PHD3 regulates differentiation, tumour growth and angiogenesis in pancreatic cancer

pancreatic cance

FACT - Performance of the first cherenkov telescope observing with SiPMs

The First G-APD Cherenkov Telescope (FACT) is pioneering the usage of silicon photo multipliers (SIPMs also known as G-APDs) for the imaging atmospheric Cherenkov technique. It is located at the Observatorio Roque de los Muchachos on the Canary island of La Palma. Since first light in October 2011, it is monitoring bright TeV blazars in the northern sky. By now, FACT is the only imaging atmospheric Cherenkov telescope operating with SIPMs on a nightly basis. Over the course of the last five years, FACT has been demonstrating their reliability and excellent performance. Moreover, their robustness allowed for an increase of the duty cycle including nights with strong moon light without the need for UV-filters. In this contribution, we will present the performance of the first Cherenkov telescope using solid state photo sensors, which was determined in analysis of data from Crab Nebula, the so called standard candle in gamma-ray astronomy. The presented analysis chain utilizes modern data mining methods and unfolding techniques to obtain the energy spectrum of this source. The characteristical results of such an analysis will be reported providing, e.g., the angular and energy resolution of FACT, as well as, the energy spectrum of the Crab Nebula. Furthermore, these results are discussed in the context of the performance of coexisting Cherenkov telescopes.M. Noethe, J. Adam, M.L. Ahnen, D. Baack, M. Balbo, A. Biland, M. Blank, T. Bretz, K. Bruegge, J. Buss, A. Dmytriiev, D. Dorner, S. Einecke, D. Elsaesser, C. Hempfling, T. Herbst, D. Hildebrand, L. Kortmann, L. Linhoff, M. Mahlke, K. Mannheim, S. Mueller, D. Neise, A. Neronov, J. Oberkirch, A. Paravac, F. Pauss, W. Rhode, B. Schleicher, F. Schulz, A. Shukla, V. Sliusar, F. Temme, J. Thaele, R. Walte

Measuring the optical point spread function of FACT using the Cherenkov camera

FACT, the First G-APD Cherenkov Telescope, is an Imaging Air Cherenkov Telescope (IACT) operating since 2011 at the Observatorio del Roque de los Muchachos on the Canary Island of La Palma. As typical for IACTs, its reflector is comprised of smaller mirror facets and not protected by a dome. In the case of FACT, 30 hexagonal facets form a total mirror area of 9:5m². Hence, it is crucial to monitor the optical properties of this system and realign the facets if necessary. Up to now, measuring the Point Spread Function of FACT required human interaction to mount a screen and an optical camera. In this contribution, a new method to measure the optical Point Spread Function using directly the Cherenkov camera of the telescope is presented. Inspired by the method radio telescopes use to determine their resolution, the telescope is pointed towards a fixed position on the trajectory of a star. During the star’s passage through the field of view, the camera is read out using a fixed rate. In each event, the pedestal variance is determined for each pixel. This value is directly correlated with the amount of night sky background light a pixel received. Translating the time of the measurement to the position of the star in the camera enables to determine the optical point spread function from this measurement. As the measurement is done for each pixel along the trajectory of the star, the Point Spread Function can be determined not only for the camera center but for the entire field of view. In this contribution, the new method will also be compared with the existing methods of determining the optical Point Spread Function: direct measurement with an optical camera and the width of Muon ring events.M. Noethe, J. Adam, M. L. Ahnen, D. Baack, M. Balbo, A. Biland, M. Blank, T. Bretz, K. Bruegge, J. Buss, A. Dmytriiev, D. Dorner, S. Einecke, D. Elsaesser, C. Hempfling, T. Herbst, D. Hildebrand, L. Kortmann, L. Linhoff, M. Mahlke, K. Mannheim, S. A. Mueller, D. Neise, A. Neronov, J. Oberkirch, A. Paravac, F. Pauss, W. Rhode, B. Schleicher, F. Schulz, A. Shukla, V. Sliusar, F. Temme, J. Thaele, R. Walte

FACT - Time-resolved blazar SEDs

Blazars are highly variable objects and their spectral energy distribution (SED) features two peaks. The emission at low energies is understood, however, the origin of the emission at TeV energies is strongly debated. While snapshots of SEDs usually can be explained with simple models, the evolution of SEDs challenges many models and allows for conclusions on the emission mechanisms. Leptonic models expect a correlation between the two peaks, while hadronic models can accommodate more complex correlations. To study time-resolved SEDs, we set up a target-of-opportunity program triggering high-resolution X-ray observations based on the monitoring at TeV energies by the First G-APD Cherenkov Telescope (FACT). To search for time lags and identify orphan flares, this is accompanied by X-ray monitoring with the Swift satellite. These observations provide an excellent multi-wavelength (MWL) data sample showing the temporal behaviour of the blazar emission along the electromagnetic spectrum. To constrain the origin of the TeV emission, we extract the temporal evolution of the low energy peak from Swift data and calculate the expected flux at TeV energies using a theoretical model. Comparing this to the flux measured by FACT, we want to conclude on the underlying physics. Results from more than five years of monitoring will be discussed.D. Dorner, J. Adam, M.L. Ahnen, D. Baack, M. Balbo, A. Biland, M. Blank, T. Bretz, a, K. Bruegge, M. Bulinski, J. Buss, A. Dmytriiev, S. Einecke, D. Elsaesser, C. Hempfling, T. Herbst, D. Hildebrand, L. Kortmann, L. Linhoff, M. Mahlke, a, K. Mannheim, S.A. Mueller, D. Neise, A. Neronov, M. Noethe, J. Oberkirch, A. Paravac, F. Pauss, W. Rhode, B. Schleicher, F. Schulz, A. Shukla, V. Sliusar, F. Temme, J. Thaele, R. Walter, FACT Collaboration, A. Kreikenbohm, K. Leite

An intermittent extreme BL Lac: MWL study of 1ES 2344+514 in an enhanced state

Extreme high-frequency BL Lacs (EHBL) feature their synchrotron peak of the broad-band spectral energy distribution (SED) at nu(s) >= 10(17) Hz. The BL Lac object 1ES 2344+514 was included in the EHBL family because of its impressive shift of the synchrotron peak in 1996. During the following years, the source appeared to be in a low state without showing any extreme behaviours. In 2016 August, 1ES 2344+514 was detected with the groundbased gamma-ray telescope FACT during a high gamma-ray state, triggering multiwavelength (MWL) observations. We studied the MWL light curves of 1ES 2344+514 during the 2016 flaring state, using data from radio to very-high-energy (VHE) gamma-rays taken with OVRO, KAIT, KVA, NOT, some telescopes of the GASP-WEBT collaboration at the Teide, Crimean, and St. Petersburg observatories, Swift-UVOT, Swift-XRT, Fermi-LAT, FACT, and MAGIC. With simultaneous observations of the flare, we built the broad-band SED and studied it in the framework of a leptonic and a hadronic model. The VHE gamma-ray observations show a flux level of 55 per cent of the Crab Nebula flux above 300 GeV, similar to the historical maximum of 1995. The combination of MAGIC and Fermi-LAT spectra provides an unprecedented characterization of the inverse-Compton peak for this object during a flaring episode. The Gamma index of the intrinsic spectrum in the VHE gamma-ray band is 2.04 +/- 0.12(stat) +/- 0.15(sys). We find the source in an extreme state with a shift of the position of the synchrotron peak to frequencies above or equal to 1018 Hz

The Impact of IT Bootcamp on Student Learning - Experience from ICT Enabled Experiential-Based Course

We have been teaching an experiential-based course for fist year master students. In the last two years, we have added to the course external activities such as Hackathon and Bootcamp. These external activities helped students internalize how important are soft skills and involvement of external stakeholders to succeed in developing relevant startup projects. This year, we wanted to evaluate if students were getting what we declared. We conducted a survey on students’ perception of different dimensions: soft skills challenges (teamwork, communication with stakeholders, presentation, negotiation, and innovation), technical challenges and project management (PM) challenges, before and at the end of the Bootcamp days. We found out that the mean values regarding soft skill challenges and project management vary, while values regarding technical challenge have not changed before and after Bootcamp. The overall outcomes of the study contribute to conceptualizing an early model integrating student startup formation with course learning outcomes

A bivalent glycopeptide to target two putative carbohydrate binding sites on FimH

FimH is a mannose-specific bacterial lectin found on type 1 fimbriae with a monovalent carbohydrate recognition domain (CRD) that is known from X-ray studies. However, binding studies with multivalent ligands have suggested an additional carbohydrate-binding site on this protein. In order to prove this hypothesis, a bivalent glycopeptide ligand with the capacity to bridge two putative carbohydrate binding sites on FimH was designed and synthesized. Anti-adhesion assays with the new bivalent ligand and type 1-fimbriated bacteria have revealed, that verification of the number of carbohydrate binding sites on FimH with a tailor-made bivalent glycopeptide requires further investigation to be conclusive