Theory, reality, and possibilities for a digital/communicative socialist network society

Digital capitalism is guided by the organising principles of digital automation, information processing, and communication. It rests on the consolidation of relations of exploitation of digital labour based on flexibility and generating precarity. It makes profit from user data under conditions of surveillance. What would an alternative paradigm look like? This paper aims to sketch a possible socialist society resting on digital technology but organised on a different logic, namely that of autonomous production, leisure, and social engagement. It draws on relevant theories of the Left, evaluates them against the reality of digital capitalism, and suggests structural and user practice alternatives that can pave the way towards a digital/communicative socialism. This paper engages with the works of Czech philosopher Radovan Richta (1924-1983) and Austrian-French philosopher André Gorz (1923-2007). It shows that their ideas on the scientific and technological revolution and post-industrial socialism are highly relevant for the analysis and discussion of digital/communicative socialism

The state and the development of an information society: Greek policy and experience

The paper looks into the dynamics of information society policy and its implementation in the Greek context. It argues that information society development is a contested process, influenced by pre-existing state, economy and society relations. Based on this, it looks into the different aspects of the idiosyncratic path which the evolution of the Greek information society has followed, particularly after 2000. Using Bob Jessop's strategic-relational approach (SRA) to the state as an analytical framework and drawing on a number of in-depth interviews with relevant political actors, it provides insights into policy implementation by examining: the public management of information technology projects, how such projects were received in bureaucratic structures and practices, as well as the relationship between the state and the information and communication technology (ICT) sector in public procurement processes. The emphasis is on the period 2000–2008, during which a major operational programme on the information society in Greece was put into effect. The paper also touches upon the post-2008 experience, suggesting that information society developments might include dynamics operating independently and even in contradiction to the state agenda

Media Policy and Independent Journalism in Greece

Today, Greece is the European Union member state where journalism and the media face their most acute crisis. This study identifies the urgent problems facing media policy in Greece and how they affect independent journalism. Since the 1980s and ’90s, deregulation has increased the viewing choices for audiences in Greece. At the same time, the legal and regulatory framework has helped concentrate ownership of press, television, and radio outlets. Private channels operate with temporary licenses and independent regulatory authorities function superficially and ambivalently. As a result, the market has been dominated by a handful of powerful newspaper interests, which have expanded into audiovisual and online media. Recent laws have further liberalized media ownership and cross-ownership. Media Policy and Independent Journalism in Greece, based partly on in-depth interviews with key actors, explores these issues and more in this six-chapter report

Community Networks and Sustainability: a Survey of Perceptions, Practices, and Proposed Solutions

Community network (CN) initiatives have been around for roughly two decades, evangelizing a distinctly different paradigm for building, maintaining, and sharing network infrastructure but also defending the basic human right to Internet access. Over this time they have evolved into a mosaic of systems that vary widely with respect to their network technologies, their offered services, their organizational structure, and the way they position themselves in the overall telecommunications’ ecosystem. Common to all these highly differentiated initiatives is the sustainability challenge. We approach sustainability as a broad term with an economical, political, and cultural context. We first review the different perceptions of the term. These vary both across and within the different types of stakeholders involved in CNs and are reflected in their motivation to join such initiatives. Then, we study the diverse approaches of CN operators towards the sustainability goal. Given the rich context of the term, these range all the way from mechanisms to fund their activities, to organizational structures and social activities serving as incentives for the engagement of their members. We iterate on incentive mechanisms that have been proposed and theoretically analyzed in the literature for CNs as well as tools and processes that have been actually implemented in them. Finally, we enumerate lessons that have been learned out of these two decades of CNs’ operation and discuss additional technological and regulatory issues that are key to their longer-term sustainability

Alternative digital journalism in Greece under conditions of austerity

This chapter investigates how alternative digital journalism operates in the broader context of the austerity economy in Greece. Using as a background the historical interweaving of interests between economic power, political power and media, the chapter explores the current state of digital journalism in Greece and whether it can flourish and serve the ideals of independence, objectivity and pluralism. The internet provides new possibilities for pluralism in journalism and gives rise to alternative media outlets that purport objectivity and independence from vested economic interests (e.g. advertising) and political pressures. However, the financial sustainability of such ventures is questionable and the regulatory framework in a heavily concentrated Greek media ecology weak or non-existing. In this chapter we examine the origins and mission statements of selected cases of alternative digital media outlets/projects, as well as their financing sources and business models. We then discuss sustainability issues and the limits to alternative digital journalism. Our empirical data derive from desktop research, short structured interviews with academics and longer semi-structured interviews with key actors of alternative digital media

Alternative digital journalism in Greece under conditions of austerity

This chapter investigates how alternative digital journalism operates in the broader context of the austerity economy in Greece. Using as a background the historical interweaving of interests between economic power, political power and media, the chapter explores the current state of digital journalism in Greece and whether it can flourish and serve the ideals of independence, objectivity and pluralism. The internet provides new possibilities for pluralism in journalism and gives rise to alternative media outlets that purport objectivity and independence from vested economic interests (e.g. advertising) and political pressures. However, the financial sustainability of such ventures is questionable and the regulatory framework in a heavily concentrated Greek media ecology weak or non-existing. In this chapter we examine the origins and mission statements of selected cases of alternative digital media outlets/projects, as well as their financing sources and business models. We then discuss sustainability issues and the limits to alternative digital journalism. Our empirical data derive from desktop research, short structured interviews with academics and longer semistructured interviews with key actors of alternative digital media

Cytoscape Automation: empowering workflow-based network analysis

Cytoscape is one of the most successful network biology analysis and visualization tools, but because of its interactive nature, its role in creating reproducible, scalable, and novel workflows has been limited. We describe Cytoscape Automation (CA), which marries Cytoscape to highly productive workflow systems, for example, Python/R in Jupyter/RStudio. We expose over 270 Cytoscape core functions and 34 Cytoscape apps as REST-callable functions with standardized JSON interfaces backed by Swagger documentation. Independent projects to create and publish Python/R native CA interface libraries have reached an advanced stage, and a number of automation workflows are already published

Circular RNAs in the ageing African turquoise killifish

CircRNAs are a subgroup of RNAs which form a circular molecule. During the splicing process the 3’ splice donor loops back to form a covalent bond with an upstream 5’ splice acceptor instead of the downstream 5’ acceptor. The majority of circRNAs are non-coding splice isoforms of protein coding genes showing tissue and time specific expression. Because circRNAs have no 5’ cap nor 3’ poly-A tail, they degrade slower than their linear host genes. Only few studies were able to show a specific function for circRNAs.In this work we sequenced 23 samples from three tissues (brain, muscle, and gut) at three (two for gut) time points throughout the life of the naturally short-lived African turquoise killifish (Nothobranchius furzeri). We identified 1810 unique circRNAs, half of which are conserved with humans and mice. With this study we provide a comprehensive atlas to the circRNA landscape in the ageing African turquoise killifish, which serves as a novel resource to the circRNA as well as the ageing community

The regulatory interaction of EVI1 with the TCL1A oncogene impacts cell survival and clinical outcome in CLL

Dysregulated T-cell leukemia/lymphoma-1A (TCL1A), a modulator in B-cell receptor (BCR) signaling, is causally implicated in chronic lymphocytic leukemia (CLL). However, the mechanisms of the perturbed TCL1A regulation are largely unknown. To characterize TCL1A-upstream networks, we functionally screened for TCL1A-repressive micro-RNAs (miRs) and their transcriptional regulators. We identified the novel miR-484 to target TCL1A's 3'-UTR and to be downregulated in CLL. In chromatin immunoprecipitations and reporter assays, the oncogenic transcription factor of myeloid cells, EVI1, bound and activated the miR-484 promoter. Most common in CLL was a pan-EVI1 transcript variant. EVI1 protein expression revealed distinct normal-tissue and leukemia-associated patterns of EVI1/TCL1A co-regulation. EVI1 levels were particularly low in TCL1A-high CLL or such cellular subsets. Global gene expression profiles from a 337-patient set linked EVI1 networks to BCR signaling and cell survival via TCL1A, BTK and other molecules of relevance in CLL. Enforced EVI1, as did miR-484, repressed TCL1A. Furthermore, it reduced phospho-kinase levels, impaired cell survival, mitigated BCR-induced Ca-flux and diminished the in vitro ibrutinib response. Moreover, TCL1A and EVI1 showed a strongly interactive hazard prediction in prospectively treated patients. Overall, we present regressive EVI1 as a novel regulatory signature in CLL. Through enhanced TCL1A and other EVI1-targeted hallmarks of CLL, this contributes to an aggressive cellular and clinical phenotype