Asymmetries in Naming Accuracy and in Event-related Potentials for Laterally Presented Words of Variable Morphological Complexity

Recent studies indicate that hemispheric asymmetries in lexical access exist, with the left hemisphere being superior in processing morphologically complex words. The present study looks for asymmetries in naming accuracy and in topographically displayed event-related potentials to laterally presented words. Data were collected from six subjects while words were presented to both visual fields. Right visual field superiority in naming accuracy was demonstrated for suffixed forms as expected, indicating a potential left hemisphere advantage for morphological processing. Event-related potential data revealed stimulus-relevant positive parietal peaks around 320 msec.This work was supported in part by a grant from the National Institutes of Health (1 R01 NS22606-01) to W. Cowart, and a research grant from the OSU Department of Linguistics

Refining Lucy Mission Delta-V During Spacecraft Design Using Trajectory Optimization Within High-Fidelity Monte Carlo Maneuver Analysis

Recent advances linking medium-fidelity trajectory optimization and high-fidelity trajectory propagation/maneuver design software with Monte Carlo maneuver analysis and parallel processing enabled realistic statistical delta-V estimation well before launch. Completing this high-confidence, refined statistical maneuver analysis early enabled release of excess delta-V margin for increased dry mass margin for the Lucy Jupiter Trojan flyby mission. By 3.3 years before launch, 16 of 34 TCMs had 1000 re-optimized trajectory design samples, yielding tens of m/s lower 99%-probability delta-V versus targeting maneuvers to one optimal trajectory. One year later, 1000 re-optimized samples of all deterministic maneuvers and subsequent flybys further lowered estimated delta-V

Effect of Processing on Morphology of Hydroxyapatites: Bioactive Glasses and Crystalline Composites

Recent studies on multinary oxides for applications as laser hosts and high dielectric capacitors have shown that processing at high temperature provides glassy or crystalline materials based on thermal treatments and cooling rates. Since hydroxyapatites are now subject of great interests due to their bioactivity, interest in producing soft and hard materials with glassy and crystalline nature by processing parameters has become very important. Crystalline materials by using Bridgman, Czochralski and flux growth methods are costly and require huge investment. We have observed that even low temperature solidification in organic flux produced oriented fibers. This organic treated material has different characteristics than in situ oxide materials prepared by sintering and grain growth. Examples of phosphate and silicate-based systems will be presented to demonstrate soft and hard materials. Effect of TiO2 and other hardening elements will be also reported

Studies on the disbonding initiation of interfacial cracks.

With the continuing trend of decreasing feature sizes in flip-chip assemblies, the reliability tolerance to interfacial flaws is also decreasing. Small-scale disbonds will become more of a concern, pointing to the need for a better understanding of the initiation stage of interfacial delamination. With most accepted adhesion metric methodologies tailored to predict failure under the prior existence of a disbond, the study of the initiation phenomenon is open to development and standardization of new testing procedures. Traditional fracture mechanics approaches are not suitable, as the mathematics assume failure to originate at a disbond or crack tip. Disbond initiation is believed to first occur at free edges and corners, which act as high stress concentration sites and exhibit singular stresses similar to a crack tip, though less severe in intensity. As such, a 'fracture mechanics-like' approach may be employed which defines a material parameter--a critical stress intensity factor (K{sub c})--that can be used to predict when initiation of a disbond at an interface will occur. The factors affecting the adhesion of underfill/polyimide interfaces relevant to flip-chip assemblies were investigated in this study. The study consisted of two distinct parts: a comparison of the initiation and propagation phenomena and a comparison of the relationship between sub-critical and critical initiation of interfacial failure. The initiation of underfill interfacial failure was studied by characterizing failure at a free-edge with a critical stress intensity factor. In comparison with the interfacial fracture toughness testing, it was shown that a good correlation exists between the initiation and propagation of interfacial failures. Such a correlation justifies the continuing use of fracture mechanics to predict the reliability of flip-chip packages. The second aspect of the research involved fatigue testing of tensile butt joint specimens to determine lifetimes at sub-critical load levels. The results display an interfacial strength ranking similar to that observed during monotonic testing. The fatigue results indicate that monotonic fracture mechanics testing may be an adequate screening tool to help predict cyclic underfill failure; however lifetime data is required to predict reliability

Concordance of in vitro and in vivo measures of non-replicating rotavirus vaccine potency

Rotavirus infections remain a leading cause of morbidity and mortality among infants residing in low- and middle-income countries. To address the large need for protection from this vaccine-preventable disease we are developing a trivalent subunit rotavirus vaccine which is currently being evaluated in a multinational Phase 3 clinical trial for prevention of serious rotavirus gastroenteritis. Currently, there are no universally accepted in vivo or in vitro models that allow for correlation of field efficacy to an immune response against serious rotavirus gastroenteritis. As a new generation of non-replicating rotavirus vaccines are developed the lack of an established model for evaluating vaccine efficacy becomes a critical issue related to how vaccine potency and stability can be assessed. Our previous publication described the development of an in vitro ELISA to quantify individual vaccine antigens adsorbed to an aluminum hydroxide adjuvant to address the gap in vaccine potency methods for this non-replicating rotavirus vaccine candidate. In the present study, we report on concordance between ELISA readouts and in vivo immunogenicity in a guinea pig model as it relates to vaccine dosing levels and sensitivity to thermal stress. We found correlation between in vitro ELISA values and neutralizing antibody responses engendered after animal immunization. Furthermore, this in vitro assay could be used to demonstrate the effect of thermal stress on vaccine potency, and such results could be correlated with physicochemical analysis of the recombinant protein antigens. This work demonstrates the suitability of the in vitro ELISA to measure vaccine potency and the correlation of these measurements to an immunologic outcome

Optimization of the Lucy Interplanetary Trajectory via Two-Point Direct Shooting

Lucy is NASAs next Discovery-class mission and will explore the Trojan asteroids in the Sun-Jupiter L4 and L5 regions. This paper details the design of Lucys interplanetary trajectory using a two-point direct shooting transcription, nonlinear programming, and monotonic basin hopping. These techniques are implemented in the Evolutionary Mission Trajectory Generator (EMTG), a trajectory optimization tool developed at NASA Goddard Space Flight Center. We present applications to the baseline trajectory design, Monte Carlo analysis, and operations

Habitat III Regional Report on Housing and Urban Development for the UNECE Region: Towards a City-Focused, People-Centred and Integrated Approach to the New Urban Agenda

Recognition that sustainable development needs to be the central pillar of urbanisation has become a clear and present concern of stakeholders in the 20 years since Habitat II. The attention of stakeholders to sustainable development in urbanisation has been steadily increasing in the last several years in all regions of the world. In the region covered by United Nations Economic Commission for Europe with its 56 member States, the importance of sustainable urban development and the role of cities is now central to public, political, business and scientific debates. This regional report to Habitat III will not only contribute to the debate among stakeholders in the region but also inform the New Urban Agenda and the negotiations on the outcome document of the Third United Nations Conference on Housing and Sustainable Urban Development that will take place in Quito, Ecuador, in October 2016. This analysis of urban development in the large and diverse region of UNECE, together with the conference conclusions, will serve a wide range of stakeholders in their efforts to improve the quality of urban development and to use this as a positive force to enable a more sustainable development in their cities and communities. It addresses a wide variety of issues that have a strong regional interconnected urban dimension – from urban structure, through environment and climate change, to job creation, affordable housing and equality. Sustainable urban development can be achieved through regional and sub-regional frameworks which guide the effective translation of sustainable development policies into concrete actions at the national and sub-national levels. UNECE and UN-Habitat will continue to work in close partnership by joining forces with the Programmes, Funds and Agencies of the United Nations to advance the findings of this Report in implementing the transformative Agenda 2030 and the outcome of Habitat III. We will strengthen joint efforts to promote existing instruments like the Geneva UN Charter on Sustainable Housing to make housing safer, more affordable, resilient, and available while encouraging investment and growth. Or the International Guidelines on Urban and Territorial Planning that provide national governments, local authorities, civil society organizations and planning professionals with a global reference framework promoting more compact, socially inclusive, better integrated and connected cities and territories that foster sustainable urban development. Together, we will support policies and actions and encourage international cooperation at all levels to serve the Member States, their cities, and all stakeholders in their quest for sustainable urban development

Exploring gender and fear retrospectively:stories of women’s fear during the ‘Yorkshire Ripper’ murders

The murder of 13 women in the North of England between 1975 and 1979 by Peter Sutcliffe who became known as the Yorkshire Ripper can be viewed as a significant criminal event due to the level of fear generated and the impact on local communities more generally. Drawing upon oral history interviews carried out with individuals living in Leeds at the time of the murders, this article explores women’s accounts of their fears from the time. This offers the opportunity to explore the gender/fear nexus from the unique perspective of a clearly defined object of fear situated within a specific spatial and historical setting. Findings revealed a range of anticipated fear-related emotions and practices which confirm popular ‘high-fear’ motifs; however, narrative analysis of interviews also highlighted more nuanced articulations of resistance and fearlessness based upon class, place and biographies of violence, as well as the way in which women drew upon fear/fearlessness in their overall construction of self. It is argued that using narrative approaches is a valuable means of uncovering the complexity of fear of crime and more specifically provides renewed insight onto women’s fear

Early Navigation Performance of the OSIRIS-REx Approach to Bennu

The New Frontiers-class OSIRIS-REx (Origins, Spectral Interpretation, Resource Identification, Security-Regolith Explorer) mission is the first American endeavor to return a sample from an asteroid. In preparation for retrieving the sample, OSIRIS-REx is conducting a campaign of challenging proximity-operations maneuvers and scientific observations, bringing the spacecraft closer and closer to the surface of near-Earth asteroid (101955) Bennu. Ultimately, the spacecraft will enter a 900-meter-radius orbit about Bennu and conduct a series of reconnaissance flybys of candidate sample sites before being guided into contact with the surface for the Touch and Go sample collection event. Between August and December 2018, the OSIRIS-REx team acquired the first optical observations of Bennu and used them for navigation. We conducted a series of maneuvers with the main engine, Trajectory Correction Maneuver, and Attitude Control System thruster sets to slow the OSIRIS-REx approach to Bennu and achieve rendezvous on December 3, 2018. This paper describes the trajectory design, navigation conops, and key navigation results from the Approach phase of the OSIRIS-REx mission