p53 isoforms change p53 paradigm

Although p53 defines cellular responses to cancer treatment it is not clear how p53 can be used to control cell fate outcome. Data demonstrate that so-called p53 does not exist as a single protein, but is in fact a group of p53 protein isoforms whose expression can be manipulated to control the cellular response to treatment

Conformal dimension and random groups

We give a lower and an upper bound for the conformal dimension of the boundaries of certain small cancellation groups. We apply these bounds to the few relator and density models for random groups. This gives generic bounds of the following form, where $l$ is the relator length, going to infinity. (a) 1 + 1/C < \Cdim(\bdry G) < C l / \log(l), for the few relator model, and (b) 1 + l / (C\log(l)) < \Cdim(\bdry G) < C l, for the density model, at densities $d < 1/16$. In particular, for the density model at densities $d < 1/16$, as the relator length $l$ goes to infinity, the random groups will pass through infinitely many different quasi-isometry classes.Comment: 32 pages, 4 figures. v2: Final version. Main result improved to density < 1/16. Many minor improvements. To appear in GAF

Unital quantum operators on the Bloch ball and Bloch region

For one qubit systems, we present a short, elementary argument characterizing unital quantum operators in terms of their action on Bloch vectors. We then show how our approach generalizes to multi-qubit systems, obtaining inequalities that govern when a ``diagonal'' superoperator on the Bloch region is a quantum operator. These inequalities are the n-qubit analogue of the Algoet-Fujiwara conditions. Our work is facilitated by an analysis of operator-sum decompositions in which negative summands are allowed.Comment: Revised and corrected, to appear in Physical Review

Effect of Maturation on Hemodynamic and Autonomic Control Recovery Following Maximal Running Exercise in Highly Trained Young Soccer Players

The purpose of this study was to examine the effect of maturation on post-exercise hemodynamic and autonomic responses. Fifty-five highly trained young male soccer players (12–18 years) classified as pre-, circum-, or post-peak height velocity (PHV) performed a graded running test to exhaustion on a treadmill. Before (Pre) and after (5th–10th min, Post) exercise, heart rate (HR), stroke volume (SV), cardiac output (CO), arterial pressure (AP), and total peripheral resistance (TPR) were monitored. Parasympathetic (high frequency [HFRR] of HR variability (HRV) and baroreflex sensitivity [Ln BRS]) and sympathetic activity (low frequency [LFSAP] of systolic AP variability) were estimated. Post-exercise blood lactate [La]b, the HR recovery (HRR) time constant, and parasympathetic reactivation (time-varying HRV analysis) were assessed. In all three groups, exercise resulted in increased HR, CO, AP, and LFSAP (P < 0.001), decreased SV, HFRR, and Ln BRS (all P < 0.001), and no change in TPR (P = 0.98). There was no “maturation × time” interaction for any of the hemodynamic or autonomic variables (all P > 0.22). After exercise, pre-PHV players displayed lower SV, CO, and [La]b, faster HRR and greater parasympathetic reactivation compared with circum- and post-PHV players. Multiple regression analysis showed that lean muscle mass, [La]b, and Pre parasympathetic activity were the strongest predictors of HRR (r2 = 0.62, P < 0.001). While pre-PHV players displayed a faster HRR and greater post-exercise parasympathetic reactivation, maturation had little influence on the hemodynamic and autonomic responses following maximal running exercise. HRR relates to lean muscle mass, blood acidosis, and intrinsic parasympathetic function, with less evident impact of post-exercise autonomic function

A laser triggered electron source for pulsed radiolysis

We present the design of a photo-injector based accelerator for pulsed radiolysis applications. This machine is destined to meet the needs of the physical chemistry community at the Universite de Paris XI. A 4 MeV Energy electron pulse of a few picoseconds duration and with a charge in the range of 1 to 10 nC is produced from a Cs/sub 2 /Te photocathode. The photocathode is placed in the half energy spread cell of a 1-1/2 cell, 3 GHz RF gun, whose design is based on the gun used for the drive beam of the CERN CLIC Test facility. A 4 cell "booster" cavity is then used to accelerate the beam to an energy of 9 MeV. The transport system consists of a quadrupole triplet downsteam of the booster, two rectangular, 30 degree bend, dipoles with a pair of quadrupoles between them and a second triplet downstream of the second dipole. Energy dependent path length effects in the two dipoles allow the possibility of magnetic bunch compression depending on the phase-energy correlation of the bunch exiting the booster cavity. The beam envelope and the bunch length have been calculated through the transport line using TRACE-3d and PARMELA. These codes allow us to verify the required beam parameters at the experimental areas. We discuss the adjustment of the optics, aimed at producing the minimum electron bunch length at the experimental targets. (4 refs)

Toward systems biology in brown algae to explore acclimation and adaptation to the shore environment.

International audienceBrown algae belong to a phylogenetic lineage distantly related to land plants and animals. They are almost exclusively found in the intertidal zone, a harsh and frequently changing environment where organisms are submitted to marine and terrestrial constraints. In relation with their unique evolutionary history and their habitat, they feature several peculiarities, including at the level of their primary and secondary metabolism. The establishment of Ectocarpus siliculosus as a model organism for brown algae has represented a framework in which several omics techniques have been developed, in particular, to study the response of these organisms to abiotic stresses. With the recent publication of medium to high throughput profiling data, it is now possible to envision integrating observations at the cellular scale to apply systems biology approaches. As a first step, we propose a protocol focusing on integrating heterogeneous knowledge gained on brown algal metabolism. The resulting abstraction of the system will then help understanding how brown algae cope with changes in abiotic parameters within their unique habitat, and to decipher some of the mechanisms underlying their (1) acclimation and (2) adaptation, respectively consequences of (1) the behavior or (2) the topology of the system resulting from the integrative approach

Weighted composition operators on Korenblum type spaces of analytic functions

[EN] We investigate the continuity, compactness and invertibility of weighted composition operators W-psi,W-phi: f -> psi(f circle phi) when they act on the classical Korenblum space A(-infinity) and other related Frechet or (LB)-spaces of analytic functions on the open unit disc which are defined as intersections or unions of weighted Banach spaces with sup-norms. Some results about the spectrum of these operators are presented in case the self-map phi has a fixed point in the unit disc. A precise description of the spectrum is obtained in this case when the operator acts on the Korenblum space.This research was partially supported by the research project MTM2016-76647-P and the grant BES-2017-081200.Gomez-Orts, E. (2020). Weighted composition operators on Korenblum type spaces of analytic functions. Revista de la Real Academia de Ciencias Exactas Físicas y Naturales Serie A Matemáticas. 114(4):1-15. https://doi.org/10.1007/s13398-020-00924-1S1151144Abramovich, Y.A., Aliprantis, C.D.: An invitation to operator theory. Graduate Studies in Mathematics. Amer. Math. Soc., 50 (2002)Albanese, A.A., Bonet, J., Ricker, W.J.: The Cesàro operator in the Fréchet spaces $$\ell ^{p+}$$ and $$L^{p-}$$. Glasgow Math. J. 59, 273–287 (2017)Albanese, A.A., Bonet, J., Ricker, W.J.: The Cesàro operator on Korenblum type spaces of analytic functions. Collect. Math. 69(2), 263–281 (2018)Albanese, A.A., Bonet, J., Ricker, W.J.: Operators on the Fréchet sequence spaces $$ces(p+), 1\le p\le \infty$$. Rev. R. Acad. Cienc. Exactas Fís. Nat. Ser. A Mat. RACSAM 113(2), 1533–1556 (2019)Albanese, A.A., Bonet, J., Ricker, W.J.: Linear operators on the (LB)-sequence spaces $$ces(p-), 1\le p\le \infty$$. Descriptive topology and functional analysis. II, 43–67, Springer Proc. Math. Stat., 286, Springer, Cham (2019)Arendt, W., Chalendar, I., Kumar, M., Srivastava, S.: Powers of composition operators: asymptotic behaviour on Bergman, Dirichlet and Bloch spaces. J. Austral. Math. Soc. 1–32. https://doi.org/10.1017/S1446788719000235Aron, R., Lindström, M.: Spectra of weighted composition operators on weighted Banach spaces of analytic funcions. Israel J. Math. 141, 263–276 (2004)Bierstedt, K.D., Summers, W.H.: Biduals of weighted Banach spaces of analytic functions. J. Austral. Math. Soc., Ser. A, 54(1), 70–79 (1993)Bonet, J.: A note about the spectrum of composition operators induced by a rotation. RACSAM 114, 63 (2020). https://doi.org/10.1007/s13398-020-00788-5Bonet, J., Domański, P., Lindström, M., Taskinen, J.: Composition operators between weighted Banach spaces of analytic functions. J. Austral. Math. Soc., Ser. A, 64(1), 101–118 (1998)Bourdon, P.S.: Essential angular derivatives and maximum growth of Königs eigenfunctions. J. Func. Anal. 160, 561–580 (1998)Bourdon, P.S.: Invertible weighted composition operators. Proc. Am. Math. Soc. 142(1), 289–299 (2014)Carleson, L., Gamelin, T.: Complex Dynamics. Springer, Berlin (1991)Cowen, C., MacCluer, B.: Composition Operators on Spaces of Analytic Functions. CRC Press, Boca Raton, FL (1995)Contreras, M., Hernández-Díaz, A.G.: Weighted composition operators in weighted Banach spacs of analytic functions. J. Austral. Math. Soc., Ser. A 69, 41–60 (2000)Eklund, T., Galindo, P., Lindström, M.: Königs eigenfunction for composition operators on Bloch and $$H^\infty$$ spaces. J. Math. Anal. Appl. 445, 1300–1309 (2017)Hedenmalm, H., Korenblum, B., Zhu, K.: Theory of Bergman Spaces. Grad. Texts in Math. 199. Springer, New York (2000)Jarchow, H.: Locally Convex Spaces. Teubner, Stuttgart (1981)Kamowitz, H.: Compact operators of the form $$uC_{\varphi }$$. Pac. J. Math. 80(1) (1979)Korenblum, B.: An extension of the Nevanlinna theory. Acta Math. 135, 187–219 (1975)Köthe, G.: Topological Vector Spaces II. Springer, New York Inc (1979)Lusky, W.: On the isomorphism classes of weighted spaces of harmonic and holomophic functions. Stud. Math. 75, 19–45 (2006)Meise, R., Vogt, D.: Introduction to functional analysis. Oxford Grad. Texts in Math. 2, New York, (1997)Montes-Rodríguez, A.: Weighted composition operators on weighted Banach spaces of analytic functions. J. Lond. Math. Soc. 61(3), 872–884 (2000)Queffélec, H., Queffélec, M.: Diophantine Approximation and Dirichlet series. Hindustain Book Agency, New Delhi (2013)Shapiro, J.H.: Composition Operators and Classical Function Theory. Springer, New York (1993)Shields, A.L., Williams, D.L.: Bounded projections, duality and multipliers in spaces of analytic functions. Trans. Amer. Math. Soc. 162, 287–302 (1971)Zhu, K.: Operator Theory on Function Spaces, Math. Surveys and Monographs, Amer. Math. Soc. 138 (2007

Childhood acute illness and nutrition (CHAIN) network: A protocol for a multi-site prospective cohort study to identify modifiable risk factors for mortality among acutely ill children in Africa and Asia

Introduction: Children admitted to hospitals in resource-poor settings remain at risk of both inpatient and post-discharge mortality. While known risk factors such as young age and nutritional status can identify children at risk, they do not provide clear mechanistic targets for intervention. The Childhood Acute Illness and Nutrition (CHAIN) cohort study aims to characterise the biomedical and social risk factors for mortality in acutely ill children in hospitals and after discharge to identify targeted interventions to reduce mortality.Methods and analysis: The CHAIN network is currently undertaking a multi-site, prospective, observational cohort study, enrolling children aged 1 week to 2 years at admission to hospitals at nine sites located in four African and two South Asian countries. The CHAIN Network supports the sites to provide care according to national and international guidelines. Enrolment is stratified by anthropometric status and children are followed throughout hospitalisation and for 6 months after discharge. Detailed clinical, demographic, anthropometric, laboratory and social exposures are assessed. Scheduled visits are conducted at 45, 90 and 180 days after discharge. Blood, stool and rectal swabs are collected at enrolment, hospital discharge and follow-up. The primary outcome is inpatient or post-discharge death. Secondary outcomes include readmission to hospital and nutritional status after discharge. Cohort analysis will identify modifiable risks, children with distinct phenotypes, relationships between factors and mechanisms underlying poor outcomes that may be targets for intervention. A nested case-control study examining infectious, immunological, metabolic, nutritional and other biological factors will be undertaken.Ethics and dissemination: This study protocol was reviewed and approved primarily by the Oxford Tropical Research Ethics Committee, and the institutional review boards of all partner sites. The study is being externally monitored. Results will be published in open access peer-reviewed scientific journals and presented to academic and policy stakeholders

Yin and yang, or peas in a pod? Individual-sport versus team-sport athletes and altitude training

The question of whether altitude training can enhance subsequent sea-level performance has been well investigated over many decades. However, research on this topic has focused on athletes from individual or endurance sports, with scant number of studies on team-sport athletes. Questions that need to be answered include whether this type of training may enhance team-sport athlete performance, when success in team-sport is often more based on technical and tactical ability rather than physical capacity per se. This review will contrast and compare athletes from two sports representative of endurance (cycling) and team-sports (soccer). Specifically, we draw on the respective competition schedules, physiological capacities, activity profiles and energetics of each sport to compare the similarities between athletes from these sports and discuss the relative merits of altitude training for these athletes. The application of conventional live-high, train-high; live-high, train-low; and intermittent hypoxic training for team-sport athletes in the context of the above will be presented. When the above points are considered, we will conclude that dependent on resources and training objectives, altitude training can be seen as an attractive proposition to enhance the physical performance of team-sport athletes without the need for an obvious increase in training load