18 research outputs found
Analysis of atomic-clock data to constrain variations of fundamental constants
We present a new framework to study the time variation of fundamental
constants in a model-independent way. Model independence implies more free
parameters than assumed in previous studies. Using data from atomic clocks
based on Sr, Yb and Cs, we set bounds on parameters
controlling the variation of the fine-structure constant, , and the
electron-to-proton mass ratio, . We consider variations on timescales
ranging from a minute to almost a day. In addition, we use our results to
derive some of the tightest limits to date on the parameter space of models of
ultralight dark matter and axion-like particles
4. TITLE AND SUBTITLE Lithium Gadolinium Borate in Plastic Scintillator as an Antineutrino Detection Material
Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instruction, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden, t
Multifunctional human monoclonal antibody combination mediates protection against Rift Valley fever virus at low doses
Abstract The zoonotic Rift Valley fever virus (RVFV) can cause severe disease in humans and has pandemic potential, yet no approved vaccine or therapy exists. Here we describe a dual-mechanism human monoclonal antibody (mAb) combination against RVFV that is effective at minimal doses in a lethal mouse model of infection. We structurally analyze and characterize the binding mode of a prototypical potent Gn domain-A-binding antibody that blocks attachment and of an antibody that inhibits infection by abrogating the fusion process as previously determined. Surprisingly, the Gn domain-A antibody does not directly block RVFV Gn interaction with the host receptor low density lipoprotein receptor-related protein 1 (LRP1) as determined by a competitive assay. This study identifies a rationally designed combination of human mAbs deserving of future investigation for use in humans against RVFV infection. Using a two-pronged mechanistic approach, we demonstrate the potent efficacy of a rationally designed combination mAb therapeutic
Analysis of atomic-clock data to constrain variations of fundamental constants
We present a new framework to study the time variation of fundamental constants in a model-independent way. Model independence implies more free parameters than assumed in previous studies. Using data from atomic clocks based on ^87 Sr, ^171 Yb ^+ and ^133 Cs, we set bounds on parameters controlling the variation of the fine-structure constant, α , and the electron-to-proton mass ratio, µ . We consider variations on timescales ranging from a minute to almost a day. In addition, we use our results to derive some of the tightest limits to date on the parameter space of models of ultralight dark matter and axion-like particles