Observational evidence for stochastic biasing

We show that the galaxy density in the Las Campanas Redshift Survey (LCRS) cannot be perfectly correlated with the underlying mass distribution since various galaxy subpopulations are not perfectly correlated with each other, even taking shot noise into account. This rules out the hypothesis of simple linear biasing, and suggests that the recently proposed stochastic biasing framework is necessary for modeling actual data.Comment: 4 pages, with 2 figures included. Minor revisions to match accepted ApJL version. Links and color fig at http://www.sns.ias.edu/~max/r_frames.html or from [email protected]

Comparing and combining the Saskatoon, QMAP and COBE CMB maps

We present a method for comparing and combining maps with different resolutions and beam shapes, and apply it to the Saskatoon, QMAP and COBE/DMR data sets. Although the Saskatoon and QMAP maps detect signal at the 21 sigma and 40 sigma levels, respectively, their difference is consistent with pure noise, placing strong limits on possible systematic errors. In particular, we obtain quantitative upper limits on relative calibration and pointing errors. Splitting the combined data by frequency shows similar consistency between the Ka- and Q-bands, placing limits on foreground contamination. The visual agreement between the maps is equally striking. Our combined QMAP+Saskatoon map, nicknamed QMASK, is publicly available at www.hep.upenn.edu/~xuyz/qmask.html together with its 6495x6495 noise covariance matrix. This thoroughly tested data set covers a large enough area (648 square degrees -- currently the largest degree-scale map available) to allow a statistical comparison with COBE/DMR, showing good agreement.Comment: Replaced to match accepted PRD version. 12 pages, 11 figs. Map and covariance matrix at http://www.hep.upenn.edu/~xuyz/qmask.html or from [email protected]

Genetic mechanisms of critical illness in COVID-19.

Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 ×  10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice

The Shallow or the Deep Ecological Economics Movement?

Ecological economics and its policy recommendations have become overwhelmed by economic valuation, shadow pricing, sustainability measures, and squeezing Nature into the commodity boxes of goods, services and capital in order to make it part of mainstream economic, financial and banking discourses. There are deeper concerns which touch upon the understanding of humanity in its various social, psychological, political and ethical facets. The relationship with Nature proposed by the ecological economics movement has the potential to be far reaching. However, this is not the picture portrayed by surveying the amassed body of articles from this journal or by many of those claiming affiliation. A shallow movement, allied to a business as usual politics and economy, has become dominant and imposes its preoccupation with mainstream economic concepts and values. If, instead, ecological economists choose a path deep into the world of interdisciplinary endeavour they will need to be prepared to transform themselves and society. The implications go far beyond the pragmatic use of magic numbers to convince politicians and the public that ecology still has something relevant to say in the 21st Century. (author's abstract)Series: SRE - Discussion Paper