106 research outputs found
The Grizzly, October 1, 2015
Get PDFSafety First: New Campus Safety Officer Looks to Connect with Students β’ Artist Transforms Ursinus Faces into Famous Painting β’ Design Philly Festival Kicks Off with Pop-up Exhibition β’ Politics Professor Looks to Expand Research on Africa β’ U-Imagine Center Promotes Entrepreneurship β’ UC Students Get Down to the Heart of the Matter β’ Putting Passion into Practice β’ Opinions: Is Fun Home Appropriate for CIE?; The Cleaning Staff Should Not be Ignored β’ In the Swing of Things β’ Men\u27s and Women\u27s Rugby Teams Prepare for Seasonhttps://digitalcommons.ursinus.edu/grizzlynews/1672/thumbnail.jp
Recommended from our members
Complexity-Based Measures Inform Effects of Tai Chi Training on Standing Postural Control: Cross-Sectional and Randomized Trial Studies
Get PDFBackground: Diminished control of standing balance, traditionally indicated by greater postural sway magnitude and speed, is associated with falls in older adults. Tai Chi (TC) is a multisystem intervention that reduces fall risk, yet its impact on sway measures vary considerably. We hypothesized that TC improves the integrated function of multiple control systems influencing balance, quantifiable by the multi-scale βcomplexityβ of postural sway fluctuations. Objectives: To evaluate both traditional and complexity-based measures of sway to characterize the short- and potential long-term effects of TC training on postural control and the relationships between sway measures and physical function in healthy older adults. Methods: A cross-sectional comparison of standing postural sway in healthy TC-naΓ―ve and TC-expert (24.5Β±12 yrs experience) adults. TC-naΓ―ve participants then completed a 6-month, two-arm, wait-list randomized clinical trial of TC training. Postural sway was assessed before and after the training during standing on a force-plate with eyes-open (EO) and eyes-closed (EC). Anterior-posterior (AP) and medio-lateral (ML) sway speed, magnitude, and complexity (quantified by multiscale entropy) were calculated. Single-legged standing time and Timed-Upβand-Go tests characterized physical function. Results: At baseline, compared to TC-naΓ―ve adults (n = 60, age 64.5Β±7.5 yrs), TC-experts (n = 27, age 62.8Β±7.5 yrs) exhibited greater complexity of sway in the AP EC (P = 0.023), ML EO (P<0.001), and ML EC (P<0.001) conditions. Traditional measures of sway speed and magnitude were not significantly lower among TC-experts. Intention-to-treat analyses indicated no significant effects of short-term TC training; however, increases in AP EC and ML EC complexity amongst those randomized to TC were positively correlated with practice hours (P = 0.044, P = 0.018). Long- and short-term TC training were positively associated with physical function. Conclusion: Multiscale entropy offers a complementary approach to traditional COP measures for characterizing sway during quiet standing, and may be more sensitive to the effects of TC in healthy adults. Trial Registration ClinicalTrials.gov NCT0134036
Direct Detection of Reactive Nitrogen Species in Experimental Autoimmune Uveitis
Get PDFPURPOSE: Demonstrate unequivocally the generation of nitric oxide in experimental autoimmune uveoretinitis by electron spin resonance spectroscopy (ESR) using ferrous iron complex of N-methyl-D-glucamine dithiocarbamate, (MGD)(2)-Fe(2+), as a spin trap. METHODS: Experimental autoimmune uveitis was induced in Lewis rats, and at the peak of the intraocular inflammation, the animals received intravitreous injections of the spin trap. The retina and choroid dissected from the enucleated globes were subjected to ESR. Similarly, the retina and choroid obtained at the peak of experimental autoimmune uveo-retinitis (EAU) were placed in a vial containing luminal, and chemiluminescence was counted on a Packard liquid scintillation analyzer. RESULTS: The ESR three-line spectrum (g=2.04; a(N)=12.5 G) obtained was characteristic of the adduct [(MGD)(2)-Fe(2+)-NO]. The majority of this signal was eliminated by the inducible nitric oxide synthase (iNOS) specific inhibitor aminoguanidine injected inflamed retina was detected when compared with that of the non inflamed controls. The chemiluminescent activity was further increased two-fold by the addition of bicarbonate to the inflamed retina; the phenomenon is attributable only to the presence of a high steady-state concentration of peroxynitrite. CONCLUSIONS: The study shows an unequivocal presence of nitric oxide in EAU retina and choroid and the generation of peroxynitrite. High levels of these reactive nitrogen species generated in the inflamed retina and choroids are certain to cause irreversible tissue damage, especially at the susceptible sites such as photoreceptors
The Lantern, 2014-2015
Get PDFβ’ The Retreat β’ Part of Eve\u27s Discussion β’ Buchanan β’ Hypotheticals β’ The Baby Hippo β’ Sertraline and Cheerios β’ Margins β’ Anatomy of Me β’ Orange β’ Ode to Mathematics β’ Garden Path β’ Periphery β’ 10n Power=Our Maybe Domains β’ Hillside β’ Baltimore//Analogues β’ Work is a Religion β’ At the Bridal Shower β’ November β’ Revisionist History β’ Cold Front β’ Lung (for D. Avitabile) β’ Tether β’ Hold Still β’ Reverb β’ An Almost English Major and His Daughter β’ Clocks β’ In the Kitchen on a Sunday Afternoon β’ Amy β’ Nine β’ Customary Thoughts β’ Showers β’ Te Encuentro β’ I Find You β’ Literary Analysis β’ The Diamond on My Face β’ Catherine β’ Hunsberger Woods, 11:42 on a School Night β’ Cabbage β’ After Class β’ For Chell β’ To Whom It May Concern β’ Contra β’ Shards β’ Smoke and Roses β’ Polaroid β’ Spring\u27s Debut β’ The Deadline β’ A Previous Life β’ Wet Canvas β’ Obsessions and Compulsions β’ For Xandra β’ The Seagulls of 17th Street β’ No Man\u27s Land β’ Summer Flowers β’ Float β’ Dana Reads β’ A Barcelona Moment β’ Business Meeting β’ Posted β’ Champagnehttps://digitalcommons.ursinus.edu/lantern/1181/thumbnail.jp
The Lantern, 2016-2017
Get PDFβ’ Our Lady of Perpetual Virginity β’ Essential Terms for the Audience β’ Stories Untold β’ Jesus Camp β’ The Second Avenue Schmear β’ Driving to the Beach β’ Thanks, Alice β’ Decay β’ Peanut Butter Rhapsody β’ Transactions β’ Traffic β’ Sissy β’ Melting Wings β’ Ocean β’ Small Town Summer β’ Third Story β’ Family Trees β’ Mixed, Just Like Me β’ Sour Graves β’ How Sweet the Sound β’ Goodnight, Halfmoon β’ I\u27m Going to Ask Him How β’ Music β’ Pizza β’ Manhoodlike β’ Meditations From a Bunk Bed in a Home on Mount Pocono β’ Soft β’ Twilight\u27s Palette β’ The Oracle β’ Cynicism β’ River Ganges β’ Pinata Body and Hearing the Gun Shot β’ Song With No Music β’ Of Mornings Considering Womanhood β’ 10 Hours in Philadelphia β’ To Cut β’ Sachrang β’ Bavarian Wave Swinger β’ Irish Rain β’ Remembrances, Well β’ The Roses β’ Buttermilk β’ The Universe Will Always Listen if You Ask Her, Which is Why I Like Her More Than God β’ A Lukewarm Light β’ A Thought of Death β’ Hobson β’ Decaying Light β’ Window Women β’ Dead Bee β’ The Imagery β’ For Rent β’ Mona Lisa MMXVIhttps://digitalcommons.ursinus.edu/lantern/1185/thumbnail.jp
The Lantern, 2015-2016
Get PDFβ’ Ghosts β’ Going to China β’ 98% Guaranteed β’ Constellation/Boulevard β’ Prayer β’ The Little One β’ Burning β’ The Amber Macaroon β’ Becoming β’ Requiem β’ Construction Site β’ Thirteen Ways of Looking at a Dragon β’ Charlie β’ No Sleep β’ A Lesson in Physical Education β’ Statues β’ Who Can Love a Black Woman? β’ Apples β’ Fun Craft β’ The Door at Midnight β’ Eve as a Book in the Bible β’ Boys β’ Diamond Heart β’ To Apollo β’ Joanne and Her July Garden β’ Option A, 1936 β’ Young White Girls, Hollow Bodies, and Home β’ Mama\u27s Stance on Sugar β’ The Mariana Trench β’ Hurricane β’ Part of the Job β’ Avenue H Blues β’ Hour of Nones β’ Send Toilet Paper β’ Grave Robbing β’ Wild Turkey β’ The Creek β’ Let\u27s Go for a Walk β’ Deaconess β’ Border of Love β’ Your Father, Rumpelstiltskin β’ Purchasing Poplars β’ Red Tatters β’ Sunken β’ Whispers β’ Existence β’ God Took a Cigarette Break with Police Officers β’ Martian Standoff β’ In the Headlights β’ It\u27s a Subtle Thing β’ Dear Kent β’ Hanako-san β’ A Brief Interlude β’ On Fencing, Gummy Worms, and my Inescapable Fear of Living in the Moment β’ Stolen Soul β’ Block β’ Mortem Mei Fratris β’ Kalki β’ Lake Placid β’ Atom and Eve β’ The Baerie Queene β’ Gladston β’ Soldiers at Gettysburg β’ Pattern β’ Foliage β’ Mass Media β’ Arrow β’ Move Out β’ Wanderers β’ Riverside Gardenhttps://digitalcommons.ursinus.edu/lantern/1182/thumbnail.jp
Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial
Get PDFBackground
Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy
One year prospective survey of Candida bloodstream infections in Scotland
Get PDFA 12 month survey of candidaemia in Scotland, UK, in which every Scottish hospital laboratory submitted all blood isolates of yeasts for identification, strain typing and susceptibility testing, provided 300 isolates from 242 patients, generating incidence data of 4.8 cases per 100β000 population per year and 5.9 cases per 100β000 acute occupied bed days; 27.9β% of cases occurred in intensive care units. More than half the patients with candidaemia had an underlying disease involving the abdomen, 78β% had an indwelling intravenous catheter, 62β% had suffered a bacterial infection within the 2 weeks prior to candidaemia and 37β% had undergone a laparotomy. Candida albicans was the infecting species in 50β% of cases, followed by Candida glabrata (21β%) and Candida parapsilosis (12β%). Seven cases of candidaemia were caused by Candida dubliniensis, which was more prevalent even than Candida lusitaniae and Candida tropicalis (six cases each). Among C. glabrata isolates, 55β% showed reduced susceptibility to fluconazole, but azole resistance among other species was extremely low. Multilocus sequence typing showed isolates with high similarity came from different hospitals across the country, and many different types came from the hospitals that submitted the most isolates, indicating no tendency towards hospital-specific endemic strains. Multiple isolates of C. albicans and C. glabrata from individual patients were of the same strain type with single exceptions for each species. The high prevalence of candidaemia in Scotland, relative to other population-based European studies, and the high level of reduced fluconazole susceptibility of Scottish C. glabrata isolates warrant continued future surveillance of invasive Candida infections
Effects of IKAP/hELP1 Deficiency on Gene Expression in Differentiating Neuroblastoma Cells: Implications for Familial Dysautonomia
Get PDFFamilial dysautonomia (FD) is a developmental neuropathy of the sensory and autonomous nervous systems. The IKBKAP gene, encoding the IKAP/hELP1 subunit of the RNA polymerase II Elongator complex is mutated in FD patients, leading to a tissue-specific mis-splicing of the gene and to the absence of the protein in neuronal tissues. To elucidate the function of IKAP/hELP1 in the development of neuronal cells, we have downregulated IKBKAP expression in SHSY5Y cells, a neuroblastoma cell line of a neural crest origin. We have previously shown that these cells exhibit abnormal cell adhesion when allowed to differentiate under defined culture conditions on laminin substratum. Here, we report results of a microarray expression analysis of IKAP/hELP1 downregulated cells that were grown on laminin under differentiation or non-differentiation growth conditions. It is shown that under non-differentiation growth conditions, IKAP/hELP1 downregulation affects genes important for early developmental stages of the nervous system, including cell signaling, cell adhesion and neural crest migration. IKAP/hELP1 downregulation during differentiation affects the expression of genes that play a role in late neuronal development, in axonal projection and synapse formation and function. We also show that IKAP/hELP1 deficiency affects the expression of genes involved in calcium metabolism before and after differentiation of the neuroblastoma cells. Hence, our data support IKAP/hELP1 importance in the development and function of neuronal cells and contribute to the understanding of the FD phenotype
A Novel Role for the NLRC4 Inflammasome in Mucosal Defenses against the Fungal Pathogen Candida albicans
Get PDFCandida sp. are opportunistic fungal pathogens that colonize the skin and oral cavity and, when overgrown under permissive conditions, cause inflammation and disease. Previously, we identified a central role for the NLRP3 inflammasome in regulating IL-1Ξ² production and resistance to dissemination from oral infection with Candida albicans. Here we show that mucosal expression of NLRP3 and NLRC4 is induced by Candida infection, and up-regulation of these molecules is impaired in NLRP3 and NLRC4 deficient mice. Additionally, we reveal a role for the NLRC4 inflammasome in anti-fungal defenses. NLRC4 is important for control of mucosal Candida infection and impacts inflammatory cell recruitment to infected tissues, as well as protects against systemic dissemination of infection. Deficiency in either NLRC4 or NLRP3 results in severely attenuated pro-inflammatory and antimicrobial peptide responses in the oral cavity. Using bone marrow chimeric mouse models, we show that, in contrast to NLRP3 which limits the severity of infection when present in either the hematopoietic or stromal compartments, NLRC4 plays an important role in limiting mucosal candidiasis when functioning at the level of the mucosal stroma. Collectively, these studies reveal the tissue specific roles of the NLRP3 and NLRC4 inflammasome in innate immune responses against mucosal Candida infection
- β¦
