Examining Aspects of Role and Practice Changes for School Psychologists in Georgia: A Mixed Methods Analysis

Throughout the 1980\u27s and onward, professional commentary, editorials and models have been put forward to expand roles for school psychologists beyond assessment and special education. The harbinger has been to move away from traditional roles towards including all students in prevention, mental health and regular education initiatives. Recent legislation passed including NCLB, 2001 and IDEA, 2004 for schools across the country represented a major change for the directions of public school curriculum to include scientific based research instruction, more accountability and increased assessment at each grade level. This study was conducted in light of the historical context, these recent legislative changes and changes within Georgia\u27s curriculum structure with standards based instruction and the implementation of the pyramid of interventions. The research conducted investigated changes in the roles and practice of school psychologists in Georgia and the perceptions of changes in the field using mixed methods inquiry through survey and interview data collected. Participants in the survey included 444 school psychologists from the membership of the Georgia Association of School Psychologists. There were also 15 interview volunteers from small, medium and large school systems included in the research. The survey data collected were compared with the results of Kimball\u27s (1998) study to examine any changes in the roles and practices of school psychologists in Georgia over the last 12 years. While a rank order comparison of role involvement reflected similar findings to Kimball\u27s research, there were implications of role change with statistically significant differences obtained in four of the five role areas measured. Additionally, reported percentages of involvement also noted changes in the roles for school psychologists in Georgia. Interview information helped contextualize the degree of changes in roles and the difficulties encountered in the transformative process. Results noted agreement on the decrease in assessment for school psychologists in the field, feelings of uncertainty for the role changes and perceptions that RtI was helping students in the regular education setting. Barriers and empowerments to change for school psychologists were also reported

Science live: Surveying the landscape of live public science events

The field of informal science learning and communication is comprised of many sectors—after school programs, science center exhibitions and programs, television and film, print and new media, to name just a few. Each of these is understood to make unique contributions, present unique opportunities, and require unique support. Science Live began with the observation that it time to similarly acknowledge the practice of live public science events.Public science events are live, in-person programs designed to engage publics with science in a social context that is at least as meaningful as the content and messages delivered. The overall objective of Science Live is to support the development of a distinct professional sector based on live public science events so that the practitioners, researchers, and external supporters of this sector are able to maximize the beneficial impacts of events and widen participation in this activity.The following survey of the live public science events landscape is the product of a one-year, Phase I grant from the Science Learning+ funding program. This funding program has enabled Science Live to take a transatlantic approach, with an initial focus on fostering connections between the US and UK,and between practitioners and researchers.The following landscape survey is based on informal conversations, phone interviews following a research protocol, and two project convenings, one each in the US and UK. A total of 111 practitioners and researchers attended project convenings, and scores more were consulted by phone.The many quotes appearing in the following pages are taken directly from these conversations. This landscape survey seeks to summarize a year of dialogue, but is not explicitly endorsed by the many practitioners and researchers that participated.The world of live public science events is wide, varied, and rapidly changing. There is no way to represent the many initiatives that populate this remarkable landscape in a way that properly does each justice. Please see www.livescienceevents.org for links to participating programs, research,and sites for further exploration

Faecal Microbiota Transplantation plus selected use of antibiotics for severe-complicated Clostridium difficile infection: description of a protocol with high success rate

Background Severe and severe/complicated Clostridium difficile infection (CDI) can result in ICU admission, sepsis, toxic megacolon and death. In this setting, colectomy is the standard of care but it is associated with a 50% mortality. Aim To evaluate safety and efficacy of a sequential faecal microbiota transplantation (FMT) and antibiotic protocol in severe and severe/complicated CDI patients who are at high risk for colectomy. Methods All patients with severe and severe/complicated CDI refractory to oral vancomycin ± rectal vancomycin and intravenous metronidazole therapy were offered FMT. Treatment consisted of sequential FMTs via colonoscopy with the need for repeat FMT and continued vancomycin guided by clinical response and pseudomembranes at colonoscopy. Results A total of 29 patients underwent FMT between July 2013 and August 2014. The overall treatment response of endoscopic sequential FMT was 93% (27/29), with 100% (10/10) for severe CDI and 89% (17/19) for severe/complicated CDI. A single FMT was performed in 62%, two FMTs were performed in 31% and three FMTs in 7% of patients. The use of non-CDI antibiotics predicted repeat FMT (odds ratio = 17.5). The 30-day all-cause mortality after FMT was 7%, and the cumulative 3-month survival was 76%. Of the two patients who died within 30 days, one underwent colectomy and succumbed to sepsis; the other died from septic shock related to CDI. Conclusion The success of a treatment protocol for severe and severe/complicated involving faecal microbiota transplantation and continued vancomycin in selected patients was high, and it warrants further evaluation

Development of a Multicenter Interventional Cardiology Database: The Blue Cross Blue Shield of Michigan Cardiovascular Consortium (BMC2) Experience

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72219/1/j.1540-8183.2002.tb01072.x.pd

Coformulation of Broadly Neutralizing Antibodies 3BNC117 and PGT121: Analytical Challenges During Preformulation Characterization and Storage Stability Studies

This work is licensed under a Creative Commons Attribution 4.0 International License.In this study, we investigated analytical challenges associated with the formulation of 2 anti-HIV broadly neutralizing antibodies (bnAbs), 3BNC117 and PGT121, both separately at 100 mg/mL and together at 50 mg/mL each. The bnAb formulations were characterized for relative solubility and conformational stability followed by accelerated and real-time stability studies. Although the bnAbs were stable during 4°C storage, incubation at 40°C differentiated their stability profiles. Specific concentration-dependent aggregation rates at 30°C and 40°C were measured by size exclusion chromatography for the individual bnAbs with the mixture showing intermediate behavior. Interestingly, although the relative ratio of the 2 bnAbs remained constant at 4°C, the ratio of 3BNC117 to PGT121 increased in the dimer that formed during storage at 40°C. A mass spectrometry-based multiattribute method, identified and quantified differences in modifications of the Fab regions for each bnAb within the mixture including clipping, oxidation, deamidation, and isomerization sites. Each bnAb showed slight differences in the levels and sites of lysine residue glycations. Together, these data demonstrate the ability to differentiate degradation products from individual antibodies within the bnAb mixture, and that degradation rates are influenced not only by the individual bnAb concentrations but also by the mixture concentration.Bill and Melinda Gates Foundation, Seattle, WA [grant number OPP1138851 and Investment ID 25617

Co-formulation of broadly neutralizing antibodies 3BNC117 and PGT121:Analytical challenges during pre-formulation characterization and storage stability studies

In this study, we investigated analytical challenges associated with the formulation of two broadly neutralizing anti-HIV monoclonal antibodies (bnAbs), 3BNC117 and PGT121, both separately at 100 mg/mL and together at 50 mg/mL each. The bnAb formulations were characterized for relative solubility and conformational stability followed by accelerated and real-time stability studies. While the bnAbs were stable during 4°C storage, incubation at 40°C differentiated their stability profiles. Specific concentration dependent aggregation rates at 30°C and 40°C were measured by size exclusion chromatography for the individual bnAbs with the mixture showing intermediate behavior. Please download the file below for full content

Divergent Relationships between Fecal Microbiota and Metabolome following Distinct Antibiotic-Induced Disruptions

This is an openaccess article distributed under the terms of the Creative Commons attribution 4.0 International license.The intestinal microbiome plays an essential role in regulating many aspects of host physiology, and its disruption through antibiotic exposure has been implicated in the development of a range of serious pathologies. The complex metabolic relationships that exist between members of the intestinal microbiota and the potential redundancy in functional pathways mean that an integrative analysis of changes in both structure and function are needed to understand the impact of antibiotic exposure. We used a combination of next-generation sequencing and nuclear magnetic resonance (NMR) metabolomics to characterize the effects of two clinically important antibiotic treatments, ciprofloxacin and vancomycin-imipenem, on the intestinal microbiomes of female C57BL/6 mice. This assessment was performed longitudinally and encompassed both antibiotic challenge and subsequent microbiome reestablishment. Both antibiotic treatments significantly altered the microbiota and metabolite compositions of fecal pellets during challenge and recovery. Spearman’s correlation analysis of microbiota and NMR data revealed that, while some metabolites could be correlated with individual operational taxonomic units (OTUs), frequently multiple OTUs were associated with a significant change in a given metabolite. Furthermore, one metabolite, arginine, can be associated with increases/decreases in different sets of OTUs under differing conditions. Taken together, these findings indicate that reliance on shifts in one data set alone will generate an incomplete picture of the functional effect of antibiotic intervention. A full mechanistic understanding will require knowledge of the baseline microbiota composition, combined with both a comparison and an integration of microbiota, metabolomics, and phenotypic data

Degradation of Spacesuit Fabrics in Low Earth Orbit

Six samples of pristine and dust-abraded outer layer spacesuit fabrics were included in the Materials International Space Station Experiment-7, in which they were exposed to the wake-side low Earth orbit environment on the International Space Station (ISS) for 18 months in order to determine whether abrasion by lunar dust increases radiation degradation. The fabric samples were characterized using optical microscopy, optical spectroscopy, field emission scanning electron microscopy, atomic force microscopy, and tensile testing before and after exposure on the ISS. Comparison of pre- and post-flight characterizations showed that the environment darkened and reddened all six fabrics, increasing their integrated solar absorptance by 7 to 38 percent. There was a decrease in the ultimate tensile strength and elongation to failure of lunar dust abraded Apollo spacesuit fibers by a factor of four and an increase in the elastic modulus by a factor of two