The Effects of the Laurentide Ice Sheet on North American Climate during the Last Glacial Maximum

A climate model, consisting of an atmospheric general circulation model coupled with a simple model of the oceanic mixed layer, is used to investigate the effects of the continental ice distribution of the last glacial maximum (LGM) on North American climate. This model has previously been used to simulate the LGM climate, producing temperature changes reasonably in agreement with paleoclimatic data. The LGM distribution of continental ice according to the maximum reconstruction of HUGHES et al. (1981) is used as input to the model. In response to the incorporation of the expanded continental ice of the LGM, the model produces major changes in the climate of North America. The ice sheet exerts an orographic effect on the tropospheric flow, resulting in a splitting of the midlatitude westerlies in all seasons but summer. Winter temperatures are greatly reduced over a wide region south of the Laurentide ice sheet, although summer cooling is less extensive. An area of reduced soil moisture develops in the interior of North America just south of the ice margin. At the same time, precipitation increases in a belt extending from the extreme southeastern portion of the ice sheet eastward into the North Atlantic. Some of these findings are similar to paleoclimatic inferences based on geological evidence.Un modèle climatique, composé d'un modèle de circulation atmosphérique général associé à un modèle simple de la couche océanique mixte, a servi à étudier l'influence de la répartition des glaciers continentaux sur le climat de l'Amérique du Nord au dernier pléniglaciaire. Ce modèle avait déjà servi pour simuler le climat au dernier pléniglaciaire; il a montré des changements de températures concordant assez bien avec les données paléoclimatiques. La répartition des glaces continentales pendant le pléniglaciaire selon l'hypothèse d'extension maximale de HUGHES et al. (1981) a servi à la modélisation. En réponse à l'incorporation des données de cette hypothèse, le modèle fait voir des changements majeurs dans le climat de l'Amérique du Nord. La présence de la calotte glaciaire fait ressortir l'influence de l'orographie sur le flux troposphérique qui se concrétise par une séparation des vents d'ouest aux latitudes moyennes durant toutes les saisons, sauf l'été. Les températures hivernales s'abaissent substantiellement dans une vaste région située au sud de la calotte laurentidienne, bien que le refroidissement soit moindre durant l'été. Une zone sèche se développe immédiatement au sud de la marge glaciaire. Au même moment, les précipitations augmentent dans la région qui s'étend de l'extrémité sud-est de la calotte glaciaire jusque dans l'Atlantique Nord, à l'est. Certains de ces résultats sur la nature du paléoclimat sont similaires aux déductions que les données géologiques ont inspirées.Um die Auswirkungen der kontinentalen Eisverbreitung im jüngsten glazialen Maximum auf das nordamerikanische Klima zu erforschen, wird ein Klima-Modell benutzt. das aus einem Modell der Hauptluftströmung in Verbindung mit einem einfachen Modell der gemischten ozeanischen Schicht besteht. Frùher wurde dieses Modell benutzt, um das Klima im jüngsten glazialen Maximum zu simulieren. Die Ergebnisse haben Temperaturschwankungen ergeben, die einigermapen genau mit den paleoklimatischen Daten übereinstimmten. Ausgegangen wurde bei dem Modell von der Verteilung des kontinentalen Eises im jüngsten glazialen Maximum entsprechend der Maximum-Rekonstruktion von HUGHES et al. (1981). AIs Antwort auf die Einverleibung des ausgedehnten kontinentalen Eises im jüngsten glazialen Maximum produziert das Modell bedeutende Veränderungen im nordamerikanischen Klima. Die Eisdecke übt eine orographische Wirkung auf die troposphärische Luftströmung aus, was zu einer Aufsplitterung der westlichen Winde mittlerer Breite in alien Jahreszeiten auBer im Sommer führt. Die Winter-Temperaturen sinken stark in einem weiten Gebiet südlich der laurentischen Eisdecke, während die sommerliche Abkühlung weniger stark ausfällt. Im Innern Nordamerikas südlich der Eisgrenze entwickelt sich ein Gebiet verringerter Bodenfeuchtigkeit. Gleichzeitig nehmen die Niederschläge innerhalb eines Gürtels zu, der von dem äupersten südöstlichen Teil der Eisdecke ostwärts in den Nordatlantik reicht. Einige dieser Ergebnisse decken sich mit paleoklimatischen Folgerungen, die sich auf geologische Nachweise stützen

Physiological responses of garden cress (L. sativum) to different types of microplastics

In this study, for the first time, acute and chronic toxicity caused by four different kinds of microplastics: polypropylene (PP), polyethylene (PE), polyvinylchloride (PVC), and a commercial mixture (PE + PVC) on Lepidium sativum were evaluated. Parameters considered were: i) biometric parameters (e.g. percentage inhibition of seed germination, plant height, leaf number and fresh biomass productions); and ii) oxidative stress (e.g. levels of hydrogen peroxide, glutathione, and ascorbic acid). On plants exposed to chronic stress chlorophylls, carotenoids, aminolaevulinic acid, and proline productions were, also, evaluated. PVC resulted the most toxic than other plastic materials tested. This study represents the first paper highlighting microplastics are able to produce oxidative burst in tested plants and could represent an important starting point for future researches on biochemical effects of microplastic in terrestrial environments such as agroecosystems

Community-based social determinants of three measures of mortality in Rhode Island cities and towns

Background: Efforts to understand and address the causes of place-based health disparities have focused primarily on understanding the social determinants of health on a large geographic level, such as the region, state, or county. However, there is a growing need to assess and understand how place-based characteristics at smaller geographic areas relate to of local place-based neighborhood characteristics on population health. Therefore, the objective of this study was to evaluate the magnitude of the associations between social determinants of health and life expectancy (LE) and related measures on the community level. Methods: LE at birth (LE0), remaining LE at age 65 (LE65), and age-specific mortality rates (ASMR) were calculated from mortality data (2009–2011) collected by the Rhode Island Department of Health (RIDoH) using abridged life table methods for each RI city/town. The city/town-specific LE and ASMR were linked to data collected by the US Census, RIDoH, the Federal Bureau of Investigation, and other databases that include information about multiple social, environmental, and demographic determinants of health. Bivariate correlations between city/town-level LE0, LE65, and ASMR and social determinants: demographics, household composition, income and poverty, education, environment, food insecurity, crime, transportation, and rural-urban status were examined. Results: LE0 (range: 75.9–83.3 years) was strongly associated with the percent of the population with a graduate/professional degree (r = 0.687, p \u3c  0.001), violent crime rate (r = − 0.598, p \u3c  0.001), and per capita income (r = 0.553, p \u3c  0.001). Similar results were observed for ASMR: ASMR was associated with the percent of the population with a graduate/professional degree (r = − 0.596, p \u3c  0.001), violent crime rate (r = 0.450, p = 0.005), and per capita income (r = − 0.533, p \u3c 0.001). The associations between LE65 and social determinants were more attenuated. Of note, none of the measures (LE0, LE65, or ASMR) were associated with any of the race/ethnicity variables. Conclusions: There are several important place-based characteristics associated with mortality (LE and ASMR) among RI cities/towns. Additionally, some communities had unexpectedly high LE and low ASMR, despite poor social indicators

Chemical composition of microplastic in sediments and protected detritivores from different marine habitats (Salina Island)

This study estimates chemical composition of microplastic in sediments and benthic detritivores (sea cucumbers) collected from different marine rocky bottom habitat types (bank, landslide, cliff) of Salina Island (Aeolian Archipelago, Italy). Also, species richness and bottom coverings by benthic species were recorded at each sampling station. Correlations among chemical composition of microplastic in sediments and in detritivores were explored linking recorded variability to the factor \u201chabitat type\u201d. Results evidence that the habitat types considered in this study are characterized by wide species richness and by high percentages of bottom coverage by protected species by international conventions. In spite of the high ecological value of habitats considered in this study, microplastics were recorded both in sediments (PVC, PET, PE, PS, PA, PP) and in stomach contents of sea cucumbers (PET, PA) collected in all sampling sites, confirming the exposure of benthic species to microplastic pollution

Arx acts as a regional key selector gene in the ventral telencephalon mainly through its transcriptional repression activity

AbstractThe homeobox-containing gene Arx is expressed during ventral telencephalon development and required for correct GABAergic interneuron tangential migration from the ganglionic eminences to the olfactory bulbs, cerebral cortex and striatum. Its human ortholog is associated with a variety of neurological clinical manifestations whose symptoms are compatible with the loss of cortical interneurons and altered basal ganglia-related activities. Herein, we report the identification of a number of genes whose expression is consistently altered in Arx mutant ganglionic eminences. Our analyses revealed a striking ectopic expression in the ganglionic eminences of several of these genes normally at most marginally expressed in the ventral telencephalon. Among them, Ebf3 was functionally analyzed. Thus, its ectopic expression in ventral telencephalon was found to prevent neuronal tangential migration. Further, we showed that Arx is sufficient to repress Ebf3 endogenous expression and that its silencing in Arx mutant tissues partially rescues tangential cell movement. Together, these data provide new insights into the molecular pathways regulated by Arx during telencephalon development

Community-based perceptions of emergency care in Kenya

Access to quality emergency services is an essential component of the human right to health, but barriers to emergency care are found throughout Africa and the wider world. Data to support the development of emergency care are essential to improve access to care and further infrastructure development. We undertook this study to understand the community\u27s emergency care needs and the barriers they face when trying to access care and to engage community members with developing high impact solutions to expand access to essential emergency services. To accomplish this, we used a qualitative research methodology to conduct 59 focus groups with 528 total Kenyan community member participants. Data were coded, aggregated, and analysed using the content analysis approach. Participants were uniformly selected from all eight of the historical Kenyan provinces (Central. Coast, Eastern, Nairobi, North Eastern, Nyanza, Rift Valley, and Western), with equal rural and urban community representation. We found that socioeconomic and cultural factors play a major role both in seeking and reaching emergency care. Community members in Kenya experience a wide range of medical emergencies and seem to understand their time-critical nature. They rely on one another for assistance in the face of substantial barriers to care: a lack of a structured system, resources, transportation, trained healthcare providers, and initial care on scene. The results of this study indicate the need for specific interventions to reduce barriers to access essential emergency services in Kenya. Access to emergency care can be improved by encouraging recognition and initial treatment of emergent illness in the community, strengthening the pre­-hospital care system, improving emergency care delivery at health facilities, and creating new policies at both county and national levels

Ecotoxicity of basil (Ocimum Basilicum) extract in aquaculture feeds: Is it really eco-safe for the aquatic environment?

Plant extract and essential oils are gaining application in aquaculture, but data about their environmental impact are limited and their potential effects on aquatic organisms are largely unknown. For this study, ecotoxicity tests were performed under standardized conditions on fish feed supplemented with 3 % w/w of a basil supercritical extract (F1-BEO; substance A), F1-BEO extract (substance B), and fish feed without F1-BEO extract (substance C) on three model species of different trophic levels (bacteria, primary producer, primary consumer) considered representative for freshwater (Aliivibrio fischeri, Raphidocelis subcapitata, Daphnia magna) and marine (A. fischeri, Phaeodactylum tricornutum, Paracentrotus lividus) ecosystems. Ecotoxicological response was largely comparable within the same trophic level (whichever the ecosystem). EC50 was not calculable in the concentration range here tested (3.9–500 mg/L) for freshwater and marine microalgae, suggesting that none of the substances were toxic for primary producers. Reduction of A. fischeri bioluminescence at the tested concentration (0.5–10 mg/L) was observed only for substance A (EC50 9.53 mg/L and 9 mg/L for freshwater and marine ecosystems, respectively). Notably, in P. lividus embryotoxicity was higher for substances A (EC50 1.80 mg/L) and C (EC50 4.6 mg/L) than for substance B (EC50 7.10 mg/L), suggesting a toxic effect due to feed dissolution. In contrast, substance B was more toxic (EC50 0.34 mg/L) in D. magna than substances A (EC50 3.98 mg/L) and C (EC50 5.50 mg/L). Based on the Globally Harmonized System of Classification and Labelling of Chemicals, all substances were categorized Acute 2, except for substance A which was categorized Acute 1 for D. magna. Overall, the substances were found to be potentially toxic for an aquatic ecosystem, especially for primary consumer. Further study of plant extract and essential oils is needed to better understand their effects and fate on the aquatic environment

Long-term efficacy and safety of ibrutinib in the treatment of CLL patients: A real life experience

Ibrutinib has demonstrated a significant clinical impact in patients with de novo and relapsed/refractory chronic lymphocytic leukemia (CLL), even in cases with unfavorable cytogenetics and molecular markers. All CLL patients’ data treated at our Institute with ibrutinib have been retrospectively reviewed. Forty-six patients received ibrutinib either as frontline (10) or second or more advanced treatment (36). Five patients presented with TP53 mutations; 11 had the deletion of chromosome 17p; 17 displayed an unmutated immunoglobulin variable heavy chain status. The median number of cycles administered was 26. Among patients treated frontline, the best overall response rate (ORR) was 90.0%. In patients receiving ibrutinib as a second or later line ORR was 97.2%. Median progression-free survival was 28.8 and 21.1 months for patients treated frontline and as second/later line, respectively. Median overall survival was not reached for those treated frontline and resulted in 4.9 years for patients treated as second/later line. Grade 3–4 hematological toxicities were neutropenia, thrombocytopenia, and anemia. Grade 3–4 extrahematological toxicities included diarrhea, cutaneous rash, utero-vesical prolapse, vasculitis, and sepsis. Ibrutinib is effective and well tolerated in CLL. Responses obtained in a real-life setting are durable and the safety profile of the drug is favorable

Role of PET/CT in the detection of liver metastases from colorectal cancer

The aim of this study was to compare the diagnostic accuracy of 2-[fluorine-18] fluoro-2-deoxy-D-glucose positron emission tomography (F-18-FDG-PET) and computed tomography (CT) with PET/CT in the detection of liver metastases during tumour staging in patients suffering from colorectal carcinoma for the purposes of correct surgical planning and follow-up. A total of 467 patients underwent a PET/CT scan using an iodinated contrast medium. We compared images obtained by the single PET scan, the single CT scan and by the fusion of the two procedures (PET/CT). The final diagnosis was obtained by histological examination and/or by the follow-up of all patients, including those who did not undergo surgery or biopsy. The PET scan had 94.05% sensitivity, 91.60% specificity and 93.36% accuracy; the CT scan had 91.07% sensitivity, 95.42% specificity and 92.29% accuracy. The combined procedures (PET/CT) had the following values: sensitivity 97.92%, specificity 97.71% and accuracy 97.86%. This study indicates that PET/CT is very useful in staging and restaging patients suffering from colorectal cancer. It was particularly useful when recurrences could not be visualised either clinically or by imaging despite increasing tumour markers, as it guaranteed an earlier diagnosis. PET/CT not only provides high diagnostic performance in terms of sensitivity and specificity, enabling modification of patient treatment, but it is also a unique, high-profile procedure that can produce cost savings