Determinación del efecto de la preparación y distribución de paladio soportado en Gamma Alúmina en una reacción de oxidación parcial de un alcohol

This work analyzes the effect of the time of impregnatingand previous state of the support in the distribution ofPd/ -Al O prepared by impregnation method varying 2 3time between 1 and 5 hours and considering twoprevious states (wet and dry). The characterization of thesupport and the catalysts and after using them in a PBRfor the partial oxidation of the Isopropanol to atemperature of 180°C and two time factors W/F (15 y 8 AOgcat/mol/h) was made by means of techniques like X-RayDiffraction (XRD), superficial area by BET method,Scanning Electron Microscopy (SEM), among others. Theproducts of the reaction were quantified by means of GasChromatography. Uniform and Egg shell distributionswere obtained, uniform catalysts activated by reductionand calcination were used.Se analizó el efecto del tiempo de impregnación y estadoprevio del soporte en la distribución del Pd/ -Al O 2 3preparado mediante la técnica de impregnaciónconsiderando dos tiempos (1 y 5 horas) y variando elestado previo (húmedo y seco). Se caracterizó el soportey los catalizadores antes y después de usarlos en unreactor de lecho empacado (PBR) para la oxidaciónparcial del Isopropanol a una temperatura de 180°C ydos factores de tiempo W/F (15 y 8 gcat/mol/h). Las AOtécnicas de caracterización usadas fueron Difracción deRayos X (XRD), área superficial por el método BET, yMicroscopía Electrónica de Barrido (SEM), entre otras.Los productos de la reacción fueron cuantificadosmediante Cromatografía de Gases. Se obtuvierondistribuciones uniforme y cáscara de huevo, se usaroncatalizadores uniformes activados por reducción ycalcinación

Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies

Background Genome-wide association studies (GWAS) in Parkinson's disease have increased the scope of biological knowledge about the disease over the past decade. We aimed to use the largest aggregate of GWAS data to identify novel risk loci and gain further insight into the causes of Parkinson's disease. Methods We did a meta-analysis of 17 datasets from Parkinson's disease GWAS available from European ancestry samples to nominate novel loci for disease risk. These datasets incorporated all available data. We then used these data to estimate heritable risk and develop predictive models of this heritability. We also used large gene expression and methylation resources to examine possible functional consequences as well as tissue, cell type, and biological pathway enrichments for the identified risk factors. Additionally, we examined shared genetic risk between Parkinson's disease and other phenotypes of interest via genetic correlations followed by Mendelian randomisation. Findings Between Oct 1, 2017, and Aug 9, 2018, we analysed 7·8 million single nucleotide polymorphisms in 37 688 cases, 18 618 UK Biobank proxy-cases (ie, individuals who do not have Parkinson's disease but have a first degree relative that does), and 1·4 million controls. We identified 90 independent genome-wide significant risk signals across 78 genomic regions, including 38 novel independent risk signals in 37 loci. These 90 variants explained 16–36% of the heritable risk of Parkinson's disease depending on prevalence. Integrating methylation and expression data within a Mendelian randomisation framework identified putatively associated genes at 70 risk signals underlying GWAS loci for follow-up functional studies. Tissue-specific expression enrichment analyses suggested Parkinson's disease loci were heavily brain-enriched, with specific neuronal cell types being implicated from single cell data. We found significant genetic correlations with brain volumes (false discovery rate-adjusted p=0·0035 for intracranial volume, p=0·024 for putamen volume), smoking status (p=0·024), and educational attainment (p=0·038). Mendelian randomisation between cognitive performance and Parkinson's disease risk showed a robust association (p=8·00 × 10−7). Interpretation These data provide the most comprehensive survey of genetic risk within Parkinson's disease to date, to the best of our knowledge, by revealing many additional Parkinson's disease risk loci, providing a biological context for these risk factors, and showing that a considerable genetic component of this disease remains unidentified. These associations derived from European ancestry datasets will need to be followed-up with more diverse data. Funding The National Institute on Aging at the National Institutes of Health (USA), The Michael J Fox Foundation, and The Parkinson's Foundation (see appendix for full list of funding sources)

Determinación del efecto de la preparación y distribución de paladio soportado en Gamma Alúmina en una reacción de oxidación parcial de un alcohol

This work analyzes the effect of the time of impregnatingand previous state of the support in the distribution ofPd/ -Al O prepared by impregnation method varying 2 3time between 1 and 5 hours and considering twoprevious states (wet and dry). The characterization of thesupport and the catalysts and after using them in a PBRfor the partial oxidation of the Isopropanol to atemperature of 180°C and two time factors W/F (15 y 8 AOgcat/mol/h) was made by means of techniques like X-RayDiffraction (XRD), superficial area by BET method,Scanning Electron Microscopy (SEM), among others. Theproducts of the reaction were quantified by means of GasChromatography. Uniform and Egg shell distributionswere obtained, uniform catalysts activated by reductionand calcination were used.Se analizó el efecto del tiempo de impregnación y estadoprevio del soporte en la distribución del Pd/ -Al O 2 3preparado mediante la técnica de impregnaciónconsiderando dos tiempos (1 y 5 horas) y variando elestado previo (húmedo y seco). Se caracterizó el soportey los catalizadores antes y después de usarlos en unreactor de lecho empacado (PBR) para la oxidaciónparcial del Isopropanol a una temperatura de 180°C ydos factores de tiempo W/F (15 y 8 gcat/mol/h). Las AOtécnicas de caracterización usadas fueron Difracción deRayos X (XRD), área superficial por el método BET, yMicroscopía Electrónica de Barrido (SEM), entre otras.Los productos de la reacción fueron cuantificadosmediante Cromatografía de Gases. Se obtuvierondistribuciones uniforme y cáscara de huevo, se usaroncatalizadores uniformes activados por reducción ycalcinación

Determinación del efecto de la preparación y distribución de paladio soportado en Gamma Alúmina en una reacción de oxidación parcial de un alcohol

This work analyzes the effect of the time of impregnatingand previous state of the support in the distribution ofPd/ -Al O prepared by impregnation method varying 2 3time between 1 and 5 hours and considering twoprevious states (wet and dry). The characterization of thesupport and the catalysts and after using them in a PBRfor the partial oxidation of the Isopropanol to atemperature of 180°C and two time factors W/F (15 y 8 AOgcat/mol/h) was made by means of techniques like X-RayDiffraction (XRD), superficial area by BET method,Scanning Electron Microscopy (SEM), among others. Theproducts of the reaction were quantified by means of GasChromatography. Uniform and Egg shell distributionswere obtained, uniform catalysts activated by reductionand calcination were used.Se analizó el efecto del tiempo de impregnación y estadoprevio del soporte en la distribución del Pd/ -Al O 2 3preparado mediante la técnica de impregnaciónconsiderando dos tiempos (1 y 5 horas) y variando elestado previo (húmedo y seco). Se caracterizó el soportey los catalizadores antes y después de usarlos en unreactor de lecho empacado (PBR) para la oxidaciónparcial del Isopropanol a una temperatura de 180°C ydos factores de tiempo W/F (15 y 8 gcat/mol/h). Las AOtécnicas de caracterización usadas fueron Difracción deRayos X (XRD), área superficial por el método BET, yMicroscopía Electrónica de Barrido (SEM), entre otras.Los productos de la reacción fueron cuantificadosmediante Cromatografía de Gases. Se obtuvierondistribuciones uniforme y cáscara de huevo, se usaroncatalizadores uniformes activados por reducción ycalcinación

Alirocumab and cardiovascular outcomes after acute coronary syndrome

BACKGROUN

Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome

BACKGROUN