Childhood Peer Status and the Clustering of Adverse Living Conditions in Adulthood

Within the context of the school class, children attain a social position in the peer hierarchy to which varying amounts of status are attached. Several studies have shown that children’s peer status is associated with a wide range of social and health-related outcomes. These studies commonly target separate outcomes, paying little attention to the fact that such circumstances are likely to go hand in hand. The overarching aim of the present study was therefore to examine the impact of childhood peer status on the clustering of living conditions in adulthood. Based on a 1953 cohort born in Stockholm, Sweden, multinomial regression analysis demonstrated that children who had lower peer status also had exceedingly high risks of ending up in more problem-burdened clusters as adults. Moreover, these associations remained after adjusting for a variety of family-related circumstances. We conclude that peer status constitutes a central aspect of children’s upbringing with important consequences for subsequent life chances, over and above the influences originating from the family.childhood; peer status; cohort; life course; outcome profiles; living conditions

Acceptable noise level: Repeatability with Danish and non-semantic speech materials for adults with normal hearing

Objective: The acceptable noise level (ANL) is used to quantify the amount of background noise that subjects can accept while listening to speech, and is suggested for prediction of individual hearing-aid use. The aim of this study was to assess the repeatability of the ANL measured in normal-hearing subjects using running Danish and non-semantic speech materials as stimuli and modulated speech-spectrum and multi-talker babble noises as competing stimuli. Design: ANL was measured in both ears at two test sessions separated by a period ranging from 12 to 77 days. At each session the measurements at the first and the second ear were separated in time by 15-30 minutes. Bland-Altman plots and calculation of the coefficient of repeatability (CR) were used to estimate the repeatability. Study sample: Thirty nine normal-hearing subjects. Results: The ANL CR was 6.0-8.9 dB for repeated tests separated by about 15-30 minutes and 7.2-10.2 dB for repeated tests separated by 12 days or more. Conclusions: The ANL test has poor repeatability when assessed with Danish and non-semantic speech materials on normal-hearing subjects. The same CR among hearing-impaired subjects would imply too poor repeatability to predict individual patterns of future hearing-aid use

Acceptable noise level with Danish, Swedish, and non-semantic speech materials.

Objective: Acceptable noise level (ANL) has been established as a method to quantify the acceptance of background noise while listening to speech presented at the most comfortable level. The aim of the present study was to generate Danish, Swedish, and a non-semantic version of the ANL test and investigate normal-hearing Danish and Swedish subjects' performance on these tests. Design: ANL was measured using Danish and Swedish running speech with two different noises: Speech-weighted amplitude-modulated noise, and multitalker speech babble. ANL was also measured using the non-semantic international speech test signal (ISTS) as speech signal together with the speech-weighted amplitude-modulated noise. The latter condition was identical in both populations. Study sample: Forty Danish and 40 Swedish normal-hearing subjects. Results: In both populations ANL results were similar to previously reported results from American studies. Generally, significant differences were seen between test conditions using different types of noise within ears in each population. Significant differences were seen for ANL across populations, also when the non-semantic ISTS was used as speech signal. Conclusions: The present findings indicate that there are extrinsic factors, such as instructions, affecting the ANL results. Summario Objetivo: Se ha establecido el Nivel de Ruido Aceptable (ANL) como un método para cuantifi car la aceptación de ruido de fondo mientras se escucha lenguaje presentado al nivel más confortable. El objetivo de este estudio fue generar las versiones sueca, danesa y una no-semántica de la prueba ANL e investigar el desempeño de sujetos normoyentes daneses y suecos en estas pruebas. Diseño: Se midió el ANL utilizando un discurso continuo en danés y sueco con dos diferentes ruidos: ruido con amplitud modulada en el rango del lenguaje y balbuceo de varios hablantes. También se midió el ANL utilizando la prueba internacional no-semántica de señal de lenguaje (ISTS) como la señal lingüística junto con ruido con amplitud modulada en el rango del lenguaje. Esta última condición fue idéntica en ambas poblaciones. Muestra: Cuarenta sujetos daneses y 40 sujetos suecos normoyentes. Resultados: en ambas poblaciones los resultados de ANL fueron muy similares a los reportado previamente en estudios americanos. Generalmente, se vieron diferencias signifi cativas para el ANL entre poblaciones, también cuando el ISTS no semántico fue utilizado como señal lingüística. Conclusiones: Estos hallazgos indican que hay factores extrínsecos tales como las instrucciones, que afectan los resultados de ANL

Long-term NEET among young adults with experience of out-of-home care : A comparative study of three Nordic countries

Peer reviewe

Aggression replacement training (ART) for reducing antisocial behavior in adolescents and adults: A systematic review

AbstractObjectiveAggression Replacement Training (ART) is a multimodal program aiming at replacing antisocial behaviors by actively teaching desirable behaviors. The program is frequently used and has been provided within a wide variety of settings, but its effectiveness in its own right has not been addressed in previous reviews. This systematic review examines the effect of ART on antisocial behavior in young people and adults.MethodsPublished and unpublished literature was searched to identify randomized and non-randomized studies comparing ART for adults and youth with usual care, other interventions, or no intervention. Primary outcomes included recidivism in antisocial behavior, while secondary outcomes were related to social skills, anger management and moral reasoning.FindingsThis review identified 16 studies with considerable clinical and methodological diversity. The methodological quality and the post-intervention follow-up of the studies were limited. Almost half of the studies were conducted by researchers who have vested interests in the intervention.ConclusionsThere is an insufficient evidence-base to substantiate the hypothesis that ART has a positive impact on recidivism, self-control, social skills or moral development in adolescents and adults. Further research is warranted by independent investigators exploring the effects of ART on clearly-defined target groups using high standard evaluation designs

Observational cohort study of rilpivirine (RPV) utilization in Europe

INTRODUCTION: Data on safety and effectiveness of RPV from the real-world setting as well as comparisons with other NNRTIs such as efavirenz (EFV) remain scarce. METHODS: Participants of EuroSIDA were included if they had started a RPV- or an EFV-containing regimen over November 2011-December 2017. Statistical testing was conducted using non-parametric Mann-Whitney U test and Chi-square test. A logistic regression model was used to compare participants' characteristics by treatment group. Kaplan-Meier analysis was used to estimate the cumulative risk of virological failure (VF, two consecutive values > 50 copies/mL). RESULTS: 1,355 PLWH who started a RPV-based regimen (11% ART-naïve), as well as 333 initiating an EFV-containing regimen were included. Participants who started RPV differed from those starting EFV for demographics (age, geographical region) and immune-virological profiles (CD4 count, HIV RNA). The cumulative risk of VF for the RPV-based group was 4.5% (95% CI 3.3-5.7%) by 2 years from starting treatment (71 total VF events). Five out of 15 (33%) with resistance data available in the RPV group showed resistance-associated mutations vs. 3/13 (23%) among those in the EFV group. Discontinuations due to intolerance/toxicity were reported for 73 (15%) of RPV- vs. 45 (30%) of EFV-treated participants (p = 0.0001). The main difference was for toxicity of central nervous system (CNS, 3% vs. 22%, p  50 copies/mL and resistance in participants treated with RPV were similar to those reported by other studies. RPV safety profile was favourable with less frequent discontinuation due to toxicity than EFV (especially for CNS)

Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence

International audienceThe BabA adhesin mediates high-affinity binding of Helicobacter pylori to the ABO blood group antigen-glycosylated gastric mucosa. Here we show that BabA is acid responsive-binding is reduced at low pH and restored by acid neutralization. Acid responsiveness differs among strains; often correlates with different intragastric regions and evolves during chronic infection and disease progression; and depends on pH sensor sequences in BabA and on pH reversible formation of high-affinity binding BabA multimers. We propose that BabA's extraordinary reversible acid responsiveness enables tight mucosal bacterial adherence while also allowing an effective escape from epithelial cells and mucus that are shed into the acidic bactericidal lumen and that bio-selection and changes in BabA binding properties through mutation and recombination with babA-related genes are selected by differences among individuals and by changes in gastric acidity over time. These processes generate diverse H. pylori subpopulations, in which BabA's adaptive evolution contributes to H. pylori persistence and overt gastric disease

The network as an asset : reflections on an industrial case

Godkänd; 2004; Bibliografisk uppgift: Network: Theory, Research & Application Ph.D. Course 2004; 20120223 (andbra

Timing of higher education completion in out-of-home care experienced individuals : On schedule or delayed?

It is well known that individuals with out-of-home care (OHC) experience tend to have lower educational attainment than their peers in young adulthood, and a number of interventions have been implemented to increase their higher education outcomes. However, the timing of their higher education completion, and whether they experience educational recovery over the life course, is largely unknown. Using longitudinal Swedish data from a birth cohort of more than 13,000 individuals, this study examined OHC experienced individuals’ chances of having a higher education, here defined as a record of postsecondary education of two years or more, in midlife (age 50) and whether the timing of completion differs between them and a group of individuals who had child welfare contact (CWC) without being placed, and a group of general population peers. Results from multivariable logistic regressions corroborated prior findings that individuals who have been placed in OHC were less likely to have completed higher education compared to their general population peers. However, among those who did, they were more likely to have completed it later in life. Overall, there were no differences between the OHC group and the CWC group, both groups may thus not only benefit from specific support but also from more general inclusive education policies that allow for life-long learning