4,773 research outputs found

    Exploring mentalization-based psychoeducation groups for people with borderline personality disorder

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    Borderline Personality Disorder (BPD) is a distressing difficulty prevalent within UK secondary-care settings. Previous qualitative studies have examined individual experiences of long term Mentalization-Based Therapy (MBT) groups for people with BPD. However, the psychoeducational component of MBT has not yet been researched coherently. The current study explored lived experiences of manualised MBT-psychoeducation groups for people with BPD within NHS secondary care settings. Eight participants took part in interviews about their recent participation in these groups. Interpretative phenomenological analysis was used to interpret individual meaning-making of these experiences. While some accounts were characterised by contradictions, MBT-psychoeducation was generally viewed as a challenging but predominantly beneficial experience. Three main themes emerged, comprising eight sub-themes. These highlighted individuals’ attempts to manage complex group processes, strategies for personalising knowledge, and the power and fear of increased self-reflection. Participant’s felt the group had impacted their sense of self, their understanding of others and their impulsivity, particularly within interpersonal relationships. Research and clinical implications of these findings are discussed. Particular importance is given to the implications of some individual’s perceived need for additional support or coping, the desire for further MBT group therapy and the possibility that these findings support propositions that the groups provide a useful mechanism to stimulate mentalizing

    Building a Stronger System for Tracking Nutrition-Sensitive Spending: A Methodology and Estimate of Global Spending for Nutrition-Sensitive Foreign Aid

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    Background: There is growing awareness that the necessary solutions for improving nutrition outcomes are multisectorial. As such, investments are increasingly directed toward nutrition-sensitive approaches that not only address an underlying or basic determinant of nutrition but also seek to achieve an explicit nutrition goal or outcome. Understanding how and where official development assistance (ODA) for nutrition is invested remains an important but complex challenge, as development projects components vary in their application to nutrition outcomes. Currently, no systematic method exists for tracking nutrition-sensitive ODA. Objective: To develop a methodology for classifying and tracking nutrition-sensitive ODA and to produce estimates of the amount of nutrition-sensitive aid received by countries with a high burden of undernutrition. Methods: We analyzed all financial flows reported to the Organization for Economic Co-Operation and Development\u27s Development Assistance Committee Creditor Reporting Service in 2010 to estimate these investments. We assessed the relationships between national stunting prevalence, stunting burden, under-5 mortality, and the amount of nutrition-specific and nutrition-sensitive ODA. Results: We estimate that, in 2010, a total of 379.4million(M)USdollars(USD)wascommittedtonutritionspecificprojectsandprogramsofwhich25designatedbeneficiaries(countriesandregions)accountedfornearly85379.4 million (M) US dollars (USD) was committed to nutrition-specific projects and programs of which 25 designated beneficiaries (countries and regions) accounted for nearly 85% (320 M). A total of 1.79billion(B)wascommittedtonutritionsensitivespending,ofwhichthetop25countries/regionsaccountedfor1.79 billion (B) was committed to nutrition-sensitive spending, of which the top 25 countries/regions accounted for 1.4 B (82%). Nine categories of development activities accounted for 75% of nutrition-sensitive spending, led by Reproductive Health Care (30.4%), Food Aid/Food Security Programs (14.1%), Emergency Food Aid (13.2%), and Basic Health Care (5.0%). Multivariate linear regression models indicate that the amount of nutrition-sensitive (P = .001) and total nutrition ODA was significantly predicted by stunting prevalence (P = .001). The size of the total population of stunted children significantly predicted the amount of nutrition-specific ODA (P \u3c .001). Conclusion: The recipient profile of nutrition-specific and nutrition-sensitive ODA is related but distinct. Nutrition indicators are associated with the level of nutrition-related ODA commitments to recipient countries. A reliable estimate of nutrition spending is critical for effective planning by both donors and recipients and key for success, as the global development community recommits to a new round of goals to address the interrelated causes of undernutrition in low-income countries

    Sn-modification of Pt7/alumina model catalysts: Suppression of carbon deposition and enhanced thermal stability.

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    An atomic layer deposition process is used to modify size-selected Pt7/alumina model catalysts by Sn addition, both before and after Pt7 cluster deposition. Surface science methods are used to probe the effects of Sn-modification on the electronic properties, reactivity, and morphology of the clusters. Sn addition, either before or after cluster deposition, is found to strongly affect the binding properties of a model alkene, ethylene, changing the number and type of binding sites, and suppressing decomposition leading to carbon deposition and poisoning of the catalyst. Density functional theory on a model system, Pt4Sn3/alumina, shows that the Sn and Pt atoms are mixed, forming alloy clusters with substantial electron transfer from Sn to Pt. The presence of Sn also makes all the thermally accessible structures closed shell, such that ethylene binds only by π-bonding to a single Pt atom. The Sn-modified catalysts are quite stable in repeated ethylene temperature programmed reaction experiments, suggesting that the presence of Sn also reduces the tendency of the sub-nano-clusters to undergo thermal sintering

    Intra- and interspecies interactions between prion proteins and effects of mutations and polymorphisms

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    Recently, crystallization of the prion protein in a dimeric form was reported. Here we show that native soluble homogenous FLAG-tagged prion proteins from hamster, man and cattle expressed in the baculovirus system are predominantly dimeric. The PrP/PrP interaction was confirmed in Semliki Forest virus-RNA transfected BHK cells co-expressing FLAG- and oligohistidine-tagged human PrP. The yeast two-hybrid system identified the octarepeat region and the C-terminal structured domain (aa90-aa230) of PrP as PrP/PrP interaction domains. Additional octarepeats identified in patients suffering from fCJD reduced (wtPrP versus PrP+90R) and completely abolished (PrP+90R versus PrP+90R) the PrP/PrP interaction in the yeast two-hybrid system. In contrast, the Met/Val polymorphism (aa129), the GSS mutation Pro102Leu and the FFI mutation Asp178Asn did not affect PrP/PrP interactions. Proof of interactions between human or sheep and bovine PrP, and sheep and human PrP, as well as lack of interactions between human or bovine PrP and hamster PrP suggest that interspecies PrP interaction studies in the yeast two-hybrid system may serve as a rapid pre-assay to investigate species barriers in prion diseases

    Aeroelastic Analysis of SUGAR Truss-Braced Wing Wind-Tunnel Model Using FUN3D and a Nonlinear Structural Model

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    Considerable attention has been given in recent years to the design of highly flexible aircraft. The results of numerous studies demonstrate the significant performance benefits of strut-braced wing (SBW) and trussbraced wing (TBW) configurations. Critical aspects of the TBW configuration are its larger aspect ratio, wing span and thinner wings. These aspects increase the importance of considering fluid/structure and control system coupling. This paper presents high-fidelity Navier-Stokes simulations of the dynamic response of the flexible Boeing Subsonic Ultra Green Aircraft Research (SUGAR) truss-braced wing wind-tunnel model. The latest version of the SUGAR TBW finite element model (FEM), v.20, is used in the present simulations. Limit cycle oscillations (LCOs) of the TBW wing/strut/nacelle are simulated at angle-of-attack (AoA) values of -1, 0 and +1 degree. The modal data derived from nonlinear static aeroelastic MSC.Nastran solutions are used at AoAs of -1 and +1 degrees. The LCO amplitude is observed to be dependent on AoA. LCO amplitudes at -1 degree are larger than those at +1 degree. The LCO amplitude at zero degrees is larger than either -1 or +1 degrees. These results correlate well with both wind-tunnel data and the behavior observed in previous studies using linear aerodynamics. The LCO onset at zero degrees AoA has also been computed using unloaded v.20 FEM modes. While the v.20 model increases the dynamic pressure at which LCO onset is observed, it is found that the LCO onset at and above Mach 0.82 is much different than that produced by an earlier version of the FEM, v. 19

    DEFINING AND REDUCING WILDLIFE HAZARDS TO AVIATION IN THE USA

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    The U.S. Department of Agriculture’s National Wildlife Research Center (NWRC), through an interagency agreement with the U.S. Federal Aviation Administration (FAA), conducts a national research program to define and reduce bird and other wildlife hazards to aircraft. The goal is to provide the FAA and airports nationwide with a scientific foundation for policies and recommendations related to wildlife and aviation safety. Research tasks conducted by NWRC under the agreement include: 1) investigations of habitat management and land-use practices on and near airports to reduce bird activity; 2) development and evaluation of bird repellent and frightening methods for airports; 3) management and analysis of the National Wildlife Strike Database for civil aviation; and 4) development of publications, including a manual on wildlife hazard management, for use by airport operators nationwide. The research, coordinated by NWRC’s Sandusky, Ohio Field Station, has resulted in over 100 scientific publications since 1992. Recent highlights include 1) development of a wildlife strike database for civil aviation with about 28,000 strike reports, 1990-1999; 2) publication of a report, based on analyses of data in the bird strike database, which indicated wildlife collisions with aircraft cost U.S. civil aviation over $300 million/year, 1990-1998; 3) partnership with private industry to develop chemical repellents for use against Canada geese on airports; 4) development of management program at JFK International Airport, New York, that resulted in a 90% reduction in gull-aircraft collisions; and 5) publication of a comprehensive manual for airport personnel entitled “Wildlife Hazard Management at Airports”
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