18 research outputs found

    Analysis of atomic-clock data to constrain variations of fundamental constants

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    We present a new framework to study the time variation of fundamental constants in a model-independent way. Model independence implies more free parameters than assumed in previous studies. Using data from atomic clocks based on 87^{87}Sr, 171^{171}Yb+^+ and 133^{133}Cs, we set bounds on parameters controlling the variation of the fine-structure constant, α\alpha, and the electron-to-proton mass ratio, μ\mu. We consider variations on timescales ranging from a minute to almost a day. In addition, we use our results to derive some of the tightest limits to date on the parameter space of models of ultralight dark matter and axion-like particles

    4. TITLE AND SUBTITLE Lithium Gadolinium Borate in Plastic Scintillator as an Antineutrino Detection Material

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    Multifunctional human monoclonal antibody combination mediates protection against Rift Valley fever virus at low doses

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    Abstract The zoonotic Rift Valley fever virus (RVFV) can cause severe disease in humans and has pandemic potential, yet no approved vaccine or therapy exists. Here we describe a dual-mechanism human monoclonal antibody (mAb) combination against RVFV that is effective at minimal doses in a lethal mouse model of infection. We structurally analyze and characterize the binding mode of a prototypical potent Gn domain-A-binding antibody that blocks attachment and of an antibody that inhibits infection by abrogating the fusion process as previously determined. Surprisingly, the Gn domain-A antibody does not directly block RVFV Gn interaction with the host receptor low density lipoprotein receptor-related protein 1 (LRP1) as determined by a competitive assay. This study identifies a rationally designed combination of human mAbs deserving of future investigation for use in humans against RVFV infection. Using a two-pronged mechanistic approach, we demonstrate the potent efficacy of a rationally designed combination mAb therapeutic

    Analysis of atomic-clock data to constrain variations of fundamental constants

    No full text
    We present a new framework to study the time variation of fundamental constants in a model-independent way. Model independence implies more free parameters than assumed in previous studies. Using data from atomic clocks based on ^87 Sr, ^171 Yb ^+ and ^133 Cs, we set bounds on parameters controlling the variation of the fine-structure constant, α , and the electron-to-proton mass ratio, µ . We consider variations on timescales ranging from a minute to almost a day. In addition, we use our results to derive some of the tightest limits to date on the parameter space of models of ultralight dark matter and axion-like particles
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