Unique transcriptomic landscapes identified in idiopathic spontaneous and infection related preterm births compared to normal term births.

Preterm birth (PTB) is leading contributor to infant death in the United States and globally, yet the underlying mechanistic causes are not well understood. Histopathological studies of preterm birth suggest advanced villous maturity may have a role in idiopathic spontaneous preterm birth (isPTB). To better understand pathological and molecular basis of isPTB, we compared placental villous transcriptomes from carefully phenotyped cohorts of PTB due to infection or isPTB between 28-36 weeks gestation and healthy term placentas. Transcriptomic analyses revealed a unique expression signature for isPTB distinct from the age-matched controls that were delivered prematurely due to infection. This signature included the upregulation of three IGF binding proteins (IGFBP1, IGFBP2, and IGFBP6), supporting a role for aberrant IGF signaling in isPTB. However, within the isPTB expression signature, we detected secondary signature of inflammatory markers including TNC, C3, CFH, and C1R, which have been associated with placental maturity. In contrast, the expression signature of the gestational age-matched infected samples included upregulation of proliferative genes along with cell cycling and mitosis pathways. Together, these data suggest an isPTB molecular signature of placental hypermaturity, likely contributing to the premature activation of inflammatory pathways associated with birth and providing a molecular basis for idiopathic spontaneous birth

Comparative transcriptomic analysis of human placentae at term and preterm delivery.

Preterm birth affects 1 out of every 10 infants in the United States, resulting in substantial neonatal morbidity and mortality. Currently, there are few predictive markers and few treatment options to prevent preterm birth. A healthy, functioning placenta is essential to positive pregnancy outcomes. Previous studies have suggested that placental pathology may play a role in preterm birth etiology. Therefore, we tested the hypothesis that preterm placentae may exhibit unique transcriptomic signatures compared to term samples reflective of their abnormal biology leading to this adverse outcome. We aggregated publicly available placental villous microarray data to generate a preterm and term sample dataset (n = 133, 55 preterm placentae and 78 normal term placentae). We identified differentially expressed genes using the linear regression for microarray (LIMMA) package and identified perturbations in known biological networks using Differential Rank Conservation (DIRAC). We identified 129 significantly differentially expressed genes between term and preterm placenta with 96 genes upregulated and 33 genes downregulated (P-valu

Useful Exergy as an Intermediate Input in a Two-Sector Model of the United States Economy

Conventional economic growth models treat production/consumption as abstractions linked only by money flows, disregarding their connection to the physical world. Nevertheless, the existing literature suggests that energy flows can influence production and links useful exergy prices with economic growth. Useful exergy is energy measured at the stage where it produces an end-use (and is a measurement of energy quality). Not all approaches in the literature use this metric and they often consider energy as a primary input (despite it being an intermediate input). We explore the relationship between energy flows and economic growth for the US through a framework where useful exergy, the output of an “extended energy sector” (where all effects of increasing primary-to-final-to-useful exergy efficiency are located), is an intermediate input for a “non-energy sector”. Together, they encompass the entire economy. We conclude that the share of investment in the extended energy sector grew with the overall economic growth throughout 1960–2020, while the labour share decreased. The non-energy sector contributed the largest share of consumption, exports, imports and labour. In recent years, the energy sector has overtaken it in terms of investment. Our two-sector model has important implications for current climate policy, namely regarding the Integrated Assessment Models on which it is based

A Search for leptophilic Z_(l) boson at future linear colliders

We study the possible dynamics associated with leptonic charge in future linear colliders. Leptophilic massive vector boson, Z_(l), have been investigated through the process e^(+)e^(-) -> mu^(+)mu^(-). We have shown that ILC and CLIC will give opportunity to observe Z_(l) with masses up to the center of mass energy if the corresponding coupling constant g_(l) exceeds 10^(-3).Comment: 12 pages, 10 figure

Photon Spectrum Produced by the Late Decay of a Cosmic Neutrino Background

We obtain the photon spectrum induced by a cosmic background of unstable neutrinos. We study the spectrum in a variety of cosmological scenarios and also we allow for the neutrinos having a momentum distribution (only a critical matter dominated universe and neutrinos at rest have been considered until now). Our results can be helpful when extracting bounds on neutrino electric and magnetic moments from cosmic photon background observations.Comment: RevTex, 14 pages, 3 figures; minor changes, references added. To appear in Phys. Rev.

Constraints on Variant Axion Models

A particular class of variant axion models with two higgs doublets and a singlet is studied. In these models the axion couples either to the $u$-quark or $t$-quark or both, but not to $b$, $c$, $s$, or $d$. When the axion couples to only one quark the models possess the desirable feature of having no domain wall problem, which makes them viable candidates for a cosmological axion string scenario. We calculate the axion couplings to leptons, photons and nucleons, and the astrophysical constraints on the axion decay constant $v_a$ are investigated and compared to the DFSZ axion model. We find that the most restrictive lower bound on $v_a$, that from SN1987a, is lowered by up to a factor of about 30, depending on the model and also the ratio of the vacuum expectation values of the higgs doublets. For scenarios with axionic strings, the allowed window for $v_a$ in the $u$ quark model can be more than two orders of magnitude. For inflationary scenarios, the cosmological upper bound on $v_a/N$, where $N$ is the QCD anomaly factor, is unaffected: however, the variant models have $N$ either 3 or 6 times smaller than the DFSZ model.Comment: 21pp RevTeX, 1 eps fig, uses graphics style, typo corrected, and corrected file sent this time. To appear in Physical Review

Integrated assessment modelling of degrowth scenarios for Australia

Empirical evidence increasingly indicates that to achieve sufficiently rapid decarbonisation, high-income economies may need to adopt degrowth policies, scaling down less-necessary forms of production and demand, in addition to rapid deployment of renewables. Calls have been made for degrowth climate mitigation scenarios. However, so far these have not been modelled within the established Integrated Assessment Models (IAMs) for future scenario analysis of the energy-economy-emission nexus, partly because the architecture of these IAMs has growth ‘baked in’. In this work, we modify one of the common IAMs–MESSAGEix–to make it compatible with degrowth scenarios. We simulate scenarios featuring low and negative growth in a high-income economy (Australia). We achieve this by detaching MESSAGEix from its monotonically growing utility function, and by formulating an alternative utility function based on non-monotonic preferences. The outcomes from such modified scenarios reflect some characteristics of degrowth futures, including reduced aggregate production and declining energy and emissions. However, further work is needed to explore other key degrowth features such as sectoral differentiation, redistribution, and provisioning system transformation

Downscaling down under: towards degrowth in integrated assessment models

IPCC reports, to date, have not featured ambitious mitigation scenarios with degrowth in high-income regions. Here, using MESSAGEix-Australia, we create 51 emissions scenarios for Australia with near-term GDP growth going from +3%/year to rapid reductions (−5%/year) to explore how a traditional integrated assessment model (IAM) represents degrowth from an economic starting point, not just energy demand reduction. We find that stagnating GDP per capita reduces the mid-century need for upscaling solar and wind energy by about 40% compared to the SSP2 growth baseline, and limits future material needs for renewables. Still, solar and wind energy in 2030 is more than quadruple that of 2020. Faster reductions in energy demand may entail higher socio-cultural feasibility concerns, depending on the policies involved. Strong reductions in inequality reduce the risk of lowered access to decent living services. We discuss research needs and possible IAM extensions to improve post-growth and degrowth scenario modelling

Dimming Supernovae without Cosmic Acceleration

We present a simple model where photons propagating in extra-galactic magnetic fields can oscillate into very light axions. The oscillations may convert some of the photons departing a distant supernova into axions, making the supernova appear dimmer and hence more distant than it really is. Averaging over different configurations of the magnetic field we find that the dimming saturates at about 1/3 of the light from the supernovae at very large redshifts. This results in a luminosity-distance vs. redshift curve almost indistinguishable from that produced by the accelerating Universe, if the axion mass and coupling scale are m ~ 10^-16 eV, M ~ 4 10^11 GeV. This phenomenon may be an alternative to the accelerating Universe for explaining supernova observations.Comment: 11 pages, LaTex, 2 figures included. Comments on effects of refraction within galaxies and references adde