Ge:Ga testing at Cornell

The spiking and memory behavior of a number of Ge:Ga detectors was studied. The detectors were manufactured at a number of locations using several different contacting techniques. Two detectors manufactured for the IRAS program by Rockwell International were studied more extensively than the others. These detectors IRD 1981 and IRD 1982 were 'witness sample' detectors for the IRAS bands 4 and 3, respectively. During the testing period both the apparatus and the test procedures were changed numerous times. At each change consistency checks were made. The data are believed to be internally consistent from end to end

A practical multi-spectrum Hadamard Transform Spectrometer

A Hadamard Transform Spectrometer (HTS) which simultaneously obtains fifteen infrared spectra, each having 255 spectral elements was constructed. Spectra are obtained essentially in real time through use of a minicomputer with 8K words of memory and a CRT display. This permits operation of the instrument in the field

Detection of sulphur in the galactic center

A strong detection at the (SIII) 18.71 micron line is reported for the Galactic Center region, Sgr A West. A line flux of 1.7 + or - 0.2x10 to the -17th power W cm(-2) is found for a 20-arc second beam-size measurement centered on IRS 1. A preliminary analysis indicates that the SIII abundance relative to hydrogen is consistent with the cosmic abundance of sulfur, 1.6x10 to the -5th power, if a filling factor of unity within the known clumps is assumed. However, the sulfur abundance in the Galactic Center may be as much as a factor of 3 overabundant if a filling factor of 0.03 is adopted, a value found to hold for some galactic HII regions

Determinations of SIII, OIV and NeV abundances in planetary nebulae from IR lines

Airborne observations of the infrared forbidden lines (SIII) 18.71 microns, (NeV) 24.28 microns and (OIV) 25.87 microns were made for twelve planetary nebulae. One or more of the lines was detected in seven of these nebulae and ionic abundances were calculated. These results are insensitive to nebula temperatures, in contrast to the case for optical or UV lines. However, density estimates from optical and UV forbidden lines were required to obtain abundances. The NeV infrared line flux from NGC 7662 was combined with the 3426A flux to obtain a NeV electron temperature of 11,200 (+2000, - 1100) K, which overlaps OIII temperature measurements. Since the ionization potential of NeIV is much greater than that of OII, T sub e (NeV) would be expected to be much greater than T sub e (OIII). In fact, numerical models predict T sub e (NeV) (16-20) x 1000 K. This discrepancy may indicate inaccuracies in currently available atomic parameters for NeV

Abundances in galactic H2 regions, 3: G25.4-0.2, G45.5+0.06, M8, S159 and DR22

Measurements of the ARII (6.99 microns), ArIII (8.99 microns), NeII (12.81 microns), SIII (18.71 microns), and SIV (10.51 microns) lines are presented for five compact HII regions along with continuum spectroscopy. From these data and radio data, lower limits to the elemental abundances of Ar, S, and Ne were deduced. The complex G25.4-0.2 is only 5.5 kpc from the galactic center, and is considerably overabundant in all these elements. Complex G45.5+0.06 is at seven kpc from the galactic center, and appears to be approximately consistent with solar abundance. The complex S159 in the Perseus Arm, at 12 kpc from the galactic center, has solar abundance, while M8 in the solar neighborhood may be somewhat overabundant in Ar and Ne. Complex DR 22, at 10 kpc from the galactic center in the Cygnus Arm, is overabundant in Ar. A summary of results from a series of papers on abundances is given

High resolution 10 mu spectrometry at different planetary latitudes. A practical Hadamard transform spectrometer for astronomical application

Infrared observations at different latitudes were studied in order to obtain spectra in the 10 micrometers region to understand differences in chemical composition or physical structure of the optical features. In order to receive such spectra of a rotating planet, simultaneous observations at different latitudes were made. A Hadamard transform spectrometer with 15 entrance slits was used to obtain 15 simultaneous spectra, at a resolution of 0.01 micrometers. The spectral band covered contained 255 spectral elements

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

10.1038/s41467-020-20851-4Nature Communications121125

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele. © 2022, The Author(s)

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele