4,604 research outputs found
Analysis of surface tris (2,3-dibromopropyl) phosphate on chlorobutyl rubber SCAPE suits
Tris (2,30-dibromopropyl) phosphate was used to confer flame retardant properties on butyl rubber formulations used in protective clothing such as the self-contained atmospheric protective ensembles (SCAPE suits) worn at Kennedy Space Center in support of Apollo, Skylab, and Apollo-Soyuz missions since 1966. Because tris (2,3-dibromopropyl) phosphate is mutagenic, surface concentrations of the compound in SCAPE suits were investigated as were as potential methods of removing or isolating it. Analytical procedures for determining surface concentrations of the tris compound on non-porous materials are described. Soap-and-water washing is the most efficient method of removing the compound from fabricated SCAPE suits and unused material
Total column CO_2 measurements at Darwin, Australia – site description and calibration against in situ aircraft profiles
An automated Fourier Transform Spectroscopic (FTS) solar observatory was established in Darwin, Australia in August 2005. The laboratory is part of the Total Carbon Column Observing Network, and measures atmospheric column abundances of CO_2 and O_2 and other gases. Measured CO_2 columns were calibrated against integrated aircraft profiles obtained during the TWP-ICE campaign in January–February 2006, and show good agreement with calibrations for a similar instrument in Park Falls, Wisconsin. A clear-sky low airmass relative precision of 0.1% is demonstrated in the CO2 and O2 retrieved column-averaged volume mixing ratios. The 1% negative bias in the FTS X_(CO_2) relative to the World Meteorological Organization (WMO) calibrated in situ scale is within the uncertainties of the NIR spectroscopy and analysis
Links between energy budgets, somatic condition, and life history reveal heterogeneous energy management tactics in a group-living mesocarnivore
Peer reviewe
Dust around red supergiants in the Magellanic Clouds
It is both surprising and exciting to find that young galaxies at high redshift contain large dust masses. For galaxies at z \u3e 5, after only 1 Gyr, there has not been time for low-mass stars to have evolved to the AGB phase and produce dust. In such galaxies, Type II SNe and red supergiants (RSGs) may even dominate the dust production rate. It has long been known that RSG atmospheres produce dust, but little is known about it. We are pursuing three parallel studies to better understand RSG dust. First, we are using optical spectra and JHK photometry to characterize the optical and near-IR extinction curves of the RSGs. Second, we are using the optical spectra combined with 2MASS, IRAC and MIPS photometry to estimate the dust mass loss rates from Local Group RSGs. In addition, we will use our Monte Carlo radiative transfer models to analyze the emission from dust in the circumstellar shells. Third, the final piece of the puzzle is being provided by obtaining new IRS spectra of LMC and SMC RSGs. We plan to use the IRS to make a systematic study of the dust properties in RSG shells in the LMC and SMC so that we can probe how they may vary with a large range of galactic metallicities. The derived stellar SEDs and extinction curves will be combined with Spitzer IRAC and MIPS photometry and IRS spectra for use as inputs to our Monte Carlo codes which will be used to study the composition, size distributions and clumpiness of the dust. © 2009 International Astronomical Union
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The working alliance in stuttering treatment: a neglected variable?
Background
Multiple factors can influence the working alliance and treatment outcome in speech and language therapy. The ‘working alliance’ is an important concept in treatment and can be described as the degree to which a treatment dyad is engaged in collaborative, purposive work. To date, relatively little attention has been paid to this concept within speech and language treatment in general, and within stuttering treatment research in particular.
Aims
To investigate the role of the working alliance within stuttering treatment, and to evaluate whether the quality of the working alliance correlated with clients’ concept of motivation and treatment outcomes 6 months post‐therapy.
Methods & Procedures
Eighteen adults (21‐61 years) participated in this multiple single‐case treatment study, with treatment facilitated by an experienced speech and language therapist. The working alliance was investigated using the Working Alliance Inventory—Short Version Revised (WAI‐SR), an Extended version of the Client Preferences for Stuttering Treatment (CPST‐E), the Overall Assessment of Speakers’ Experience of Stuttering—Adult version (OASES‐A), the Wright & Ayre Stuttering Self‐Rating Profile (WASSP) and the Hospital Anxiety and Depression Scale (HADS).
Outcomes & Results
Analyses demonstrated significant associations between the working alliance and client motivation (r = 0.781) and treatment outcomes (r = 0.644) 6 months post‐treatment. The association between client‐led goals and therapy tasks appeared particularly important.
Conclusions & Implications
The working alliance between speech and language therapists and persons who stutter matters. Within the alliance, the level of client–clinician agreement on treatment goals and therapy tasks may be of greater importance than the bond between client and clinician. Further research with greater numbers of participants is warranted
Engineered carbon-nanomaterial-based electrochemical sensors for biomolecules
The study of electrochemical behavior of bioactive molecules has become one of the most rapidly developing scientific fields. Biotechnology and biomedical engineering fields have a vested interest in constructing more precise and accurate voltammetric/amperometric biosensors. One rapidly growing area of biosensor design involves incorporation of carbon-based nanomaterials in working electrodes, such as one-dimensional carbon nanotubes, two-dimensional graphene, and graphene oxide. In this review article, we give a brief overview describing the voltammetric techniques and how these techniques are applied in biosensing, as well as the details surrounding important biosensing concepts of sensitivity and limits of detection. Building on these important concepts, we show how the sensitivity and limit of detection can be tuned by including carbon-based nanomaterials in the fabrication of biosensors. The sensing of biomolecules including glucose, dopamine, proteins, enzymes, uric acid, DNA, RNA, and H2O2 traditionally employs enzymes in detection; however, these enzymes denature easily, and as such, enzymeless methods are highly desired. Here we draw an important distinction between enzymeless and enzyme-containing carbon-nanomaterial-based biosensors. The review ends with an outlook of future concepts that can be employed in biosensor fabrication, as well as limitations of already proposed materials and how such sensing can be enhanced. As such, this review can act as a roadmap to guide researchers toward concepts that can be employed in the design of next generation biosensors, while also highlighting the current advancements in the field.ope
Seminal plasma as a source of prostate cancer peptide biomarker candidates for detection of indolent and advanced disease
Background:Extensive prostate specific antigen screening for prostate cancer generates a high number of unnecessary biopsies and over-treatment due to insufficient differentiation between indolent and aggressive tumours. We hypothesized that seminal plasma is a robust source of novel prostate cancer (PCa) biomarkers with the potential to improve primary diagnosis of and to distinguish advanced from indolent disease.
<br>Methodology/Principal Findings: In an open-label case/control study 125 patients (70 PCa, 21 benign prostate hyperplasia, 25 chronic prostatitis, 9 healthy controls) were enrolled in 3 centres. Biomarker panels a) for PCa diagnosis (comparison of PCa patients versus benign controls) and b) for advanced disease (comparison of patients with post surgery Gleason score <7 versus Gleason score >>7) were sought. Independent cohorts were used for proteomic biomarker discovery and testing the performance of the identified biomarker profiles. Seminal plasma was profiled using capillary electrophoresis mass spectrometry. Pre-analytical stability and analytical precision of the proteome analysis were determined. Support vector machine learning was used for classification. Stepwise application of two biomarker signatures with 21 and 5 biomarkers provided 83% sensitivity and 67% specificity for PCa detection in a test set of samples. A panel of 11 biomarkers for advanced disease discriminated between patients with Gleason score 7 and organ-confined (<pT3a) or advanced (≥pT3a) disease with 80% sensitivity and 82% specificity in a preliminary validation setting. Seminal profiles showed excellent pre-analytical stability. Eight biomarkers were identified as fragments of N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase,prostatic acid phosphatase, stabilin-2, GTPase IMAP family member 6, semenogelin-1 and -2. Restricted sample size was the major limitation of the study.</br>
<br>Conclusions/Significance: Seminal plasma represents a robust source of potential peptide makers for primary PCa diagnosis. Our findings warrant further prospective validation to confirm the diagnostic potential of identified seminal biomarker candidates.</br>
NOAA Coastal Change Analysis Program (C-CAP): Guidance for Regional Implementation
EXECUTIVE SUMMARY:
The Coastal Change Analysis Programl (C-CAP) is developing
a nationally standardized database on landcover and habitat change in the coastal regions of the United States. C-CAP is part of the Estuarine Habitat Program (EHP) of NOAA's Coastal Ocean Program (COP). C-CAP inventories coastal submersed habitats, wetland habitats, and adjacent uplands and monitors changes in these habitats on a one- to five-year cycle. This type of information and frequency of detection are required to improve scientific understanding of the linkages of coastal and submersed wetland habitats with adjacent uplands and with the distribution, abundance,
and health of living marine resources. The monitoring
cycle will vary according to the rate and magnitude of
change in each geographic region. Satellite imagery
(primarily Landsat Thematic Mapper), aerial photography,
and field data are interpreted, classified, analyzed,
and integrated with other digital data in a geographic
information system (GIS). The resulting landcover
change databases are disseminated in digital form
for use by anyone wishing to conduct geographic analysis
in the completed regions. C-CAP spatial information on coastal change will be input to EHP conceptual and predictive models to support coastal resource policy planning and analysis. CCAP products will include 1) spatially registered digital databases and images, 2) tabular summaries by state, county, and hydrologic unit, and 3) documentation. Aggregations to larger areas (representing habitats, wildlife refuges, or management districts) will be provided on a case-by-case basis. Ongoing C-CAP research will continue to explore techniques for remote determination of biomass, productivity, and functional status of wetlands and will evaluate new technologies (e.g. remote sensor systems, global positioning systems, image processing algorithms) as they become available. Selected hardcopy land-cover change maps will be produced at local (1:24,000) to regional scales (1:500,000) for distribution. Digital land-cover change data will be provided to users for the cost of reproduction.
Much of the guidance contained in this document was developed through a series of professional workshops
and interagency meetings that focused on a) coastal wetlands and uplands; b) coastal submersed habitat including aquatic beds; c) user needs; d) regional
issues; e) classification schemes; f) change detection
techniques; and g) data quality. Invited participants
included technical and regional experts and representatives
of key State and Federal organizations. Coastal habitat managers and researchers were given an opportunity for review and comment. This document summarizes C-CAP protocols and procedures that are to be used by scientists throughout the United States to develop consistent and reliable coastal change information for input to the C-CAP nationwide database. It also provides useful guidelines for contributors working on related projects. It is considered a working document subject to periodic review and revision.(PDF file contains 104 pages.
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