How the Neoproterozoic S-isotope record illuminates the genesis of vein gold systems: an example from the Dalradian Supergroup in Scotland

The genesis of quartz vein-hosted gold mineralization in the Neoproterozoic–early Palaeozoic Dalradian Supergroup of Scotland remains controversial. An extensive new dataset of S-isotope analyses from the Tyndrum area, together with correlation of the global Neoproterozoic sedimentary S-isotope dataset to the Dalradian stratigraphy, demonstrates a mixed sedimentary and magmatic sulphur source for the mineralization. d34S values for early molybdenite- and later gold-bearing mineralization range from 22 to +12‰, but show distinct populations related to mineralization type. Modelling of the relative input of magmatic and sedimentary sulphur into gold-bearing quartz veins with d34S values of +12‰ indicates a maximum of 68% magmatic sulphur, and that S-rich, SEDEX-bearing, Easdale Subgroup metasedimentary rocks lying stratigraphically above the host rocks represent the only viable source of sedimentary sulphur in the Dalradian Supergroup. Consequently, the immediate host rocks were not a major source of sulphur to the mineralization, consistent with their low bulk sulphur and lack of metal enrichment. Recent structural models of the Tyndrum area suggest that Easdale Subgroup metasedimentary rocks, enriched in 34S, sulphur and metals, are repeated at depth owing to folding, and it is suggested that these are the most likely source of sedimentary sulphur, and possibly metals, for the ore fluids

The black-hole masses of Seyfert galaxies and quasars

The central black-hole masses of a sample of 30 luminous quasars are estimated using H-beta FWHM measurements from a combination of new and previously-published nuclear spectra. The quasar black-hole mass estimates are combined with reverberation-mapping measurements for a sample of Seyfert galaxies (Wandel 1999) in order to study AGN black-hole masses over a wide range in nuclear luminosity. It is found that black-hole mass and bulge luminosity are well correlated and follow a relation consistent with that expected if black-hole and bulge mass are directly proportional. Contrary to the results of Wandel (1999) no evidence is found that Seyfert galaxies follow a different Mblack-Mbulge relation to quasars. However, the black-hole mass distributions of the radio-loud and radio-quiet quasar sub-samples are found to be significantly different, with the median black-hole mass of the radio-loud quasars a factor of three larger than their radio-quiet counterparts. Finally, utilizing the elliptical galaxy fundamental plane to provide stellar velocity dispersion estimates, a comparison is performed between the virial H-beta black-hole mass estimates and those of the Mblack-sigma correlations of Gebhardt et al. (2000a) and Merritt & Ferrarese (2000). With the disc-like geometry of the broad-line region adopted in this paper, the virial H-beta black-hole masses indicate that the correct normalization of the black-hole vs. bulge mass relation is Mblack=0.0025Mbulge, while the standard assumption of purely random broad-line velocities leads to Mblack=0.0008Mbulge. The normalization of Mblack=0.0025Mbulge provided by the disc model is in remarkably good agreement with that inferred for our quasar sample using the (completely independent) Mblack-sigma correlations.Comment: 10 pages, 6 figures, accepted for publication in MNRA

Application of activated barrier hopping theory to viscoplastic modeling of glassy polymers

YesAn established statistical mechanical theory of amorphous polymer deformation has been incorporated as a plastic mechanism into a constitutive model and applied to a range of polymer mechanical deformations. The temperature and rate dependence of the tensile yield of PVC, as reported in early studies, has been modeled to high levels of accuracy. Tensile experiments on PET reported here are analyzed similarly and good accuracy is also achieved. The frequently observed increase in the gradient of the plot of yield stress against logarithm of strain rate is an inherent feature of the constitutive model. The form of temperature dependence of the yield that is predicted by the model is found to give an accurate representation. The constitutive model is developed in two-dimensional form and implemented as a user-defined subroutine in the finite element package ABAQUS. This analysis is applied to the tensile experiments on PET, in some of which strain is localized in the form of shear bands and necks. These deformations are modeled with partial success, though adiabatic heating of the instability causes inaccuracies for this isothermal implementation of the model. The plastic mechanism has advantages over the Eyring process, is equally tractable,and presents no particular difficulties in implementation with finite elements.F. Boutenel acknowledges an Erasmus Programme Scholarshi

InterMEL: An international biorepository and clinical database to uncover predictors of survival in early-stage melanoma

INTRODUCTION: We are conducting a multicenter study to identify classifiers predictive of disease-specific survival in patients with primary melanomas. Here we delineate the unique aspects, challenges, and best practices for optimizing a study of generally small-sized pigmented tumor samples including primary melanomas of at least 1.05mm from AJTCC TNM stage IIA-IIID patients. We also evaluated tissue-derived predictors of extracted nucleic acids' quality and success in downstream testing. This ongoing study will target 1,000 melanomas within the international InterMEL consortium. METHODS: Following a pre-established protocol, participating centers ship formalin-fixed paraffin embedded (FFPE) tissue sections to Memorial Sloan Kettering Cancer Center for the centralized handling, dermatopathology review and histology-guided coextraction of RNA and DNA. Samples are distributed for evaluation of somatic mutations using next gen sequencing (NGS) with the MSK-IMPACTTM assay, methylation-profiling (Infinium MethylationEPIC arrays), and miRNA expression (Nanostring nCounter Human v3 miRNA Expression Assay). RESULTS: Sufficient material was obtained for screening of miRNA expression in 683/685 (99%) eligible melanomas, methylation in 467 (68%), and somatic mutations in 560 (82%). In 446/685 (65%) cases, aliquots of RNA/DNA were sufficient for testing with all three platforms. Among samples evaluated by the time of this analysis, the mean NGS coverage was 249x, 59 (18.6%) samples had coverage below 100x, and 41/414 (10%) failed methylation QC due to low intensity probes or insufficient Meta-Mixed Interquartile (BMIQ)- and single sample (ss)- Noob normalizations. Six of 683 RNAs (1%) failed Nanostring QC due to the low proportion of probes above the minimum threshold. Age of the FFPE tissue blocks (p<0.001) and time elapsed from sectioning to co-extraction (p = 0.002) were associated with methylation screening failures. Melanin reduced the ability to amplify fragments of 200bp or greater (absent/lightly pigmented vs heavily pigmented, p<0.003). Conversely, heavily pigmented tumors rendered greater amounts of RNA (p<0.001), and of RNA above 200 nucleotides (p<0.001). CONCLUSION: Our experience with many archival tissues demonstrates that with careful management of tissue processing and quality control it is possible to conduct multi-omic studies in a complex multi-institutional setting for investigations involving minute quantities of FFPE tumors, as in studies of early-stage melanoma. The study describes, for the first time, the optimal strategy for obtaining archival and limited tumor tissue, the characteristics of the nucleic acids co-extracted from a unique cell lysate, and success rate in downstream applications. In addition, our findings provide an estimate of the anticipated attrition that will guide other large multicenter research and consortia

Track D Social Science, Human Rights and Political Science

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138414/1/jia218442.pd

A MODEST review

We present an account of the state of the art in the fields explored by the research community invested in 'Modeling and Observing DEnse STellar systems'. For this purpose, we take as a basis the activities of the MODEST-17 conference, which was held at Charles University, Prague, in September 2017. Reviewed topics include recent advances in fundamental stellar dynamics, numerical methods for the solution of the gravitational N-body problem, formation and evolution of young and old star clusters and galactic nuclei, their elusive stellar populations, planetary systems, and exotic compact objects, with timely attention to black holes of different classes of mass and their role as sources of gravitational waves. Such a breadth of topics reflects the growing role played by collisional stellar dynamics in numerous areas of modern astrophysics. Indeed, in the next decade, many revolutionary instruments will enable the derivation of positions and velocities of individual stars in the Milky Way and its satellites and will detect signals from a range of astrophysical sources in different portions of the electromagnetic and gravitational spectrum, with an unprecedented sensitivity. On the one hand, this wealth of data will allow us to address a number of long-standing open questions in star cluster studies; on the other hand, many unexpected properties of these systems will come to light, stimulating further progress of our understanding of their formation and evolution.Comment: 42 pages; accepted for publication in 'Computational Astrophysics and Cosmology'. We are much grateful to the organisers of the MODEST-17 conference (Charles University, Prague, September 2017). We acknowledge the input provided by all MODEST-17 participants, and, more generally, by the members of the MODEST communit