Magnetic phase transitions in Ta/CoFeB/MgO multilayers

We study thin films and magnetic tunnel junction nanopillars based on Ta/Co$_{20}$Fe$_{60}$B$_{20}$/MgO multilayers by electrical transport and magnetometry measurements. These measurements suggest that an ultrathin magnetic oxide layer forms at the Co$_{20}$Fe$_{60}$B$_{20}$/MgO interface. At approximately 160 K, the oxide undergoes a phase transition from an insulating antiferromagnet at low temperatures to a conductive weak ferromagnet at high temperatures. This interfacial magnetic oxide is expected to have significant impact on the magnetic properties of CoFeB-based multilayers used in spin torque memories

Heterogeneous condensation of the Lennard-Jones vapor onto a nanoscale seed particle

The heterogeneous condensation of a Lennard-Jones vapor onto a nanoscale seed particle is studied using molecular dynamics simulations. Measuring the nucleation rate and the height of the free energy barrier using the mean first passage time method shows that the presence of a weakly interacting seed has little effect on the work of forming very small cluster embryos but accelerates the rate by lowering the barrier for larger clusters. We suggest that this results from a competition between the energetic and entropic features of cluster formation in the bulk and at the heterogeneity. As the interaction is increased, the free energy of formation is reduced for all cluster sizes. We also develop a simple phenomenological model of film formation on a small seed that captures the general features of the nucleation process for small heterogeneities. A comparison of our simulation results with the model shows that heterogeneous classical nucleation theory provides a good estimate of the critical size of the film but significantly over-estimates the size of the barrier.Comment: 9 pages, 10 figures, In Print J. Chem. Phy

A framework for automated conflict detection and resolution in medical guidelines

This research is supported by the MRC-funded UK Research and Innovation grant MR/S003819/1 and by EPSRC grant EP/M014290/1.Common chronic conditions are routinely treated following standardised procedures known as clinical guidelines. For patients suffering from two or more chronic conditions, known as multimorbidity, several guidelines have to be applied simultaneously, which may lead to severe adverse effects when the combined recommendations and prescribed medications are inconsistent or incomplete. This paper presents an automated formal framework to detect, highlight and resolve conflicts in the treatments used for patients with multimorbidities focusing on medications. The presented extended framework has a front-end which takes guidelines captured in a standard modelling language and returns the visualisation of the detected conflicts as well as suggested alternative treatments. Internally, the guidelines are transformed into formal models capturing the possible unfoldings of the guidelines. The back-end takes the formal models associated with multiple guidelines and checks their correctness with a theorem prover, and inherent inconsistencies with a constraint solver. Key to our approach is the use of an optimising constraint solver which enables us to search for the best solution that resolves/minimises conflicts according to medication efficacy and the degree of severity in case of harmful combinations, also taking into account their temporal overlapping. The approach is illustrated throughout with a real medical example.Publisher PDFPeer reviewe

An Application of the Utah State University Watershed Simulation Model to the Entiat Experimental Watershed, Washington State

To study the effects of a forest fire on runoff characteristics, the Utah State University Watershed Simulation Model (USUWSM) has been applied to three small drainage areas in the Entiat Experimental Watershed which is located within the Wenatchee National Forest of central Washington. Each component of the USUWSM has been described in the report, including structural changes to the model that were necessary to achieve reasonable agreement between observed and simulated runoff hydrographs. Lack of information on the spatial distribution and precipitation due to the absence of an adequate precipitation gaging network on or close to the study area was a severe handicap to the simulation study. Only a very short period of post-fire streamflow record was available and thus it was possible to make only qualative conclusions regarding the effects of the forest fire on runoff characteristics

Impact of generalized benefit functions on the evolution of cooperation in spatial public goods games with continuous strategies

Cooperation and defection may be considered as two extreme responses to a social dilemma. Yet the reality is much less clear-cut. Between the two extremes lies an interval of ambivalent choices, which may be captured theoretically by means of continuous strategies defining the extent of the contributions of each individual player to the common pool. If strategies are chosen from the unit interval, where 0 corresponds to pure defection and 1 corresponds to the maximal contribution, the question is what is the characteristic level of individual investments to the common pool that emerges if the evolution is guided by different benefit functions. Here we consider the steepness and the threshold as two parameters defining an array of generalized benefit functions, and we show that in a structured population there exist intermediate values of both at which the collective contributions are maximal. However, as the cost-to-benefit ratio of cooperation increases the characteristic threshold decreases, while the corresponding steepness increases. Our observations remain valid if more complex sigmoid functions are used, thus reenforcing the importance of carefully adjusted benefits for high levels of public cooperation.Comment: 8 two-column pages, 8 figures; accepted for publication in Physical Review

Correlation of Positive and Negative Reciprocity Fails to Confer an Evolutionary Advantage: Phase Transitions to Elementary Strategies

Economic experiments reveal that humans value cooperation and fairness. Punishing unfair behavior is therefore common, and according to the theory of strong reciprocity, it is also directly related to rewarding cooperative behavior. However, empirical data fail to confirm that positive and negative reciprocity are correlated. Inspired by this disagreement, we determine whether the combined application of reward and punishment is evolutionarily advantageous. We study a spatial public goods game, where in addition to the three elementary strategies of defection, rewarding, and punishment, a fourth strategy that combines the latter two competes for space. We find rich dynamical behavior that gives rise to intricate phase diagrams where continuous and discontinuous phase transitions occur in succession. Indirect territorial competition, spontaneous emergence of cyclic dominance, as well as divergent fluctuations of oscillations that terminate in an absorbing phase are observed. Yet, despite the high complexity of solutions, the combined strategy can survive only in very narrow and unrealistic parameter regions. Elementary strategies, either in pure or mixed phases, are much more common and likely to prevail. Our results highlight the importance of patterns and structure in human cooperation, which should be considered in future experiments

The Hawkins\Brown emission reduction tool

It is now globally accepted that human activity has caused rapid climate change, and the built environment is one of the biggest contributors to carbon emissions worldwide. There are primarily two ways in which the built environment generates carbon emissions: from energy used during operation (operational carbon) and from the materials used for building and maintenance (embodied carbon). While the industry is increasingly interrogating operational carbon, embodied carbon has historically been less understood. In 2012, Hawkins\Brown and the University College London Institute for Environmental Design and Engineering agreed to co-fund a doctoral project seeking to improve the visualisation of embodied carbon and its impact on the whole life carbon (WLC) of a project. One output of this research was the Hawkins Brown Emissions Reduction Tool (H\B:ERT), a BIM-based tool for rapid reporting and visualisation of embodied carbon in buildings. This paper outlines the tool's development and initial lessons learned from its use at Hawkins\Brown. H\B:ERT v1 measures embodied carbon. As it is available for free from the Hawkins\Brown website, it has contributed to the rapid rise in discussion and dissemination of information about embodied carbon and the contribution it plays in overall emissions. Version 2, which additionally measures WLC, has been fully integrated into the Hawkins\Brown design and BIM processes allowing consideration of WLC emissions from the earliest design stages alongside more traditional design drivers. The paper concludes by outlining how the tool can develop and what regulatory frameworks are required to ensure WLC decision-making becomes the standard method of approaching building and infrastructure design

Conditional strategies and the evolution of cooperation in spatial public goods games

The fact that individuals will most likely behave differently in different situations begets the introduction of conditional strategies. Inspired by this, we study the evolution of cooperation in the spatial public goods game, where besides unconditional cooperators and defectors, also different types of conditional cooperators compete for space. Conditional cooperators will contribute to the public good only if other players within the group are likely to cooperate as well, but will withhold their contribution otherwise. Depending on the number of other cooperators that are required to elicit cooperation of a conditional cooperator, the latter can be classified in as many types as there are players within each group. We find that the most cautious cooperators, such that require all other players within a group to be conditional cooperators, are the undisputed victors of the evolutionary process, even at very low synergy factors. We show that the remarkable promotion of cooperation is due primarily to the spontaneous emergence of quarantining of defectors, which become surrounded by conditional cooperators and are forced into isolated convex "bubbles" from where they are unable to exploit the public good. This phenomenon can be observed only in structured populations, thus adding to the relevance of pattern formation for the successful evolution of cooperation.Comment: 7 two-column pages, 7 figures; accepted for publication in Physical Review

Search for a T-odd, P-even Triple Correlation in Neutron Decay

Background: Time-reversal-invariance violation, or equivalently CP violation, may explain the observed cosmological baryon asymmetry as well as signal physics beyond the Standard Model. In the decay of polarized neutrons, the triple correlation D\cdot(p_{e}\timesp_{\nu}) is a parity-even, time-reversal- odd observable that is uniquely sensitive to the relative phase of the axial-vector amplitude with respect to the vector amplitude. The triple correlation is also sensitive to possible contributions from scalar and tensor amplitudes. Final-state effects also contribute to D at the level of 1e-5 and can be calculated with a precision of 1% or better. Purpose: We have improved the sensitivity to T-odd, P-even interactions in nuclear beta decay. Methods: We measured proton-electron coincidences from decays of longitudinally polarized neutrons with a highly symmetric detector array designed to cancel the time-reversal-even, parity-odd Standard-Model contributions to polarized neutron decay. Over 300 million proton-electron coincidence events were used to extract D and study systematic effects in a blind analysis. Results: We find D = [-0.94\pm1.89(stat)\pm0.97(sys)]e-4. Conclusions: This is the most sensitive measurement of D in nuclear beta decay. Our result can be interpreted as a measurement of the phase of the ratio of the axial-vector and vector coupling constants (CA/CV= |{\lambda}|exp(i{\phi}_AV)) with {\phi}_AV = 180.012{\deg} \pm0.028{\deg} (68% confidence level) or to constrain time-reversal violating scalar and tensor interactions that arise in certain extensions to the Standard Model such as leptoquarks. This paper presents details of the experiment, analysis, and systematic- error corrections.Comment: 21 pages, 22 figure

Posttranslational processing of concanavalin A precursors in jackbean cotyledons

Metabolic labeling of immature jackbean cotyledons with 14C-amino acids was used to determine the processing steps involved in the assembly of concanavalin A. Pulse-chase experiments and analyses of immunoprecipitated lectin forms indicated a complex series of events involving seven distinct species. The structural relatedness of all of the intermediate species was confirmed by two-dimensional mapping of 125I-tryptic peptides. An initial glycosylated precursor was deglycosylated and cleaved into smaller polypeptides, which subsequently reannealed over a period of 10-27 h. NH2-terminal sequencing of the abundant precursors confirmed that the intact subunit of concanavalin A was formed by the reannealing of two fragments, since the alignment of residues 1-118 and 119-237 was reversed in the final form of the lectin identified in the chase and the precursor first labeled. When the tissue was pulse-chased in the presence of monensin, processing of the glycosylated precursor was inhibited. The weak bases NH4Cl and chloroquine were without effect. Immunocytochemical studies showed that monensin treatment caused the accumulation of immunoreactive material at the cell surface and indicated that the ionophore had induced the secretion of a component normally destined for deposition within the protein bodies. Consideration of the tertiary structure of the glycosylated precursor and mature lectin showed that the entire series of processing events could occur without significant refolding of the initial translational product. Proteolytic events included removal of a peptide from the surface of the precursor molecule that connected the NH2- and COOH-termini of the mature protein. This processing activated the carbohydrate-binding activity of the lectin. The chase data suggest the occurrence of a simultaneous cleavage and formation of a peptide bond, raising the possibility that annealment of the fragments to give rise to the mature subunit involves a transpeptidation event rather than cleavage and subsequent religation