The Differential Vector Phase-Locked Loop for Global Navigation Satellite System Signal Tracking

A novel differential vector phase-locked loop (DVPLL) is derived that takes GNSS code-phase and carrier-phase measurements from a base station and uses them to maintain an integer ambiguity resolved quality solution directly in the vector tracking loop of a rover receiver. The only state variables estimated and used to create the replica code and carrier signals from the base station measurements are three position and two clock states for a static test. Closing the individual loops solely through the navigation filter makes this a pure vector method. For short baselines, where differential atmospheric errors are small, the DVPLL can be used on single-frequency data. An L1-only live-sky static test was performed using the method resulting in a 3D accuracy of 5.3 mm for an 18.5 m baseline. An acquisition algorithm is also developed to initialize the DVPLL. The algorithm performs a search in the space-time domain vice the measurement domain. An upper bound on the failure rate of the algorithm can be set by the user. The algorithm was tested on 24-h dual- and single-frequency CORS data sets with close to a 100% success rate and on a 15- min data set of single-frequency IF samples with a 100% success rate

An Analysis of Poverty Convergence: Evidence from Pennsylvania Counties

This paper extends applications of unconditional and conditional β-convergence and σ-convergence analysis to poverty rates in a panel data sample of Pennsylvania counties during the period 1990-2019. Spatial structural breaks between rural and urban counties in Pennsylvania plus the possibility that Philadelphia County is an outlier are acknowledged to avoid spurious inferences. The findings support the existence of unconditional β-convergence in the pooled, urban, and rural samples with non-metropolitan areas exhibiting the greatest convergence. However, the largest conditional β-convergence is observed for urban counties, and this outcome is robust to the exclusion of Philadelphia County. Graphical evidence evinces a greater degree of σ-divergence in rural areas relative to the pooled and urban samples with metropolitan areas exhibiting neither convergence nor divergence in the absence of Philadelphia County. Statistical evidence based on ADF and DF-GLS tests reveals the presence of σ-divergence in the pooled and rural samples but weaker findings for the urban counties. Panel data tests for unit roots indicate σ-convergence for the full and rural samples but mixed results for the urban sample depending upon the test employed and whether Philadelphia County is included or not. The findings indicate that further investigation of tailored policy responses to poverty in different geographic areas within the same state is warranted

Tau and atrophy: domain-specific relationships with cognition.

BackgroundLate-onset Alzheimer's disease (AD) is characterized by primary memory impairment, which then progresses towards severe deficits across cognitive domains. Here, we report how performance in cognitive domains relates to patterns of tau deposition and cortical thickness.MethodsWe analyzed data from 131 amyloid-β positive participants (55 cognitively normal, 46 mild cognitive impairment, 30 AD) of the Alzheimer's Disease Neuroimaging Initiative who underwent magnetic resonance imaging (MRI), flortaucipir (FTP) positron emission tomography, and neuropsychological testing. Surface-based vertex-wise and region-of-interest analyses were conducted between FTP and cognitive test scores, and between cortical thickness and cognitive test scores.ResultsFTP and thickness were differentially related to cognitive performance in several domains. FTP-cognition associations were more widespread than thickness-cognition associations. Further, FTP-cognition patterns reflected cortical systems that underlie different aspects of cognition.ConclusionsOur findings indicate that AD-related decline in domain-specific cognitive performance reflects underlying progression of tau and atrophy into associated brain circuits. They also suggest that tau-PET may have better sensitivity to this decline than MRI-derived measures of cortical thickness

Antigen depot is not required for alum adjuvanticity

Alum adjuvants have been in continuous clinical use for more than 80 yr. While the prevailing theory has been that depot formation and the associated slow release of antigen and/or inflammation are responsible for alum enhancement of antigen presentation and subsequent T- and B-cell responses, this has never been formally proven. To examine antigen persistence, we used the chimeric fluorescent protein EαGFP, which allows assessment of antigen presentation in situ, using the Y-Ae antibody. We demonstrate that alum and/or CpG adjuvants induced similar uptake of antigen, and in all cases, GFP signal did not persist beyond 24 h in draining lymph node antigen-presenting cells. Antigen presentation was first detectable on B cells within 6–12 h of antigen administration, followed by conventional dendritic cells (DCs) at 12–24 h, then finally plasmacytoid DCs at 48 h or later. Again, alum and/or CpG adjuvants did not have an effect on the magnitude or sequence of this response; furthermore, they induced similar antigen-specific T-cell activation in vivo. Notably, removal of the injection site and associated alum depot, as early as 2 h after administration, had no appreciable effect on antigen-specific T- and B-cell responses. This study clearly rules out a role for depot formation in alum adjuvant activity

Women can bear a bigger burden: ante- and post-mortem evidence for reserve in the face of tau.

In this study, we aimed to assess whether women are able to withstand more tau before exhibiting verbal memory impairment. Using data from 121 amyloid-β-positive Alzheimer's Disease Neuroimaging Initiative participants, we fit a linear model with Rey Auditory Verbal Learning Test score as the response variable and tau-PET standard uptake value ratio as the predictor and took the residuals as an estimate of verbal memory reserve for each subject. Women demonstrated higher reserve (i.e. residuals), whether the Learning (t = 2.78, P = 0.006) or Delay (t = 2.14, P = 0.03) score from the Rey Auditory Verbal Learning Test was used as a measure of verbal memory ability. To validate these findings, we examined 662 National Alzheimer's Coordinating Center participants with a C2/C3 score (Consortium to Establish a Registry for Alzheimer's Disease) at autopsy. We stratified our National Alzheimer's Coordinating Center sample into Braak 1/2, Braak 3/4 and Braak 5/6 subgroups. Within each subgroup, we compared Logical Memory scores between men and women. Men had worse verbal memory scores within the Braak 1/2 (Logical Memory Immediate: β = -5.960 ± 1.517, P < 0.001, Logical Memory Delay: β = -5.703 ± 1.677, P = 0.002) and Braak 3/4 (Logical Memory Immediate: β = -2.900 ± 0.938, P = 0.002, Logical Memory Delay: β = -2.672 ± 0.955, P = 0.006) subgroups. There were no sex differences in Logical Memory performance within the Braak 5/6 subgroup (Logical Memory Immediate: β = -0.314 ± 0.328, P = 0.34, Logical Memory Delay: β = -0.195 ± 0.287, P = 0.50). Taken together, our results point to a sex-related verbal memory reserve

Air/surface exchange of gaseous elemental mercury at different landscapes in Mississippi, USA

© 2019 by the authors. Mercury (Hg) is a global pollutant with human health and ecological impacts. Gas exchange between terrestrial surfaces and the atmosphere is an important route for Hg to enter and exit ecosystems. Here, we used a dynamic flux chamber to measure gaseous elemental Hg (GEM) exchange over different landscapes in Mississippi, including in situ measurements for a wetland (soil and water), forest floor, pond, mowed field and grass-covered lawn, as well as mesocosm experiments for three different agricultural soils. Fluxes were measured during both the summer and winter. Mean ambient levels of GEM ranged between 0.93-1.57 ng m-3. GEM emission fluxes varied diurnally with higher daytime fluxes, driven primarily by solar radiation, and lower and more stable nighttime fluxes, dependent mostly on temperature. GEM fluxes (ng m-2 h-1) were seasonally dependent with net emission during the summer (mean 2.15, range 0.32 to 4.92) and net deposition during the winter (-0.12, range -0.32 to 0.12). Total Hg concentrations in the soil ranged from 17.1 ng g-1 to 127 ng g-1 but were not a good predictor of GEM emissions. GEM flux and soil temperature were correlated over the forest floor, and the corresponding activation energy for Hg emission was ~31 kcal mol-1 using the Arrhenius equation. There were significant differences in GEM fluxes between the habitats with emissions for grass \u3e wetland soil \u3e mowed field \u3e pond \u3e wetland water ≈ forest ≈ agriculture soils. Overall, we demonstrate that these diverse landscapes serve as both sources and sinks for airborne Hg depending on the season and meteorological factors

A novel cellular pathway of antigen presentation and CD4 T cell activation in vivo

Dendritic cell activation of CD4 T cells in the lymph node draining a site of infection or vaccination is widely considered the central event in initiating adaptive immunity. The accepted dogma is that this occurs by stimulating local activation and antigen acquisition by dendritic cells, with subsequent lymph node migration, however the generalizability of this mechanism is unclear. Here we show that in some circumstances antigen can bypass the injection site inflammatory response, draining freely and rapidly to the lymph nodes where it interacts with subcapsular sinus (SCS) macrophages resulting in their death. Debris from these dying SCS macrophages is internalized by monocytes recruited from the circulation. This coordinated response leads to antigen presentation by monocytes and interactions with naïve CD4 T cells that can drive the initiation of T cell and B cell responses. These studies demonstrate an entirely novel pathway leading to initiation of adaptive immune responses in vivo

Stressed Oxidation of C/SiC Composites

Constant load, stressed oxidation testing was performed on T-300 C/SiC composites with a SiC seal coat. Test conditions included temperatures ranging from 350 C to 1500 C at stresses of 69 MPa and 172 MPa (10 and 25 ksi). The coupon subjected to stressed oxidation at 550 C/69 MPa for 25 hours had a room temperature residual strength one-half that of the as-received coupons. The coupon tested at the higher stress and all coupons tested at higher temperatures failed in less than 25 hr. Microstructural analysis of the fracture surfaces, using SEM (scanning electron microscopy), revealed the formation of reduced cross-sectional fibers with pointed tips. Analysis of composite cross-sections show pathways for oxygen ingress. The discussion will focus on fiber/matrix interphase oxidation and debonding as well as the formation and implications of the fiber tip morphology

Carcass Traits and M. Longissimus Lumborum Palatability Attributes of Calf- and Yearling-Finished Steers

A 2-yr experiment was conducted to compare carcass characteristics and meat palatability attributes of steers (³⁄₄ British, ¹⁄₄ Continental) finished postweaning as calves or yearlings. Calves and yearlings of the same contemporary group were designated to a finishing system at weaning. Calves (n = 73) were finished in the feedlot (191 d) on a high-concentrate diet. Yearlings (n = 84) grazed crop residues after weaning, followed by spring and summer pasture grazing, and concluded with a short finishing period (91 d) in the feedlot. All steers were fed to a constant, fat thickness endpoint of 1 cm. The M. longissimus lumborum steaks from each production system were aged for 7, 14, or 21 d for Warner-Bratzler shear force determination and for 7 or 14 d for in-house sensory panel evaluation. Insoluble, percent soluble, and total collagen were determined. Yearlings produced heavier (P \u3c 0.001) carcasses with larger (P \u3c 0.001) LM areas and lower (P \u3c 0.001) marbling scores and quality grades. Calves possessed greater amounts of total collagen (P \u3c 0.001), with a significantly greater percentage of soluble collagen compared with yearlings (39.72 vs. 24.38%). Calves produced steaks with lower (P \u3c 0.001) shear force values and greater (P \u3c 0.001) sensory ratings for flavor. The USDA Choice steaks from the calves were more (P \u3c 0.001) tender and more (P \u3c 0.050) palatable than Choice steaks from yearlings, and USDA Select steaks from calves were rated more tender (P \u3c 0.001), juicy (P = 0.012), and desirable (P \u3c 0.001) than Select steaks from yearlings. As expected, increasing aging time from 7- to 14- to 21-d produced steaks with lower (P \u3c 0.001) shear force values, regardless of the production system. Risk probabilities showed 1.24% of the steaks from calf finished steers and 21.22% of steaks from yearling-finished steers to be tough. Sensory rating probabilities showed the steaks from the calves were most likely to be desirable for tenderness, whereas steaks from the yearlings were most likely to be undesirable for tenderness, juiciness, flavor, and overall acceptability. Thus, calf-finished steers produce carcasses superior in quality and palatability compared with those from yearling finished steers. However, yearling-finished steers can produce tender beef with extended aging