Newer drugs for focal epilepsy in adults

A 28 year old woman sees her general practitioner after experiencing what sounds like a convulsion without any apparent provoking factor. Over the past month she has also had “blank spells” during which her husband noticed her to be unresponsive. Her general practitioner suspects she may have developed focal epilepsy and refers her to an epilepsy specialist. The specialist elicits from the patient and her husband additional features in the history that are highly compatible with seizures arising from the temporal lobe (lip smacking, ipsilateral motor automatism, and contralateral dystonia) and confirms the diagnosis by finding focal epileptiform discharges on electroencephalography and cortical dysplasia in the left temporal lobe on brain imaging. To prevent further seizures the specialist advises treatment with antiepileptic drugs (AEDs). The patient is reluctant to start treatment because she has read that AEDs have many adverse effects, could interact with her oral contraception, and are harmful for babies. She wonders if there are newer AEDs that for her might be better than the traditional ones

Virtually connected, practically mobile

This is the post-print version of the Chapter. The official published version can be accessed from the links below - Copyright @ 2006 SpringerThis chapter addresses a central issue in studies of mobile work and mobile technology – what is the work of mobile workers, and how do they use the resources that they have to undertake this work (i.e. the work they have to do in order to do their work)? In contrast to many of the other papers in this collection, the objective of this chapter is to examine individual mobile work, and not teamwork and co-operation other than where it impacts on the work of individuals. We present data from a study of mobile workers, examining a range of mobile workers to produce a rich picture of their work. Our analysis reveals insights into how mobile workers mix their mobility with their work, home and social lives, their use of mobile technology, the problems – technological and otherwise – inherent in being mobile, and the strategies that they use to manage their work, time, other resources and availability. Our findings demonstrate important issues in understanding mobile work, including the maintenance of communities of practice, the role and management of interpersonal awareness and co-ordination, how environmental resources affect activity, the impact of mobility on family/social relationships and the crossover between the mobile workers’ private and working lives, how preplanning is employed prior to travel, and how mobile workers perform activity multitasking, for example through making use of ‘dead time’. Finally, we turn to the implications of this data for the design and deployment of mobile virtual work (MVW) technologies for individuals and a broader organisational context

Evaluation of greenwaste mulch to control runoff quality from landfill sites during frequent storms

This paper describes a preliminary evaluation of two types of greenwaste (fresh and aged) used as a mulch layer to control runoff from disturbed landfill areas. Fresh greenwaste refers to woody and herbaceous garden waste that has been recently collected, chopped and shredded. Aged greenwaste is greenwaste which has been stockpiled for 18 months. We used rainfall simulator tests to investigate two aspects: (1) the performance of greenwaste mulch in reducing runoff during designed storm events with a high frequency of occurrence and (2) the release of pollutants via runoff as total suspended solids (TSS) and total organic carbon (TOC) during rain. Rainfall of <5-year average recurrence interval (ARI) was generally applied, consistent with stormwater compliance requirements for many Australian landfills. TOC released from fresh greenwaste material was higher in concentration than from aged greenwaste. However when used as a 10cm-deep mulch layer, fresh greenwaste was able to completely prevent runoff, even when tested under rainfalls up to 50 year ARI duration. An equivalent mulch layer of aged greenwaste was also effective in reducing runoff volume and TSS concentration compared with the bare soil during a 3.5-year ARI rainfall, but mean TOC concentration was higher. Based on these preliminary results, fresh greenwaste mulching of bare soils is an attractive option to control runoff and erosion from areas subject to intermittent landfill operations and worthy of further investigations

Plethodon elongatus

Number of Pages: 2Integrative BiologyGeological Science

Effect of closing facilities on electroconvulsive therapy use in Glasgow

&lt;p&gt;Objectives: To assess the effect of closure of electroconvulsive therapy (ECT) centers on ECT use. Electroconvulsive therapy remains a recommended and effective treatment for mental disorders. Declining rates of ECT use in the United Kingdom have been observed over the last 20 years with anecdotal observations that use has declined as the result of centralization of provision. In Glasgow, there have been site closures in the north with no such rationing taking place in the south.&lt;/p&gt; &lt;p&gt;Methods: A naturalistic retrospective survey of the number of ECT courses commenced each year in Glasgow, with a comparison made between the north and the south of the city. Data were available from 1996 to 2008.&lt;/p&gt; &lt;p&gt;Results: Our analysis showed no change in the mean number of ECT courses commenced in southern AQ2 Glasgow (period 1, 42.25; period 2, 41.83; period 3, 31; F = 1.369; P = 0.298). There was a significant reduction in the mean number of ECT treatments commenced in northern Glasgow (period 1, 91.25; period 2, 51; period 3, 33.33; F = 10.06; P = 0.04).&lt;/p&gt; &lt;p&gt;Conclusions: In northern Glasgow, where there have been 2 site closures since 1996, ECT use has declined. This trend was not replicated in the south of the city. This would suggest that the closure of ECT centers does reduce the use of ECT. However, there may be a number of confounding variables that could not be factored into the analysis because of lack of available data.&lt;/p&gt

Post-Welfare Lawyering: Clinical Legal Education and a New Poverty Law Agenda

Ours is the “post-welfare” era, and it is ripe with opportunities for poverty lawyers to shape a new poverty law agenda. This era is characterized by the millions of former welfare recipients who entered the wage-labor force, and by a new public dialogue about post-welfare poverty. Journalists, social scientists, and policymakers have been watching these “welfare leavers,” assessing their labor market participation, their “success,” and their economic well-being. Together, these observers and actors have created a new academic, political, and cultural terrain on which American poverty is debated and constructed—one where “the working poor” has replaced “the welfare recipient” as the trope of American poverty. Poverty lawyers must account for this new social category and, I argue, should take advantage of the current historical moment to expand justice for these workers and others in post-welfare poverty

On ‘Organized Crime’ in the illicit antiquities trade: moving beyond the definitional debate

The extent to which ‘organized crime’ is involved in illicit antiquities trafficking is unknown and frequently debated. This paper explores the significance and scale of the illicit antiquities trade as a unique transnational criminal phenomenon that is often said to be perpetrated by and exhibit traits of so-called ‘organized crime.’ The definitional debate behind the term ‘organized crime’ is considered as a potential problem impeding our understanding of its existence or extent in illicit antiquities trafficking, and a basic progression-based model is then suggested as a new tool to move beyond the definitional debate for future research that may help to elucidate the actors, processes and criminal dynamics taking place within the illicit antiquities trade from source to market. The paper concludes that researchers should focus not on the question of whether organized criminals- particularly in a traditionally conceived, mafia-type stereotypical sense- are involved in the illicit antiquities trade, but instead on the structure and progression of antiquities trafficking itself that embody both organized and criminal dynamics