Datos del subsuelo y su conocimiento para las Ciudades del Mañana: lecciones aprendidas de Glasgow y su aplicabilidad en otros lugares

El conocimiento del subsuelo es de vital importancia en la planificación y ejecución exitosa de proyectos de construcción y regeneración urbanas. Para abordar en el área de Glasgow éste y otros temas del subsuelo urbano (por ejemplo, la planificación, las inundaciones, la contaminación), el proyecto Clyde-Urban Super-Project (CUSP) del Servicio Geológico Británico (BGS, por sus siglas en inglés) ha desarrollado modelos 3D y 4D del subsuelo. Asimismo, se han producido otros conjuntos de datos de geociencias (geoquímica, agua subterránea, geología de ingeniería). Los modelos basados en información obtenida de decenas de miles de perforaciones y otras fuentes, proporcionan nuevos conocimientos sobre: la geología compleja de Glasgow, los impactos de su legado industrial, y las oportunidades para aprovechar el calor de las explotaciones mineras abandonadas. Para que los modelos y datos del proyecto CUSP fueran más accesibles, el BGS y el Ayuntamiento de Glasgow, socio clave, han establecido una red para acceder al conocimiento del subsuelo (ASK, por sus siglas en inglés). Esta red permite el intercambio de datos y conocimientos, implicando a socios de los sectores público y privado. ASK promueve el libre flujo digital de datos del subsuelo y el conocimiento entre sus socios. Las lecciones aprendidas en Glasgow se comparten a través de la Acción Europea COST (Sub-Urban), centrada en el uso sostenible del subsuelo urbano, y en la transformación de las relaciones entre los que desarrollan el conocimiento del subsuelo urbano y los que pueden beneficiarse más de él, los planificadores y promotores de las ciudades del futuro

Defining the store : geological interpretation and storage modelling

The identification of a suitable storage site for CO2 is fundamental to a viable CCS methodology. In this chapter we describe a workflow for the process of identification, interpretation and geological modelling of a potential aquifer storage site. The construction of a valid and testable geological model is an essential pre-requisite to carrying out any reservoir simulation of CO2 flow and storage capacity modelling. A well constructed model enhances confidence in the numerical simulations and monitorability assesment and importantly, also delivers a visual understanding of the sub-surface to the nongeologist. Geologists visualise geology in 3D and previously have translated this onto 2D maps and sections. Modern technology now permits the routine construction of digital models at all scales and for these to be exported to other software packages. The construction of models based on limited data is, by necessity, open to multiple interpretation; and one of the key outcomes of our investigation has been to recognise the importance of the development and early application of a set of first response tools for geological interpretation and storage modelling. Use of this methodology and tool set should lead to best available data analysis, improved decision making and confidence in reservoir simulation (see Glossary for a full definition of terms used in this chapter)

Le Paléolithique supérieur de l’abri Pataud (Dordogne)

La fouille de l’abri Pataud (Les Eyzies, Dordogne) fut dans la seconde moitié du xxe s. l’un des grands programmes de recherche internationaux et interdisciplinaires sur la Préhistoire française. Conduit par H. L. Movius. Jr., il donna lieu à des innovations dans le domaine des techniques de fouille et de l’analyse des objets et contribua ainsi à une synthèse méthodologique qui servit de base à la recherche actuelle. L’abri Pataud est une des séquences clefs des débuts du Paléolithique supérieur dans le Sud-Ouest. La publication, qui débuta en 1975, resta inachevée à la mort du Pt Movius en 1987. Ses plus proches collaborateurs ont résumé ici les résultats de ce programme, incluant des études inédites d’occupations du Protomagdalénien, du Périgordien moyen et de l’Aurignacien, de nouvelles datations par le radiocarbone et une réévaluation de la géochronologie. S’y ajoute un inventaire critique des sites aurignaciens et périgordiens de Dordogne replaçant l’abri Pataud dans son contexte régional.One of the large international and interdisciplinary research projects on the Palaeolithic of France during the middle of the 20th century was the excavation of the abri Pataud (Les Eyzies, Dordogne). From this project, directed by Hallam L. Movius, Jr., came innovations in excavation technique and artifact analysis that have contributed to the methodological synthesis underlying current research. The abri Pataud is one of the key sequences of the earlier Upper Palaeolithic in the Southwest. The publication began in 1975 but was left unfinished because of the death of Pr Movius in 1987. His closest collaborators have summarized here the results of the project, including unpublished studies of the Protomagdalenian, Middle Perigordian, and Aurignacian occupations, new radiocarbon dates, a reappraisal of the geochronology, and an extensively annotated catalogue of Aurignacian and Perigordian sites in Dordogne which allows the abri Pataud to be seen in its regional context

Protocol of DREAM3R : DuRvalumab with chEmotherapy as first-line treAtment in advanced pleural Mesothelioma-a phase 3 randomised trial

Introduction: There is a strong theoretical rationale for combining checkpoint blockade with cytotoxic chemotherapy in pleural mesothelioma and other cancers. Two recent single-arm, phase 2 trials [DuRvalumab with chEmotherapy as first-line treAtment in advanced pleural Mesothelioma (DREAM) and Phase II multicenter study of anti-PD-L1, durvalumab, in combination with cisplatin and pemetrexed for the first-line treatment of unresectable malignant pleural mesothelioma (PrE0505)] combining the programmed death ligand-1 (PD-L1) inhibitor durvalumab with standard first-line chemotherapy exceeded prespecified safety and activity criteria to proceed to a phase 3 confirmatory trial to assess this combination. We present the protocol of the DREAM3R trial. Methods and analysis: This multicentre open-label randomised trial will recruit 480 treatment-naïve adults with advanced pleural mesothelioma, randomised (2:1) to either 3-weekly durvalumab 1500 mg plus 3-weekly doublet chemotherapy (cisplatin 75 mg/m 2 or carboplatin, Area Under the Curve,AUC 5 and pemetrexed 500 mg/m 2) 4-6 cycles, followed by 4-weekly durvalumab 1500 mg until disease progression, unacceptable toxicity or patient withdrawal; OR doublet chemotherapy alone for 4-6 cycles, followed by observation. The target accrual time is 27 months, with follow-up for an additional 24 months. This provides over 85% power if the true HR for overall survival (OS) is 0.70, with two-sided alpha of 0.05, assuming a median OS of 15 months in the control group. Randomisation is stratified by age (18-70 years vs >70), sex, histology (epithelioid vs non-epithelioid), platinum agent (cisplatin vs carboplatin) and region (USA vs Australia/New Zealand vs Other). The primary endpoint is OS. Secondary endpoints include progression-free survival, objective tumour response (by mRECIST V.1.1 and iRECIST), adverse events, health-related quality of life and healthcare resource use. Tertiary correlative objectives are to explore and validate potential prognostic and/or predictive biomarkers (including features identified in the DuRvalumab with chEmotherapy as first-line treAtment in advanced pleural Mesothelioma (DREAM) and PrE0505 studies, PD-L1 expression, tumour mutational burden, genomic characteristics and human leukocyte antigen subtypes) in tissue and serial blood samples. An imaging databank will be assembled for validation of radiological measures of response, and studies of possible radiomic biomarkers in mesothelioma. Ethics and dissemination: The protocol was approved by human research ethics review committees for all participating sites. Results will be disseminated in peer-reviewed journals and at scientific conferences. Drug Supply AstraZeneca. Protocol version CTC 0231/TOGA 18/001/PrE0506 3.0, 29 July 2021.</p

CO2 Aquifer Storage Site Evaluation and Monitoring (CASSEM) Understanding the challenges of CO2 storage: results of the CASSEM Project

Carbon capture and storage (CCS) brings new entrants to subsurface exploration and reservoir engineering who require very high levels of confidence in the technology, in the geological analysis and in understanding the risks before committing large sums of capital to high-cost drilling operations. Many of the subsurface techniques used for hydrocarbon exploration are capable of translation to CCS activities. Unfamiliarity may, however, lead new entrants to openly question their applicability in order to transform their current understanding to a level where large capital investment can be organisationally justified. For example, some may make the erroneous assumption that a good CO2 subsurface store should resemble the pressure vessel type of containment that is prevalent with surface installations. Basic concepts such as utilising the rock structure and mineralogy to control fluid flow and securing the CO2 by residual trapping (between the rock grains) or by dissolution, as a superior storage mechanism, are counter intuitive and challenging to communicate effectively. To achieve success and reliable operation in CO2 emission reduction for coal- and gas-burning electricity power generation, all elements of the CCS chain have to function. In 2008 the CO2 Aquifer Storage Site Evaluation and Monitoring project (CASSEM) was one of the first UK based projects to attempt integration and full-chain connectivity from, capture and transport to injection, storage and monitoring. Its research is aimed at development of workflows that describe a CCS entry path for a target audience of potential new entrants, i.e. power utilities, engineering sector and government. In contrast to other studies, the CASSEM project has applied the specification of the full CCS chain, using two exemplar sites (coal-fired power plants) with contrasting geological conditions in the subsurface, to tailor storage site selection and analysis. Centred on the Ferrybridge Power Station in Yorkshire (Figure 1.1), a 'simple' site underlain by a thick, uniform sandstone with diverse legacy information available was sought onshore in the English Midlands. The offshore extension of this (Bunter) sandstone has been highlighted as a large potential aquifer store for CO2 captured from power plants in eastern and South East England. A 'complex' site was sought offshore of eastern Scotland, centred on the Longannet Power Station on the Firth of Forth near Edinburgh (Figure 1.2). This site was intended to confront the difficulties of investigating subsea structures with sparse legacy and incomplete information from hydrocarbon investigations. The selected site is a faulted and folded geological structure and the issues of seismic reflection surveys, detection of faults and fractures, and quality of the target reservoir, are similar to those which challenge offshore hydrocarbon exploration beneath the North Sea.Carbon capture and storage (CCS) brings new entrants to subsurface exploration and reservoir engineering who require very high levels of confidence in the technology, in the geological analysis and in understanding the risks before committing large sums of capital to high-cost drilling operations. Many of the subsurface techniques used for hydrocarbon exploration are capable of translation to CCS activities. Unfamiliarity may, however, lead new entrants to openly question their applicability in order to transform their current understanding to a level where large capital investment can be organisationally justified. For example, some may make the erroneous assumption that a good CO2 subsurface store should resemble the pressure vessel type of containment that is prevalent with surface installations. Basic concepts such as utilising the rock structure and mineralogy to control fluid flow and securing the CO2 by residual trapping (between the rock grains) or by dissolution, as a superior storage mechanism, are counter intuitive and challenging to communicate effectively. To achieve success and reliable operation in CO2 emission reduction for coal- and gas-burning electricity power generation, all elements of the CCS chain have to function. In 2008 the CO2 Aquifer Storage Site Evaluation and Monitoring project (CASSEM) was one of the first UK based projects to attempt integration and full-chain connectivity from, capture and transport to injection, storage and monitoring. Its research is aimed at development of workflows that describe a CCS entry path for a target audience of potential new entrants, i.e. power utilities, engineering sector and government. In contrast to other studies, the CASSEM project has applied the specification of the full CCS chain, using two exemplar sites (coal-fired power plants) with contrasting geological conditions in the subsurface, to tailor storage site selection and analysis. Centred on the Ferrybridge Power Station in Yorkshire (Figure 1.1), a 'simple' site underlain by a thick, uniform sandstone with diverse legacy information available was sought onshore in the English Midlands. The offshore extension of this (Bunter) sandstone has been highlighted as a large potential aquifer store for CO2 captured from power plants in eastern and South East England. A 'complex' site was sought offshore of eastern Scotland, centred on the Longannet Power Station on the Firth of Forth near Edinburgh (Figure 1.2). This site was intended to confront the difficulties of investigating subsea structures with sparse legacy and incomplete information from hydrocarbon investigations. The selected site is a faulted and folded geological structure and the issues of seismic reflection surveys, detection of faults and fractures, and quality of the target reservoir, are similar to those which challenge offshore hydrocarbon exploration beneath the North Sea

The role of ultrasound in the diagnosis of fetal genetic syndromes

The use of ultrasound in the prenatal diagnosis of fetal genetic syndromes is rapidly evolving. Advancing technology and new research findings are aiding in the increased accuracy of ultrasound-based diagnosis in combination with other methods of non-invasive and invasive fetal testing. Ultrasound as a screening tool for aneuploidy and other anomalies is increasingly being used throughout pregnancy, beginning in the first trimester. Given the number of recorded syndromes, it is important to identify patterns and establish a strategy for identifying abnormalities on ultrasound. These syndromes encompass a wide range of causes from viral, substance-linked, chromosomal, and other genetic syndromes. Despite the ability of those experienced in ultrasound, it is important to note that not all fetal genetic syndromes can be identified prenatally, and even common syndromes often have no associated ultrasound findings. Here, we review the role of ultrasound in the diagnosis of fetal genetic syndromes