A case report of a huge congenital granular cell epulis operated under local anesthesia

Congenital granular cell epulis (CGCE) is a very rare benign soft tissue lesion of the neonate, it most frequently located on the anterior maxillary alveolar ridge. It has a female predilection. It is a tumor with no tendency to recur after excision. The exact histogenesis of this tumor remains unresolved and it may be hamartomata.Key words: Congenital granular cell tumor, gingival tumor, newborn, local anesthesi

Cervical hibernoma in a two year old boy

Hibernomas are uncommon benign soft tissue tumours mimicking brown fat. They are mostly seen in the fourth and fifth decades of life. Only few cases in the cervical area have been reported. Because of its rarity in pediatrics and diffcult diagnosis, we report a tow year-old patient with a cervical tumor. Ultrasound and computed tomography exams showed an infiltrative, with hypervascular and lipomatous features. After tumor excision,   histopathological exam confirmed the diagnosis of hibernoma or brown fat tumor. This presentation describes the characteristics of this type of tumor, rare in children

Kyste hydatique pulmonaire chez l’enfant traité par thoracoscopie: huit ans d’expérience

L'échinococcose kystique est une pathologie fréquente en zone d'endémie: pourtour méditerranéen, Afrique de l'est et l'Amérique du Sud. L'hydatidose reste à l'heure actuelle un problème majeur de santé publique. Notre travail consiste en une étude rétrospective de 27 malades opérés pour kyste hydatique pulmonaire (KHP) par thoracoscopie, au service de chirurgie pédiatrique du centre hospitalier universitaire HASSAN II à Fès, sur une période de huit ans allant de janvier 2004 au décembre 2011.Key words: Kyste hydatique, thoracoscopie, enfant, Maro

Le tératome cervical: A propos de 2 cas

Le tératome est une tumeur embryonnaire généralement localisé au niveau sacro-coccygien. La localisation cervicale est rare, et ne représente que3%, elle est associée à un fort taux de mortalité arrivant jusqu’à 80 % à la période néonatale du fait de l’obstruction des voies aériennes.L’immaturité n’est pas un signe de malignité quand la tumeur est prise en charge à la période néonatale. Nous rapportons 2 cas colligés au servicede chirurgie pédiatrique du CHU HASSAN II de Fès, en mettant en relief qu’il existe encore un manque de diagnostic anténatal, malgrél’amélioration de la prise en charge des nouveaux nés.Key words: Tératome cervical géant, nouveau né, chirurgi

Experimental Investigation of the Free Surface Effect on the Conical Taylor-Couette Flow System

The aim of this work is to highlight the critical thresholds corresponding to the onset of different instabilities considered in the flow between two vertical coaxial cones with and without free surface. The inner cone is rotating and the outer one is maintained at rest. Both cones have the same apex angle Φ =12° giving a constant annular gap δ =d/R1max. The height of the fluid column is H=155mm and It can be progressively decreased for each studied case of the flow system. Two kinds of configurations are studied, small and large gap. The working fluid is assumed as Newtonian and having constant properties like density and viscosity within the range of the required experimental conditions. By means of visualization technique of the flow we have been able to show the different transition modes occurring in the conical flow system according to the aspect ratio and then the induced action of the free surface which introduces a delay in the onset of different instability modes. The obtained results in term of features and stability of the flow are compared to those of Wimmer and Noui-Mehidi

UNE TUMEUR VESICALE RARE : L’ADENOCARCINOME COLLOÏDE PRIMITIF. A PROPOS D’UNE OBSERVATION ET REVUE DE LA LITTERATURE

Primary mucinous adenocarcinoma is a rare bladder’s tumor, accounting for 14,6% of all primary bladder’s adenocarcinomas. Immunohistochemical analysis is important to define the primitive origin of the tumor and to eliminate a dissemination of other adenocarcinomas such as colorectal, prostate and gynecological tract or an urachous degenerescence. The treatment is meanly surgical by radical cystectomy. The prognosis becomes poor. In this observation, we report the case of a 52 year’s old man treated for a bladder’s primary mucinous adenocarcinoma by a radical cystectomiy and enterocystoplasty. He’s still alive after four years.L’adénocarcinome colloïde primitif est une tumeur vésicale rare, représentant 14,6 % de l’ensemble des adénocarcinomes primitifs de vessie. Il siège fréquemment au niveau du dôme de la vessie. L’étude immunohistochimique est capitale pour retenir la nature primitive de la tumeur et éliminer une origine ouraquienne ou une extension prostatique, colorectale ou gynécologique. Le traitement est essentiellement chirurgical dominé par la cystectomie totale. Le pronostic de cette tumeur demeure réservé. Dans cette observation, nous rapportons le cas d’un patient de 51 ans pris en charge pour adénocarcinome colloïde primitif de vessie, traité par cystectomie totale et entérocystoplastie de remplacement. Le recul est de 04 ans

Game theory framework for MAC parameter optimization in energy-delay constrained sensor networks

Optimizing energy consumption and end-to-end (e2e) packet delay in energy-constrained, delay-sensitive wireless sensor networks is a conflicting multiobjective optimization problem. We investigate the problem from a game theory perspective, where the two optimization objectives are considered as game players. The cost model of each player is mapped through a generalized optimization framework onto protocol-specific MAC parameters. From the optimization framework, a game is first defined by the Nash bargaining solution (NBS) to assure energy consumption and e2e delay balancing. Secondy, the Kalai-Smorodinsky bargaining solution (KSBS) is used to find an equal proportion of gain between players. Both methods offer a bargaining solution to the duty-cycle MAC protocol under different axioms. As a result, given the two performance requirements (i.e., the maximum latency tolerated by the application and the initial energy budget of nodes), the proposed framework allows to set tunable system parameters to reach a fair equilibrium point that dually minimizes the system latency and energy consumption. For illustration, this formulation is applied to six state-of-the-art wireless sensor network (WSN) MAC protocols: B-MAC, X-MAC, RI-MAC, SMAC, DMAC, and LMAC. The article shows the effectiveness and scalability of such a framework in optimizing protocol parameters that achieve a fair energy-delay performance trade-off under the application requirements

A phase 1/2, open-label, multicenter study of isatuximab in combination with cemiplimab in patients with lymphoma

Patients with relapsed or refractory lymphoma have limited treatment options, requiring newer regimens. In this Phase 1/2 study (NCT03769181), we assessed the safety, efficacy, and pharmacokinetics of isatuximab (Isa, anti-CD38 antibody) in combination with cemiplimab (Cemi, anti-programmed death-1 [PD-1] receptor antibody; Isa + Cemi) in patients with classic Hodgkin lymphoma (cHL), diffuse large B-cell lymphoma (DLBCL), and peripheral T-cell lymphoma (PTCL). In Phase 1, we characterized the safety and tolerability of Isa + Cemi with planned dose de-escalation to determine the recommended Phase 2 dose (RP2D). Six patients in each cohort were treated with a starting dose of Isa + Cemi to determine the RP2D. In Phase 2, the primary endpoints were complete response in Cohort A1 (cHL anti-PD-1/programmed death-ligand 1 [PD-L1] naïve), and objective response rate in Cohorts A2 (cHL anti-PD-1/PD-L1 progressors), B (DLBCL), and C (PTCL). An interim analysis was performed when the first 18 (Cohort A1), 12 (Cohort A2), 17 (Cohort B), and 11 (Cohort C) patients in Phase 2 had been treated and followed up for 24 weeks. Isa + Cemi demonstrated a manageable safety profile with no new safety signals. No dose-limiting toxicities were observed at the starting dose; thus, the starting dose of each drug was confirmed as the RP2D. Based on the Lugano 2014 criteria, 55.6% (Cohort A1), 33.3% (Cohort A2), 5.9% (Cohort B), and 9.1% (Cohort C) of patients achieved a complete or partial response. Pharmacokinetic analyses suggested no effect of Cemi on Isa exposure. Modest clinical efficacy was observed in patients with cHL regardless of prior anti-PD-1/PD-L1 exposure. In DLBCL or PTCL cohorts, interim efficacy analysis results did not meet prespecified criteria to continue enrollment in Phase 2 Stage 2. Isa + Cemi did not have a synergistic effect in these patient populations

How to design graphs with low forwarding index and limited number of edges

International audienceThe (edge) forwarding index of a graph is the minimum, over all possible rout-ings of all the demands, of the maximum load of an edge. This metric is of a great interest since it captures the notion of global congestion in a precise way: the lesser the forwarding-index, the lesser the congestion. In this paper, we study the following design question: Given a number e of edges and a number n of vertices, what is the least congested graph that we can construct? and what forwarding-index can we achieve? Our problem has some distant similarities with the well-known (∆, D) problem, and we sometimes build upon results obtained on it. The goal of this paper is to study how to build graphs with low forwarding indices and to understand how the number of edges impacts the forwarding index. We answer here these questions for different families of graphs: general graphs, graphs with bounded degree, sparse graphs with a small number of edges by providing constructions, most of them asymptotically optimal. For instance, we provide an asymptotically optimal construction for (n, n + k) cubic graphs-its forwarding index is ∼ n 2 3k log 2 (k). Our results allow to understand how the forwarding-index drops when edges are added to a graph and also to determine what is the best (i.e least congested) structure with e edges. Doing so, we partially answer the practical problem that initially motivated our work: If an operator wants to power only e links of its network, in order to reduce the energy consumption (or wiring cost) of its networks, what should be those links and what performance can be expected