Religious Freedom – The 21st Century’s Paradigm

In 1982, I arrived in China to teach, by ship incidentally.  No one knew whether religion had survived China’s Cultural Revolution that sought to stamp out all religious symbols and practices. To my surprise and the surprise of most scholars, I found that religion not only survived, but grew behind – what was then – called the Bamboo Curtain

Focused Group Interviews as an Innovative Quanti- Qualitative Methodology (QQM ): Integrating Quantitative Elements into a Qualitative Methodology

There is a sharp divide between quantitative and qualitative methodologies in the social sciences. We investigate an innovative way to bridge this gap that incorporates quantitative techniques into a qualitative method, the “quanti-qualitative method” (QQM). Specifically, our research utilized small survey questionnaires and experiment-like activities as part of the question rout e in a series of five focused group interviews on nutrition education. We show how these quantitative-type activities fit naturally with our question route and contributed to testing the hypotheses within the context of the five important characteristics of focused group interviews. The innovative use of QQM in focused group interviews makes data analysis easier and more transparent and permits collection of richer, more multifaceted data in a cost-effective fashion

Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma

The molecular basis for the inverse relationship between differentiation and tumorigenesis is unknown. The function of runx2, a master regulator of osteoblast differentiation belonging to the runt family of tumor suppressor genes, is consistently disrupted in osteosarcoma cell lines. Ectopic expression of runx2 induces p27KIP1, thereby inhibiting the activity of S-phase cyclin complexes and leading to the dephosphorylation of the retinoblastoma tumor suppressor protein (pRb) and a G1 cell cycle arrest. Runx2 physically interacts with the hypophosphorylated form of pRb, a known coactivator of runx2, thereby completing a feed-forward loop in which progressive cell cycle exit promotes increased expression of the osteoblast phenotype. Loss of p27KIP1 perturbs transient and terminal cell cycle exit in osteoblasts. Consistent with the incompatibility of malignant transformation and permanent cell cycle exit, loss of p27KIP1 expression correlates with dedifferentiation in high-grade human osteosarcomas. Physiologic coupling of osteoblast differentiation to cell cycle withdrawal is mediated through runx2 and p27KIP1, and these processes are disrupted in osteosarcoma