581 research outputs found
Estimating Wind Stress at the Ocean Surface From Scatterometer Observations
Abstract—Wind stress is the most important ocean forcing for driving tropical surface currents. Stress can be estimated from scatterometer-reported wind measurements at 10 m that have been extrapolated to the surface, assuming a neutrally stable atmosphere and no surface current. Scatterometer calibration is designed to account for the assumption of neutral stability; however, the assumption of a particular sea state and negligible current often introduces an error in wind stress estimations. Since the fundamental scatterometer measurement is of the surface radar backscatter (sigma-0) which is related to surface roughness and, thus, stress, we develop a method to estimate wind stress directly from the scatterometer measurements of sigma-0 and their associated azimuth angle and incidence angle using a neural network approach. We compare the results with in situ estimations and observe that the wind stress estimations from this approach are more accurate compared with those obtained from the conventional estimations using 10-m-height wind measurements. Index Terms—Atmospheric stability, neutral stability, scatterometer, wind stress. I
Restenosis and its determinants in first and repeat coronary angioplasty
Restenosis is the main problem limiting long-term success of percutaneous transluminal coronary angioplasty (PTCA) and is most accurately evaluated by follow-up angiography. We compared the primary and long-term results of angioplasty in 268 consecutive patients (293 segments) with first PTCA (PTCA 1, angiographic follow-up 98%) and in 66 patients (76 segments) with repeat PTCA after restenosis (PTCA 2, angiographic follow-up 92%). Forty clinical, angiographic and procedural factors were assessed in relation to outcome. Primary success rate was higher in PTCA 2 (91% vs 67.5%) and major complications were fewer (4.5% vs 16%).Higher inflation pressure (7.9 ± 2.3 vs 6.8 ± 1.8 atm, P70%) after PTCA 1 and after PTC A 2 (27% vs 36%, P = NS) and the mean time to recurrence (4.7 vs 5.3 months, P = NS) were similar. Procedural factors were the main determinants of long-term success in primary PTCA. The restenosis risk was independently related to residual stenosis >45% (P<0.001), variant angina (P<0.05) and multivessel disease (P<0.05) after PTCA 1 and to male sex (P<0.001) and higher inflation pressure (P<0.05) after PTCA 2. Mild to moderate intimal tearing was associated with less restenosis after PTC A 1, but not after PTCA 2. Including 9 patients (10 segments) with a third PTCA, 70% of the 66 patients with repeat PTCA had a successful long-term outcome. Repeat angioplasty should therefore be considered as an integral part of PTCA therapy. Restenosis however remains a major concern. An optimal primary result with a minimal residual stenosis is decisive for first PTCA, whereas avoidance of a dissection by using lower inflation pressure on a restenosis might improve the long-term outcome of repeat PTC
Resting Heart Rate and Metabolic Syndrome in Patients With Diabetes and Coronary Artery Disease in Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Trial
The relation between the metabolic syndrome (MetS) and resting heart rate (rHR) in patients with diabetes and coronary artery disease is unknown. The authors examined the cross-sectional association at baseline between components of the MetS and rHR and between rHR and left ventricular ejection fraction in the population from the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) randomized clinical trial. The mean rHR in the MetS group was significantly higher than in those without (68.4±12.3 vs 65.6±11.8 beats per min, P=.0017). The rHR was higher (P<.001 for trend) with increasing number of components for MetS. Linear regression analyses demonstrated that as compared to individuals without MetS, rHR was significantly higher in participants with MetS (regression coefficient, 2.9; P=.0015). In patients with type 2 diabetes and coronary artery disease, the presence of higher rHR is associated with increasing number of criteria of MetS and the presence of ventricular dysfunction.Prev Cardiol. 2010;13:112–116. © 2009 Wiley Periodicals, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/79383/1/j.1751-7141.2010.00067.x.pd
Networks of nonlinear superconducting transmission line resonators
We investigate a network of coupled superconducting transmission line
resonators, each of them made nonlinear with a capacitively shunted Josephson
junction coupling to the odd flux modes of the resonator. The resulting
eigenmode spectrum shows anticrossings between the plasma mode of the shunted
junction and the odd resonator modes. Notably, we find that the combined device
can inherit the complete nonlinearity of the junction, allowing for a
description as a harmonic oscillator with a Kerr nonlinearity. Using a dc SQUID
instead of a single junction, the nonlinearity can be tuned between 10 kHz and
4 MHz while maintaining resonance frequencies of a few gigahertz for realistic
device parameters. An array of such nonlinear resonators can be considered a
scalable superconducting quantum simulator for a Bose-Hubbard Hamiltonian. The
device would be capable of accessing the strongly correlated regime and be
particularly well suited for investigating quantum many-body dynamics of
interacting particles under the influence of drive and dissipation.Comment: 18 pages, 3 figure
UK Housing Market: Time Series Processes with Independent and Identically Distributed Residuals
The paper examines whether a univariate data generating process can be identified which explains the data by having residuals that are independent and identically distributed, as verified by the BDS test. The stationary first differenced natural log quarterly house price index is regressed, initially with a constant variance and then with a conditional variance. The only regression function that produces independent and identically distributed standardised residuals is a mean process based on a pure random walk format with Exponential GARCH in mean for the conditional variance. There is an indication of an asymmetric volatility feedback effect but higher frequency data is required to confirm this. There could be scope for forecasting the index but this is tempered by the reduction in the power of the BDS test if there is a non-linear conditional variance process
Beyond the Jaynes-Cummings model: circuit QED in the ultrastrong coupling regime
In cavity quantum electrodynamics (QED), light-matter interaction is probed
at its most fundamental level, where individual atoms are coupled to single
photons stored in three-dimensional cavities. This unique possibility to
experimentally explore the foundations of quantum physics has greatly evolved
with the advent of circuit QED, where on-chip superconducting qubits and
oscillators play the roles of two-level atoms and cavities, respectively. In
the strong coupling limit, atom and cavity can exchange a photon frequently
before coherence is lost. This important regime has been reached both in cavity
and circuit QED, but the design flexibility and engineering potential of the
latter allowed for increasing the ratio between the atom-cavity coupling rate
and the cavity transition frequency above the percent level. While these
experiments are well described by the renowned Jaynes-Cummings model, novel
physics is expected in the ultrastrong coupling limit. Here, we report on the
first experimental realization of a superconducting circuit QED system in the
ultrastrong coupling limit and present direct evidence for the breakdown of the
Jaynes-Cummings model.Comment: 5 pages, 3 figure
Intra-Host Evolution Analyses in an Immunosuppressed Patient Supports SARS-CoV-2 Viral Reservoir Hypothesis.
Throughout the SARS-CoV-2 pandemic, several variants of concern (VOCs) have been identified, many of which share recurrent mutations in the spike glycoprotein's receptor-binding domain (RBD). This region coincides with known epitopes and can therefore have an impact on immune escape. Protracted infections in immunosuppressed patients have been hypothesized to lead to an enrichment of such mutations and therefore drive evolution towards VOCs. Here, we present the case of an immunosuppressed patient that developed distinct populations with immune escape mutations throughout the course of their infection. Notably, by investigating the co-occurrence of substitutions on individual sequencing reads in the RBD, we found quasispecies harboring mutations that confer resistance to known monoclonal antibodies (mAbs) such as S:E484K and S:E484A. These mutations were acquired without the patient being treated with mAbs nor convalescent sera and without them developing a detectable immune response to the virus. We also provide additional evidence for a viral reservoir based on intra-host phylogenetics, which led to a viral substrain that evolved elsewhere in the patient's body, colonizing their upper respiratory tract (URT). The presence of SARS-CoV-2 viral reservoirs can shed light on protracted infections interspersed with periods where the virus is undetectable, and potential explanations for long-COVID cases
Detection of Extrasolar Planets by Gravitational Microlensing
Gravitational microlensing provides a unique window on the properties and
prevalence of extrasolar planetary systems because of its ability to find
low-mass planets at separations of a few AU. The early evidence from
microlensing indicates that the most common type of exoplanet yet detected are
the so-called "super-Earth" planets of ~10 Earth-masses at a separation of a
few AU from their host stars. The detection of two such planets indicates that
roughly one third of stars have such planets in the separation range 1.5-4 AU,
which is about an order of magnitude larger than the prevalence of gas-giant
planets at these separations. We review the basic physics of the microlensing
method, and show why this method allows the detection of Earth-mass planets at
separations of 2-3 AU with ground-based observations. We explore the conditions
that allow the detection of the planetary host stars and allow measurement of
planetary orbital parameters. Finally, we show that a low-cost, space-based
microlensing survey can provide a comprehensive statistical census of
extrasolar planetary systems with sensitivity down to 0.1 Earth-masses at
separations ranging from 0.5 AU to infinity.Comment: 43 pages. Very similar to chapter 3 of Exoplanets: Detection,
Formation, Properties, Habitability, John Mason, ed. Springer (April 3, 2008
Relative drifts and biases between six ozone limb satellite measurements from the last decade
As part of European Space Agency’s (ESA) climate change initiative, high vertical resolution ozone profiles from three instruments all aboard ESA’s Envisat (GOMOS, MIPAS, SCIAMACHY) and ESA’s third party missions (OSIRIS, SMR, ACE-FTS) are to be combined in order to create an essential climate variable data record for the last decade. A prerequisite before combining data is the examination of differences and drifts between the data sets. In this paper, we present a detailed analysis of ozone profile differences based on pairwise collocated measurements, including the evolution of the differences with time. Such a diagnosis is helpful to identify strengths and weaknesses of each data set that may vary in time and introduce uncertainties in long-term trend estimates. The analysis reveals that the relative drift between the sensors is not statistically significant for most pairs of instruments. The relative drift values can be used to estimate the added uncertainty in physical trends. The added drift uncertainty is estimated at about 3% decade (1σ). Larger differences and variability in the differences are found in the lowermost stratosphere (below 20 km) and in the mesosphere
Progress in operational modeling in support of oil spill response
Following the 2010 Deepwater Horizon accident of a massive blow-out in the Gulf of Mexico, scientists from government, industry, and academia collaborated to advance oil spill modeling and share best practices in model algorithms, parameterizations, and application protocols. This synergy was greatly enhanced by research funded under the Gulf of Mexico Research Initiative (GoMRI), a 10-year enterprise that allowed unprecedented collection of observations and data products, novel experiments, and international collaborations that focused on the Gulf of Mexico, but resulted in the generation of scientific findings and tools of broader value. Operational oil spill modeling greatly benefited from research during the GoMRI decade. This paper provides a comprehensive synthesis of the related scientific advances, remaining challenges, and future outlook. Two main modeling components are discussed: Ocean circulation and oil spill models, to provide details on all attributes that contribute to the success and limitations of the integrated oil spill forecasts. These forecasts are discussed in tandem with uncertainty factors and methods to mitigate them. The paper focuses on operational aspects of oil spill modeling and forecasting, including examples of international operational center practices, observational needs, communication protocols, and promising new methodologies
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