Discovery of prognostic markers in laryngeal cancer treated with radiotherapy

Head and neck cancer is the eighth most common cancer in the world with annually 890,000 new patients. Approximately 25% of all head and neck tumors are located in the larynx. In the Netherlands, 700 new patients are observed each year. A large proportion of the laryngeal cancers are treated with radiotherapy in order to preserve the larynx (important for voice, swallowing and breathing). Unfortunately, after radiotherapy in around 25% of patients the tumor recurs. In order to improve outcome for the individual patient with laryngeal cancer, it is necessary to select those patients that will benefit from radiotherapy. Therefore, Leonie Bruine de Bruin investigated several prognostic tumor markers during her PhD-study.Because a lack of oxygen in tumor tissue (tumor hypoxia) is associated with poor response to radiotherapy in head and neck tumors, she investigated whether a specific PET scan, 18F-FAZA-PET scan, could visualize tumor hypoxia in head and neck tumors. In patients with laryngeal cancer, the relationship between the findings on the 18F-FAZA-PET scan and immunohistochemical expression of classical hypoxic markers in the same tumor tissue was also examined.Furthermore, several tumor markers are investigated in relation to the response to radiotherapy in patients with laryngeal cancer. An association was found between high expression of 3 tumor markers (PTEN, pATM and DNMT1) and poor response to treatment. Based on her findings, in future studies the use of new innovative drugs that specifically inhibit the activity of these tumor markers, might be investigate to improve treatment of laryngeal cancer

Aging and Competence in Decision Making

Around the world, average life expectancy is increasing. Adults of all ages face important decisions that affect their life outcomes and overall well-being. This paper reviews recent developments in research on age differences in decision-making competence. The measurement of age differences in decision-making competence is grounded in normative theories of decision making, which posit how people should be making decisions, as well as descriptive research, which aims to examine how people actually make decisions. Studies on age differences in decision making have shown mixed patterns of results, perhaps because of having included a wide range of decision-making competence tasks. Each decision task may rely on a different combination of skills, with some showing age-related declines and others showing no change or improvements with age. Here, I discuss the potential skills that may contribute to making good decisions, including cognitive deliberation, experience, emotions, and motivation. Although fluid cognitive abilities that underlie cognitive deliberation are known to decline with age, the others show different developments with age. I also discuss potential interventions that aim to target cognitive deliberation, experience, emotions, and motivation, so as to promote better decisions and associated life outcomes across the life span

Capitalizing on order effects in the bids of peer-reviewed conferences to secure reviews by expert referees

International audiencePeer review supports scientific conferences in selecting high quality papers for publication. Referees are expected to evaluate submissions equitably according to objective criteria (e.g., originality of the contribution, soundness of the theory, validity of the experiments). We argue that the submission date of papers is a subjective factor playing a role in the way they are evaluated. Indeed, program committee (PC) chairs and referees process submission lists that are usually sorted by paperIDs. This order conveys chronological information, as papers are numbered sequentially upon reception.We show that order effects lead to unconsciously favor early-submitted papers to the detriment of later-submitted papers. Our point is supported by a study of 42 peer-reviewed conferences in Computer Science showing a decrease in the number of bids placed on submissions with higher paperIDs. It is advised to counterbalance order effects during the bidding phase of peer review by promoting the submissions with fewer bids to potential referees. This manipulation intends to better share bids out among submissions in order to attract qualified referees for all submissions. This would secure reviews from confident referees, who are keen on voicing sharp opinions and recommendations (acceptance or rejection) about submissions. This work contributes to the integrity of peer review, which is mandatory to maintain public trust in science

Public priorities and expectation of climate change impacts in the United Kingdom

Irrespective of the success of climate mitigation efforts, societies worldwide face the challenge of adapting to a changing climate. In this paper, we examine UK residents’ expectations of future threats and opportunities associated with climate change impacts, along with willingness to prioritise different climate change impacts for investment. Using a national survey (n = 2007), we report on three main findings. First, UK residents tend to expect threats related to flooding and wet weather to be more likely and concerning than heat extremes or opportunities. Second, UK residents’ expectations of climate change impacts do not align with expert assessments, especially showing lower estimates of heat-related threats as compared to experts. Third, willingness to allocate resources to potential climate change impacts tends to be more strongly associated with anticipated concern should they occur than climate change belief or the expected likelihood of them occurring. We discuss the implications of our findings for policies and communications about climate change adaptation in the UK and elsewhere

How is cervical cancer screening information communicated in UK websites? A cross-sectional analysis of content and quantitative presentation formats

Objectives: To investigate whether UK websites about cervical cancer screening targeted to the public include (1) information about benefits and risks of screening, possible screening results and cervical cancer statistics, (2) quantitative presentation formats recommended in the risk communication literature and (3) appeals for participation and/or informed decision-making. Design: Cross-sectional analysis of websites using a comprehensive checklist of information items on screening benefits, risks, possible results and cervical cancer statistics. Outcome measures: We recorded the number of websites that contained each of the information items, and the presentation format used for probabilistic information (no quantification provided, verbal quantifiers only, different types of numerical formats and/or graphs). We also recorded the number of websites containing appeals for participation and/or informed decision-making. Setting: Websites were identified through the most common Google search terms used in the UK to find information on cervical screening, according to GoogleTrends and a commercial internet-monitoring programme. Two additional websites were identified by the authors as relevant. Results: After applying exclusion criteria, 14 websites were evaluated, including websites of public and private health service providers, charities, a medical society and a pharmacy. The websites mentioned different benefits, risks of screening and possible results. However, specific content varied between websites. Probabilistic information was often presented using non-recommended formats, including relative risk reductions to express screening benefits, and verbal quantifiers without numbers to express risks. Appeals for participation were present in most websites, with almost half also mentioning informed decision-making. Conclusions: UK websites about cervical cancer screening were generally balanced. However, benefits and risks were presented using different formats, potentially hindering comparisons. Additionally, recommendations from the literature to facilitate understanding of quantitative information and facilitate informed decisions were often not followed. Designing websites that adhere to existing recommendations may support informed screening uptake

Improving survey measures of household inflation expectations

Expectations about future inflation are generally thought to play an important role in households’ decisions about spending and saving. They are also of great interest to central bankers, who take them into account when determining policy or assessing the effectiveness of communications with the public. To help improve existing survey measures of inflation expectations, the Federal Reserve Bank of New York recently joined with other institutions and academic consultants to develop a set of survey questions that will yield more reliable information on households’ inflation expectations, inflation uncertainty, and expectations about future wage changes.Inflation (Finance) ; Households - Economic aspects ; Economic surveys ; Federal Reserve Bank of New York ; Economic forecasting

Labeling energy cost on light bulbs lowers implicit discount rates

Lighting accounts for nearly 20% of overall U.S. electricity consumption and 18% of U.S. residential electricity consumption. A transition to alternative energy-efficient technologies could reduce this energy consumption considerably. To quantify the influence of factors that drive consumer choices for light bulbs, we conducted a choice-based conjoint field experiment with 183 participants. We estimated discrete choice models from the data, and found that politically liberal consumers have a stronger preference for compact fluorescent lighting technology and for low energy consumption. Greater willingness to pay for lower energy consumption and longer life was observed in conditions where estimated operating cost information was provided. Providing estimated annual cost information to consumers reduced their implicit discount rate by a factor of five, lowering barriers to adoption of energy efficient alternatives with higher up-front costs; however, even with cost information provided, consumers continued to use implicit discount rates of around 100%, which is larger than that experienced for other energy technologies

How Do Women Interpret the NHS Information Leaflet about Cervical Cancer Screening?

Background. Organized screening programs often rely on written materials to inform the public. In the United Kingdom, women invited for cervical cancer screening receive a leaflet from the National Health Service (NHS) to support screening decisions. However, information about screening may be too complex for people to understand, potentially hindering informed decision making. Objectives. We aimed to identify women’s difficulties in interpreting the leaflet used in England and negative and positive responses to the leaflet. Methods. We used a sequential mixedmethods design involving 2 steps: cognitive think-aloud interviews (n = 20), followed by an England-wide survey (n = 602). Data were collected between June 2017 and December 2018, and participants included women aged 25 to 64 y with varying sociodemographics. Results. Interview results revealed misunderstandings concerning screening results, benefits, and additional tests and treatment, although participants tended to react positively to numerical information. Participants were often unfamiliar with the potential harms associated with screening (i.e., screening risks), key aspects of human papillomavirus, and complex terms (e.g., dyskaryosis). Survey results indicated that interpretation difficulties were common (M correct items = 12.5 of 23). Lower understanding was associated with lower educational level (b’s .0.15, P’s \0.001), lower numeracy scores (b = 0.36, P \ 0.001), and nonwhite ethnicity (b = 0.10, P = 0.007). The leaflet was evaluated positively overall. Conclusions. Despite previous user testing of the leaflet, key information may be too complex for some recipients. As a consequence, they may struggle to make informed decisions about screening participation based on the information provided. We discuss implications for the improvement of communications about screening and decision support

Public perceptions of how to reduce carbon footprints of consumer food choices

Carbon footprints – the greenhouse gas (GHG) emissions associated with consumer food choices –substantially contribute to climate change. Life cycle analyses from climate and environmental sciences have identified effective rules for reducing these food-related carbon footprints, including eating seasonal produce and replacing dairy and red meat with plant-based products. In a national UK survey, we studied how many and which rules our participants generated for reducing GHG emissions of produce, dairy, and protein-rich products. We also asked participants to estimate GHG emission reductions associated with pre-selected rules, expressed in either grams or percentages. We found that participants generated few and relatively less effective rules, including ambiguous ones like 'Buy local'. Furthermore, participants' numerical estimates of pre-selected rules were less accurate when they assessed GHG emission reductions in grams rather than in percentages. Findings suggest a need for communicating fewer rules in percentages, for informing consumers about reducing food-related GHG emissions