5,555 research outputs found
Minimal Surfaces, Screw Dislocations and Twist Grain Boundaries
Large twist-angle grain boundaries in layered structures are often described
by Scherk's first surface whereas small twist-angle grain boundaries are
usually described in terms of an array of screw dislocations. We show that
there is no essential distinction between these two descriptions and that, in
particular, their comparative energetics depends crucially on the core
structure of their screw-dislocation topological defects.Comment: 10 pages, harvmac, 1 included postscript figure, final versio
Local spin fluctuations in iron-based superconductors: 77Se and 87Rb NMR measurements of Tl0.47Rb0.34Fe1.63Se2
We report nuclear magnetic resonance (NMR) studies of the intercalated iron
selenide superconductor (Tl, Rb)FeSe ( K).
Single-crystal measurements up to 480 K on both Se and Rb nuclei
show a superconducting phase with no magnetic order. The Knight shifts and
relaxation rates increase very strongly with temperature above ,
before flattening at 400 K. The quadratic -dependence and perfect
proportionality of both and data demonstrate their origin in
paramagnetic moments. A minimal model for this pseudogap-like response is not a
missing density of states but two additive contributions from the itinerant
electronic and local magnetic components, a framework unifying the and
data in many iron-based superconductors
Identification of z~>2 Herschel 500 micron sources using color-deconfusion
We present a new method to search for candidate z~>2 Herschel 500{\mu}m
sources in the GOODS-North field, using a S500{\mu}m/S24{\mu}m "color
deconfusion" technique. Potential high-z sources are selected against
low-redshift ones from their large 500{\mu}m to 24{\mu}m flux density ratios.
By effectively reducing the contribution from low-redshift populations to the
observed 500{\mu}m emission, we are able to identify counterparts to high-z
500{\mu}m sources whose 24{\mu}m fluxes are relatively faint. The recovery of
known z~4 starbursts confirms the efficiency of this approach in selecting
high-z Herschel sources. The resulting sample consists of 34 dusty star-forming
galaxies at z~>2. The inferred infrared luminosities are in the range
1.5x10^12-1.8x10^13 Lsun, corresponding to dust-obscured star formation rates
(SFRs) of ~260-3100 Msun/yr for a Salpeter IMF. Comparison with previous SCUBA
850{\mu}m-selected galaxy samples shows that our method is more efficient at
selecting high-z dusty galaxies with a median redshift of z=3.07+/-0.83 and 10
of the sources at z~>4. We find that at a fixed luminosity, the dust
temperature is ~5K cooler than that expected from the Td-LIR relation at z<1,
though different temperature selection effects should be taken into account.
The radio-detected subsample (excluding three strong AGN) follows the
far-infrared/radio correlation at lower redshifts, and no evolution with
redshift is observed out to z~5, suggesting that the far-infrared emission is
star formation dominated. The contribution of the high-z Herschel 500{\mu}m
sources to the cosmic SFR density is comparable to that of SMG populations at
z~2.5 and at least 40% of the extinction-corrected UV samples at z~4
(abridged).Comment: 33 pages in emulateapj format, 24 figures, 2 tables, accepted for
publication in the ApJ
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Ultralow-threshold, continuous-wave upconverting lasing from subwavelength plasmons.
Miniaturized lasers are an emerging platform for generating coherent light for quantum photonics, in vivo cellular imaging, solid-state lighting and fast three-dimensional sensing in smartphones1-3. Continuous-wave lasing at room temperature is critical for integration with opto-electronic devices and optimal modulation of optical interactions4,5. Plasmonic nanocavities integrated with gain can generate coherent light at subwavelength scales6-9, beyond the diffraction limit that constrains mode volumes in dielectric cavities such as semiconducting nanowires10,11. However, insufficient gain with respect to losses and thermal instabilities in nanocavities has limited all nanoscale lasers to pulsed pump sources and/or low-temperature operation6-9,12-15. Here, we show continuous-wave upconverting lasing at room temperature with record-low thresholds and high photostability from subwavelength plasmons. We achieve selective, single-mode lasing from Yb3+/Er3+-co-doped upconverting nanoparticles conformally coated on Ag nanopillar arrays that support a single, sharp lattice plasmon cavity mode and greater than wavelength λ/20 field confinement in the vertical dimension. The intense electromagnetic near-fields localized in the vicinity of the nanopillars result in a threshold of 70 W cm-2, orders of magnitude lower than other small lasers. Our plasmon-nanoarray upconverting lasers provide directional, ultra-stable output at visible frequencies under near-infrared pumping, even after six hours of constant operation, which offers prospects in previously unrealizable applications of coherent nanoscale light
A Study of Two-Temperature Non-Equilibrium Ising Models: Critical Behavior and Universality
We study a class of 2D non-equilibrium Ising models based on competing
dynamics induced by contact with heat-baths at two different temperatures. We
make a comparative study of the non-equilibrium versions of Metropolis, heat
bath/Glauber and Swendsen-Wang dynamics and focus on their critical behavior in
order to understand their universality classes. We present strong evidence that
some of these dynamics have the same critical exponents and belong to the same
universality class as the equilibrium 2D Ising model. We show that the bond
version of the Swendsen-Wang update algorithm can be mapped into an equilibrium
model at an effective temperature.Comment: 12 pages of LaTeX plus 18 pages of postscript figures in a uuencoded
file (608k
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Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy.
BackgroundThe trans-neuronal propagation of tau has been implicated in the progression of tau-mediated neurodegeneration. There is critical knowledge gap in understanding how tau is released and transmitted, and how that is dysregulated in diseases. Previously, we reported that lysine acetyltransferase p300/CBP acetylates tau and regulates its degradation and toxicity. However, whether p300/CBP is involved in regulation of tau secretion and propagation is unknown.MethodWe investigated the relationship between p300/CBP activity, the autophagy-lysosomal pathway (ALP) and tau secretion in mouse models of tauopathy and in cultured rodent and human neurons. Through a high-through-put compound screen, we identified a new p300 inhibitor that promotes autophagic flux and reduces tau secretion. Using fibril-induced tau spreading models in vitro and in vivo, we examined how p300/CBP regulates tau propagation.ResultsIncreased p300/CBP activity was associated with aberrant accumulation of ALP markers in a tau transgenic mouse model. p300/CBP hyperactivation blocked autophagic flux and increased tau secretion in neurons. Conversely, inhibiting p300/CBP promoted autophagic flux, reduced tau secretion, and reduced tau propagation in fibril-induced tau spreading models in vitro and in vivo.ConclusionsWe report that p300/CBP, a lysine acetyltransferase aberrantly activated in tauopathies, causes impairment in ALP, leading to excess tau secretion. This effect, together with increased intracellular tau accumulation, contributes to enhanced spreading of tau. Our findings suggest that inhibition of p300/CBP as a novel approach to correct ALP dysfunction and block disease progression in tauopathy
Orbits for the Impatient: A Bayesian Rejection Sampling Method for Quickly Fitting the Orbits of Long-Period Exoplanets
We describe a Bayesian rejection sampling algorithm designed to efficiently
compute posterior distributions of orbital elements for data covering short
fractions of long-period exoplanet orbits. Our implementation of this method,
Orbits for the Impatient (OFTI), converges up to several orders of magnitude
faster than two implementations of MCMC in this regime. We illustrate the
efficiency of our approach by showing that OFTI calculates accurate posteriors
for all existing astrometry of the exoplanet 51 Eri b up to 100 times faster
than a Metropolis-Hastings MCMC. We demonstrate the accuracy of OFTI by
comparing our results for several orbiting systems with those of various MCMC
implementations, finding the output posteriors to be identical within shot
noise. We also describe how our algorithm was used to successfully predict the
location of 51 Eri b six months in the future based on less than three months
of astrometry. Finally, we apply OFTI to ten long-period exoplanets and brown
dwarfs, all but one of which have been monitored over less than 3% of their
orbits, producing fits to their orbits from astrometric records in the
literature.Comment: 32 pages, 28 figures, Accepted to A
T-PHOT: A new code for PSF-matched, prior-based, multiwavelength extragalactic deconfusion photometry
We present T-PHOT, a publicly available software aimed at extracting accurate
photometry from low-resolution images of deep extragalactic fields, where the
blending of sources can be a serious problem for the accurate and unbiased
measurement of fluxes and colours. T-PHOT has been developed within the
ASTRODEEP project and it can be considered as the next generation to TFIT,
providing significant improvements above it and other similar codes. T-PHOT
gathers data from a high-resolution image of a region of the sky, and uses it
to obtain priors for the photometric analysis of a lower resolution image of
the same field. It can handle different types of datasets as input priors: i) a
list of objects that will be used to obtain cutouts from the real
high-resolution image; ii) a set of analytical models; iii) a list of
unresolved, point-like sources, useful e.g. for far-infrared wavelength
domains. We show that T-PHOT yields accurate estimations of fluxes within the
intrinsic uncertainties of the method, when systematic errors are taken into
account (which can be done thanks to a flagging code given in the output).
T-PHOT is many times faster than similar codes like TFIT and CONVPHOT (up to
hundreds, depending on the problem and the method adopted), whilst at the same
time being more robust and more versatile. This makes it an optimal choice for
the analysis of large datasets. In addition we show how the use of different
settings and methods significantly enhances the performance. Given its
versatility and robustness, T-PHOT can be considered the preferred choice for
combined photometric analysis of current and forthcoming extragalactic optical
to far-infrared imaging surveys. [abridged]Comment: 23 pages, 20 figures, 2 table
Probability distribution of the order parameter for the 3D Ising model universality class: a high precision Monte Carlo study
We study the probability distribution P(M) of the order parameter (average
magnetization) M, for the finite-size systems at the critical point. The
systems under consideration are the 3-dimensional Ising model on a simple cubic
lattice, and its 3-state generalization known to have remarkably small
corrections to scaling. Both models are studied in a cubic box with periodic
boundary conditions. The model with reduced corrections to scaling makes it
possible to determine P(M) with unprecedented precision. We also obtain a
simple, but remarkably accurate approximate formula describing the universal
shape of P(M).Comment: 6 pages, 6 Postscript figures, uses RevTe
Origin of electrochemical activity in nano-Li2MnO3; Stabilization via a 'point defect scaffold'
Molecular dynamics (MD) simulations of the charging of Li2MnO3 reveal that the reason nanocrystalline-Li2MnO3 is electrochemically active, in contrast to the parent bulk-Li2MnO3, is because in the nanomaterial the tunnels, in which the Li ions reside, are held apart by Mn ions, which act as a pseudo 'point defect scaffold'. The Li ions are then able to diffuse, via a vacancy driven mechanism, throughout the nanomaterial in all spatial dimensions while the 'Mn defect scaffold' maintains the structural integrity of the layered structure during charging. Our findings reveal that oxides, which comprise cation disorder, can be potential candidates for electrodes in rechargeable Li-ion batteries. Moreover, we propose that the concept of a 'point defect scaffold' might manifest as a more general phenomenon, which can be exploited to engineer, for example, two or three-dimensional strain within a host material and can be fine-tuned to optimize properties, such as ionic conductivity
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