Versatile Multimodality Imaging System Based on Detectorless and Scanless Optical Feedback Interferometry-A Retrospective Overview for A Prospective Vision

In this retrospective compendium, we attempt to draw a "fil rouge" along fifteen years of our research in the field of optical feedback interferometry aimed at guiding the readers to the verge of new developments in the field. The general reader will be moved at appreciating the versatility and the still largely uncovered potential of the optical feedback interferometry, for both sensing and imaging applications. By discovering the broad range of available wavelengths (0.4-120 μm), the different types of suitable semiconductor lasers (Fabry-Perot, distributed feedback, vertical-cavity, quantum-cascade), and a number of unconventional tenders in multi-axis displacement, ablation front progression, self-referenced measurements, multispectral, structured light feedback imaging and compressive sensing, the specialist also could find inspirational suggestions to expand his field of research

Terahertz near-field nanoscopy based on detectorless laser feedback interferometry under different feedback regimes

Near-field imaging techniques, at terahertz frequencies (1–10 THz), conventionally rely on bulky laser sources and detectors. Here, we employ a semiconductor heterostructure laser as a THz source and, simultaneously, as a phase-sensitive detector, exploiting optical feedback interferometry combined with scattering near-field nanoscopy. We analyze the amplitude and phase sensitivity of the proposed technique as a function of the laser driving current and of the feedback attenuation, discussing the operational conditions ideal to optimize the nano-imaging contrast and the phase sensitivity. As a targeted nanomaterial, we exploit a thin (39 nm) flake of Bi2Te2.2Se0.8, a topological insulator having infrared active optical phonon modes. The self-mixing interference fringes are analyzed within the Lang–Kobayashi formalism to rationalize the observed variations as a function of Acket's parameter C in the full range of weak feedback (C < 1)

QT interval prolongation related to psychoactive drug treatment: a comparison of monotherapy versus polytherapy

BACKGROUND: Several antipsychotic agents are known to prolong the QT interval in a dose dependent manner. Corrected QT interval (QTc) exceeding a threshold value of 450 ms may be associated with an increased risk of life threatening arrhythmias. Antipsychotic agents are often given in combination with other psychotropic drugs, such as antidepressants, that may also contribute to QT prolongation. This observational study compares the effects observed on QT interval between antipsychotic monotherapy and psychoactive polytherapy, which included an additional antidepressant or lithium treatment. METHOD: We examined two groups of hospitalized women with Schizophrenia, Bipolar Disorder and Schizoaffective Disorder in a naturalistic setting. Group 1 was composed of nineteen hospitalized women treated with antipsychotic monotherapy (either haloperidol, olanzapine, risperidone or clozapine) and Group 2 was composed of nineteen hospitalized women treated with an antipsychotic (either haloperidol, olanzapine, risperidone or quetiapine) with an additional antidepressant (citalopram, escitalopram, sertraline, paroxetine, fluvoxamine, mirtazapine, venlafaxine or clomipramine) or lithium. An Electrocardiogram (ECG) was carried out before the beginning of the treatment for both groups and at a second time after four days of therapy at full dosage, when blood was also drawn for determination of serum levels of the antipsychotic. Statistical analysis included repeated measures ANOVA, Fisher Exact Test and Indipendent T Test. RESULTS: Mean QTc intervals significantly increased in Group 2 (24 ± 21 ms) however this was not the case in Group 1 (-1 ± 30 ms) (Repeated measures ANOVA p < 0,01). Furthermore we found a significant difference in the number of patients who exceeded the threshold of borderline QTc interval value (450 ms) between the two groups, with seven patients in Group 2 (38%) compared to one patient in Group 1 (7%) (Fisher Exact Text, p < 0,05). CONCLUSIONS: No significant prolongation of the QT interval was found following monotherapy with an antipsychotic agent, while combination of these drugs with antidepressants caused a significant QT prolongation. Careful monitoring of the QT interval is suggested in patients taking a combined treatment of antipsychotic and antidepressant agents

Applying the Disruption Index procedure to evaluate the urban seismic risk in the Mt. Etna area (Italy)

The Disruption Index is used here for the assessment of urban disruption in the Mt. Etna area after a natural disaster. The first element of the procedure is the definition of the seismic input, which is based on information about the historical seismicity and seismogenic faults. The second element is the computation of the seismic impact on the building stock and infrastructure in the region considered. Information on urban-scale vulnerability was collected and a geographic information system was used to organize the data relating to buildings and network systems (e. g., typologies, schools, strategic structures, lifelines). The central idea underlying the definition of the Disruption Index is the identification and evaluation of the impacts on a target community, considering the physical elements that contribute most to the severe disruption. The results of this study are therefore very useful for earthquake preparedness planning and for the development of strategies to minimize the risks from earthquakes. This study is a product of the European “Urban Disaster Prevention Strategies using Macroseismic Fields and Fault Sources” project (UPStrat-MAFA European project 2013).PublishedTorino, Italy3T. Pericolosità sismica e contributo alla definizione del rischioope

Geo Satellites’ Manufacturing Markers From Photometric Colors

We present the photometric analysis of 23 GEO satellites, by using more than 1,200 multi-band images acquired in the Johnson-Cousin photometric system (BVRI). The dataset was acquired by three optical telescopes geographically located in different observational sites (in Italy and Mexico). By using an observational strategy based on alternating the V-R-I filter-sequence, we obtained consecutive multi-band images we used to reconstruct satellites’ color-lightcurves. We calculated the color-indexes of GEO satellites by taking into account the average value of color-lightcurves. We investigated the color-indexes in the color-color planes. Moreover, we studied a possible correlation among colors and satellite manufacturing and peculiar features. We obtained that some of the considered parameters seem to significantly affect the color indexes

On assessing importance of components in dysfunction urban systems given an earthquake: the case of Mt. Etna region

Mt Etna region (Sicily, Italy) is one of the test areas studied in the European Project “Urban disaster Prevention Strategies using MAcroseismic fields and FAult sources” ( UPStrat-MAFA) to which the methodology of Disruption Index (hereafter DI), recently developed to evaluate the dysfunction of urban systems caused by earthquakes (Ferreira et al., 2014), has been applied on a trial basis

Off-label long acting injectable antipsychotics in real-world clinical practice: a cross-sectional analysis of prescriptive patterns from the STAR Network DEPOT study

Introduction Information on the off-label use of Long-Acting Injectable (LAI) antipsychotics in the real world is lacking. In this study, we aimed to identify the sociodemographic and clinical features of patients treated with on- vs off-label LAIs and predictors of off-label First- or Second-Generation Antipsychotic (FGA vs. SGA) LAI choice in everyday clinical practice. Method In a naturalistic national cohort of 449 patients who initiated LAI treatment in the STAR Network Depot Study, two groups were identified based on off- or on-label prescriptions. A multivariate logistic regression analysis was used to test several clinically relevant variables and identify those associated with the choice of FGA vs SGA prescription in the off-label group. Results SGA LAIs were more commonly prescribed in everyday practice, without significant differences in their on- and off-label use. Approximately 1 in 4 patients received an off-label prescription. In the off-label group, the most frequent diagnoses were bipolar disorder (67.5%) or any personality disorder (23.7%). FGA vs SGA LAI choice was significantly associated with BPRS thought disorder (OR = 1.22, CI95% 1.04 to 1.43, p = 0.015) and hostility/suspiciousness (OR = 0.83, CI95% 0.71 to 0.97, p = 0.017) dimensions. The likelihood of receiving an SGA LAI grew steadily with the increase of the BPRS thought disturbance score. Conversely, a preference towards prescribing an FGA was observed with higher scores at the BPRS hostility/suspiciousness subscale. Conclusion Our study is the first to identify predictors of FGA vs SGA choice in patients treated with off-label LAI antipsychotics. Demographic characteristics, i.e. age, sex, and substance/alcohol use co-morbidities did not appear to influence the choice towards FGAs or SGAs. Despite a lack of evidence, clinicians tend to favour FGA over SGA LAIs in bipolar or personality disorder patients with relevant hostility. Further research is needed to evaluate treatment adherence and clinical effectiveness of these prescriptive patterns

The Role of Attitudes Toward Medication and Treatment Adherence in the Clinical Response to LAIs: Findings From the STAR Network Depot Study

Background: Long-acting injectable (LAI) antipsychotics are efficacious in managing psychotic symptoms in people affected by severe mental disorders, such as schizophrenia and bipolar disorder. The present study aimed to investigate whether attitude toward treatment and treatment adherence represent predictors of symptoms changes over time. Methods: The STAR Network \u201cDepot Study\u201d was a naturalistic, multicenter, observational, prospective study that enrolled people initiating a LAI without restrictions on diagnosis, clinical severity or setting. Participants from 32 Italian centers were assessed at three time points: baseline, 6-month, and 12-month follow-up. Psychopathological symptoms, attitude toward medication and treatment adherence were measured using the Brief Psychiatric Rating Scale (BPRS), the Drug Attitude Inventory (DAI-10) and the Kemp's 7-point scale, respectively. Linear mixed-effects models were used to evaluate whether attitude toward medication and treatment adherence independently predicted symptoms changes over time. Analyses were conducted on the overall sample and then stratified according to the baseline severity (BPRS &lt; 41 or BPRS 65 41). Results: We included 461 participants of which 276 were males. The majority of participants had received a primary diagnosis of a schizophrenia spectrum disorder (71.80%) and initiated a treatment with a second-generation LAI (69.63%). BPRS, DAI-10, and Kemp's scale scores improved over time. Six linear regressions\u2014conducted considering the outcome and predictors at baseline, 6-month, and 12-month follow-up independently\u2014showed that both DAI-10 and Kemp's scale negatively associated with BPRS scores at the three considered time points. Linear mixed-effects models conducted on the overall sample did not show any significant association between attitude toward medication or treatment adherence and changes in psychiatric symptoms over time. However, after stratification according to baseline severity, we found that both DAI-10 and Kemp's scale negatively predicted changes in BPRS scores at 12-month follow-up regardless of baseline severity. The association at 6-month follow-up was confirmed only in the group with moderate or severe symptoms at baseline. Conclusion: Our findings corroborate the importance of improving the quality of relationship between clinicians and patients. Shared decision making and thorough discussions about benefits and side effects may improve the outcome in patients with severe mental disorders

Deliverable Report of Task B of the European project UPStrat-MAFA - Deliverable/Task Leader: CNR-IMATI

DESCRIPTION OF TASK B The Task B “Probabilistic analysis of macroseismic data to forecast damage scenarios” includes the following seven Actions: Action B.1 Setting-up of aWorking Group on the macroseismic database (INGV); Action B.2 Exploratory analysis of macroseismic fields for their clustering in classes of attenuation decay (CNR-IMATI); Action B.3 Estimation of the probability distribution of the site-intensity Is , given epicentral intensity and distance from epicentre (isotropic case) (CNR-IMATI); Action B.4 Exploratory analysis of observed and synthetic macroseismic fields for their clustering in classes of anisotropic attenuation decay (CNR-IMATI); Action B.5 Estimation of the probability distribution of the site-intensity Is , given epicentral intensity and distance from epicentre (anisotropic case) (CNR-IMATI); Action B.6 Application of scoring rules (CNR-IMATI); Action B.7 Probabilistic analysis of macroseismic data using the logistic model (INGV) This report is basically divided into two parts. The former (Chapter I) deals with the methodological aspects of the Actions B2 - B6; it describes a clustering procedure to select classes of macroseismic fields with similar attenuation trend within a database, it proposes a probability model and an estimation method to evaluate the distribution of the intensity at site in both isotropic and anisotropic cases, and finally it presents three validation criteria by which to compare observed and estimated intensity at sites. The latter part of the report (Chapters II - V) focuses on the results obtained and provides solutions to specific issues arosen in applying the above-mentioned methods to the test areas considered in the project (Mt. Etna (Italy), Portugal and Azores Islands, Alicante-Murcia (Spain), Iceland). In addition to the collection of the data related to the test areas, Action B1 has also dealt with the digitalization in a GIS of isoseismal images drawn from the literature, and related to two historical earthquakes occurred in North Iceland (Chapter V). Action B7 was planned to compare the beta-binomial probability model analyzed in the project with the other probability model (logistic model) for the seismic attenuation given in the literature. The discussions had with the partners during the course of the project led us to prefer the comparison with the deterministic attenuation relationships currently used in the hazard evaluation of the test areas. The results of these comparisons are illustrated in Deliverable B6.1.The research was co-financed by EU-Civil Protection Financial Instrument (Grant Agreement n. 230301/2011/613486/SUB/A5)Unpublished3T. Pericolosità sismica e contributo alla definizione del rischioope

Crystalline Microparticles of a Beta-Agonist Coated with a Fatty Acid

Crystalline microparticles consisting of a phenylalkylamino beta2-adrenergic agonist coated with a C 12-C20 fatty acid to be used for the preparation of pharmaceutical aerosol formulations in form of suspension in a liquefied propellant gas or powder formulations