Introduction to the Special Issue on Teaching Inquiry (Part II): Implementing Inquiry

We provide an introduction to the special issue on Teaching Inquiry, through its motivation and themes, focusing here on Part II: Implementing Inquiry

Introduction to the Special Issue on Teaching Inquiry (Part I): Illuminating Inquiry

We provide an introduction to the special issue on Teaching Inquiry, through its motivation and themes. We focus here on Part I: Illuminating Inquiry

Automatic Detection of Cone Photoreceptors In Split Detector Adaptive Optics Scanning Light Ophthalmoscope Images

Quantitative analysis of the cone photoreceptor mosaic in the living retina is potentially useful for early diagnosis and prognosis of many ocular diseases. Non-confocal split detector based adaptive optics scanning light ophthalmoscope (AOSLO) imaging reveals the cone photoreceptor inner segment mosaics often not visualized on confocal AOSLO imaging. Despite recent advances in automated cone segmentation algorithms for confocal AOSLO imagery, quantitative analysis of split detector AOSLO images is currently a time-consuming manual process. In this paper, we present the fully automatic adaptive filtering and local detection (AFLD) method for detecting cones in split detector AOSLO images. We validated our algorithm on 80 images from 10 subjects, showing an overall mean Dice’s coefficient of 0.95 (standard deviation 0.03), when comparing our AFLD algorithm to an expert grader. This is comparable to the inter-observer Dice’s coefficient of 0.94 (standard deviation 0.04). To the best of our knowledge, this is the first validated, fully-automated segmentation method which has been applied to split detector AOSLO images

Accumulation of glial fibrillary acidic protein and histone H4 in brain storage bodies of Tibetan terriers with hereditary neuronal ceroid lipofuscinosis

The neuronal ceroid lipofuscinoses (NCLs) are inherited neurodegenerative diseases characterized by massive accumulation of autofluorescent storage bodies in neurons and other cells. A late-onset form of NCL occurs in Tibetan terrier dogs. Gel electrophoretic analyses of isolated storage body proteins from brains of affected dogs indicated that a protein of approximately 50 kDa was consistently prominent and a 16 kDa component was present in some brain storage body preparations. Mass spectral analysis identified the 50 kDa protein as glial fibrillary acidic protein (GFAP), isoform 2. GFAP identification was supported by immunoblot and immunohistochemical analyses. Histone H4 was the major protein in the 16 kDa component. Specific accumulation of GFAP and histone H4 in storage bodies has not been previously reported for any of the NCLs. Tibetan terrier NCL may be the canine correlate of one of the human adult-onset NCLs for which the genetic bases and storage body compositions have not yet been determined

A National Study on the Effects of Concussion in Collegiate Athletes and US Military Service Academy Members: The NCAA-DoD Concussion Assessment, Research and Education (CARE) Consortium Structure and Methods

BACKGROUND: The natural history of mild traumatic brain injury (TBI) or concussion remains poorly defined and no objective biomarker of physiological recovery exists for clinical use. The National Collegiate Athletic Association (NCAA) and the US Department of Defense (DoD) established the Concussion Assessment, Research and Education (CARE) Consortium to study the natural history of clinical and neurobiological recovery after concussion in the service of improved injury prevention, safety and medical care for student-athletes and military personnel. OBJECTIVES: The objectives of this paper were to (i) describe the background and driving rationale for the CARE Consortium; (ii) outline the infrastructure of the Consortium policies, procedures, and governance; (iii) describe the longitudinal 6-month clinical and neurobiological study methodology; and (iv) characterize special considerations in the design and implementation of a multicenter trial. METHODS: Beginning Fall 2014, CARE Consortium institutions have recruited and enrolled 23,533 student-athletes and military service academy students (approximately 90% of eligible student-athletes and cadets; 64.6% male, 35.4% female). A total of 1174 concussions have been diagnosed in participating subjects, with both concussion and baseline cases deposited in the Federal Interagency Traumatic Brain Injury Research (FITBIR) database. CONCLUSIONS: Challenges have included coordinating regulatory issues across civilian and military institutions, operationalizing study procedures, neuroimaging protocol harmonization across sites and platforms, construction and maintenance of a relational database, and data quality and integrity monitoring. The NCAA-DoD CARE Consortium represents a comprehensive investigation of concussion in student-athletes and military service academy students. The richly characterized study sample and multidimensional approach provide an opportunity to advance the field of concussion science, not only among student athletes but in all populations at risk for mild TBI

Mirror Manifolds in Higher Dimension

We describe mirror manifolds in dimensions different from the familiar case of complex threefolds. We emphasize the simplifying features of dimension three and supply more robust methods that do not rely on such special characteristics and hence naturally generalize to other dimensions. The moduli spaces for Calabi--Yau $d$-folds are somewhat different from the ``special K\"ahler manifolds'' which had occurred for $d=3$, and we indicate the new geometrical structures which arise. We formulate and apply procedures which allow for the construction of mirror maps and the calculation of order-by-order instanton corrections to Yukawa couplings. Mathematically, these corrections are expected to correspond to calculating Chern classes of various parameter spaces (Hilbert schemes) for rational curves on Calabi--Yau manifolds. Our results agree with those obtained by more traditional mathematical methods in the limited number of cases for which the latter analysis can be carried out. Finally, we make explicit some striking relations between instanton corrections for various Yukawa couplings, derived from the associativity of the operator product algebra.Comment: 44 pages plus 3 tables using harvma

Churn, Baby, Churn: Strategic Dynamics Among Dominant and Fringe Firms in a Segmented Industry

This paper integrates and extends the literatures on industry evolution and dominant firms to develop a dynamic theory of dominant and fringe competitive interaction in a segmented industry. It argues that a dominant firm, seeing contraction of growth in its current segment(s), enters new segments in which it can exploit its technological strengths, but that are sufficiently distant to avoid cannibalization. The dominant firm acts as a low-cost Stackelberg leader, driving down prices and triggering a sales takeoff in the new segment. We identify a “churn” effect associated with dominant firm entry: fringe firms that precede the dominant firm into the segment tend to exit the segment, while new fringe firms enter, causing a net increase in the number of firms in the segment. As the segment matures and sales decline in the segment, the process repeats itself. We examine the predictions of the theory with a study of price, quantity, entry, and exit across 24 product classes in the desktop laser printer industry from 1984 to 1996. Using descriptive statistics, hazard rate models, and panel data methods, we find empirical support for the theoretical predictions

The Grizzly, November 9, 1984

Program Board Attends Activities Conference • Fraternity Sponsors Thanksgiving Food Drive • Smith Addresses Value of Liberal Arts • Editorials: Newspaper Reflects Campus News and Views; Pulling the Big Lever • Letters to the Editor: Mock Election Coverage Questioned; Intervention Policy Must Go • College Bowl Season Underway • Ursinus in a Box • Shorts: Ec. Council Programs; Photo Exhibit in Library; Turkey Trot; UPB Trips Scheduled; Dutch Folk Songs; USGA Report • Bear Booters Win ECA Conference Bid • Runners Second in MAC\u27s • A Student\u27s View of The Training Facility • Mers Shine at Relay Carnival • Middle East Forum Scheduled • Theater Review: A Thurber Carnival • Student Teachers Hard at Work • News of Yesteryear: Judy Collins to Appear in Concert at Ursinushttps://digitalcommons.ursinus.edu/grizzlynews/1127/thumbnail.jp

The Grizzly, November 9, 1984

Program Board Attends Activities Conference • Fraternity Sponsors Thanksgiving Food Drive • Smith Addresses Value of Liberal Arts • Editorials: Newspaper Reflects Campus News and Views; Pulling the Big Lever • Letters to the Editor: Mock Election Coverage Questioned; Intervention Policy Must Go • College Bowl Season Underway • Ursinus in a Box • Shorts: Ec. Council Programs; Photo Exhibit in Library; Turkey Trot; UPB Trips Scheduled; Dutch Folk Songs; USGA Report • Bear Booters Win ECA Conference Bid • Runners Second in MAC\u27s • A Student\u27s View of The Training Facility • Mers Shine at Relay Carnival • Middle East Forum Scheduled • Theater Review: A Thurber Carnival • Student Teachers Hard at Work • News of Yesteryear: Judy Collins to Appear in Concert at Ursinushttps://digitalcommons.ursinus.edu/grizzlynews/1127/thumbnail.jp