Συμπληρωματικά περί Μακεδόνων κλεφτών και αρματολών

No abstractNo abstrac

Powder preparation and UV absorption properties of selected compositions in the CeO₂-Y₂O₃ system

International audienceSeveral approaches have been investigated to prepare fluorite-type compositions within the (1−x) CeO2 - x YO1.5 system. The optical properties of the resulting modified-ceria materials have been characterized in order to evaluate their potential abilities as inorganic UV absorbers. Diffuse reflectance analyses reveal a strong optical absorption between 390 and 400 nm for all substituted compositions and the spectral selectivities are estimated suitable for the targeted application. Additionally, time resolved microwave conductivity (TRMC) and phenol photodegradation analyses do not indicate any photocalatytic activity for these compositions. Aqueous colloidal suspensions of the Ce0.7Y0.3O1.85 UV absorber have been carried out

Antibiotic Consumption 2017–2022 in 30 Private Hospitals in France: Impact of Antimicrobial Stewardship Tools and COVID-19 Pandemic

Our aim was to determine the impact of antimicrobial stewardship tools (ASTs) and the COVID-19 pandemic on antibiotic consumption (AC). We used the national software Consores® to determine AC in DDD/1000 days of hospitalization from 2017 to 2022 in voluntary private hospitals in France. The ASTs considered were: 1. internal guidelines; 2. the list of antibiotics with restricted access; 3. the presence of an antibiotic referent or 4. an ID specialist; and 5. proof of an annual meeting on antimicrobial resistance. Institutions with dedicated units for COVID-19 patients were specified. In 30 institutions, the total AC varied from (means) 390 to 405 DDD/1000 DH from 2017 to 2022. Fluoroquinolones and amoxicillin/clavulanate consumption decreased from 50 to 36 (p = 0.003) and from 112 to 77 (p = 0.025), respectively, but consumption of piperacillin/tazobactam increased from 9 to 21 (p p p = 0.065) and with an acceleration of piperacillin/tazobactam consumption from 2020 to 2022 (p ≤ 0.003). Antibiotic consumption in 30 private hospitals in France was inversely related to the number of AST. The COVID-19 pandemic was associated with limited impact on AC, but special attention should be paid to piperacillin/tazobactam consumption

Adaptation aux changements climatiques et à l’augmentation du niveau de la mer en zones côtières

La collection d'articles présentée dans ce hors-série est en grande partie issue du colloque « Adaptation aux changements climatiques et à l’augmentation du niveau de la mer en zones côtières : une perspective mondiale » tenu dans le cadre du 82e Congrès de l’Acfas à l'Université Concordia. L'intention du colloque était d'explorer la manière dont les communautés côtières à travers le monde s'adaptent aux problèmes causés par les changements climatiques et l'augmentation du niveau de la mer. Comment est-ce que la vulnérabilité, la résilience et la capacité d'adaptation se déclinent selon les différents contextes ? Comment est-ce que les processus sociaux se comparent d'une étude de cas à l'autre ? Comment est que les différents acteurs, dont les scientifiques, sont capables de relever les défis qui se posent aux communautés et quels sont les freins à une adaptation efficace ? Ce hors-série amène ainsi la lectrice et le lecteur dans un voyage à travers le monde, incluant Madagascar, le Vietnam, la France et l'Europe de l'Ouest, le Québec, le Nouveau-Brunswick et le monde virtuel du web

Analysis of LMNB1 Duplications in Autosomal Dominant Leukodystrophy Provides Insights into Duplication Mechanisms and Allele-Specific Expression

Autosomal dominant leukodystrophy (ADLD) is an adult onset demyelinating disorder that is caused by duplications of the lamin B1 (LMNB1) gene. However, as only a few cases have been analyzed in detail, the mechanisms underlying LMNB1 duplications are unclear. We report the detailed molecular analysis of the largest collection of ADLD families studied, to date. We have identified the minimal duplicated region necessary for the disease, defined all the duplication junctions at the nucleotide level and identified the first inverted LMNB1 duplication. We have demonstrated that the duplications are not recurrent; patients with identical duplications share the same haplotype, likely inherited from a common founder and that the duplications originated from intrachromosomal events. The duplication junction sequences indicated that nonhomologous end joining or replication-based mechanisms such fork stalling and template switching or microhomology-mediated break induced repair are likely to be involved. LMNB1 expression was increased in patients’ fibroblasts both at mRNA and protein levels and the three LMNB1 alleles in ADLD patients show equal expression, suggesting that regulatory regions are maintained within the rearranged segment. These results have allowed us to elucidate duplication mechanisms and provide insights into allele-specific LMNB1 expression levels

L'éducation dans le monde

Dans son dernier numéro, la Revue internationale d’éducation de Sèvres éditée par le Centre international d’études pédagogiques rend compte des « Rencontres internationales » organisées au CIEP en avril 2005 à l’occasion du 10e anniversaire de la Revue. Celles-ci ont réuni 120 experts français et étrangers autour des grandes problématiques éducatives qui parcourent, quels que soient les pays et les thèmes abordés, l’ensemble des articles publiés depuis dix ans par la Revue. >>Lire la suite