СТАН СУДИННОГО ГОМЕОСТАЗУ У ЖІНОК З НЕПЛІДДЯМ ПІСЛЯ ВИКОРИСТАННЯ ДОПОМІЖНИХ РЕПРОДУКТИВНИХ ТЕХНОЛОГІЙ.

The aim of the study – to establish the role of vascular disorders of regulation in the event of perinatal complications in pregnant women at high risk.Materials and Methods. The study involved 50 pregnant women after assisted reproductive technologies with infertility hormonal origin (study group), 50 pregnant women after assisted reproductive technology because of tubal-peritoneal factor infertility (group) and 50 somatically healthy women with non-simulate pregnancy (control group) in the period of gestation 14–16 weeks. The level of homocysteine was determined by enzyme cyclic reaction, using a set Diasyis (Germany) using the analyzer Respons 920 (Germany) of manufacturer. Content L "arginine levels determined using photometric method, which is based on the reaction of L" with hipobromidnym naphthol reagent. For the quantitative determination of human placental growth factor (PLGF) in samples of blood plasma we used immunochemical method with electrochemiluminescent detection (ECLIA).Results and Discussion. To determine the role of violations of the regulation of vascular homeostasis in the event of pregnancy complications in the study group 2 groups were allocated: group 1 – 9 women with essential obstetric and perinatal disorders (miscarriages and died of pregnancy, preeclampsia severe, decompensated fetal distress), group 2 – 31 women without such disorders. It was established that pregnancy after assisted reproductive technology programs held from particularly severe complications in women with infertility of hormonal origin, where early pregnancy placenta formation and development took place in conditions of endothelial dysfunction, negative impact homocysteine, disorders of angiogenesis processes.Consequently, these factors may be early prognostic markers of severe obstetric and perinatal disorders in pregnancy induced infertility in women of various origins.Conclusions. In terms of homeostatic imbalance in this category of women abuse endothelium and vascular regulation factors underlying the pathogenesis of reproductive, obstetric and perinatal complications, which is the theoretical precondition for the development of complex pathogenesis reasonable prevention and treatment aimed at correcting violations.Цель иследования – установить роль нарушений сосудистой регуляции в возникновении перинатальных осложнений у беременных высокого риска.Материалы и методы. Обследовано 50 беременных женщин после вспомогательных репродуктивных технологий с бесплодием гормонального генеза (основная группа), 50 беременных женщин после вспомогательных репродуктивных технологий в результате трубно-перитонеального фактора бесплодия (группа сравнения) и 50 соматически здоровых женщин с неиндуцированной беременностью (контрольная группа) в сроке гестации 14–16 недель. Уровень гомоцистеина определено методом ферментативной циклической реакции, с помощью набора Diasyis (Германия) с использованием анализатора Respons 920 (Германия) по методике производителя. Содержание L-аргинина в крови определено с помощью фотометрического метода, в основу которого положено реакцию L-нафтола с гипобромидным реактивом. Для количественного определения плацентарного фактора роста человека (PLGF) в образцах плазмы крови использовано иммунохимический метод с электрохемилюминесцентной детекцией (ECLIA). Результаты исследования и их обсуждение. Для определения роли нарушений регуляции сосудистого гомеостаза в возникновении осложнений беременности в основной группе выделено 2 подгруппы: 1-я – 9 женщин с существенными акушерскими и перинатальными нарушениями (выкидыши и замершие беременности, преэклампсия тяжелой степени, декомпенсированный дистресс плода), 2-я – 31 женщина без таких нарушений. Установлено, что беременность после программ вспомогательных репродуктивных технологий проходила с особо тяжелыми осложнениями у тех женщин с бесплодием гормонального генеза, в которых уже в начале беременности формирование и развитие плаценты происходили в условиях эндотелиальной дисфункции: негативного воздействия гомоцистеина, нарушений процессов ангиогенеза.Итак, эти факторы могут быть ранними прогностическими маркерами тяжелых акушерских и перинатальных нарушений при индуцированной беременности у женщин с бесплодием различного генеза.Вывод. В условиях гомеостатического дисбаланса в данной категории женщин нарушение эндотелия и факторов сосудистой регуляции лежат в основе патогенеза репродуктивных, акушерских и перинатальных осложнений, является теоретической предпосылкой для разработки патогенетически обоснованного комплекса профилактики и лечения, направленного на коррекцию выявленных нарушений.Мета – встановити роль порушень судинної регуляції у виникненні перинатальних ускладнень у вагітних високого ризику.Методи дослідження. Обстежено 50 вагітних жінок після допоміжних репродуктивних технологій із непліддям гормонального генезу (основна група), 50 вагітних жінок після допоміжних репродуктивних технологій внаслідок трубно-перитонеального фактору непліддя (група порівняння) і 50 соматично здорових жінок із неіндукованою вагітністю (контрольна група) у терміні гестації 14–16 тижнів. Рівень гомоцистеїну визначено методом ферментативної циклічної реакції, за допомогою набору Diasyis (Німеччина) з використанням аналізатора Respons 920 (Німеччина) за методикою виробника. Вміст L"аргініну в крові визначено за допомогою фотометричного методу, в основу якого покладено реакцію L"нафтола з гіпобромідним реактивом. Для кількісного визначення плацентарного фактора росту людини (PLGF) в зразках плазми крові використано імунохімічний метод з електрохемілюмінесцентною детекцією (ECLIA).Результати. Для визначення ролі порушень регуляції судинного гомеостазу у виникненні ускладнень вагітності в основній групі виділено 2 підгрупи: 1"ша – 9 жінок із суттєвими акушерськими й перинатальними порушеннями (викидні та завмерлі вагітності, прееклампсія тяжкого ступеня, декомпенсований дистрес плода), 2"га – 31 жінка без таких порушень. Встановлено, що вагітність після програм допоміжних репродуктивних технологій проходила з особливо тяжкими ускладненнями в тих жінок із непліддям гормонального генезу, в яких вже на початку вагітності формування і розвиток плаценти відбувались в умовах ендотеліальної дисфункції: негативної дії гомоцистеїну, порушень процесів ангіогенезу.Отже, ці фактори можуть бути ранніми прогностичними маркерами тяжких акушерських і перинатальних порушень при індукованій вагітності в жінок із непліддям різного генезу.                          Висновки. В умовах гомеостатичного дисбалансу в даної категорії жінок порушення ендотелію та факторів судинної регуляції лежать в основі патогенезу репродуктивних, акушерських і перинатальних ускладнень, що є теоретичною передумовою для розробки патогенетично обґрунтованого комплексу профілактики й лікування, спрямованого на корекцію виявлених порушень.

LOCAL DRUG TREATMENT OF GENERALIZED PERIODONTITIS IN PREGNANT WOMEN WITH IRON DEFICIENCY ANEMIA

The disease of periodontal tissues occupies first place in the structure of dental diseases that can be detected during pregnancy. More profound changes in the homeostasis of the oral cavity occur when abnormal pregnancy. One of the most common diseases that complicate pregnancy is iron deficiency anemia. IDA – a clinical and hematological syndrome characterized by a decrease in the amount of iron in the body (blood, bone marrow and depot), which disrupted the synthesis of heme and proteins that contain iron (myoglobin, iron-tissue enzymes). The aim of the study. Periodontology is an urgent need to develop a local drug treatment of generalized periodontitis in pregnant women against the backdrop of iron deficiency anemia. Materials and Methods. The effectiveness of the proposed local health-care complex was performed using index evaluation of perio-dentistry status in 32 pregnant women, patients with generalized periodontitis against the background of iron deficiency anemia. We studied the dynamics of changes in clinical indicators of periodontal tissues, namely the health index Green Vermilyona index for bleeding Muhlemann, depth of paradontium pockets, index Ramfyorda. Results and Discussion. It was established efficacy of topically to rinse the mouth with antiseptic solution based on octenidine dihydrochloride and 2-phenoxyethanol "Oktenisept" for applications – gel based on hyaluronic acid 0.2 % "Henhihel". Conclusions. Using the proposed method of local treatment of generalized parodontium allows a stabilization of process and providing a long-term remission

ВНУТРІШНЬОПЕЧІНКОВИЙ ХОЛЕСТАЗ ВАГІТНИХ ПІСЛЯ ЗАСТОСУВАННЯ ДОПОМІЖНИХ РЕПРОДУКТИВНИХ ТЕХНОЛОГІЙ: КЛІНІЧНІ ОСОБЛИВОСТІ

80 pregnant women were examined after assisted reproductive technology (ART) programs: 40 women with manifestations of intrahepatic cholestasis of pregnant women (IHP) - the main group and 40 women without manifestations of IHP (comparison group).In the majority (62.5%) of patients after ART, the diagnosis of IHP established after 30 weeks of pregnancy. Some patients (27.5%) reported short-term episodes of IHP up to 24 weeks of gestation. In 17.5% of women, IHP had a severe course. Almost a third (27.5%) of women are over 35 years old. Women with IHP have a significantly higher frequency of allergies in the anamnesis (35.0%), liver pathology (20.0%) and diseases of the gastrointestinal tract (25.0%). In one third of women, IHP developed repeatedly, 42.5% of the main patients indicated a family history burdened with IHP. Almost a third of women (27.5% vs. 12.5%, p<0.05) had a history of polycystic ovary syndrome.The current pregnancy characterized by a high frequency of complications. A quarter of patients (25.0%) had early preeclampsia. In the second half of pregnancy, the threat of preterm birth noted in most women during the manifestation of IHP (60.0%). The incidence of fetal distress in women with IHP was almost 2 times higher than in patients without this complication (47.5% vs. 25.0%, respectively, p <0.05). The frequency of preeclampsia is also higher (40.0%).The vast majority of women in the main group were born by cesarean section (70.0%). Almost half of patients with IHP were premature (45.0%). A third of women (35.0%) had fetal distress in childbirth. In 27.5%, childbirth complicated by bleeding of more than 5% of body weight. The postpartum period was characterized by a 4-fold increase in the frequency of late bleeding (20.0% vs. 5.0%, p <0.05).One case of antenatal mortality noted in pregnant women after ART with IHP. Almost half of the children were born with asphyxia of varying severity (48.7%), with 10.3% diagnosed with severe asphyxia. One third of children were born with a body weight below 2500 g (30.8%). In 74.4% of newborns from mothers of the main group, various disorders of the period of early neonatal adaptation were noted, among which the most prominent were: RDS (35.9%), jaundice (43.6%) and gastrointestinal syndrome (30.8%). The 2-fold increased incidence of hemorrhagic syndrome (17.9%) is noteworthy.80 pregnant women were examined after assisted reproductive technology (ART) programs: 40 women with manifestations of intrahepatic cholestasis of pregnant women (IHP) - the main group and 40 women without manifestations of IHP (comparison group).In the majority (62.5%) of patients after ART, the diagnosis of IHP established after 30 weeks of pregnancy. Some patients (27.5%) reported short-term episodes of IHP up to 24 weeks of gestation. In 17.5% of women, IHP had a severe course. Almost a third (27.5%) of women are over 35 years old. Women with IHP have a significantly higher frequency of allergies in the anamnesis (35.0%), liver pathology (20.0%) and diseases of the gastrointestinal tract (25.0%). In one third of women, IHP developed repeatedly, 42.5% of the main patients indicated a family history burdened with IHP. Almost a third of women (27.5% vs. 12.5%, p<0.05) had a history of polycystic ovary syndrome.The current pregnancy characterized by a high frequency of complications. A quarter of patients (25.0%) had early preeclampsia. In the second half of pregnancy, the threat of preterm birth noted in most women during the manifestation of IHP (60.0%). The incidence of fetal distress in women with IHP was almost 2 times higher than in patients without this complication (47.5% vs. 25.0%, respectively, p <0.05). The frequency of preeclampsia is also higher (40.0%).The vast majority of women in the main group were born by cesarean section (70.0%). Almost half of patients with IHP were premature (45.0%). A third of women (35.0%) had fetal distress in childbirth. In 27.5%, childbirth complicated by bleeding of more than 5% of body weight. The postpartum period was characterized by a 4-fold increase in the frequency of late bleeding (20.0% vs. 5.0%, p <0.05).One case of antenatal mortality noted in pregnant women after ART with IHP. Almost half of the children were born with asphyxia of varying severity (48.7%), with 10.3% diagnosed with severe asphyxia. One third of children were born with a body weight below 2500 g (30.8%). In 74.4% of newborns from mothers of the main group, various disorders of the period of early neonatal adaptation were noted, among which the most prominent were: RDS (35.9%), jaundice (43.6%) and gastrointestinal syndrome (30.8%). The 2-fold increased incidence of hemorrhagic syndrome (17.9%) is noteworthy

Prothrombotic states as risk factor of in vitro fertilization failures in women with infertility and psychosomatic disorders.

Failures of in vitro fertilization (IVF) may be associated with prothrombotic states, the circulation of antiphospholipid antibodies (APA). 93 women with infertility were screened: 1 group - 32 women without severe psychosomatic disorders; 2 group - 61 women with psychosomatic disorders. The control group consisted of 30 fertile women. The level of AFA to membrane phospholipids (phosphatidylethanolamine, phosphatidylserine, cardiolipinum), antibodies to β2-glycoprotein (β2-GPI), hemostasis (platelet count, ADP-induced platelet aggregation index, fibrinogen concentration, prothrombin index, activated partial thromboplastin time - APTT, test for soluble fibrin-monomeric complexes, D-dimer), homocysteine in the blood serum was defined. The frequency of significant AFA titres in the group of women without psychosomatic disorders was 18.9%, and if they were present - 44.3%, the rate of β2-GPI 9.6% versus 24.5%, respectively. Only in 11.5% of women in 2 groups, elevated levels of APA were associated with β2-GPI and/or one or more clinical criteria for antiphospholipid syndrome (APS). In patients with infertility and psychosomatic disorders, increased platelet aggregation in the context of relative thrombocytopenia, higher fibrinogen levels, soluble fibrin-monomeric complexes, and prolonged APTT with elevated D-dimer levels was revealed. Some patients have hyperhomocysteinemia. Factors that adversely affect the efficiency of IVF in the patients with psychosomatic disorders were noted: elevation of APA; reduction in the number of platelets; growth of the ADP-induced aggregation index; extension of APTT; increase of fibrinogen, D-dimer; homocysteine. The presence of prothrombotic states associated with APS should be taken into account when preparing for IVF and perform their appropriate correction

Prothrombotic states as risk factor of in vitro fertilization failures in women with infertility and psychosomatic disorders.

Failures of in vitro fertilization (IVF) may be associated with prothrombotic states, the circulation of antiphospholipid antibodies (APA). 93 women with infertility were screened: 1 group - 32 women without severe psychosomatic disorders; 2 group - 61 women with psychosomatic disorders. The control group consisted of 30 fertile women. The level of AFA to membrane phospholipids (phosphatidylethanolamine, phosphatidylserine, cardiolipinum), antibodies to β2-glycoprotein (β2-GPI), hemostasis (platelet count, ADP-induced platelet aggregation index, fibrinogen concentration, prothrombin index, activated partial thromboplastin time - APTT, test for soluble fibrin-monomeric complexes, D-dimer), homocysteine in the blood serum was defined. The frequency of significant AFA titres in the group of women without psychosomatic disorders was 18.9%, and if they were present - 44.3%, the rate of β2-GPI 9.6% versus 24.5%, respectively. Only in 11.5% of women in 2 groups, elevated levels of APA were associated with β2-GPI and/or one or more clinical criteria for antiphospholipid syndrome (APS). In patients with infertility and psychosomatic disorders, increased platelet aggregation in the context of relative thrombocytopenia, higher fibrinogen levels, soluble fibrin-monomeric complexes, and prolonged APTT with elevated D-dimer levels was revealed. Some patients have hyperhomocysteinemia. Factors that adversely affect the efficiency of IVF in the patients with psychosomatic disorders were noted: elevation of APA; reduction in the number of platelets; growth of the ADP-induced aggregation index; extension of APTT; increase of fibrinogen, D-dimer; homocysteine. The presence of prothrombotic states associated with APS should be taken into account when preparing for IVF and perform their appropriate correction

Common mechanisms of placental dysfunction in preeclampsia, gestational diabetes, and COVID-19 in pregnant women

COVID-19 infection, preeclampsia and gestational diabetes mellitus in pregnancy cause similar changes in the placenta and influence development of the fetus between conception and birth in gestation. Proper uterine and placental vascularization is essential for normal fetal development. The transplacental exchange is regulated and maintained by the placental endothelium. During placental implantation, the trophoblast differentiates into two distinct layers, the inner cytotrophoblast and outer syncytiotrophoblast, which are key elements of the human placental barrier. Proinflammatory cytokines exacerbate ischemic events and create an upward spiral of an inflammatory reaction in the placenta. Placental pathology in gestational COVID-19 shows desquamation and damage of trophoblast and chronic histiocytic intervillositis. Similar lesions also occur in gestational diabetes mellitus and preeclampsia. The systemic inflammatory response of the mother, the increased inflammation in the placenta and cytokine production by placental trophoblasts should be monitored throughout pregnancy. Placental angiogenesis can be evaluated by serum vascular endothelial growth factor, Annexin A2, placental growth factor or sclerostin. Tissue damage can be assessed by measuring levels of serum lactate dehydrogenase and myeloperoxidase. Blood flow can be monitored with three-dimensional Doppler and pathological changes can be documented with paraffin-embedded tissue sections stained with hematoxylin and eosin, and electron microscope images as well as immunohistochemistry tests for vascular endothelial growth factor, placental growth factor, sclerostin and Annexin A2. The damage of maternal and fetal vascular perfusion (villitis and fibrin deposition) is a common mechanism of gestational diseases. The placenta lesions liberate anti-endothelial factors that lead to anti-angiogenic conditions and are the common mechanism of maternal placental vascular malperfusion in gestational diseases. Keywords: dysfunction, inflammation, pathology, placenta, pregnancy, vascularizatio

How Malthusian Ideology crept into the Newsroom: British tabloids and the coverage of the ‘underclass’

This article argues that Malthusianism as a series of discursive regimes, developed in the Victorian-era, serves in times of austerity to reproduce an elite understanding of social exclusion in which those in a state of poverty are to blame for their own situation. It highlights that Malthusianism is present in the public discourse, becoming an underlining feature in news coverage of the so-called ‘underclass’. Our findings broadly contradict the normative claim that journalism ‘speaks truth to power’, and suggest instead that overall as a political practice, journalism tends to reproduce and reinforce hegemonic discourses of power. The piece is based on critical discourse analysis (CDA), which has been applied to a significant sample of news articles published by tabloid newspapers in Britain which focussed on the concept of the ‘underclass’. By looking at the evidence, the authors argue that the ‘underclass’ is a concept used by some journalists to cast people living in poverty as ‘undeserving’ of public and state support. In so doing, these journalists help create a narrative which supports cuts in welfare provisions and additional punitive measures against some of the most vulnerable members of society

ALLELIC GSTS GENE POLYMORPHISM IN MOTHERS WITH PLACENTAL DYSFUNCTION AND THEIR NEWBORNS: OBSTETRIC AND PERINATAL OUTCOMES

Summary. The role of the placenta caused by the implementation of a number of functional mechanisms of growth and fetal development. Glutathione-S-transferase is actively involved in the removal of products peroxidation lipid peroxides and DNA, restoring organic hydroperoxide to alcohol and contributing isomerization some steroids and prostaglandins. If there are certain polymorphic variants GSTT1, GSTM1, GSTP1 gene family of glutathione-S-transferase is hlutation dependent AOD depletion and inhibition of detoxification function of the placenta. The aim of the study – to determine the allelic polymorphism gene glutathione-S-transferase GSTT1 and GSTM1 in women with placental dysfunction in healthy newborns and infants with intrauterine growth retardation conducted molecular genetic study of umbilical cord blood. Materials and Methods. The study involved 105 women; the main group included 33 women with placental dysfunction (PD) without intrauterine growth retardation (IUGR) in children born by them (I group) and 17 women with IUGR, and PD (II group). The control group consisted of 55 women (III group) who gave birth to healthy term infants. Results and Discussion. It is established that the risk of PD and PD with IUGR by the dominant model of inheritance (313AG + 313GG versus 313AA) significantly increased. The promising prognostication models of intergenic interaction for the assessment of the development of placental dysfunction imply the analysis of GSTM1 and GSTP1 gene polymorphisms and for the assessment of the development of placental dysfunction with intrauterine growth retardation – of GSTT1, GSTM1 and GSTP1. An analysis of serum samples of umbilical cord blood and obtained data revealed that the frequency of GSTM1 polymorphic variant "+" in the field of newborns was 42.69 % and GSTM1 "–" – 57.30 %. The frequency of polymorphic variants GSTT1 «+» in all newborns region was 79.77 % and GSTT1 “–“ – 20.22 %. Conclusions. The study of the distribution of different allelic variants of genes GSTM1 and GSTT1 proved their differences in different groups of newborns. We found significant difference between the frequencies of GSTM1 gene deletion variant in healthy infants and newborns with IUGR. A pooled analysis of the combined impact of several factors found that pregnancy in women with PD, preeclampsia and GSTM1deletion genotype is associated with a significant increased risk of IUGR fetuses

Морфометрические изменения bcl-2+ клеток коры теменной доли, индуцированные неполной глобальной ишемией-реперфузией головного мозга у самцов-крыс со стрептозотоциновым сахарным диабетом.

Исследована динамика реакции морфометрических параметров Bcl-2+-нейронов и глиальных клеток коры теменной доли на неполную глобальную ишемию-реперфузию у крыс без сахарного диабета и с наличием последнего. Показано, что у животных без сахарного диабета 20-минутная двусторонняя каротидная ишемия с одночасовой реперфузией модифицирует коэффициент формы и элонгации Bcl-2+-нейроцитов и коэффициент формы глиоцитов. На 12-е сутки наблюдения указанные изменения Bcl-2+-нейроцитов и глиоцитов сохраняются и дополняются изменениями площади данных клеток. У животных с сахарным диабетом в раннем ишемически-реперфузионном периоде снижается площадь Bcl-2+-нейронов коры теменной доли, а на 12-е сутки изменения претерпевают все исследованные морфометрические параметры нервных клеток. В оба срока наблюдения изменений морфометрических параметров глиоцитов не обнаружено

Морфометричні зміни Bcl-2+-клітин кори тім'яної частки, індуковані неповною глобальною ішемією-реперфузією головного мозку в самців-щурів зі стрептозотоциновим цукровим діабетом.

Background. Trigger mechanisms causing death of the nerve and glial cells in the cerebral cortex by means of apoptosis under conditions of diabetes mellitus and ischemia-reperfusion are energy deficiency, ion imbalance etc. Although, certain protective mechanisms resist them, including apoptosis and antiapoptotic Bcl-2 protein in particular.       Objective of the study is to find the peculiarities of morphometric changes in Bcl-2 nerve and glial cells of the parietal lobe of cerebral cortex in during incomplete global ischemia-reperfusion in male rats with experimental diabetes. Methods. The nerve and glial cells of the parietal lobe of cerebral cortex positive for Bcl-2 protein were identified by means of immunofluorescent method with the videocamera COHU-4722. In the obtained images the computer system of digital analysis VIDAS-386 determined morphometric parameters of Bcl-2+ cells, in particular: their square surface, coefficients of the shape and elongation. Results and conclusion.        The results of the experimental study indicated the fact that in animals without diabetes mellitus 20-minute bilateral carotid ischemia with 1 hour reperfusion modifies the coefficient of the shape and elongation of Bcl-2+ nerve cells and the coefficient of the shape of glial cells. On the 12th day of the study the indicated changes of Bcl-2+ nerve and glial cells remains and are supplemented with changes in the square surface of the given cells. In animals with diabetes mellitus the square surface of Bcl-2+ nerve cells of the parietal lobe of cerebral cortex decreases in the early ischemic-reperfusion period, and on the 12th day changes are found in all the examined morphometric parameters of the nerve cells. In both periods of the study changes of the morphometric parameters in glial cells are not found.Исследована динамика реакции морфометрических параметров Bcl-2+-нейронов и глиальных клеток коры теменной доли на неполную глобальную ишемию-реперфузию у крыс без сахарного диабета и с наличием последнего. Показано, что у животных без сахарного диабета 20-минутная двусторонняя каротидная ишемия с одночасовой реперфузией модифицирует коэффициент формы и элонгации Bcl-2+-нейроцитов и коэффициент формы глиоцитов. На 12-е сутки наблюдения указанные изменения Bcl-2+-нейроцитов и глиоцитов сохраняются и дополняются изменениями площади данных клеток.У животных с сахарным диабетом в раннем ишемически-реперфузионном периоде снижается площадь Bcl-2+-нейронов коры теменной доли, а на 12-е сутки изменения претерпевают все исследованные морфометрические параметры нервных клеток. В оба срока наблюдения изменений морфометрических параметров глиоцитов не обнаружено.Досліджено динаміку реакції морфометричних параметрів Bcl-2+-нейронів та гліальних клітин кори тім’яної частки на неповну глобальну ішемію-реперфузію в щурів без цукрового діабету та з наявністю останнього. Показано, що у тварин без цукрового діабету 20-хвилинна двобічна каротидна ішемія з одногодинною реперфузією модифікує коефіцієнт форми та елонгації Bcl-2+-нейроцитів і коефіцієнт форми гліоцитів. На 12-ту добу спостереження зазначені зміни Bcl-2+-нейроцитів та гліоцитів зберігаються та доповнюються змінами площі даних клітин. У тварин із цукровим діабетом в ранньому ішемічно-реперфузійному періоді знижується площа Bcl-2+-нейронів кори тім’яної частки, а на 12-ту добу змін зазнають усі досліджені морфометричні параметри нервових клітин. В обидва терміни спостереження змін морфометричних параметрів гліоцитів не виявлено