Portfolio Vol. III N 4

Moll, Willlie. I Was in Kitchener Camp. Prose. 5-6. Barrington, John. The Pledging of Homer McGunk. Prose. 7-9. Stewart, John. In Time of Death. Prose. 10. Lindsey, Arthur Ward. Retrospect. Prose. 11-13. Phillips, Allison. Blue Moon. Poetry. 14. Yoxall, Lindsey E. Pro Patria. Prose. 15-16. Beckham, Adela. Wind--Dreams. Poetry. 18. Fields, Brooks. The Doctor Takes a Trip. Prose. 19-20. Deane, Dorothy. Review of New Books. Prose. 21. Smith, Duke. Review of New Recordings. Prose. 21. Timrud, David. Refugee. Prose. 22-23

“After a finding of Noncompliance, What?!”

Treaties have long been the cornerstones of international relations. They can be seen as one of the sole mechanisms to formalize agreements between sovereign states. In principle, these agreements are legally binding. In practice, the result is less certain. Issues ranging from the how the country views itself on the international stage to the specific treaty terms and enforcement mechanisms can all effect prospects for compliance. What is certain is the disruption and uncertainty that noncompliance causes. If not addressed, a treaty’s utility will eventually erode to the point where the agreement has no force. Other countries would also perceive little value in treaty ratification if compliance cannot be sufficiently verified. This report focuses on current issues of noncompliance with Russia, Syria, Iran, and North. Korea. Key themes arise across these cases and point to specific factors that impact treaty compliance. The report distills these key themes into general and case-specific recommendations for bringing a country back from noncompliance

University faculty and administrator responses to job strains

This study reports the relationships between job strain and several quality of life (QOL) indicators for a group of university faculty and administrators. The QOL indicators were in the domain of job satisfaction, life satisfaction, and health. Variables presumed to moderate the relationship between job strain and QOL were tested for their ability to buffer the strain effects. Analyses were carried out on faculty's and administrators' responses. The strong correlations obtained have both theoretical and practical consequences. Intervention strategies are discussed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/43599/1/11162_2004_Article_BF00991876.pd

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts