The Application Of Innovative Parking Solutions In Downtown Chapel Hill

Parking management strategies are increasingly crucial to maintaining efficient transportation networks, especially in downtown areas where adding new parking facilities is rarely an option. This study examines the ability of two such strategies to increase the efficiency of parking facility utilization in downtown Chapel Hill, North Carolina. Performance-based pricing has been touted as the premiere solution to inadequate parking supply, charging users market-determined prices to maintain desirable occupancy rates. Additionally, shared parking has been found to significantly increase parking efficiency by encouraging joint-use parking facilities shared by diverse users. Analysis results indicate that each of these strategies is in fact positively associated with increased parking efficiency. Performance-based pricing results in the utilization of 126 additional parking spaces in downtown Chapel Hill, while shared parking serves to further increase efficiency by allowing nearby uses to combine their parking needs. The results suggest that prior to implementing a pricing program, goals must be set to determine whether the most urgent need is increased occupancy within existing facilities or increased parking revenue. Furthermore, shared parking requires cooperation among local businesses and property owners, and because the extent of this cooperation is yet to be known, the degree to which the strategy achieves increased efficiency will ultimately be determined by those who take part in it. The analysis is the next logical step to creating a more sophisticated parking management program in Chapel Hill, and it sets the stage for future implementation.Master of City and Regional Plannin

Human Rights and the Global Fund to Fight AIDS, Tuberculosis and Malaria: Meeting Report

On March 3-4, 2011, UN staff, donors, and civil society representatives met in New York to discuss how the Global Fund to Fight AIDS, Tuberculosis and Malaria might best operationalize the promotion of human rights and equitable access as one of its five strategic objectives.The meeting covered the following human rights issues related to the Global Fund's 2012-2016 strategy:Scope and content of the Global Fund's human rights commitment and obligation;Promoting human rights in Global Fund-supported programs and advocacy;Oversight and monitoring and evaluation of the Global Fund's portfolio according to human rights criteria;Addressing human rights risks and violations associated with Global Fund grants.Discussion papers on each of these issues, as well as a paper exploring the relationship between human rights and equity, were prepared for the meeting

Research Synthesis for the California Zero Traffic Fatalities Task Force

This research synthesis consists of a set of white papers that jointly provide a review of research on the current practicefor setting speed limits and future opportunities to improve roadway safety. This synthesis was developed to inform thework of the Zero Traffic Fatalities Task Force, which was formed in 2019 by the California State Transportation Agencyin response to California Assembly Bill 2363 (Friedman). The statutory goal of the Task Force is to develop a structured,coordinated process for early engagement of all parties to develop policies to reduce traffic fatalities to zero. Thisreport addresses the following critical issues related to the work of the Task Force: (i) the relationship between trafficspeed and safety; (ii) lack of empirical justification for continuing to use the 85th percentile rule; (iii) why we need toreconsider current speed limit setting practices; (iv) promising alternatives to current methods of setting speed limits;and (v) improving road designs to increase road user safety

Expression of factor V by resident macrophages boosts host defense in the peritoneal cavity

Macrophages resident in different organs express distinct genes, but understanding how this diversity fits into tissue-specific features is limited. Here, we show that selective expression of coagulation factor V (FV) by resident peritoneal macrophages in mice promotes bacterial clearance in the peritoneal cavity and serves to facilitate the well-known but poorly understood macrophage disappearance reaction. Intravital imaging revealed that resident macrophages were nonadherent in peritoneal fluid during homeostasis. Bacterial entry into the peritoneum acutely induced macrophage adherence and associated bacterial phagocytosis. However, optimal control of bacterial expansion in the peritoneum also required expression of FV by the macrophages to form local clots that effectively brought macrophages and bacteria in proximity and out of the fluid phase. Thus, acute cellular adhesion and resident macrophage-induced coagulation operate independently and cooperatively to meet the challenges of a unique, open tissue environment. These events collectively account for the macrophage disappearance reaction in the peritoneal cavity

Microglial responses to amyloid β peptide opsonization and indomethacin treatment

BACKGROUND: Recent studies have suggested that passive or active immunization with anti-amyloid β peptide (Aβ) antibodies may enhance microglial clearance of Aβ deposits from the brain. However, in a human clinical trial, several patients developed secondary inflammatory responses in brain that were sufficient to halt the study. METHODS: We have used an in vitro culture system to model the responses of microglia, derived from rapid autopsies of Alzheimer's disease patients, to Aβ deposits. RESULTS: Opsonization of the deposits with anti-Aβ IgG 6E10 enhanced microglial chemotaxis to and phagocytosis of Aβ, as well as exacerbated microglial secretion of the pro-inflammatory cytokines TNF-α and IL-6. Indomethacin, a common nonsteroidal anti-inflammatory drug (NSAID), had no effect on microglial chemotaxis or phagocytosis, but did significantly inhibit the enhanced production of IL-6 after Aβ opsonization. CONCLUSION: These results are consistent with well known, differential NSAID actions on immune cell functions, and suggest that concurrent NSAID administration might serve as a useful adjunct to Aβ immunization, permitting unfettered clearance of Aβ while dampening secondary, inflammation-related adverse events

STORMTOOLS, Coastal Environmental Risk Index (CERI) Risk and Damage Assessment App

STORMTOOLS Coastal Environmental Risk Index (CERI) predicts the coastal flooding damage to individual structures using coastal flooding levels, including the effects of sea level rise (SLR), provided in terms of the base flood elevation (BFE), specifications of the structure of interest (type and first floor elevation) and the associated damage functions from the U.S. Army Corp of Engineers (USACE), North Atlantic Coast Comprehensive Study (NACCS). CERI has been applied to selected coastal communities in Rhode Island, including those in Narragansett Bay and along the southern Rhode Island shoreline. Users can access the results of CERI via ArcGIS online at the CERI website. The objective of this effort was to develop, test, distribute, and evaluate a mobile phone application (App) that allows the user to assess the risk from coastal flooding and the associated damage at the individual structure level using the CERI methodology. The App is publicly available and has been developed for both iOS and Android operating systems. Environmental data to support the App, in terms of 100 y flood BFE maps, including the effects of SLR and the selected site grade elevation, are provided in the application by the URI Environmental Data Center (EDC). The user enters the location and type of the structure of interest (residential number of stories, with or without basement, pile supported or commercial building and the first-floor elevation (FFE)) and the desired SLR. The App then calculates the percent structural damage based on the specified environmental conditions and structure specifications. The App can be applied to any structure at any coastal location within the state. The CERI App development project has been guided by an Advisory Board made up of key constituents involved in coastal management and development in the state. The effort included extensive testing of the App by various user groups. The App structure makes it simple and straightforward to transfer to coastal and inland flooded areas in other locations, requiring only the specification of BFEs and grade elevations

Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing

We employed phylogenomic methods to study molecular evolutionary processes and phylogeny in the geographically widely dispersed New World diploid cottons (Gossypium, subg. Houzingenia). Whole genome resequencing data (average of 33X genomic coverage) were generated to reassess the phylogenetic history of the subgenus and provide a temporal framework for its diversification. Phylogenetic analyses indicate that the subgenus likely originated following trans-oceanic dispersal from Africa about 6.6 mya, but that nearly all of the biodiversity evolved following rapid diversification in the mid-Pleistocene (0.5-2.0 mya), with multiple long-distance dispersals required to account for range expansion to Arizona, the Galapagos Islands, and Peru. Comparative analyses of cpDNA vs. nuclear data indicate that this history was accompanied by several clear cases of interspecific introgression. Repetitive DNAs contribute roughly half of the total 880 Mb genome, but most transposable element families are relatively old and stable among species. In the genic fraction, pairwise synonymous mutation rates average 1% per my, with non-synonymous changes being about seven times less frequent. Over 1.1 million indels were detected and phylogenetically polarized, revealing a two-fold bias toward deletions over small insertions. We suggest that this genome down-sizing bias counteracts genome size growth by TE amplification and insertions, and helps explain the relatively small genomes that are restricted to this subgenus. Compared to the rate of nucleotide substitution, the rate of indel occurrence is much lower averaging about 17 nucleotide substitutions per indel event

Treatment outcomes and roles of transplantation and maintenance rituximab in patients with previously untreated mantle cell lymphoma: Results from large real-world cohorts

PURPOSE: Commonly used first-line (1L) treatments for mantle cell lymphoma include high-dose cytarabine-based induction followed by autologous stem-cell transplant (ASCT) for younger patients and several chemoimmunotherapy regimens for older patients. Continuous debates exist on the role of ASCT in younger patients and maintenance rituximab (MR) after bendamustine plus rituximab (BR). METHODS: Retrospective data from 4,216 patients with mantle cell lymphoma in the Flatiron Health electronic record-derived deidentified database diagnosed between 2011 and 2021, mostly in US community oncology settings, were evaluated for treatment patterns and outcomes. The efficacy findings with ASCT and MR were validated in an independent cohort of 1,168 patients from 12 academic centers. RESULTS: Among 3,614 patients with documented 1L treatment, BR was the most used. Among 1,265 patients age \u3c 65 years, 30.5% received cytarabine-based induction and 23.5% received ASCT. There was no significant association between ASCT and real-world time to next treatment (hazard ratio [HR], 0.84; 95% CI, 0.68 to 1.03; CONCLUSION: In this large cohort of patients treated primarily in the US community setting, only one in four young patients received cytarabine or ASCT consolidation, suggesting the need to develop treatments that can be delivered effectively in routine clinical practice. Together with the validation cohort, data support future clinical trials exploring regimens without ASCT consolidation in young patients, whereas MR should be considered for patients after 1L BR and rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone

Anti-androgens act jointly in suppressing spiggin concentrations in androgen-primed female three-spined sticklebacks - Prediction of combined effects by concentration addition

This is the post-print version of the final paper published in Aquatic Toxicology. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. Copyright @ 2013 Elsevier B.V.Increasing attention is being directed at the role played by anti-androgenic chemicals in endocrine disruption of wildlife within the aquatic environment. The co-occurrence of multiple contaminants with anti-androgenic activity highlights a need for the predictive assessment of combined effects, but information about anti-androgen mixture effects on wildlife is lacking. This study evaluated the suitability of the androgenised female stickleback screen (AFSS), in which inhibition of androgen-induced spiggin production provides a quantitative assessment of anti-androgenic activity, for predicting the effect of a four component mixture of anti-androgens. The anti-androgenic activity of four known anti-androgens (vinclozolin, fenitrothion, flutamide, linuron) was evaluated from individual concentration-response data and used to design a mixture containing each chemical at equipotent concentrations. Across a 100-fold concentration range, a concentration addition approach was used to predict the response of fish to the mixture. Two studies were conducted independently at each of two laboratories. By using a novel method to adjust for differences between nominal and measured concentrations, good agreement was obtained between the actual outcome of the mixture exposure and the predicted outcome. This demonstrated for the first time that androgen receptor antagonists act in concert in an additive fashion in fish and that existing mixture methodology is effective in predicting the outcome, based on concentration-response data for individual chemicals. The sensitivity range of the AFSS assay lies within the range of anti-androgenicity reported in rivers across many locations internationally. The approach taken in our study lays the foundations for understanding how androgen receptor antagonists work together in fish and is essential in informing risk assessment methods for complex anti-androgenic mixtures in the aquatic environment.European Commission and Natural Environment Research Council