230 research outputs found
Bootbandit: A macOS Bootloader Attack
Full disk encryption (FDE) is used to protect a computer system against data theft by physical access. If a laptop or hard disk drive protected with FDE is stolen or lost, the data remains unreadable without the encryption key. To foil this defense, an intruder can gain physical access to a computer system in a so-called âevil maidâ attack, install malware in the boot (pre-operating system) environment, and use the malware to intercept the victimâs password. Such an attack relies on the fact that the system is in a vulnerable state before booting into the operating system. In this paper, we discuss an evil maid type of attack, in which the victimâs password is stolen in the boot environment, passed to the macOS user environment, and then exfiltrated from the system to the attackerâs remote command and control server. On a macOS system, this attack has additional implications due to âpassword forwardingâ technology, in which usersâ account passwords also serve as FDE passwords
Mutation in Fas Ligand Impairs Maturation of Thymocytes Bearing Moderate Affinity T Cell Receptors
Fas ligand, best known as a death-inducer, is also a costimulatory molecule required for maximal proliferation of mature antigen-specific CD4+ and CD8+ T cells. We now extend the role of Fas ligand by showing that it can also influence thymocyte development. T cell maturation in some, but not all, strains of TCR transgenic mice is severely impaired in thymocytes expressing mutant Fas ligand incapable of interacting with Fas. Mutant Fas ligand inhibits neither negative selection nor death by neglect. Instead, it appears to modulate positive selection of thymocytes expressing both class Iâ and class IIârestricted T cell receptors of moderate affinity for their positively selecting ligands. Fas ligand is therefore an inducer of death, a costimulator of peripheral T cell activation, and an accessory molecule in positive selection
Recommended from our members
Pd-Catalyzed Aryl CâH Imidation with Arene as the Limiting Reagent
An amine-N-oxide-ligated palladium complex, in conjunction with a silver cocatalyst, catalyzes imidation of arenes by the reagent N-fluorobenzenesulfonimide. The reaction enables imidation of a variety of arenes at or below room temperature, requires no coordinating directing group on the substrate, and gives synthetically useful yields with only 1 equiv of arene. Mechanistic data implicate an unusual mechanism devoid of commonly invoked organometallic intermediates: oxidation of the Pd catalyst occurs as the turnover-limiting step, while CâH bond functionalization occurs subsequently at a high oxidation state of the catalyst.Chemistry and Chemical Biolog
All-photochemical rotation of molecular motors with a phosphorus stereoelement
Unidirectional molecular rotation based on alternating photochemical and thermal isomerizations of overcrowded alkenes is well established, but rotary cycles based purely on photochemical isomerizations are rare. Herein we report three new second-generation molecular motors featuring a phosphorus center in the lower half, which engenders a unique element of axial chirality. These motors exhibit unusual behavior, in that all four diastereomeric states can interconvert solely photochemically. Kinetic analysis and modeling reveal that the behavior of the new motors is consistent with all-photochemical unidirectional rotation. Furthermore, X-ray crystal structures of all four diastereomeric states of two of these new motors were obtained, which constitute the first achievements of crystallographic characterization of the full 360° rotational cycle of overcrowded-alkene-based molecular motors. Finally, the axial phosphorus stereoelement in the phosphine motor can be thermally inverted, and this epimerization enables a âshortcutâ of the traditional rotational cycle of these compounds
Recommended from our members
A Fluoride-Derived Electrophilic Late-Stage Fluorination Reagent for PET Imaging
The unnatural isotope fluorine-18 is used as a positron emitter in molecular imaging. Currently, many potentially useful -labeled probe molecules are inaccessible for imaging because no fluorination chemistry is available to make them. The 110-minute half-life of requires rapid syntheses for which fluoride is the preferred source of fluorine because of its practical access and suitable isotope enrichment. However, conventional fluoride chemistry has been limited to nucleophilic fluorination reactions. We report the development of a palladium-based electrophilic fluorination reagent derived from fluoride and its application to the synthesis of aromatic -labeled molecules via late-stage fluorination. Late-stage fluorination enables the synthesis of conventionally unavailable positron emission tomography (PET) tracers for anticipated applications in pharmaceutical development as well as preclinical and clinical PET imaging.Chemistry and Chemical Biolog
Three-State Switching of an Anthracene Extended Bis-thiaxanthylidene with a Highly Stable Diradical State
A multistable molecular switching system based on an anthracene-extended bis-thiaxanthylidene with three individually addressable states that can be interconverted by electrochemical, thermal, and photochemical reactions is reported. Besides reversible switching between an open-shell diradical- and a closed-shell electronic configuration, our findings include a third dicationic state and control by multiple actuators. This dicationic state with an orthogonal conformation can be switched electrochemically with the neutral open-shell triplet state with orthogonal conformation, which was characterized by EPR. The remarkably stable diradical shows kinetic stability as a result of a significant activation barrier for isomerization to a more stable neutral closed-shell folded geometry. We ascribe this activation barrier of ÎGâĄ(293 K) = 25.7 kcal mol-1 to steric hindrance in the fjord region of the overcrowded alkene structure. The folded closed-shell state can be converted back to the diradical state by irradiation with 385 nm. The folded state can also be oxidized to the dicationic state. These types of molecules with multiple switchable states and in particular stable diradicals show great potential in the design of new functional materials such as memory devices, logic gates, and OFETs. </p
NKAP is required for T cell maturation and acquisition of functional competency
The transcriptional repressor NKAP drives T cell maturation after positive selection in the thymus, with NKAP deficiency resulting in functionally immature peripheral T cells that maintain the phenotype of recent thymic emigrants
Transgenic Bcl-3 slows T cell proliferation
Immunological adjuvants, such as bacterial LPS, increase the mRNA levels of the IkB-related NF-ÎșB transcriptional transactivator, Bcl-3, in activated T cells. Adjuvants also increase the life expectancy of activated T cells, as does over-expression of Bcl-3, suggesting that Bcl-3 is part of the pathway whereby adjuvants affect T cell lifespans. However, previous reports, confirmed here, show that adjuvants also increase the life expectancies of Bcl-3-deficient T cells, making Bcl-3âs role and effects in adjuvant-induced survival uncertain. To investigate the functions of Bcl-3 further, here we confirm the adjuvant-induced expression of Bcl-3 mRNA and show Bcl-3 induction at the protein level. Bcl-3 was expressed in mice via a transgene driven by the human CD2 promoter. Like other protective events, over-expression of Bcl-3 slows T cell activation very early in T cell responses to antigen, both in vitro and in vivo. This property was intrinsic to the T cells over-expressing the Bcl-3 and did not require Bcl-3 expression by other cells such as antigen-presenting cells
A peripheral CD4+ T cell precursor for naive, memory, and regulatory T cells
CD4+ T cells expressing very low amounts of CD44 on their surface act as peripheral precursors of a diverse CD4+ T cell pool
Lipid phosphate phosphatase 3 enables efficient thymic egress
Lipid phosphate phosphatase 3 in endothelial and epithelial cells promotes efficient T cell emigration from the thymus to the periphery
- âŠ