Density Perturbations in Chain Inflation

We consider the model of ``Chain Inflation,'' in which the period of inflation in our universe took the form of a long sequence of quantum tunneling events. We find that in the simplest such scenario, in which the tunneling processes are uniform, approximately 10^4 vacua per e-folding of inflation are required in order that the density perturbations produced are of an acceptable size. We arrive at this conclusion through a combination of analytic and numerical techniques, which could also serve as starting points for calculations with more general sets of assumptions.Comment: 28 pages, 16 figures; v2: corrected typos, increased resolution on D=2+1 data point

A Close and Supportive Interparental Bond During Pregnancy Predicts Greater Decline in Sexual Activity From Pregnancy to Postpartum: Applying an Evolutionary Perspective

A common topic for advice given to parents after childbirth – both from relationship experts and popular media – is how to “bounce back” to one’s pre-pregnancy sexuality, with warnings that postpartum declines in sexual frequency will take a serious toll on one’s relationship. However, these admonishments may not accurately reflect the ways in which the unique reproductive context of pregnancy and the postpartum transition alter associations between sexual frequency and relationship quality. Evolutionary perspectives on reproductive strategies would suggest that in the postpartum context, decreased sexual activity would help target parental investment in the current offspring (rather than creating new offspring); however, if the parental relationship is lacking in intimacy and support, continued sexual activity may help seal the cracks in the bond. We tested this theory in a longitudinal dyadic study of changes in relationship quality and sexual frequency from pregnancy to 6 months postpartum among 159 heterosexual couples. We found that across three different measures of relationship quality taken from interviews and behavioral observation of couple interactions, higher relationship quality (i.e., greater support, intimacy, and responsiveness) predicted greater decline in sexual frequency whereas sexual frequency remained relatively stable in lower quality relationships. These findings suggest that, during the postpartum transition, decreased sexual frequency may not be a reliable signal of poor relationship quality

Existential mental health implications for kin-caregivers of Alzheimer\u27s victims

The purpose of this paper is to briefly outline assessment and progression of Alzheimer\u27s disease (AD) in afflicted individuals (i.e., care recipients [CRs]) and review relevant research concerning the effects of AD progression on caregivers (CGs) as they care for loved ones. With this background, consideration will be made of how these findings suggest relevant tenets of Existential therapy. The author will also identify implications that could be meaningful to mental health professionals in their efforts to assist CGs as they attempt to cope with the emotional impact this disease has on them during caregiving and after the eventual death of the CR. The premise of this paper is that Existential Therapy (ET) is particularly well suited for this area of psychotherapy because of the salient issues involved and because ET concepts can be utilized within many psychotherapeutic approaches (Yalom, 1980)

Stratigraphy, Geochronology and Detrital Zircon Provenance of Two Silicic Ash Layers at Hagerman Fossil Beds National Monument, Idaho

Hagerman Fossil Beds National Monument (HAFO) is home to the world-famous Hagerman Horse Quarry. This site gives important insight into Pliocene age paleontology. Absolute ages of this site have been elusive, although researchers have assumed the site to be around 3.2 Ma. This study sought to determine more precise ages for the previously documented Hagerman Horse Quarry and Peters Gulch ash layers at HAFO thereby defining a more specific date for the Hagerman fossil assemblage, and to describe and interpret their sedimentary horizons. Detailed stratigraphic columns were created to describe sedimentary layers and establish marker beds. The sedimentology and stratigraphy are consistent with that of fluvial/flood plain depositional environments. Two ash samples were collected and analyzed using U/Pb zircon geochronology via laser ablation inductively coupled plasma mass spectrometry (LA-ICPMS). Similar to previous studies, the majority of zircon crystals in these volcanic ashes are detrital in origin, ranging in age from 4 Ma to Precambrian. While the depositional age of these ash beds remains elusive, the detrital ages were grouped into three major volcanic events and described in order to identify the source of the detrital zircons and hosting sediment. These source areas include the Atlanta Lobe of the Idaho Batholith (80 – 100 Ma), the Challis Volcanic Group (45 – 52 Ma), and rhyolitic Yellowstone-Snake River Plain volcanics (4 – 17 Ma)

Absence of an embryonic stem cell DNA methylation signature in human cancer.

BackgroundDifferentiated cells that arise from stem cells in early development contain DNA methylation features that provide a memory trace of their fetal cell origin (FCO). The FCO signature was developed to estimate the proportion of cells in a mixture of cell types that are of fetal origin and are reminiscent of embryonic stem cell lineage. Here we implemented the FCO signature estimation method to compare the fraction of cells with the FCO signature in tumor tissues and their corresponding nontumor normal tissues.MethodsWe applied our FCO algorithm to discovery data sets obtained from The Cancer Genome Atlas (TCGA) and replication data sets obtained from the Gene Expression Omnibus (GEO) data repository. Wilcoxon rank sum tests, linear regression models with adjustments for potential confounders and non-parametric randomization-based tests were used to test the association of FCO proportion between tumor tissues and nontumor normal tissues. P-values of < 0.05 were considered statistically significant.ResultsAcross 20 different tumor types we observed a consistently lower FCO signature in tumor tissues compared with nontumor normal tissues, with 18 observed to have significantly lower FCO fractions in tumor tissue (total n = 6,795 tumor, n = 922 nontumor, P < 0.05). We replicated our findings in 15 tumor types using data from independent subjects in 15 publicly available data sets (total n = 740 tumor, n = 424 nontumor, P < 0.05).ConclusionsThe results suggest that cancer development itself is substantially devoid of recapitulation of normal embryologic processes. Our results emphasize the distinction between DNA methylation in normal tightly regulated stem cell driven differentiation and cancer stem cell reprogramming that involves altered methylation in the service of great cell heterogeneity and plasticity

Uncertainties of predictions from parton distribution functions II: the Hessian method

We develop a general method to quantify the uncertainties of parton distribution functions and their physical predictions, with emphasis on incorporating all relevant experimental constraints. The method uses the Hessian formalism to study an effective chi-squared function that quantifies the fit between theory and experiment. Key ingredients are a recently developed iterative procedure to calculate the Hessian matrix in the difficult global analysis environment, and the use of parameters defined as components along appropriately normalized eigenvectors. The result is a set of 2d Eigenvector Basis parton distributions (where d=16 is the number of parton parameters) from which the uncertainty on any physical quantity due to the uncertainty in parton distributions can be calculated. We illustrate the method by applying it to calculate uncertainties of gluon and quark distribution functions, W boson rapidity distributions, and the correlation between W and Z production cross sections.Comment: 30 pages, Latex. Reference added. Normalization of Hessian matrix changed to HEP standar