A Paradigm for color gamut mapping of pictorial images

In this thesis, a paradigm was generated for color gamut mapping of pictorial images. This involved the development and testing of: 1.) a hue-corrected version of the CIELAB color space, 2.) an image-dependent sigmoidal-lightness-rescaling process, 3.) an image-gamut- based chromatic-compression process, and 4.) a gamut-expansion process. This gamut-mapping paradigm was tested against some gamut-mapping strategies published in the literature. Reproductions generated by gamut mapping in a hue-corrected CIELAB color space more accurately preserved the perceived hue of the original scenes compared to reproductions generated using the CIELAB color space. The results of three gamut-mapping experiments showed that the contrast-preserving nature of the sigmoidal-lightness-remapping strategy generated gamut-mapped reproductions that were better matches to the originals than reproductions generated using linear-lightness-compression functions. In addition, chromatic-scaling functions that compressed colors at a higher rate near the gamut surface and less near the achromatic axis produced better matches to the originals than algorithms that performed linear chroma compression throughout color space. A constrained gamut-expansion process, similar to the inverse of the best gamut-compression process found in this experiment, produced reproductions preferred over an expansion process utilizing unconstrained linear expansion

Color gamut mapping in a hue-linearized CIELAB color space

Color gamut mapping plays a crucial role in color management. Depending on the application, it is sometimes desirable to perform color gamut mapping by shifting the lightness and compressing the chroma of an out-of-gamut color while preserving the perceived hue of the color. The term perceived hue is used to distinguish between the visual sensation of hue and metric hue angle (e.g., CIELAB hue angle (hab) ). If a gamut-mapping task constrains CIELAB metric hue angle in the blue region of CIELAB, a perceived-hue shift will result. Due to these nonlinearities, two hue-linearized versions of the CIELAB color space were generated, one from the Hung and Berns visual data (1995) and one from the Ebner and Fairchild data set (1998). Both data sets consist of visually mapped hue data to planes of constant visual hue. These modified versions of the CIELAB color space were psychophysically tested for their hue-linearity characteristics against the CIELAB color space. The results of these experiments show that, in the blue region of CIELAB, the hue-corrected color spaces are more visually uniform and perform better than CIELAB in gamut mapping situations with respect to perceived hue. However, the CIELAB color space performed as good as or better than either hue-corrected spaces outside of the blue region

Gamut Mapping for Pictorial Images

A psychophysical evaluation was performed to test the quality of several color gamut mapping algorithms. The task was to determine which mapping strategy produced the best matches to the original image. Observer preference was not considered. The algorithms consisted of both device dependent and image-dependent mappings. Three types of lightness scaling functions (linear compression, chroma weighted linear compression, and image dependent sigmoidal compression) and four types of chromatic mapping functions were tested (linear compression, knee-point compression, sigmoidlike compression, and clipping). The source and destination devices considered were a monitor and a plain-paper inkjet printer respectively. The results showed that, for all of the images tested, the algorithms that used image-dependent sigmoidal lightness remapping functions produced superior matches to those that utilized linear lightness scaling. In addition, the results support using chromatic compression functions that were closely related to chromatic clipping functions

A Trip to the Moon: Personalized Animated Movies for Self-reflection

Self-tracking physiological and psychological data poses the challenge of presentation and interpretation. Insightful narratives for self-tracking data can motivate the user towards constructive self-reflection. One powerful form of narrative that engages audience across various culture and age groups is animated movies. We collected a week of self-reported mood and behavior data from each user and created in Unity a personalized animation based on their data. We evaluated the impact of their video in a randomized control trial with a non-personalized animated video as control. We found that personalized videos tend to be more emotionally engaging, encouraging greater and lengthier writing that indicated self-reflection about moods and behaviors, compared to non-personalized control videos

The Methyltransferase Smyd1 Mediates LPS-Triggered Up-Regulation of IL-6 in Endothelial Cells

The lysine methyltransferase Smyd1 with its characteristic catalytic SET-domain is highly enriched in the embryonic heart and skeletal muscles, participating in cardiomyogenesis, sarcomere assembly and chromatin remodeling. Recently, significant Smyd1 levels were discovered in endothelial cells (ECs) that responded to inflammatory cytokines. Based on these biochemical properties, we hypothesized that Smyd1 is involved in inflammation-triggered signaling in ECs and therefore, investigated its role within the LPS-induced signaling cascade. Human endothelial cells (HUVECs and EA.hy926 cells) responded to LPS stimulation with higher intrinsic Smyd1 expression. By transfection with expression vectors containing gene inserts encoding either intact Smyd1, a catalytically inactive Smyd1-mutant or Smyd1-specific siRNAs, we show that Smyd1 contributes to LPS-triggered expression and secretion of IL-6 in EA.hy926 cells. Further molecular analysis revealed this process to be based on two signaling pathways: Smyd1 increased the activity of NF-kappa B and promoted the trimethylation of lysine-4 of histone-3 (H3K4me3) within the IL-6 promoter, as shown by ChIP-RT-qPCR combined with IL-6-promoter-driven luciferase reporter gene assays. In summary, our experimental analysis revealed that LPS-binding to ECs leads to the up-regulation of Smyd1 expression to transduce the signal for IL-6 up-regulation via activation of the established NF-κB pathway as well as via epigenetic trimethylation of H3K4

Interaction between Retinoid Acid Receptor-Related Orphan Receptor Alpha (RORA) and Neuropeptide S Receptor 1 (NPSR1) in Asthma

Peer reviewe

A global experiment on motivating social distancing during the COVID-19 pandemic

Finding communication strategies that effectively motivate social distancing continues to be a global public health priority during the COVID-19 pandemic. This cross-country, preregistered experiment (n = 25,718 from 89 countries) tested hypotheses concerning generalizable positive and negative outcomes of social distancing messages that promoted personal agency and reflective choices (i.e., an autonomy-supportive message) or were restrictive and shaming (i.e., a controlling message) compared with no message at all. Results partially supported experimental hypotheses in that the controlling message increased controlled motivation (a poorly internalized form of motivation relying on shame, guilt, and fear of social consequences) relative to no message. On the other hand, the autonomy-supportive message lowered feelings of defiance compared with the controlling message, but the controlling message did not differ from receiving no message at all. Unexpectedly, messages did not influence autonomous motivation (a highly internalized form of motivation relying on one’s core values) or behavioral intentions. Results supported hypothesized associations between people’s existing autonomous and controlled motivations and self-reported behavioral intentions to engage in social distancing. Controlled motivation was associated with more defiance and less long-term behavioral intention to engage in social distancing, whereas autonomous motivation was associated with less defiance and more short- and long-term intentions to social distance. Overall, this work highlights the potential harm of using shaming and pressuring language in public health communication, with implications for the current and future global health challenges