Modern state of bottom and demersal fish resources in the Russian waters of the Japan Sea

Results of the bottom trawl survey conducted over the shelf and continental slope in the Russian waters of the Japan Sea from Peter the Great Bay to the Soya Strait in the period from March 31 to July 8, 2015 are presented. Species composition, biomass and spatial and bathymetric distribution of benthic and demersal fish are determined. Bulk of the biomass (> 90 %) was formed by 4 families: gadids, flounders, sculpins, and herrings. The species structure varied considerably by areas: pollock and plain sculpin dominated in Peter the Great Bay, pollock and sealyeye plaice - at southern Primorye beyond the Bay, herring - at northern Primorye, and sealyeye plaice and longsnout flounder - at southwestern Sakhalin. The highest density of distribution was recorded in Peter the Great Bay at the depths 500-700 m - 26.8 t/km², with domination of pollock, the lowest density was at southern Primorye in the depth range of 700-800 m - 2.4 t/km² with domination of sealyeye plaice. Peter the Great Bay was surveyed in conditions of winter distribution of fish distinguished by their high concentrations at the continental slope; their shift towards lower depths was observed at Primorye coast, and almost summer type of bathymetric distribution with the high concentrations on the shelf was found at southwestern Sakhalin. The biomass of benthic and demersal fish has increased slightly in compare with the 1980-1990s

Realizations of Real Low-Dimensional Lie Algebras

Using a new powerful technique based on the notion of megaideal, we construct a complete set of inequivalent realizations of real Lie algebras of dimension no greater than four in vector fields on a space of an arbitrary (finite) number of variables. Our classification amends and essentially generalizes earlier works on the subject. Known results on classification of low-dimensional real Lie algebras, their automorphisms, differentiations, ideals, subalgebras and realizations are reviewed.Comment: LaTeX2e, 39 pages. Essentially exetended version. Misprints in Appendix are correcte

Genome-wide significant association with seven novel multiple sclerosis risk loci

Objective: A recent large-scale study in multiple sclerosis (MS) using the ImmunoChip platform reported on 11 loci that showed suggestive genetic association with MS. Additional data in sufficiently sized and independent data sets are needed to assess whether these loci represent genuine MS risk factors. Methods: The lead SNPs of all 11 loci were genotyped in 10 796 MS cases and 10 793 controls from Germany, Spain, France, the Netherlands, Austria and Russia, that were independent from the previously reported cohorts. Association analyses were performed using logistic regression based on an additive model. Summary effect size estimates were calculated using fixed-effect meta-analysis. Results: Seven of the 11 tested SNPs showed significant association with MS susceptibility in the 21 589 individuals analysed here. Meta-analysis across our and previously published MS case-control data (total sample size n=101 683) revealed novel genome-wide significant association with MS susceptibility (p<5×10−8) for all seven variants. This included SNPs in or near LOC100506457 (rs1534422, p=4.03×10−12), CD28 (rs6435203, p=1.35×10−9), LPP (rs4686953, p=3.35×10−8), ETS1 (rs3809006, p=7.74×10−9), DLEU1 (rs806349, p=8.14×10−12), LPIN3 (rs6072343, p=7.16×10−12) and IFNGR2 (rs9808753, p=4.40×10−10). Cis expression quantitative locus effects were observed in silico for rs6435203 on CD28 and for rs9808753 on several immunologically relevant genes in the IFNGR2 locus. Conclusions: This study adds seven loci to the list of genuine MS genetic risk factors and further extends the list of established loci shared across autoimmune diseases

Genome-wide significant association with seven novel multiple sclerosis risk loci

Objective: A recent large-scale study in multiple sclerosis (MS) using the ImmunoChip platform reported on 11 loci that showed suggestive genetic association with MS. Additional data in sufficiently sized and independent data sets are needed to assess whether these loci represent genuine MS risk factors. Methods: The lead SNPs of all 11 loci were genotyped in 10 796 MS cases and 10 793 controls from Germany, Spain, France, the Netherlands, Austria and Russia, that were independent from the previously reported cohorts. Association analyses were performed using logistic regression based on an additive model. Summary effect size estimates were calculated using fixed-effect meta-analysis. Results: Seven of the 11 tested SNPs showed significant association with MS susceptibility in the 21 589 individuals analysed here. Meta-analysis across our and previously published MS case-control data (total sample size n=101 683) revealed novel genome-wide significant association with MS susceptibility (p<5×10−8) for all seven variants. This included SNPs in or near LOC100506457 (rs1534422, p=4.03×10−12), CD28 (rs6435203, p=1.35×10−9), LPP (rs4686953, p=3.35×10−8), ETS1 (rs3809006, p=7.74×10−9), DLEU1 (rs806349, p=8.14×10−12), LPIN3 (rs6072343, p=7.16×10−12) and IFNGR2 (rs9808753, p=4.40×10−10). Cis expression quantitative locus effects were observed in silico for rs6435203 on CD28 and for rs9808753 on several immunologically relevant genes in the IFNGR2 locus. Conclusions: This study adds seven loci to the list of genuine MS genetic risk factors and further extends the list of established loci shared across autoimmune diseases

EPMA-World Congress 2015: Bonn, Germany. 3-5 September 2015

Table of contents A1 Predictive and prognostic biomarker panel for targeted application of radioembolisation improving individual outcomes in hepatocellular carcinoma Jella-Andrea Abraham, Olga Golubnitschaja A2 Integrated market access approach amplifying value of “Rx-CDx” Ildar Akhmetov A3 Disaster response: an opportunity to improve global healthcare Russell J. Andrews, Leonidas Quintana A4 USA PPPM: proscriptive, profligate, profiteering medicine-good for 1 % wealthy, not for 99 % unhealthy Russell J. Andrews A5 The role of IDO in a murine model of gingivitis: predictive and therapeutic potentials Babak Baban, Jun Yao Liu, Xu Qin, Tailing Wang, Mahmood S. Mozaffari A6 Specific diets for personalised treatment of diabetes type 2 Viktoriia V. Bati, Tamara V. Meleshko, Olga B. Levchuk, Nadiya V. Boyko A7 Towards personalized physiotherapeutic approach Joanna Bauer, Ewa Boerner, Halina Podbielska A8 Cells, animal, SHIME and in silico models for detection and verification of specific biomarkers of non-communicable chronic diseases Alojz Bomba, Viktor O. Petrov, Volodymyr G. Drobnych, Rostyslav V. Bubnov, Oksana M. Bykova, Nadiya V. Boyko A9 INTERACT-chronic care model: Self-treatment by patients with decision support e-Health solution Hans-Peter Brunner-La Rocca, Lutz Fleischhacker, Olga Golubnitschaja, Frank Heemskerk, Thomas Helms, Tiny Jaarsma, Judita Kinkorova, Jan Ramaekers, Peter Ruff, Ivana Schnur, Emilio Vanoli, Jose Verdu A10 PPPM in cardiovascular medicine in 2015 Hans-Peter Brunner-La Rocca A11 Magnetic resonance imaging of nanoparticles in mice, potential for theranostic and contrast media development – pilot results Rostyslav V. Bubnov, Sergiy A. Grabovetskyi, Olena M. Mykhalchenko, Natalia O. Tymoshok, Oleksandr B. Shcherbakov, Igor P. Semeniv, Mykola Y. Spivak A12 Ultrasound diagnosis for diabetic neuropathy - comparative study Rostyslav V. Bubnov, Tetyana V. Ostapenko A13 Ultrasound for stratification patients with diabetic foot ulcers for prevention and personalized treatment - pilot results Rostyslav V. Bubnov, Nazarii M. Kobyliak, Nadiya M. Zholobak, Mykola Ya. Spivak A14 Project ImaGenX – designing and executing a questionnaire on environment and lifestyle risk of breast cancer John Paul Cauchi A15 Genomics – a new structural brand of predictive, preventive and personalized medicine or the new driver as well? Dmitrii Cherepakhin, Marina Bakay, Artem Borovikov, Sergey Suchkov A16 Survey of questionnaires for evaluation of the quality of life in various medical fields Barbara Cieślik, Agnieszka Migasiewicz, Maria-Luiza Podbielska, Markus Pelleter, Agnieszka Giemza, Halina Podbielska A17 Personalized molecular treatment for muscular dystrophies Sebahattin Cirak A18 Secondary mutations in circulating tumour DNA for acquired drug resistance in patients with advanced ALK + NSCLC Marzia Del Re, Paola Bordi, Valentina Citi, Marta Palombi, Carmine Pinto, Marcello Tiseo, Romano Danesi A19 Recombinant species-specific FcεRI alpha proteins for diagnosis of IgE-mediated allergies in dogs, cats and horses Lukas Einhorn, Judit Fazekas, Martina Muhr, Alexandra Schoos, Lucia Panakova, Ina Herrmann, Krisztina Manzano-Szalai, Kumiko Oida, Edda Fiebiger, Josef Singer, Erika Jensen-Jarolim A20 Global methodology for developmental neurotoxicity testing in humans and animals early and chronically exposed to chemical contaminants Arpiné A. Elnar, Nadia Ouamara, Nadiya Boyko, Xavier Coumoul, Jean-Philippe Antignac, Bruno Le Bizec, Gauthier Eppe, Jenny Renaut, Torsten Bonn, Cédric Guignard, Margherita Ferrante, Maria Liusa Chiusano, Salvatore Cuzzocrea, Gerard O'Keeffe, John Cryan, Michelle Bisson, Amina Barakat, Ihsane Hmamouchi, Nasser Zawia, Anumantha Kanthasamy, Glen E. Kisby, Rui Alves, Oscar Villacañas Pérez, Kim Burgard, Peter Spencer, Norbert Bomba, Martin Haranta, Nina Zaitseva, Irina May, Stéphanie Grojean, Mathilde Body-Malapel, Florencia Harari, Raul Harari, Kristina Yeghiazaryan, Olga Golubnitschaja, Vittorio Calabrese, Christophe Nemos, Rachid Soulimani A21 Mental indicators at young people with attributes hypertension and pre-hypertension Maria E. Evsevyeva, Elena A. Mishenko, Zurida V. Kumukova, Evgeniy V. Chudnovsky, Tatyana A. Smirnova A22 On the approaches to the early diagnosis of stress-induced hypertension in young employees of State law enforcement agencies Maria E. Evsevyeva, Ludmila V. Ivanova, Michail V. Eremin, Maria V. Rostovtseva A23 Сentral aortic pressure and indexes of augmentation in young persons in view of risk factors Maria E. Evsevyeva, Michail V. Eremin, Vladimir I. Koshel, Oksana V. Sergeeva, Nadesgda M. Konovalova A24 Breast cancer prediction and prevention: Are reliable biomarkers in horizon? Shantanu Girotra, Olga Golubnitschaja A25 Flammer Syndrome and potential formation of pre-metastatic niches: A multi-centred study on phenotyping, patient stratification, prediction and potential prevention of aggressive breast cancer and metastatic disease Olga Golubnitschaja, Manuel Debald, Walther Kuhn, Kristina Yeghiazaryan, Rostyslav V. Bubnov, Vadym M. Goncharenko, Ulyana Lushchyk, Godfrey Grech, Katarzyna Konieczka A26 Innovative tools for prenatal diagnostics and monitoring: improving individual pregnancy outcomes and health-economy in EU Olga Golubnitschaja, Jan Jaap Erwich, Vincenzo Costigliola, Kristina Yeghiazaryan, Ulrich Gembruch A27 Immunohistochemical assessment of APUD cells in endometriosis Vadym M. Goncharenko, Vasyl O. Beniuk, Olga V. Kalenska, Rostyslav V. Bubnov A28 Updating personalized management algorithm of endometrial hyperplasia in pre-menopause women Vadym M. Goncharenko, Vasyl O. Beniuk, Rostyslav V. Bubnov, Olga Melnychuk A29 The personified treatment approach of polimorbid patients with periodontal inflammatory diseases Irina A. Gorbacheva, Lyudmila Y. Orekhova, Vadim V. Tachalov A30 Ukrainian experience in hybrid war – the challenge to update algorithms for personalized care and early prevention of different military injuries Olena I. Grechanyk, Rizvan Ya. Abdullaiev, Rostyslav V. Bubnov A31 Tear fluid biomarkers: a comparison of tear fluid sampling and storage protocols Suzanne Hagan, Eilidh Martin, Ian Pearce, Katherine Oliver A32 The correlation of dietary habits with gingival problems during menstruation Cenk Haytac, Fariz Salimov, Servin Yoksul, Anatoly A. Kunin, Natalia S. Moiseeva A33 Genomic medicine in a contemporary Spanish population of prostate cancer: our experience Bernardo Herrera-Imbroda, Sergio del Río-González, Maria Fernanda Lara, Antonia Angulo, Francisco Javier Machuca Santa-Cruz A34 Challenges, opportunities and collaborations for personalized medicine applicability in uro-oncological disease Bernardo Herrera-Imbroda, Sergio del Río-González, Maria Fernanda Lara A35 Metabolic hallmarks of cancer as targets for a personalized therapy John Ionescu A36 Influence of genetic polymorphism as a predictor of the development of periodontal disease in patients with gastric ulcer and 12 duodenal ulcer Alfiya Z. Isamulaeva, Anatoly A. Kunin, Shamil Sh. Magomedov, Aida I. Isamulaeva A37 Challenges in diabetic macular edema Tatjana Josifova A38 Overview of the EPMA strategies in laboratory medicine relevant for PPPM Marko Kapalla, Juraj Kubáň, Olga Golubnitschaja, Vincenzo Costigliola A39 EPMA initiative for effective organization of medical travel: European concepts and criteria Vincenzo Costigliola, Marko Kapalla, Juraj Kubáň, Olga Golubnitschaja A40 Design and innovation in e-textiles: implications for PPPM Anthony Kent, Tom Fisher, Tilak Dias A41 Biobank in Pilsen as a member of national node BBMRI_CZ Judita Kinkorová, Ondřej Topolčan A42 Big data in personalized medicine: hype and hope Matthias Kohl A43 The 3P approach as the platform of the European Dentistry Department (DPPPD) Anatoly A. Kunin, Natalia S. Moiseeva A44 The endometrium cytokine patterns for predictive diagnosis of proliferation severity and cancer prevention Andrii I. Kurchenko, Vasyl A. Beniuk, Vadym M. Goncharenko, Rostyslav V. Bubnov, Nadiya V. Boyko, Andriy M. Strokan A45 A monocyte-based in-vitro system for testing individual responses to the implanted material: future for personalized implant construction Julia Kzhyshkowska, Alexandru Gudima, Ksenia S. Stankevich, Victor D. Filimonov4, Harald Klüter, Evgeniya M. Mamontova, Sergei I. Tverdokhlebov A46 Prediction and prevention of adverse health effects by meteorological factors: Biomarker patterns and creation of a device for self-monitoring and integrated care Ulyana B. Lushchyk, Viktor V. Novytskyy, Igor P. Babii, Nadiya G. Lushchyk, Lyudmyla S. Riabets, Ivanna I. Legka A47 Targeting "disease signatures" towards personalized healthcare Mira Marcus-Kalish, Alexis Mitelpunkt, Tal Galili, Neta Shachar, Yoav Benjamini A48 Influence of the skin imperfection on the personal quality of life and possible tools for objective diagnosis Agnieszka Migasiewicz, Markus Pelleter, Joanna Bauer, Ewelina Dereń, Halina Podbielska A49 The new direction in caries prevention based on the ultrastructure of dental hard tissues and filling materials Natalia S. Moiseeva, Anatoly A. Kunin, Dmitry A. Kunin A50 The use of LED radiation in prevention of dental diseases Natalia S. Moiseeva, Yury A. Ippolitov, Dmitry A. Kunin, Alexei N. Morozov, Natalia V. Chirkova, Nakhid T. Aliev A51 Status of endothelial progenitor cells in diabetic nephropathy: predictive and preventive potentials Mahmood S. Mozaffari, Jun Yao Liu, Babak Baban A52 The status of glucocorticoid-induced leucine zipper protein in salivary gland in Sjögren’s syndrome: predictive and personalized treatment potentials Mahmood S. Mozaffari, Jun Yao Liu, Rafik Abdelsayed, Xing-Ming Shi, Babak Baban A53 Maximal aerobic capacity - important quality marker of health Jaroslav Novák, Milan Štork, Václav Zeman A54 The EMPOWER project: laboratory medicine and Horizon 2020 Wytze P. Oosterhuis, Elvar Theodorsson A55 Personality profile manifestations in patient’s attitude to oral care and adherence to doctor’s prescriptions Lyudmila Y. Orekhova, Tatyana V. Kudryavtseva, Elena R. Isaeva, Vadim V. Tachalov, Ekaterina S. Loboda A56 Results of an European survey on personalized medicine addressed to directions of laboratory medicine Mario Pazzagli, Francesca Malentacchi, Irene Mancini, Ivan Brandslund, Pieter Vermeersch, Matthias Schwab, Janja Marc, Ron H.N. van Schaik, Gerard Siest, Elvar Theodorsson, Chiara Di Resta A57 MCI or early dementia predictive speech based diagnosis techniques Matus Pleva, Jozef Juhar A58 Personalized speech based mobile application for eHealth Matus Pleva, Jozef Juhar A59 Circulating tumor cell-free DNA as the biomarker in the management of cancer patients Jiří Polívka jr., Filip Janků, Martin Pešta, Jan Doležal, Milena Králíčková, Jiří Polívka A60 Complex stroke care – educational programme in Stroke Centre University Hospital Plzen Jiří Polívka, Alena Lukešová, Nina Müllerová, Petr Ševčík, Vladimír Rohan A61 Sleep apnea and sleep fragmentation contribute to brain aging Kneginja Richter, Lence Miloseva, Günter Niklewski A62 Personalised approach for sleep disturbances in shift workers Kneginja Richter, Jens Acker, Guenter Niklewski A63 Medical travel and innovative PPPM clusters: new concept of integration Olga Safonicheva, Vincenzo Costigliola A64 Medical travel and women health Olga Safonicheva A65 Continuity of generations in the training of specialists in the field of reconstructive microsurgery Maxim Sautin, Janna Sinelnikova, Sergey Suchkov A66 Telemonitoring of stroke patients – empirical evidence of individual risk management results from an observational study in Germany Songül Secer, Stephan von Bandemer A67 Women’s increasing breast cancer risk with n-6 fatty acid intake explained by estrogen-fatty acid interactive effect on DNA damage: implications for gender-specific nutrition within personalized medicine Niva Shapira A68 Cytobacterioscopy of the gingival crevicular fluid as a method for preventive diagnosis of periodontal diseases Aleksandr Shcherbakov, Anatoly A. Kunin, Natalia S. Moiseeva A69 Use of specially treated composites in dentistry to avoid violations of aesthetics Bogdan R. Shumilovich, Zhanna Lipkind, Yulia Vorobieva, Dmitry A. Kunin, Anastasiia V. Sudareva A70 National eHealth system – platform for preventive, predictive and personalized diabetes care Ivica Smokovski, Tatjana Milenkovic A72 The common energy levels of Prof. Szent-Györgyi, the intrinsic chemistry of melanin, and the muscle physiopathology. Implications in the context of Preventive, Predictive, and Personalized Medicine Arturo Solís-Herrera, María del Carmen Arias-Esparza, Sergey Suchkov A73 Plurality and individuality of hepatocellular carcinoma: PPPM perspectives Krishna Chander Sridhar, Olga Golubnitschaja A74 Strategic aspects of higher medical education reforms to secure newer educational platforms for getting biopharma professionals matures Maria Studneva, Sihong Song, James Creeden, Мark Мandrik, Sergey Suchkov A75 Overview of the strategies and activities of the European Federation of Clinical Chemistry and Laboratory Medicine, (EFLM) Elvar Theodorsson, EFLM A76 New spectroscopic techniques for point of care label free diagnostics Syed A. M. Tofail A77 Tumor markers for personalized medicine and oncology - the role of Laboratory Medicine Ondřej Topolčan, Judita Kinkorová, Ondřej Fiala, Marie Karlíková, Šárka Svobodová, Radek Kučera, Radka Fuchsová, Vladislav Třeška, Václav Šimánek, Ladislav Pecen, Jan Šoupal, Štěpán Svačina2 A78 Modern medical terminology (MMT) as a driver of the global educational reforms Evgeniya Tretyak, Maria Studneva, Sergey Suchkov A79 Juvenile hypertension; the relevance of novel predictive, preventive and personalized assessment of its determinants Francesca M. Trovato, G. Fabio Martines, Daniela Brischetto, Daniela Catalano, Giuseppe Musumeci, Guglielmo M. Trovato A80 Proteomarkers Biotech George Th. Tsangaris, Athanasios K. Anagnostopoulos A81 Proteomics and mass spectrometry based non-invasive prenatal testing of fetal health and pregnancy complications George Th. Tsangaris, Athanasios K. Anagnostopoulos A82 Integrated Ecosystem for an Integrated Care model for Heart Failure (HF) patients including related comorbidities (ZENITH) José Verdú, German Gutiérrez, Jordi Rovira, Marta Martinez, Lutz Fleischhacker, Donna Green, Arthur Garson, Elena Tamburini, Stefano Cuomo, Juan Martinez-Leon, Teresa Abrisqueta, Hans-Peter Brunner-La Rocca, Tiny Jaarsma, Teresa Arredondo, Cecilia Vera, Giuseppe Fico, Olga Golubnitschaja, Fernando Arribas, Martina Onderco, Isabel Vara, on behalf of ZENITH consortium A83 Predictive, preventive and personalized medicine in diabetes onset and complication (MOSAIC project) José Verdú, Francesco Sambo, Barbara Di Camillo, Claudio Cobelli, Andrea Facchinetti, Giuseppe Fico, Riccardo Bellazzi, Lucia Sacchi, Arianna Dagliati, Daniele Segnani, Valentina Tibollo, Manuel Ottaviano, Rafael Gabriel, Leif Groop, Jacqueline Postma, Antonio Martinez, Liisa Hakaste, Tiinamaija Tuomi, Konstantia Zarkogianni, on behalf of MOSAIC consortium A84 Possibilities for personalized therapy of diabetes using in vitro screening of insulin and oral hypoglycemic agents Igor Volchek, Nina Pototskaya, Andrey Petrov A85 The innovative technology for personalized therapy of human diseases based on in vitro drug screening Igor Volchek, Nadezhda Pototskaya, Andrey Petrov A86 Bone destruction and temporomandibular joint: predictive markers, pathogenetic aspects and quality of life Ülle Voog-Oras, Oksana Jagur, Edvitar Leibur, Priit Niibo, Triin Jagomägi, Minh Son Nguyen, Chris Pruunsild, Dagmar Piikov, Mare Saag A87 Sub-optimal health management – global vision for concepts in medical travel Wei Wang A88 Sub-optimal health management: synergic PPPM-TCAM approach Wei Wang A89 Innovative technologies for minimal invasive diagnostics Andreas Weinhäusel, Walter Pulverer, Matthias Wielscher, Manuela Hofner, Christa Noehammer, Regina Soldo, Peter Hettegger, Istvan Gyurjan, Ronald Kulovics, Silvia Schönthaler, Gabriel Beikircher, Albert Kriegner, Stephan Pabinger, Klemens Vierlinger A90 Rare disease diobanks for personalized medicine Ayşe Yüzbaşıoğlu, Meral Özgüç, Member of EuroBioBank - European Network of DNA, Cell and Tissue Banks for Rare Disease

Games of Kings. France and England in the Age of Emerging Absolutism (1610-1642)

Les monarques pré-absolutistes de la première moitié du XVIIe siècle avaient-ils l’appareil diplomatique correspondant à leur politique – c’est-à-dire les moyens de leurs fins – ou la politique de leur appareil diplomatique ? L’objectif principal de cette thèse vise à approfondir nos connaissances sur les relations entre la France et l’Angleterre depuis la mort d’Henri IV en 1610 jusqu’à l’année 1642, marquée à la fois par la disparition de Richelieu et le déclenchement de la révolution sur les îles Britanniques. L’étude de cette période – qui nous paraît être familière tout en restant peu étudiée et globalement perçue au prisme des romans d’Alexandre Dumas – ne se veut pas être un simple récit chronologique et événementielle des interactions politico-diplomatiques franco-anglaises, mais a pour objet d’analyser la structure et le fonctionnement de l’appareil diplomatique des deux états pré-absolutistes ainsi que le jeu de ses représentants, afin d’essayer de comprendre comment l’état des structures administratives et la sociologie des acteurs diplomatiques ont pesé sur le cours des événements politiques entre les deux Couronnes. Ainsi, cette étude s’attachera à mettre en lumière certains traits majeurs de la diplomatie dans la première modernité, telle qu’elle ressort de l’étude des rapports franco-anglais : encore peu structurée sur le plan administratif et donc en retard dans la « modernisation » des instruments de l’État pré-absolutiste, elle est l’outil d’une politique extérieure déjà intense mais protéiforme, qui emprunte plusieurs canaux pas encore exclusifs les uns des autres, mais n’en suit pas moins des codes et des protocoles très précis, dont chaque détail était investi d’un sens politique. La diplomatie peut alors à ce titre être vue comme un ensemble de rituels, une « chorégraphie » politique qui avait ceci de paradoxal que les figures étaient imposées avec une grande précision, sans être pour autant confiées à un appareil administratif structuré. En l’absence de ce dernier, le personnage de l’ambassadeur n’en est que plus central dans la diplomatie, dont il exécute les actes comme les figures d’un ballet ou d’une pièce théâtrale. À cet égard, cette thèse vise également à proposer une étude socio-professionnelle des ambassadeurs dont le but est de cerner la composition du vivier diplomatique dans lequel les monarchies puisaient afin de trouver des candidats, de comprendre comment les futurs représentants se préparaient à exercer leurs fonctions à l’étranger et de mettre en lumière les raisons du recrutement et du choix de tel ou tel homme. Qui plus est, cette étude – comparative par sa nature même – permettra de poser la question de la professionnalisation de l’activité diplomatique, inégale en France et en Angleterre, mais partout inaboutie. Par ailleurs – et c’est là un autre trait que ce travail vise à mettre en exergue – les ambassadeurs n’avaient pas le monopole des relations diplomatiques. Nous montrerons que ces relations étaient aussi le fait d’une multitude d’autres acteurs, peu articulés, de tous rangs et de toute nature, qui, foisonnant entre les deux rives de la Manche, conduisaient des missions tant officielles qu’officieuses et se trouvaient de plus en plus nombreux à jouer un jeu dans les interactions entre les deux Couronnes. Enfin, nous proposerons, dans la lignée des éléments précédents, une lecture renouvelée de certains grands mouvements politiques et stratégiques des années 1610-1642 à la lumière d’une étude structurelle de l’appareil politico-diplomatique, appuyée notamment sur l’exploitation de la correspondance diplomatique et des écrits privés des acteurs. Puiser dans ces fonds, issus des archives tant anglaises que françaises, mais aussi de tierces puissances telles que Venise, permet de s’affranchir de prismes nationaux de lecture des événements, prismes dont l’influence reste prégnante dans toute la période qui nous intéresse.Did the pre-absolutist monarchs of the first half of the 17th century have the diplomatic apparatus corresponding to their policy and aligned with their ambitions – in other words, did they have the means to their ends? Or did they rather determine their policy based on their diplomatic apparatus? The main objective of this thesis is to examine and deepen our knowledge of the relations between France and England from the death of Henry IV in 1610 until the year 1642, marked by the death of Richelieu and the outbreak of revolution and civil war in Britain. The study of this period – a period which may both seem familiar while also remaining little studied and generally perceived through the prism of the novels of Alexandre Dumas – is not intended to be a simple chronological and event-based account of French-English political-diplomatic interactions, but ambitions to analyze both the state of the administrative structures of the diplomatic apparatus of these two pre-absolutist states and the sociology of its diplomatic actors, aiming to understand how they influenced the course of political events between the two crowns. Thus, this study aims to highlight the major feature of diplomacy in early modernity as it emerges from the study of Franco-English relations: with diplomacy still poorly structured on the administrative level and therefore lagging behind in the “modernization” of the modern pre-absolutist State instruments, it is the tool of an already intense but protean foreign policy, which builds on several channels not yet exclusive of one another, but nevertheless follows codes and very precise protocols, for which every detail is invested with political undertones. From this perspective, diplomacy can thus be seen as a set of rituals, a political “choreography” but in which paradoxically, the gestures were imposed with great precision without however being entrusted to a structured administrative apparatus. In the absence of the latter, the role of the ambassador is even more central in Franco-English Baroque diplomacy, performing the acts like the artists in a ballet or a theatrical play. In this regard, this thesis also aims to propose a socio-professional study of leading official diplomatic personnel in order to identify the composition of the diplomatic pool from which the monarchies drew in order to find candidates, to understand how future ambassadors prepared for a possible exercise of functions abroad, and to shed light on the reasons for the recruitment and choice of a particular person. What is more, this study – comparative by its inherent nature – will allow us to raise the question of the professionalization of diplomatic activity, which was at unequal levels in France and England but unfinished everywhere. Furthermore – and corresponding to an additional feature that this work aims to highlight – ambassadors did not have a monopoly on diplomatic relations. We will rather show that these relations were also the work of a multitude of other actors – not very articulated – of all ranks and kind, who flourished on both sides of the Channel, carrying out both official and unofficial missions and playing, in increasing numbers, a game in the interactions between the two crowns. Finally, in line with the elements outlined above, we will propose a renewed understanding of certain major political and strategic movements of the years 1610-1642 in light of our study of the political-diplomatic apparatus structure, based in particular on the analysis of diplomatic correspondence and private writings of the actors. Drawing on these sources, from both English and French archives as well as from powerful outside actors such as Venice, allows us to go beyond national prisms in our analysis and understanding of events, prisms whose influence nevertheless remains significant throughout the period that interests us

Використання попередньо піролізованого технічного лігніну як палива для агломерації залізних руд

A promising direction of technical hydrolysis lignin utilization is metallurgical production, primarily iron ore preparation and blast furnace process. A significant potential is concentrated in the sintering process. In order to improve properties of lignin in the role of a fuel, and to remove, with the possibility of trapping, toxic substances, it is necessary to carry out preliminary pyrolysis. The effect of technical hydrolysis lignin of different pyrolization degrees on the iron ore sintering process and properties of the obtained sinter is experimentally studied. Initial lignin was subjected to preliminary heat treatment to the final temperature of 400, 600, 800 and 1000 ºС without air access. Sintering with the participation of pyrolyzed lignin has been carried out via lab-scale sinter pot. After sintering, the sinter strength and the macrostructure have been determined. The chemical composition of the sinter samples has been revealed by X-ray fluorescence analysis.As a result of the experiments, the possibility of replacing 25 % of coke breeze with lignin prepyrolyzed at 800 ºС has been determined. Under these conditions, the main indicators of the sintering process, such as vertical sintering rate, product yield and specific capacity of the lab-scale sinter pot, remain virtually unchanged. There is a slight decrease in the impact strengths and the abrasion strengths of the sinter. However, these figures remain at a technologically acceptable level. It should be noted that when using lignin as a sintering fuel, there is a tendency for some decrease in the iron content of the sinter produced with it. The study of the sinter macrostructure has shown an increase in the pore diameter when the partial replacement of coke breeze with lignin while with the increasing lignin pyrolysis temperature the pore volume increases.The studies has evidence the possibility of solving the urgent environmental issues of technical hydrolysis lignin utilization by applying it in the sintering process with preliminary pyrolization. A promising direction for further research is the development of methods for the preparation of technical hydrolysis lignin for the use in iron ore sinteringПерспективным направлением утилизации технического гидролизного лигнина является его применение в металлургическом производстве, в первую очередь при подготовке железорудного сырья и доменном процессе. Значительный резерв при этом сосредоточен в агломерационном процессе. Для улучшения топливных свойств лигнина, а также для удаления, с возможностью улавливания, токсичных веществ, следует осуществить его предварительный пиролиз. Экспериментально изучено влияние технического гидролизного лигнина разной степени пиролизации на процесс железорудной агломерации и свойства полученного агломерата. Исходный лигнин подвергался предварительной термической обработке до конечной температуры 400, 600, 800 и 1000 ºС без доступа воздуха. Спекание агломерата с участием пиролизированного лигнина проводили на лабораторной агломерационной установке. После спекания определяли прочность агломерата, исследовали его макроструктуру. Химический состав образцов агломерата исследовали методом рентгенофлуоресцентного анализа.В результате проведённых экспериментов определена возможность замены 25 % коксовой мелочи лигнином, предварительно пиролизированным при температуре 800 ºС. В этих условиях основные показатели агломерационного процесса, такие как вертикальная скорость спекания, выход годного продукта и удельная производительность установки, практически не изменяются. Наблюдается незначительное снижение прочности агломерата на удар и на истирание, однако данные показатели остаются на технологически приемлемом уровне. Следует отметить, при использовании лигнина в качестве агломерационного топлива обнаруживается тенденция к некоторому снижению содержания железа в агломерате. Исследование макроструктуры агломерата показало увеличение диаметра пор при частичной замене коксовой мелочи лигнином, причем с повышением температуры пиролиза лигнина, объем пор увеличивается.Проведенные исследования подтвердили возможность решения актуальной экологической проблемы утилизации технического лигнина, путем применения его в агломерационном процессе с предварительной его пиролизацией. Перспективным направлением дальнейших исследований является развитие способов подготовки технического гидролизного лигнина к использованию в железорудной агломерацииПерспективним напрямком утилізації технічного гідролізного лігніну є його застосування в металургійному виробництві, в першу чергу при підготовці залізорудної сировини і доменному процесі. Значний резерв при цьому зосереджений в агломераційному процесі. Для поліпшення паливних властивостей лігніну, а також для видалення, з можливістю уловлювання, токсичних речовин, слід здійснити його попередній піроліз. Експериментально вивчено вплив технічного гідролізного лігніну різного ступеня піролізації на процес залізорудної агломерації і властивості отриманого агломерату. Вихідний лігнін піддавався попередній термічній обробці до кінцевої температури 400, 600, 800 і 1000 ºС без доступу повітря. Спікання агломерату за участю піролізованого лігніну проводили на лабораторній агломераційній установці. Після спікання визначали міцність агломерату, досліджували його макроструктуру. Хімічний склад зразків агломерату досліджували методом рентгенофлуоресцентного аналізу.В результаті проведених експериментів визначена можливість заміни 25 % коксового дріб'язку лігніном, попередньо піролізованим при температурі 800 ºС. За таких умов основні показники агломераційного процесу, такі як вертикальна швидкість спікання, вихід придатного продукту і питома продуктивність установки, практично не змінюються.Спостерігається незначне зниження міцності агломерату на удар і на стирання, однак дані показники залишаються на технологічно прийнятному рівні. Слід зазначити, що при використанні лігніну в якості агломераційного палива виявляється тенденція до деякого зниження вмісту заліза в агломераті. Дослідження макроструктури агломерату показало збільшення діаметра пор при частковій заміні коксового дріб'язку лігніном, причому з підвищенням температури піролізу лігніну, обсяг пор збільшується.Проведені дослідження підтвердили можливість вирішення актуальної екологічної проблеми утилізації технічного лігніну, шляхом застосування його в агломераційному процесі з попередньою його піролізацією. Перспективним напрямком подальших досліджень є розвиток способів підготовки технічного гідролізного лігніну до використання в залізорудній агломераці