3,341 research outputs found
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STONE 6: Artificial Sedimentary Meteorites in Space
The STONE 6 experiment demonstrated the survivability of carbonaceous and microfossiliferous martian analogue sediments during atmospheric re-entry. Doped endoliths died but their carbonised cells remained
Calibration Model Maintenance in Melamine Resin Production: Integrating Drift Detection, Smart Sample Selection and Model Adaptation
The physico-chemical properties of Melamine Formaldehyde (MF) based thermosets are largely influenced by the degree of polymerization (DP) in the underlying resin. On-line supervision of the turbidity point by means of vibrational spectroscopy has recently emerged as a promising technique to monitor the DP of MF resins. However, spectroscopic determination of the DP relies on chemometric models, which are usually sensitive to drifts caused by instrumental and/or sample associated changes occurring over time. In order to detect the time point when drifts start causing prediction bias, we here explore a universal drift detector based on a faded version of the Page-Hinkley (PH) statistic, which we test in three data streams from an industrial MF resin production process. We employ committee disagreement (CD), computed as the variance of model predictions from an ensemble of partial least squares (PLS) models, as a measure for sample-wise prediction uncertainty and use the PH statistic to detect hanges in this quantity. We further explore supervised and unsupervised strategies for (semi-)automatic model adaptation upon detection of a drift. For the former, manual reference measurements are requested whenever statistical thresholds on Hotelling’s and/or Q-Residuals are violated. Models are subsequently re-calibrated using weighted partial least squares in order to increase the influence of newer samples, which increases the flexibility when adapting to new (drifted) states. Unsupervised model adaptation is carried out exploiting the dual antecedent-consequent structure of a recently developed fuzzy systems variant of PLS termed FLEXFIS-PLS. In particular, antecedent parts are updated while maintaining the internal structure of the local linear predictors (i.e. the consequents). We found improved drift detection capability of the CD compared to Hotelling’s and Q-Residuals when used in combination with the proposed PH test. Furthermore, we found that active selection of samples by active learning (AL) used for subsequent model adaptation is advantageous compared to passive (random) selection in case that a drift leads to persistent prediction bias allowing more rapid adaptation at lower reference measurement rates. Fully unsupervised adaptation using FLEXFIS-PLS could improve predictive accuracy significantly for light drifts but was not able to fully compensate for prediction bias in case of significant lack of fit w.r.t. the latent variable space
Untersuchungen zur molekularen Pathogenese und zur Therapie des AIDS-assoziierten Kaposi-Sarkoms
Equation of State, Spectra and Composition of Hot and Dense Infinite Hadronic Matter in a Microscopic Transport Model
Equilibrium properties of infinite relativistic hadron matter are
investigated using the Ultrarelativistic Quantum Molecular Dynamics (UrQMD)
model. The simulations are performed in a box with periodic boundary
conditions. Equilibration times depend critically on energy and baryon
densities. Energy spectra of various hadronic species are shown to be isotropic
and consistent with a single temperature in equilibrium. The variation of
energy density versus temperature shows a Hagedorn-like behavior with a
limiting temperature of 13010 MeV. Comparison of abundances of different
particle species to ideal hadron gas model predictions show good agreement only
if detailed balance is implemented for all channels. At low energy densities,
high mass resonances are not relevant; however, their importance raises with
increasing energy density. The relevance of these different conceptual
frameworks for any interpretation of experimental data is questioned.Comment: Latex, 20 pages including 6 eps-figure
Local Thermal and Chemical Equilibration and the Equation of State in Relativistic Heavy Ion Collisions
Thermodynamical variables and their time evolution are studied for central
relativistic heavy ion collisions from 10.7 to 160 AGeV in the microscopic
Ultrarelativistic Quantum Molecular Dynamics model (UrQMD). The UrQMD model
exhibits drastic deviations from equilibrium during the early high density
phase of the collision. Local thermal and chemical equilibration of the
hadronic matter seems to be established only at later stages of the quasi-
isentropic expansion in the central reaction cell with volume 125 fm.
distributions at all collision energies for with a unique
Baryon energy spectra in this cell are approximately reproduced by Boltzmann
rapidly dropping temperature. At these times the equation of state has a simple
form: . At 160 AGeV the strong deviation from
chemical equilibrium is found for mesons, especially for pions, even at the
late stage of the reaction. The final enhancement of pions is supported by
experimental data.Comment: 17 Pages, LaTex, 8 eps figures. Talk given at SQM'98 conference,
20-24 July 1998, Padova, Italy, submitted to J. Phys.
Are we close to the QGP? - Hadrochemical vs. microscopic analysis of particle production in ultrarelativistic heavy ion collisions
Ratios of hadronic abundances are analyzed for pp and nucleus-nucleus
collisions at sqrt(s)=20 GeV using the microscopic transport model UrQMD.
Secondary interactions significantly change the primordial hadronic cocktail of
the system. A comparison to data shows a strong dependence on rapidity. Without
assuming thermal and chemical equilibrium, predicted hadron yields and ratios
agree with many of the data, the few observed discrepancies are discussed.Comment: 12 pages, 4 figure
Structure-Activity Relationships of Triple-Action Platinum(IV) Prodrugs with Albumin-Binding Properties and Immunomodulating Ligands
Chemotherapy with
platinum complexes is essential for clinical
anticancer therapy. However, due to side effects and drug resistance,
further drug improvement is urgently needed. Herein, we report on
triple-action platinum(IV) prodrugs, which, in addition to tumor targeting via maleimide-mediated albumin binding, release the immunomodulatory
ligand 1-methyl-d-tryptophan (1-MDT). Unexpectedly, structure–activity
relationship analysis showed that the mode of 1-MDT conjugation distinctly
impacts the reducibility and thus activation of the prodrugs. This
in turn affected ligand release, pharmacokinetic properties, efficiency
of immunomodulation, and the anticancer activity in vitro and in a mouse model in vivo. Moreover, we could
demonstrate that the design of albumin-targeted multi-modal prodrugs
using platinum(IV) is a promising strategy to enhance the cellular
uptake of bioactive ligands with low cell permeability (1-MDT) and
to improve their selective delivery into the malignant tissue. This
will allow tumor-specific anticancer therapy supported by a favorably
tuned immune microenvironment
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Measurement of double-differential cross sections for top quark pair production in pp collisions at [Formula: see text][Formula: see text] and impact on parton distribution functions.
Normalized double-differential cross sections for top quark pair ([Formula: see text]) production are measured in pp collisions at a centre-of-mass energy of 8[Formula: see text] with the CMS experiment at the LHC. The analyzed data correspond to an integrated luminosity of 19.7[Formula: see text]. The measurement is performed in the dilepton [Formula: see text] final state. The [Formula: see text] cross section is determined as a function of various pairs of observables characterizing the kinematics of the top quark and [Formula: see text] system. The data are compared to calculations using perturbative quantum chromodynamics at next-to-leading and approximate next-to-next-to-leading orders. They are also compared to predictions of Monte Carlo event generators that complement fixed-order computations with parton showers, hadronization, and multiple-parton interactions. Overall agreement is observed with the predictions, which is improved when the latest global sets of proton parton distribution functions are used. The inclusion of the measured [Formula: see text] cross sections in a fit of parametrized parton distribution functions is shown to have significant impact on the gluon distribution
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