[Tamoxifen in the adjuvant setting for breast cancer: Reflexions about the risk of uterine carcinosarcoma]

International audienceA descriptive analysis of available data on reported cases of uterine carcinosarcomas associated with tamoxifen therapy is undertaken. The role of aromatase inhibitors as alternative to tamoxifen therapy in the adjuvant setting of breast cancer is discussed. The eventual implications of the presumed association of uterine carcinosarcoma and tamoxifen therapy on the choice of the therapeutic agent in the adjuvant setting of hormone-sensitive breast cancer are discussed

[Radiation-induced breast angiosarcoma following breast-conserving therapy. Report of two cases]

International audienceBreast angiosarcoma is a rare but serious complication of radiotherapy. We report two cases of radiation-induced breast angiosarcoma in two patients having benefited from breast conserving surgery with radiation. We shall put emphasis on the etiopathogeny of these tumours and their clinical and therapeutic aspects

[Uterine carcinosarcomas associated with tamoxifen therapy. Report of two cases and review of the literature]

International audienceCarcinosarcomas are rare uterine cancers and carry poor prognosis. Although these tumours usually arise de novo, some cases developed under tamoxifen therapy have been reported. We report two more cases of uterine carcinosarcoma occurring in two postmenopausal patients benefiting from tamoxifen therapy as adjuvant treatment of breast cancer. A review of the literature is undertaken

[Spontaneous rupture of the unscarred uterus during labor. Case report]

International audienceWe report a case of spontaneous uterine rupture in a 19 year-old patient Gravida 1 para 2 with no past history of uterine surgery. The diagnosis of uterine rupture, evoked in the early post-partum in the presence of acute abdominal pain, collapsus and haemoperitoneum on ultrasonography, was confirmed by laparotomy. Treatment consisted in hysterorrhaphy. The etiopathogenesis, clinical and therapeutical aspects of spontaneous unscarred uterine ruptures are discussed throughout a literature review

Feasibility of two-dimensional ultrasound shear wave elastography of human fetal lungs and liver: A pilot study

International audiencePurpose: The first aim was to evaluate feasibility and reproducibility of 2-dimensional ultrasound (2D) shear wave elastography (SWE) of human fetal lungs and liver between 24 and 34weeks of gestation. The second aim was to model fetal lung-to-liver elastography ratio (LLE ratio) and to assess its variations according to gestational age and maternal administration of corticosteroids.Material and methods: 2D-SWE examinations were prospectively performed in fetuses of women with an uncomplicated pregnancy (group 1) and fetuses of women with a threatened preterm labor requiring administration of corticosteroids (group 2). Two 2D-SWE examinations were performed at "day 0" and "day 2" in group 1; before and 24hours after a course of corticosteroid in group 2. Three operators performed 2 cycles of 3 measurements on the lung (regions A1, A2, A3) and the liver (regions IV, V, VI). Repeatability and reproducibility of measurements were calculated. The fetal LLE ratio was modeled from the most reproducible regions.Results: Fifty-five women were enrolled in group 1 and 48 in group 2. For the lung, 8.6% of measurements were considered invalid and 6.9% for the liver. The most reproducible region for the lung was A3 [ICC between 0.70 (95% CI: 0.42-0.85) and 0.78 (95% CI: 0.48-0.90)] and region VI for the liver [ICC between 0.70 (95% CI: 0.40-0.85) and 0.84 (95% CI: 0.60-0.94)]. According to gestational age, a moderate positive linear correlation was found for stiffness values of A3 (R=0.56), V (R=0.46) and VI (R=0.44). LLE ratio values at "day 0" were not different between the two groups but decreased at "day 2" in group 2 (0.2; 95% CI: 0.07-0.34; P<0.001).Conclusion: Quantitative fetal lung and liver stiffness measurements are possible with 2D-SWE with acceptable reproducibility

Preliminary results obtained with the ZEUS phasing sensor within the APE experiment

International audienceIn the framework of the Active Phasing Experiment (APE), four different phasing techniques are tested. The ZErnike Unit for Segment phasing sensor (ZEUS) is integrated on the APE bench. APE has been tested in the laboratory before it will be installed on one of the Nasmyth platform of a Very Large Telescope (VLT) Unit Telescope to perform on sky tests. The ZEUS phasing sensor concept has its origins in the Mach-Zehnder interferometer equipped with a spatial filter in its focal plane. In this paper, the ZEUS phasing sensor is described together with its theoretical background and deployment within the APE experiment. The algorithms and its elements used to reconstruct the wavefront are described. Finally, the preliminary results obtained in the laboratory are presented

Active Phasing Experiment: preliminary results and prospects

International audienceThe purpose of the Active Phasing Experiment, designed under the lead of ESO, is to study new phasing technologies and to validate wavefront control concepts for Extremely Large Telescopes. The Active Phasing Experiment is currently tested in the laboratory at the ESO headquarters and will be tested on sky at a Nasmyth focus of a VLT unit telescope at the end of 2008. The test bench contains four different phasing sensors which are tested in parallel to compare them under the same conditions. They have been developed by Istituto Nazionale di Astrofisica in Florenze, Instituto Astrofisica Canarias in Tenerife, Laboratoire d'Astrophysique de Marseille and ESO. It includes also an Active Segmented Mirror which simulates the segmentation of a primary mirror. A non-contact optical metrology has been developed by Fogale Nanotech to control it. The VLT focus and the VLT atmospheric conditions are simulated in the laboratory with a turbulence generator producing a seeing between 0.45 and 0.85 arcsec. Once installed on a VLT unit telescope, the control system of the Active Phasing Experiment will be able to control the phasing of the ASM, but also the guiding and the active optics of the VLT. This proceeding gives a brief summary of the opto-mechanical aspects of the Active Phasing experiment, describes its control system and gives an analysis of the preliminary results obtained in the laboratory