitic left dislocated object topic in an exhaustive answer and in a partial answer. In the latter, the topic expression is set aside in its own prosodic phrase, made of a rising accent (H*) followed by a !H- boundary tone. An exhaustive answer does not show such phrasing pattern. The finding of a 'partial' tune in Romance provides a solution to the pragmatic problem of defining sentence topic by supporting a bi-dimensional model of Information Structure

Correlating Infall with Deuterium Fractionation in Dense Cores

We present a survey of HCO+ (3-2) observations pointed towards dense cores with previous measurements of N(N2D+)/N(N2H+). Of the 26 cores in this survey, five show the spectroscopic signature of outward motion, nine exhibit neither inward nor outward motion, eleven appear to be infalling, and one is not detected. We compare the degree of deuterium fractionation with infall velocities calculated from the HCO+ spectra and find that those cores with [D]/[H] > 0.1 are more likely to have the signature of inward motions than cores with smaller [D]/[H] ratios. Infall motions are also much more common in cores with masses exceeding their thermal Jeans masses. The fastest infall velocity measured belongs to one of the two protostellar cores in our survey, L1521F, and the observed motions are typically on the order of the sound speed.Comment: Accepted to Ap

Oral anticoagulant therapy in atrial fibrillation older patients with previous bleeding

Oral anticoagulant therapy (OAT) with direct oral anticoagulant (DOACs) is the established treatment to reduce thromboembolic risk in patients with atrial fibrillation (AF). Bleeding risk scores are useful to identify and correct factors associated with bleeding risk in AF patients on OAT. However, the clinical scenario is more complex in patients with previous bleeding event, and the decision about whether and when starting or re-starting OAT in these patients remains a contentious issue. Major bleeding is associated with a subsequent increase in both short- and long-term mortality, and even minimal bleeding may have prognostic importance because it frequently leads to disruption of antithrombotic therapy. There is an unmet need for guidance on how to manage antithrombotic therapy after bleeding has occurred. While waiting for observational and randomized data to accrue, this paper offers a perspective on managing antithrombotic therapy after bleeding in older patients with AF

Numerical investigation on the mode coupling contact dynamic instabilities.

When dealing with complex mechanical systems, the frictional contact is at the origin of significant changes in the dynamic behavior of systems. The presence of frictional contact can give rise to mode-coupling instabilities that produce harmonic "friction induced vibrations". Unstable vibrations can reach large amplitude that could compromise the structural integrity of the system and are often associated with annoying noise emission. The study of this kind of dynamic instability has been object of many studies ranging from both theoretical and numerical study of simple lumped models to numerical and experimental study on real mechanical systems, such as automotive brakes, typically affected by such issue. In this paper the numerical analysis of a lumped system constituted by several degrees of freedom in frictional contact with a slider is presented, where the introduction of friction gives rise to an unstable dynamic behavior. Two different approaches are used to investigate the effects of friction forces. The linear Complex Eigenvalue Analysis (CEA) allows for calculating of the complex eigenvalues of the system that can be characterized by a positive real part (i.e. negative apparent modal damping). The effects of the main parameters on the system stability are investigated. In the second approach a non linear model has been developed that takes into account the stick slip behavior at the interface to solve the time-history solution and analyze the unstable vibration. The mode selection mechanism occurring in transient nonlinear analysis, when several unstable modes are predicted by the linear CEA, and driving the selection of the frequency of the unstable vibrations, is investigated. Furthermore, by means of the transient analysis, the influence of the type of perturbation at the equilibrium position on the time history of the system vibrations is analyzed. Results comparison between the two different approaches highlights how nonlinearities affect the time-history solution and how stable and unstable behavior can be predicted by the linear CEA. The obtained results have been extended to the finite element model of a simple mechanical system

Discovery of a radio relic in the low mass, merging galaxy cluster PLCK G200.9-28.2

Radio relics at the peripheries of galaxy clusters are tracers of the elusive cluster merger shocks. We report the discovery of a single radio relic in the galaxy cluster PLCK G200.9-28.2 ($z=0.22$, $M_{500} = 2.7\pm0.2 \times 10^{14} M_{\odot}$) using the Giant Metrewave Radio Telescope at 235 and 610 MHz and the Karl G. Jansky Very Large Array at 1500 MHz. The relic has a size of $\sim 1 \times 0.28$ Mpc, an arc-like morphology and is located at 0.9 Mpc from the X-ray brightness peak in the cluster. The integrated spectral index of the relic is $1.21\pm0.15$. The spectral index map between 235 and 610 MHz shows steepening from the outer to the inner edge of the relic in line with the expectation from a cluster merger shock. Under the assumption of diffusive shock acceleration, the radio spectral index implies a Mach number of $3.3\pm1.8$ for the shock. The analysis of archival XMM Newton data shows that PLCK G200.9-28.2 consists of a northern brighter sub-cluster, and a southern sub-cluster in a state of merger. This cluster has the lowest mass among the clusters hosting single radio relics. The position of the Planck Sunyaev Ze'ldovich effect in this cluster is offset by 700 kpc from the X-ray peak in the direction of the radio relic, suggests a physical origin for the offset. Such large offsets in low mass clusters can be a useful tool to select disturbed clusters and to study the state of merger.Comment: 10 pages, 7 figures, 4 tables. Accepted for publication in MNRA

Spectroscopic characterization of Phoenician-Punic coins

Sardinia hosted many Phoenician and Punic communities, as integrated forms of pacific cohabitation with the Lebanese merchants or actual colonies for the exploitation of the rich mines and wealthy coastal emporia under the Carthaginians (750-250 B.C.). One of their most important settlements is that of Mount Sirai, in the south west of the island, whose excavation revealed a complex structure of the site and allowed the discovery of excellent finds, as steles, everyday-life objects and tools, grave goods, amulets and coins. Punic coins were made by gold, electrum or, more commonly, by bronze. The first coin mintage from Carthage dates back to the IV century B.C. Whether the mintage was exclusive to Carthage or permitted outside the city too is still a matter of debate. There is the possibility that mintages were allowed in Sardinia (320-238 B.C. as well as in 216), in Spain (237-209 B.C.) and Southern Italy (216-203 B.C.). We have analyzed ten of these bronze coins (Fig. 1) to unveil the secrets of their mintage, origins and inner structure. Some traditional spectroscopic techniques such as X-ray diffraction (XRD) and fluorescence (XRF) have been used for this purpose, allowing us to learn about their mineral content (XRD) and elemental composition (XRF) [1,2]. Here we report about these findings

New Target Genes for the Peroxisome Proliferator-Activated Receptor-γ (PPARγ) Antitumour Activity: Perspectives from the Insulin Receptor

The insulin receptor (IR) plays a crucial role in mediating the metabolic and proliferative functions triggered by the peptide hormone insulin. There is considerable evidence that abnormalities in both IR expression and function may account for malignant transformation and tumour progression in some human neoplasias, including breast cancer. PPARγ is a ligand-activated, nuclear hormone receptor implicated in many pleiotropic biological functions related to cell survival and proliferation. In the last decade, PPARγ agonists—besides their known action and clinical use as insulin sensitizers—have proved to display a wide range of antineoplastic effects in cells and tissues expressing PPARγ, leading to intensive preclinical research in oncology. PPARγ and activators affect tumours by different mechanisms, involving cell proliferation and differentiation, apoptosis, antiinflammatory, and antiangiogenic effects. We recently provided evidence that PPARγ and agonists inhibit IR by non canonical, DNA-independent mechanisms affecting IR gene transcription. We conclude that IR may be considered a new PPARγ “target” gene, supporting a potential use of PPARγ agonists as antiproliferative agents in selected neoplastic tissues that overexpress the IR

CO2/CH4 separation by means of Matrimid hollow fibre membranes

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