Embolization in an adrenocortical carcinoma as palliative therapy

Background: With an annual incidence of 0.2% of new cases per 100,000 inhabitants, adrenocortical carcinoma is rare. In advanced tumor only palliative treatment modalities are practicable. Because of scarcity of the tumor, standard treatment has not been defined. The decision on therapy frequently depends on the individual situation. Tumor embolization and chemotherapy are amongst the possible options. Patient and Methods: We report on a case of a 32-year-old female patient with a large-volume hormonally active adrenocortical carcinoma and hematogenous liver metastases. This carcinoma was confirmed histologically by means of liver biopsy. Owing to the large tumor extent and metastatic spreading and also in view of the poor general condition of the patient, curative surgical therapy was not possible. For this reason, a local approach was chosen primarily with transarterial tumor embolization at the capillary level. Systemic chemotherapy was given afterwards. Results: Improvement of the patient's general condition, especially the pronounced pain symptoms, could be achieved for a short time by the embolization: both, the patient's clinical condition and the laboratory test parameters improved. However, a rapid tumor progression occured under chemotherapy, which was started after embolization. Conclusion: In advanced adrenocortical carcinoma, tumor embolization can lead to a stabilization of the disease and improvement of the symptoms as appraised by palliative criteria in some patients

An SU(3) model for octet baryon and meson fragmentation

The production of the octet of baryons and mesons in e^+ e^- collisions is analysed, based on considerations of SU(3) symmetry and a simple model for SU(3) symmetry breaking in fragmentation functions. All fragmentation functions, D_q^h(x, Q^2), describing the fragmentation of quarks into a member of the baryon octet (and similarly for fragmentation into members of the meson octet) are expressed in terms of three SU(3) symmetric functions, \alpha(x, Q^2), \beta(x, Q^2), and \gamma(x, Q^2). With the introduction of an SU(3) breaking parameter, \lambda, the model is successful in describing hadroproduction data at the Z pole. The fragmentation functions are then evolved using leading order evolution equations and good fits to currently available data at 34 GeV and at 161 GeV are obtained.Comment: 24 pages LaTeX file including 11 postscript figure file

Properties of Factorial Cumulant to Factorial Moment Ratio

It is shown that the ratio of factorial cumulant moments to factorial moments for a multiplicity distribution truncated in the tail reveals oscillations in sign similar to those observed in experimental data. It is suggested that this effect be taken into account in the analysis of data in order to obtain correct physical information on the multiplicity distributions.Comment: (LaTeX + epsfig, 8 pages including 3 PostScript figures, all encoded via uufiles), DFTT 46/9

Uncovering latent behaviors in ant colonies

Many biological systems exhibit collective behaviors that strengthen their adaptability to their environment, compared to more solitary species. Describing these behaviors is challenging yet necessary in order to understand these biological systems. We propose a probabilistic model that enables us to uncover the collective behaviors observed in a colony of ants. This model is based on the assumption that the behavior of an individual ant is a time-dependent mixture of latent behaviors that are specific to the whole colony. We apply this model to a large-scale dataset obtained by observing the mobility of nearly 1000 Camponotus fellah ants from six different colonies. Our results indicate that a colony typically exhibits three classes of behaviors, each characterized by a specific spatial distribution and a level of activity. Moreover, these spatial distributions, which are uncovered automatically by our model, match well with the ground truth as manually annotated by domain experts. We further explore the evolution of the behavior of individual ants and show that it is well captured by a second order Markov chain that encodes the fact that the future behavior of an ant depends not only on its current behavior but also on its preceding one

A methodology to estimate the residence time of estuaries

The residence time has long been used as a classification parameter for estuaries and other semi- enclosed water bodies. It aims to quantify the time water remains inside the estuary, being used as an indicator both for pollution assessment and for ecological processes. Estuaries with a short residence time will export nutrients from upstream sources more rapidly then estuaries with longer residence time. On the other hand the residence time determines if micro-algae can stay long enough to generate a bloom. As a consequence, estuaries with very short residence time are expected to have much lower algae blooms, then estuaries with longer residence time. In addition, estuaries with residence times shorter than the doubling time of algae cells will inhibit formation of algae blooms (EPA, 2001). The residence time is also an important issue for processes taking place in the sediment. The fluxes of particulate matter and associated adsorbed species from the water column to the sediment depends of the particle’s vertical velocity, water depth and residence time. This is particularly important for the fine fractions with lower sinking velocities. The question is how to compute the residence time and how does it depend on the computation method adopted

Enter exitrons

Staiger D, Simpson GG. Enter exitrons. Genome Biology. 2015;16(1): 136.Exitrons are exon-like introns located within protein-coding exons. Removal or retention of exitrons through alternative splicing increases proteome complexity and thus adds to phenotypic diversity

Strategies for the analysis of osteitic bone defects at the diaphysis of long bones

Septic diseases of the bone and the immediate surrounding soft tissue, i.e., osteitis, belong to the most alarming findings in recent traumatology and orthopedic surgery. The paramount goal of this therapy is to preserve the stable weight-bearing bones while maintaining a correct axis and proper working muscles and joints, in order to avoid permanent disability in the patient. “State-of-the-art” therapy of osteitis/osteomyelitis therapy has two priorities: eradication of the infection and reconstruction of bone and soft tissue. Surgical treatment of the affected bone segments and soft tissue, followed by reconstructive methods, continues to be the main basic therapy. It is often extremely difficult to decide whether the affected bone segment has to be resected, or whether bone continuity can be preserved. The following paper provides strategies and guidance to help guide decisions in this complex and challenging area

Carboxylate ion pairing with alkali-metal ions for β-Lactoglobulin and its role on aggregation and interfacial adsorption

We report a combined experimental and computational study of the whey protein β-lactoglobulin (BLG) in different electrolyte solutions. Vibrational sum-frequency generation (SFG) and ellipsometry were used to investigate the molecular structure of BLG modified air–water interfaces as a function of LiCl, NaCl, and KCl concentrations. Molecular dynamics (MD) simulations and thermodynamic integration provided details of the ion pairing of protein surface residues with alkali-metal cations. Our results at pH 6.2 indicate that BLG at the air–water interface forms mono- and bilayers preferably at low and high ionic strength, respectively. Results from SFG spectroscopy and ellipsometry are consistent with intimate ion pairing of alkali-metal cations with aspartate and glutamate carboxylates, which is shown to be more effective for smaller cations (Li⁺ and Na⁺). MD simulations show not only carboxylate–alkali-metal ion pairs but also ion multiplets with the alkali-metal ion in a bridging position between two or more carboxylates. Consequently, alkali-metal cations can bridge carboxylates not only within a monomer but also between monomers, thus providing an important dimerization mechanism between hydrophilic surface patches

Multiplicity distributions inside parton cascades developing in a medium

The explanation of the suppression of high-pT hadron yields at RHIC in terms of jet-quenching implies that the multiplicity distributions of particles inside a jet and jet-like particle correlations differ strongly in nucleus-nucleus collisions at RHIC or at the LHC from those observed at e+e- or hadron colliders. We present a framework for describing the medium-induced modification, which has a direct interpretation in terms of a probabilistic medium-modified parton cascade, and which treats leading and subleading partons on an equal footing. We show that our approach can account for the strong suppression of single inclusive hadron spectra measured in Au-Au collisions at RHIC, and that this implies a characteristic distortion of the single inclusive distribution of soft partons inside the jet. We determine, as a function of the jet energy, to what extent the soft fragments within a jet can be measured above some momentum cut.Comment: 5 pages, 4 eps-figures; talk given at Hot Quarks 2006, Villasimius (Sardinia, Italy), May 15-20, 200